Efficacy of and Patient Compliance with a Ketogenic Diet in Adults with Intractable Epilepsy: A Meta-Analysis

Fang Ye,Xiao-Jia Li,Wan-Lin Jiang,Hong-Bin Sun,Jie Liu 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.1

Background and Purpose Despite the successful use of a ketogenic diet in pediatric epilepsy, its application in adults has been limited. The aim of this meta-analysis was to summarize thefindings of relevant published studies in order to identify the efficacy of and compliance with aketogenic diet and its main subtypes (i.e., classic ketogenic diet and modified Atkins diet) inadults with intractable epilepsy, and to provide useful information for clinical practice. Methods Electronic searches of PubMed, EMBASE, Google Scholar, and the ISI Web of Science were conducted to identify studies of the efficacy of and patient compliance with a ketogenic diet in adults with intractable epilepsy; the included studies were reviewed. Meta-analyseswere performed using STATA to determine combined efficacy rates and combined rates of compliance with the ketogenic diet and its main subtypes. Results In total, 12 studies qualified for inclusion, and data from 270 patients were evaluated. The results of the meta-analysis revealed combined efficacy rates of all types of ketogenic diet,a classical ketogenic diet, and a modified Atkins diet were 42%, 52%, and 34%, respectively;the corresponding combined compliance rates were 45%, 38%, and 56%. Conclusions The results indicate that a ketogenic diet is a promising complementary therapyin adult intractable epilepsy, and that while a classical ketogenic diet may be more effective,adult patients are likely to be less compliant with it than with a modified Atkins diet.

Cross-layer Dynamic Subcarrier Allocation with Adaptive Service Rate Control in SC-FDMA System

( Fang Ye ),( Chunxia Su ),( Yibing Li ),( Xu Zhang ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.10

In this paper, an improved utility-based cross-layer dynamic subcarrier allocation (DSA) algorithm is proposed for single carrier frequency division multiple access (SC-FDMA) system, which adopts adaptive service rate control (ASRC) to eliminate the service rate waste and improve the spectral efficiency in heterogeneous network including non-real-time traffic and real-time traffic. In this algorithm, furthermore, a first in first out (FIFO) queuing model with finite space is established on the cross-layer scheduling framework. Simulation results indicate that by taking the service rate constraint as the necessary condition for optimality, the ASRC algorithm can effectively eliminate the service rate waste without compromising the scheduling performance. Moreover, the ASRC algorithm is able to further improve the quality of service (QoS) performance and transmission throughput by contributing an attractive performance trade-off between real-time and non-real-time applications.

MFSK Signal Individual Identification Algorithm Based on Bi-spectrum and Wavelet Analyses

( Fang Ye ),( Jie Chen ),( Yibing Li ),( Juan Ge ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.10

Signal individual reconnaissance and identification is an extremely important research topic in non-cooperative domains such as electronic countermeasures and intelligence reconnaissance. Facing the characteristics of the complexity and changeability of current communication environment, how to realize radiation source signal individual identification under the low SNR conditions is an emphasis of research. A novel emitter individual identification method combined bi-spectrum analysis with wavelet feature is presented in this paper. It makes a feature fusion of bi-spectrum slice characteristics and energy variance characteristics of the secondary wavelet transform coefficient to identify MFSK signals under the low SNR (signal-to-noise ratios) environment. Theoretical analyses and computer simulation results show that the proposed algorithm has good recognition performance with the ability to suppress noise and interference, and reaches the recognition rate of more than 90% when the SNR is -6dB.

Hybrid-clustering game Algorithm for Resource Allocation in Macro-Femto HetNet

( Fang Ye ),( Jing Dai ),( Yibing Li ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4

The heterogeneous network (HetNet) has been one of the key technologies in Long Term Evolution-Advanced (LTE-A) with growing capacity and coverage demands. However, the introduction of femtocells has brought serious co-layer interference and cross-layer interference, which has been a major factor affecting system throughput. It is generally acknowledged that the resource allocation has significant impact on suppressing interference and improving the system performance. In this paper, we propose a hybrid-clustering algorithm based on the Matern hard-core process (MHP) to restrain two kinds of co-channel interference in the HetNet. As the impracticality of the hexagonal grid model and the homogeneous Poisson point process model whose points distribute completely randomly to establish the system model. The HetNet model based on the MHP is adopted to satisfy the negative correlation distribution of base stations in this paper. Base on the system model, the spectrum sharing problem with restricted spectrum resources is further analyzed. On the basis of location information and the interference relation of base stations, a hybrid clustering method, which takes into accounts the fairness of two types of base stations is firstly proposed. Then, auction mechanism is discussed to achieve the spectrum sharing inside each cluster, avoiding the spectrum resource waste. Through combining the clustering theory and auction mechanism, the proposed novel algorithm can be applied to restrain the cross-layer interference and co-layer interference of HetNet, which has a high density of base stations. Simulation results show that spectral efficiency and system throughput increase to a certain degree.

Comparative Genomic Analysis Reveals That the 20K and 38K Prophages in Listeria monocytogenes Serovar 4a Strains Lm850658 and M7 Contribute to Genetic Diversity but Not to Virulence

( Chun Fang ),( Tong Cao ),( Ying Shan ),( Ye Xia ),( Yong Ping Xin ),( Chang Yong Cheng ),( Houhui Song ),( John Bowman ),( Xiao Liang Li ),( Xiang Yang Zhou ),( Wei Huan Fang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1

Listeria monocytogenes is a foodborne pathogen of considerable genetic diversity with varying pathogenicity. Initially, we found that the strain M7 was far less pathogenic than the strain Lm850658 though both are serovar 4a strains belonging to the lineage III. Comparative genomic approaches were then attempted to decipher the genetic basis that might govern the strain-dependent pathotypes. There are 2,761 coding sequences of 100% nucleotide identity between the two strains, accounting for 95.7% of the total genes in Lm850658 and 92.7% in M7. Lm850658 contains 33 specific genes, including a novel 20K prophage whereas strain M7 has 130 specific genes, including two large prophages (38K and 44K). To examine the roles of these specific prophages in pathogenicity, the 20K and 38K prophages were deleted from their respective strains. There were virtually no differences of pathogenicity between the deletion mutants and their parent strains, although some putative virulent factors like VirB4 are present in the 20K region or holin-lysin in the 38K region. In silico PCR analysis of 29 listeria genomes show that only strain SLCC2540 has the same 18 bp integration hotspot as Lm850658, whereas the sequence identity of their 20K prophages is very low (21.3%). The 38K and 44K prophages are located in two other different hotspots and are conserved in low virulent strains M7, HCC23, and L99. In conclusion, the 20K and 38K prophages of L. monocytogenes serovar 4a strains Lm850658 and M7 are not related to virulence but contribute to genetic diversity.

중국인 학습자를 위한 한국어 맞춤법 교육 방안 연구 : TOPIK 쓰기 결과물에 나타난 오류를 중심으로

방야(Fang Ye),박덕유(Park deokyu) 학습자중심교과교육학회 2022 학습자중심교과교육연구 Vol.22 No.3

목적 본 연구는 중국인 학습자가 TOPIK Ⅱ 쓰기의 결과물에 나타난 맞춤법 오류를 바탕으로 오류 발생 원인을 분석하여 중국인 학습자가 맞춤법을 올바르게 사용할 수 있도록 교수⋅학습 모형을 제시하는 데에 있다. 방법 <한글 맞춤법> 규정 및 TOPIK Ⅱ 쓰기 중 맞춤법의 채점 기준에 따라 TOPIK 쓰기에서 나타난 맞춤법 오류를 유형화하고, 공개된 한국어능력시험 답안지에서 중국인 학습자가 TOPIK Ⅱ 쓰기 영역의 작문형 문항에서 나타난 맞춤법 오류 사례를 추출하고 학습자가 흔히 범하는 맞춤법 오류 원인을 결합한 읽기 활동과 쓰기 맞춤법 교육 방안을 제시하였다. 결과 중국인 학습자가 TOPIK 쓰기 수행에서 한글 철자, 문법, 어휘, 띄어쓰기 등의 정확히 사용하는 데 어려움을 겪고 있다. 이를 해결하기 위해 한국어와 중국어 맞춤법 체계의 차이, 문법 지식 및 문어체 표현에 대한 인식의 결핍, <한글 맞춤법> 인지 미숙 등의 원인을 고려하여 읽기 및 쓰기 활동을 통합한 맞춤법 교수⋅학습 모형을 기반으로 학습자가 스스로 맞춤법 오류 문제를 해결하도록 기술하였다. 결론 맞춤법은 쓰기 영역에서 가장 중요하다. TOPIK Ⅱ 쓰기 영역의 작문형 문항에서 한글 맞춤법 오류를 줄이기 위해 읽기와 쓰기 활동을 통합한 ‘도입→제시→탐구⋅토의→연습→평가’ 단계의 맞춤법 교수⋅학습 모형을 제안하였다. Objectives The purpose of this study is designed to present an effective teaching and learning model to illustrate how Chinese learners can correctly use spelling by analyzing the causes of errors based on spelling errors shown in the results of TOPIK II writing. Methods According to the Korean spelling regulations and the grading criteria of spelling in TOPIK II writing, the spelling errors in TOPIK II writing field were extracted from the open Korean proficiency test answer sheet, and a reading and writing education plan was presented. Results In writing activities, Chinese learners have difficulties using Korean spelling correctly, such as Korean spelling, grammar, vocabulary, and spacing. To solve this problem, this study explains how learners solve their own spelling problems based on a spelling learning model that incorporates reading and writing activities by considering the lack of knowledge of Korean spelling and causes such as Chinese interference and spoken environment. Conclusions Spelling is the most important aspect of writing. To reduce Korean spelling errors in the writing-type questions of TOPIK II, this study proposes a spelling teaching and learning model for the “Introduction → Presentation → Exploration⋅Discussion → Writing → Evaluation” phase, which incorporates reading and writing activities.

칭찬 및 칭찬 반응의 담화 전략에 관한 연구 : 한·중 리얼리티 쇼 프로그램의 칭찬 화행을 중심으로

방야 ( Fang Ye ),박덕유 ( Park Deok-yu ) 인하대학교 교육연구소 2023 교육문화연구 Vol.29 No.4

본고의 목적은 한·중국어의 칭찬 화행에서의 담화 전략을 비교함으로써 칭찬 화행에 적용될 수 있는 담화 전략을 분석하는 데 있다. 중국인 학습자는 한국어의 언어문화를 이해하고 사회언어학적 변인을 고려하면서 칭찬 화행을 수행하는 데 어려움을 겪고 있다. 이러한 어려움을 해결하기 위해 본고에서는 한국의 칭찬 화행에서 선호하는 발화전략을 예측할 수 있다는 가설에서 출발해 실제 구어 담화 상황과 가까운 리얼리티 쇼 프로그램에서 나타난 칭찬화행을 분석하고, 칭찬 전략별의 빈도 차이를 비교함으로써 한·중국어에서 나타나는 칭찬 화행의 공통점과 차이점을 확인하였고, 이를 바탕으로 한국인 모어 화자가 즐겨 사용하는 칭찬 화행의 양상을 분석해 중국인 학습자가 적용할 수 있는 의사소통 전략 및 문법 전략을 기술하였다. The purpose of this paper is to analyze the discourse strategies and principles that can be applied to praise speech by comparing the discourse strategies in Korean and Chinese praise speech. Chinese learners face difficulties in understanding Korean language culture and producing complimenting speech acts while considering sociolinguistic factors. In order to solve these difficulties, starting from the hypothesis that Korean linguistic culture can predict preferred strategies, this paper analyzes complimenting speech acts in reality show programs that are close to actual spoken discourse situations and compares the frequency differences of complimenting strategies to identify similarities and differences in complimenting speech acts in the two languages. Based on these findings, we analyzed the aspects of complimenting speech patterns used by Korean mother tongue speakers and described discourse strategies and grammar strategies that can be applied by Chinese learners.

The Research and Implementation of Temporal Quasi-order Data Index

Xiuqin Deng,Hongyan Xing,Chengyan Fang,Xiaoping Ye 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

This study proposed a quasi-order-based temporal data structure (QOTDS) which differed from conventional, algebraic data management models. Based on this QOTDS, a temporal data index called the temporal quasi-order index (TQOindex) was established. Firstly, the study proposed the concepts of temporal quasi-order (TQO) and linear order partitioning (LOP) of time period sets and discussed the construction algorithm of LOP and the optimum (minimum) properties. On this basis, a temporal data structure was established based on LOP. This structure realized the set-at-a-time data operation-like relational data structure and improved the inquiry efficiency by using multiple threads. Subsequently, in the structural framework of TQO, we discussed the temporal data index (TQOindex) based on quasi-order extensions. This index was effectively applicable to various conventional database platforms depending on the disk (external memory)-based data management and also to big data dynamic index technology relying on the incremental updating mechanism. Finally, a corresponding experimental simulation and comparative evaluation were designed to verify the feasibility and effectiveness of TQOindex. Research and experiments showed that QOTDS were effective at temporal inquiry and management in cases involving the temporal processing and integration mechanisms in new data, such as semantic data, XML data, and moving object data.

Butyrolactones Derivatives from the Fermentation Products of an Endophytic Fungus Aspergillus versicolor

Ye, Yan-Qing,Xia, Cong-Fang,Yang, Juan-Xia,Yang, Yu-Chun,Qin, Ying,Gao, Xue-Mei,Du, Gang,Li, Xue-Mei,Hu, Qiu-Fen Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

Two new butyrolactones, asperphenol A (1) and B (2), together with four known butyrolactones (3-6) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1-6 were also tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 2 exhibited high anti-TMV activity with inhibition rate of 46.7%. The other compounds also exhibited potential anti-TMV activities with inhibition rates in the range of 21.8-28.4%.

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Colon Cancer Risk: a Meta-analysis

Fang, Xin-Yu,Xu, Wang-Dong,Huang, Qian,Yang, Xiao-Ke,Liu, Yan-Yan,Leng, Rui-Xue,Pan, Hai-Feng,Ye, Dong-Qing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Previous studies investigating the association between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and colon cancer risk have generated conflicting results. The aim of our meta-analysis was to clarify the precise association. A systematic literature search was conducted to identify all relevant studies. Pooled odds ratio (ORs) with 95% confidence interval (CI) were used to estimate the strength of the association. In this meta-analysis, a total of 13 articles, involving 5,386 cases and 8,017 controls met the inclusion criteria. Overall, a significant association was found between colon cancer risk and the MTHFR C667 polymorphism (TT vs CC+CT: OR=0.79; 95%CI=0.65-0.96; p=0.017). Stratification by ethnicity revealed that MTHFRC667 was associated with colon cancer risk in the non-Asian group (TT vs CC+CT:OR=0.77, 95%CI=0.68-0.89, p=0.000; TT vs CC: OR=0.84, 95%CI=0.73-0.97, p=0.016). Stratification by source of control indicated that MTHFR C667 also correlated with colon cancer risk in the population-based subgroup (TT vs CC: OR=0.85, 95%CI=0.74-0.97, p=0.017; TT vs CC+CT: OR=0.78, 95%CI=0.68-0.89, p=0.000) and hospital-based subgroup (TT vs CC+CT: OR=0.65, 95%CI=0.49-0.86, p=0.003). However, risk was significantly increased for MTHFR A1298C polymorphisms and colon cancer risk in hospital-based studies (C vs A: OR=1.52, 95%CI=1.26-1.83, p=0.000; CC+AC vs AA: OR=1.93, 95%CI=1.47-2.49, p=0.000) but reduced in population-based studies (CC vs AA: OR=0.83, 95%CI=0.70-0.99, p=0.042). In conclusion, the results of our meta-analysis suggest that the MTHFR C667 polymorphism is associated with reduced colon cancer risk, especially for non-Asian populations.