Poster Session : PS 0316 ; Hematology : A Case of Pancytopenia

( Filipe Filipe ),( Joana Martins ),( Catarina Espirito Santo ),( Ligia Peixoto ),( Ines Vendrell ),( Helena Luna Pais ),( Alba Acabado ),( Paulo Cantiga Duarte ),( Jose Braz Nogueira ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Megaloblastosis represents a wide group of disorders sharing a common pathophysiological pathway, due to defi cient intake or absorption of Vitamin B12 and folic acid. Major causes for this condition include alcoholism, achlorhydria, pernicious anemia or gastrectomy and celiac disease. It leads to abnormal DNA replication, impaired protein synthesis and nuclear maturation. It presents with macrocytosis, hypersegmented neutrophils, and elevated Lactate dehydrogenase (LDH) levels. It is more prevalent in underdeveloped countries and older populations, having similar gender distribution. Authors present the case of a 69-year-old man, with a previous known history of essential thrombocytosis, medicated with hydroxyurea (with irregular adherence to treatment), congestive heart failure and chronic alcoholism. He was admitted at the emergency room (ER) with symptoms of confusion, slurred speech and fatigue for a week. He presented mucosal palor, fever (38. 1ºC), splenomegaly, and a left lateral maleolar ulcer with a purulent exsudate. Blood values revealed pancytopenia (macrocytic anemia Hb 4. 1 g/dL and MCV 123 fi); Leukocytes 1110x106/L; Platelet count 30. 000x106/L), acute renal failure (blood urea nitrogen 97 mg/dL; creatinine 2. 5 mg/ dL) LDH 1545 U/L. He underwent blood transfusions at the ER, without previous iron tests screening. On subsequent evaluation, authors found levels of Vitamin B12 of 172 pg/mL and folate 0. 9 nmol/L. Patient underwent a bone marrow aspiration with bone biopsy, compatible with megaloblastic anemia. An endoscopy was performed, with histological fi ndings suggestive of atrophic gastritis, with no H. pylori bacilli found. Additional tests such as anti-gastric parietal cells antibodies and anti-intrinsic factor antibodies, were negative. The patient was medicated with Vitamin B12 injections and folic acid, with good reticulocitary response. At discharge he presented, blood values of Hb 8. 7 g/dL; Leukocytes 7110x106/L; and platelet count of 862. 000x106/L. This represents a case of severe pancytopenia, enhancing the relevance of megaloblastosis as differential diagnosis for this entity.

Determinants of neoadjuvant chemotherapy use in muscle-invasive bladder cancer

Filipe LF. Carvalho,Alexander Zeymo,Jillian Egan,Colleen H. Kelly,Chaoyi Zheng,John H. Lynch,Jonathan Hwang,Lambros Stamatakis,Ross E. Krasnow,Keith J. Kowalczyk 대한비뇨의학회 2020 Investigative and Clinical Urology Vol.61 No.4

Purpose: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is standard of care for muscle-invasive bladder cancer (MIBC). However, NAC is used in less than 20% of patients with MIBC. Our goal is to investigate factors that contribute to underutilization NAC to facilitate more routine incorporation into clinical practice. Materials and Methods: We identified 5,915 patients diagnosed with cT2-T3N0M0 MIBC who underwent RC between 2004 and 2014 from the National Cancer Database. Univariate and multivariable models were created to identify variables associated with NAC utilization. Results: Only 18.8% of patients received NAC during the study period. On univariate analyses, NAC utilization was more likely at academic hospitals, US South and Midwest (p<0.05). Higher Charlson score was associated with decrease use of NAC (p<0.05). On multivariate analysis, treatment in academic hospitals (odds ratio [OR], 1.367; 95% confidence interval [CI], 1.186–1.576), in the Midwest (OR, 1.538; 95% CI, 1.268–1.977) and South (OR, 1.424; 95% CI, 1.139–1.781) were independently associated with NAC utilization. Older age (75 to 84 years old; OR, 0.532; 95% CI, 0.427–0.664) and higher Charlson score (OR, 0.607; 95% CI, 0.439–0.839) were associated with decreased NAC utilization. Sixty-eight percent of patients did not receive NAC because it was not planned and only 2.5% of patients had contraindications for NAC treatment. Conclusions: Our study demonstrates that NAC is underutilized. Decreased utilization of NAC was associated with older patients and higher Charlson score. This underutilization may be related to practice patterns as very few patients have true contraindications.

Assessing the Promise of CO₂-driven Li-air Batteries

( Filipe Marques Mota ),( Hye Ryung Byon ),김동하 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0

In recent years, an increasing number of perspectives have reflected the languished state of the Li-O₂ research field, and the need for a focus on exploratory works toward the development of energy storage devices with analogously high theoretical energy density. The incorporation of CO₂ up to 50% in Li-air cells in a TEGDME-based electrolyte was shown to result in a 1.9-fold increase in capacity. More interestingly, results also highlighted an analogous cyclability up to at least 30% of incorporated CO₂ upon comparison with conventional Li-O₂ cells (~400-500 h). The incorporation of CO₂ favors a preferable mechanistic pathway toward CO₄ - species with complete absence of Li₂O₂ formation, and increased electrolyte stability suggested by OEMS results and detailed product characterization. These O₂-assisted Li-CO₂ cells are presumed advantageous energy storage devices that may find its way to compete in an economical and environmental level with current Li-ion cells.

Thermolectric ZnO:Al,Ga thin films

Filipe CORREIA,Luis REBOUTA,Maria BENELMEKKI,Carlos TAVARES 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Mapping mechanistic pathways driven by the effect of a Br₃^-/Br₂ redox promoter in CO₂-assisted Li-O₂ Batteries

( Filipe Marques Mota ),변혜령,김동하 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1

Rechargeable Li-air cells operating under CO₂ or O₂/CO₂ offer alternative mechanistic pathways with analogously high theoretical energy density. The Li-O₂/CO₂ cell in tetraglyme electrolyte suffers from recharge potentials at ~4.5 V required for the decomposition of the main discharge product, Li₂CO₃. In this work we assess the promise of incorporating a Br₃^-/Br₂ redox promoter. Hindered overcharges (~0.5 V) driven by electrochemically-generated Br₂ are revealed to be a function of the LiBr concentration and the insulating Li₂CO₃ structure. Coupled electrochemical and spectroscopic analyses at progressive states-of-charge are proposed as a seminal methodology to dissect the underlying complexity of involved redox shuttling steps and evaluate the appropriateness of redox mediators beyond an overcharge decrease.

Automated identification of the modal parameters of a cable-stayed bridge: Influence of the wind conditions

Filipe Magalhães,Álvaro Cunha 국제구조공학회 2016 Smart Structures and Systems, An International Jou Vol.17 No.3

This paper was written in the context of a benchmark study promoted by The Hong Kong Polytechnic University using data samples collected in an instrumented cable-stayed bridge. The main goal of the benchmark test was to study the identification of the bridge modes of vibration under different wind conditions. In this contribution, the tools developed at ViBest/FEUP for automated data processing of setups collected by dynamic monitoring systems are presented and applied to the data made available in the context of the benchmark study. The applied tools are based on parametric output only modal identification methods combined with clustering algorithms. The obtained results demonstrate that the proposed algorithms succeeded to automatically identify the modes with relevant contribution for the bridge response under different wind conditions.

Plasmon and Upconversion Photoresponse in Decorated TiO₂ Inverse Opal Nanostructures with Enhanced Photoelectrochemical Water Splitting Performance

( Filipe Marques Mota ),( Ramireddy Boppella ),( Keiji Tanaka ),김동하 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-

To harvest low energy photons, we investigated a 3D composite photoanode integrating visible-responsive plasmonic Au nanoparticles and NIR-responsive upconversion nanocrystals (UCN) into 3D TiO₂ inverse-opals (Au/UCN/TiO₂) with extended solar energy utilization in the UV-vis-NIR range for photoelectrochemical (PEC) water splitting platforms. The NIR-responsive properties of NaYF₄:Yb³⁺ UCN nanocrystals doped with Er³⁺ or Tm³⁺ ions, and the effect of an alternating sequential introduction of UCN and Au were also investigated. Our Au/Er-UCN/TiO₂ hybrid revealed a 10-fold photocurrent density enhancement under UV-vis-NIR against the pristine TiO₂.

Assessing the effect of CO₂ in Li-O₂/CO₂ Batteries with Tetraglyme Electrolyte

( Filipe Marques Mota ),변혜령,김동하 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1

Reflecting the languished research state of Li-O₂, alternative devices operating under CO₂ or O₂/CO₂ with analogously high theoretical energy density have gained recent attraction. Here, we assess the effect of CO₂ within a 5 to 100% range in Li-O₂/CO₂. In the LiTFSI/tetraglyme electrolyte, the reaction mechanism is swiftly shifted toward the formation of Li₂CO₃ even at 5% CO₂. Conspicuous product and intermediate species identification and quantification are presented. Tuning the CO₂ content is shown to offer superior cyclability, deterred byproduct formation with enhanced electrolyte stability, and extended discharge capacity (1.5-fold), correlated with an induced stabilization of metastable CO₄^-/C₂O₆^2- intermediates in tetraglyme. These findings highlight the promise of a shift in the underlying mechanism of Li-air cells upon CO₂ incorporation on conventional O₂-based devices.

Optimal voice packet classification for enhanced VoIP over priority-enabled networks

Filipe Neves,Salviano Soares,Pedro A. Amado Assuncao 한국통신학회 2018 Journal of communications and networks Vol.20 No.6

This paper proposes a method for optimal classificationof voice packets to enhance the quality of voice communicationsover priority-enabled networks when poor transmission conditionsoccur. Either high or low priority is assigned to each packetaccording to the relevance of its payload (voice segment) for thevoice intelligibility. Then, in case of constrained networking conditions,by discarding first the voice packets of lower importance,the network always delivers those segments that most contributeto the perceptual quality. The proposed method is based on a dynamicprogramming optimisation algorithm that finds the optimalsubset of m high priority voice segments in each utterance of sizen > m. Such optimal subset minimizes the reconstruction distortionover all possible subsets with the same size m (i.e., the distortionincurred by a utterance reconstructed from only m segments). The simulation results show that the proposed method consistentlyachieves higher mean opinion scores (MOS) in comparisonwith non-selective packet drop under the same random networkloss conditions, yielding better quality of experience (QoE)for the same packet loss rates (PLR). The priority classification algorithmis independent from error concealment methods and distortionmetrics used in the optimisation process, which allows generalisationfor diverse communication networks and applications.

Automatic Tools of Match Analysis: Inspecting Soccer Team`s Dispersion

( Filipe Manuel Clemente ),( Micael Santos Couceiro ),( Fernando Manuel Lourenco Martins ),( Ajit Korgaokar ) 한국스포츠정책과학원(구 한국스포츠개발원) 2012 International Journal of Applied Sports Sciences Vol.24 No.2

The contracting-expanding soccer teams` relationship is one of the most important dynamic behaviors of the game. Therefore, a soccer game was analyzed using the centroid and stretch index method, while recording the team`s ball possession status (with or without ball possession). The correlation test suggest an inverse relationship between opposing teams (r (1508)=- 0.054) during all game. When considering ball possession by the teams, the results of the stretch index confirm that there are statistical differences with a small effect between the moments with and without possession of the ball for team B (F(1; 1506)=22.777; p-value≤0.001; =0.015; Power=0.998). Therefore, it was possible to confirm that the contracting -expanding relationship is an intrinsic behaviour of a soccer game in relation to ball possession.