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Meta-analysis of Gene Expression Data Identifies Causal Genes for Prostate Cancer
Wang, Xiang-Yang,Hao, Jian-Wei,Zhou, Rui-Jin,Zhang, Xiang-Sheng,Yan, Tian-Zhong,Ding, De-Gang,Shan, Lei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Prostate cancer is a leading cause of death in male populations across the globe. With the advent of gene expression arrays, many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biologic mechanisms of prostate cancer, we conducted a meta-analysis of two studies on prostate cancer. Eight key genes were identified to be differentially expressed with progression. After gene co-expression analysis based on data from the GEO database, we obtained a co-expressed gene list which included 725 genes. Gene Ontology analysis revealed that these genes are involved in actin filament-based processes, locomotion and cell morphogenesis. Further analysis of the gene list should provide important clues for developing new prognostic markers and therapeutic targets.
Zhou, Shao-Bing,Liu, Yang-Chen,Yin, Xiao-Xiang,Ding, Wen-Xiu,Guo, Xin-Wei,Gu, Liang,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Objective: To evaluate the efficacy and adverse effects of three dimensional conformal radiotherapy (3D-CRT) with tamoxifen in treating patients with postoperative malignant glioma. Patients and Methods: 60 patients of postoperative malignant glioma were randomly assigned into two groups, 30 patients were treated with 3D-CRT plus tamoxifen (treatment group), and the other 30 patients with 3D-CRT plus temozolomide (control group). All patients were radiated by 6MV X-ray, 2.0Gy per fraction, once daily, with a total dose (DT) of 56~60Gy. Tamoxifen was delivered at $60mg/m^2/d$, temozolomide was given at $75mg/m^2/d$. All patients were treated with concurrent radiotherapy. Results: One, 2, 3 year survival rates of treatment and control group were 63.3%, 30.0%, 23.0% and 70.0%, 33.3%, 26.7%, respectively (${\chi}^2=0.01$, 0.23, 0.09, P>0.05). The rate of thromboembolism in treatment group was 6.7%. Conclusion: Therapeutic efficacy of two groups was similar, but it was more cost-effective in treatment group, and toxicity did not increase.
Yang Zhou,Chong Zhu,Shenying Xu,Bin Xiang,Riadh Marzouki 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.102 No.-
The anti-corrosion ability of Syzygium samarangense leaf extract (SSLE) was studied using electrochemicalways, topography research and theoretical calculations. The results of electrochemical tests indicatedthat SSLE can effectually control the Q235 steel corrosion in sulfuric acid environment. When the concentrationof SSLE was 400 mg/L, its anti-corrosion ability can be close to 90%. SSLE can efficaciously restrictthe cathodic and anodic reactions, and can still emerge high corrosion inhibition character at a certaintemperatures scope. The surface morphology test shows that the Q235 steel becomes smooth and brightafter adding SSLE. Theoretical calculation data indicated that SSLE can manifest high corrosion inhibitionperformance. The adsorption of SSLE at the solution/surfaces of steel accords with the Langmuir adsorptionmodel.
Liu, Yang-Chen,Zhou, Shao-Bing,Gao, Fei,Ye, Hong-Xun,Zhao, Ying,Yi, Xiao-Xiang,Huang, Xin-En,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Objective: To compare the efficacy and complications of chemotherapy and late course three-dimensional conformal radiotherapy (3DCRT) in treating patients with stage III non-small cell lung cancer (NSCLC). Patients and Methods: All patients were divided into two groups: to receive chemotherapy and late course 3DCRT (3DCRT group), or chemotherapy and conventional fraction radiation (control group). In the 3DCRT-group, patients were given 6~15 MV X-rays with a total dose of 40 Gy, followed by 3DCRT, 2.5 Gy~3.0 Gy per fraction, 1 fraction/every day, total 68 Gy~70 Gy; in the control group, with conventional fraction radiation the total dose was 64~66 Gy. The chemotherapy regimen in both cases was EP (VP-16 and DDP). Results: Sixty four patients with stage III NSCLC were divided into two groups: 32 patients into 3DCRT, 32 into the control group. One and 2-year survival rates in 3DCRT and control group were 87.5%, 56.3%mad 65.6%, 34.4%, respectively (P<0.05); local control rates were 90.6%, 81.3% and 65.6%, 53.1%, respectively (P<0.05). Conclusion: Chemotherapy and late course 3DCRT is associated with improved survival rate in patients with stage III NSCLC with good tolerability.
Active current-limiting control to handle DC line fault of overhead DC grid
MENG Zhou,WANG Xiang,WENPING Zuo,WEIXING Lin,JINYU Wen,RUIZHANG Yang,BINYE Ni,XIAOJUN Lu 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
To handle with the DC line faults in a DC grid, this paper proposed an active current-limiting controller for hybrid MMC. With this active current-limiting control strategy, the requirement of interruption current of DCCB will be significantly decreased, and the investment of DC grid will be reduced obviously. Firstly, the control architecture of active current-limiting controller is disclosed. To avoid the overvoltage of submodule capacitors during DC fault, a dynamic limiter for the reference value of the DC current controller is proposed. To decrease the peak of fault current, the feedforward controller of DC voltage is put forward. The decoupling controllability of the AC/DC voltage of hybrid MMC is disclosed. The currentlimiting mechanism of the active current-limiting controller is analysis. Then, the validity of the active current-limiting control strategy is verified by RTDS.
Zhu Xiang,Na Xin,Zeng Yueqin,Xu Yangantai,Chai Dongya,Yang Huanzhi,Miao Jingqian,Zhang Yuan,Yang Fenghua,Wang Yuehu,Zhou Yiping 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3
Background Polyphyllin I (PPI), a steroidal saponin, exhibits antitumor activity and chemosensitization effect for a broad spectrum of cancer cells, however, its toxicity and chemosensitization effect in vivo is still unknown. Objective We investigated PPI’s cytotoxic activity, toxicity and chemosensitization effect and in vitro and in vivo . Results The IC 50 values of PPI on MCF-7, H22, and S180 tumor cells were 4.37 μmol/L, 1.71 μmol/L, and 0.92 μmol/L, respectively. The LD 50 of PPI was found to be 47.9 mg/kg using ip. injection. PPI at concentrations of 0.3 mg/kg, 0.6 mg/ kg, 1.2 mg/kg, and 2.4 mg/kg (1/80 LD 50 –1/20 LD 50 ) were synergized with DOX of 0.5 mg/kg to inhibit the H22 and S180 tumor growth in vivo by inducing apoptosis without obvious immunotoxicity. PPI exhibited a remarkable hemolytic effect on rabbit erythrocytes (EC 50 = 4.3 μM), while it had no impact in mice. Conclusion Our study revealed that the PPI-sensitized chemotherapeutic effect, when used in safe doses, circumvents immunotoxic side effects of DOX in vivo; thus, helping future clinical research.
Liu, Yang-Chen,Zhou, Shao-Bing,Gao, Fei,Yin, Xiao-Xiang,Zhao, Ying,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Purpose: To evaluate the efficacy of conservative surgery plus chemo-, radio-therapy in treating patients with early stage breast cancer. Patients and Methods: Eligible patients were treated by postoperative chemotherapy as well as whole-breast irradiation with tumor bed boost. Postoperative radiotherapy consisted of 6 MV whole breast linear accelerator irradiation with two tangential half fields to a total dose of 45~50 Gy, followed by $10{\sim}15MeV{\beta}$ boost irradiation to tumor bed for 10~20Gy, total dose 56~66Gy. Results: Fifty-two patients were enrolled. Overall 1-, 2- and 3 year survival rates were 98.1%, 92.3%, and 90.4%, respectively, with a local recurrence rate of 5.77%. Cosmetic results were evaluated as good by doctors in 90.4% of patients. Conclusions: Breast conservative surgery combined with chemo- radio-therapy could be a treatment option for Chinese patients with early stage breast cancer.
Yumeng Yang,Jianzhong Liu,Xiang He,Zhihua Wang,Junhu Zhou,Kefa Cen 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.4
Same amounts of moisture were removed from Ximeng lignite (XL) with different particle size ranges pretreated at different drying temperatures. The effect of conventional drying on the grindability of the XLs was investigated. Increasing the drying temperature improved the grindability of all the samples. The results of scanning electron microscopy and mercury intrusion porosimetry revealed that the dominant mechanism enhancing the grindability of XL with high moisture was the pore structure destruction induced by the steam jet flow generated with the removal of moisture. Especially, the development of large fractures had a strong connection with the change in the grindability. According to the pore size distribution, the internal structure of the 2.5-4.0mm coal samples did not develop well under high drying temperature because of the exceedingly short heating time. Therefore, coal particle size, drying temperature, and heating time must be coordinated well to achieve the enhanced drying effect. The grindability of XL had a negative linear correlation with the pore volume fractal dimension, revealing the possibility of fractal dimension for the analysis of lignite grindability.
( Jun Pei Zhou ),( Qian Wu ),( Rui Zhang ),( Yu Ying Yang ),( Xiang Hua Tang ),( Jun Jun Li ),( Jun Mei Ding ),( Yan Yan Dong ),( Zun Xi Huang ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.6
This paper reports the production and characterization of crude xylanase from the newly isolated Humicola sp. Ly01. The highest (41.8 U/ml) production of the crude xylanase was obtained under the optimized conditions (w/v): 0.5% wheat bran, 0.2% KH2PO4, and 0.5% peptone; initial pH 7.0; incubation time 72 h; 30℃; and 150 rpm. A considerable amount of the crude xylanase was induced using hulless barley bran or soybean meal as the carbon source, but a small amount of the enzyme was produced when supplementary urea was used as the nitrogen source to wheat bran. The crude xylanase showed apparent optimal cellulase-free xylanase activity at 60℃ and pH 6.0, more than 71.8% of the maximum xylanase activity in 3.0-30.0% (v/v) ethanol and more than 82.3% of the initial xylanase activity after incubation in 3.0-30.0% (v/v) ethanol at 30℃ for 2 h. The crude xylanase was moderately resistant to both acid and neutral protease digestion, and released 7.9 and 10.9 μmol/ml reducing sugar from xylan in the simulated gastric and intestinal fluids, respectively. The xylooligosaccharides were the main products of the hydrolysis of xylan by the crude xylanase. These properties suggested the potential of the crude enzyme for being applied in the animal feed industry, xylooligosaccharides production, and high-alcohol conditions such as ethanol production and brewing.
Li, Jie,Yang, Chun-Xu,Mei, Zi-Jie,Chen, Jing,Zhang, Shi-Min,Sun, Shao-Xing,Zhou, Fu-Xiang,Zhou, Yun-Feng,Xie, Cong-Hua Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Cancer patients often suffer from local tumor recurrence after radiation therapy. Cell cycling, an intricate sequence of events which guarantees high genomic fidelity, has been suggested to affect DNA damage responses and eventual radioresistant characteristics of cancer cells. Here, we established a radioresistant lung cancer cell line, A549R, by exposing the parental A549 cells to repeated ${\gamma}$-ray irradiation with a total dose of 60 Gy. The radiosensitivity of A549 and A549R was confirmed using colony formation assays. We then focused on examination of the cell cycle distribution between A549 and A549R and found that the proportion of cells in the radioresistant S phase increased, whereas that in the radiosensitive G1 phase decreased. When A549 and A549R cells were exposed to 4 Gy irradiation the total differences in cell cycle redistribution suggested that G2-M cell cycle arrest plays a predominant role in mediating radioresistance. In order to further explore the possible mechanisms behind the cell cycle related radioresistance, we examined the expression of Cdc25 proteins which orchestrate cell cycle transitions. The results showed that expression of Cdc25c increased accompanied by the decrease of Cdc25a and we proposed that the quantity of Cdc25c, rather than activated Cdc25c or Cdc25a, determines the radioresistance of cells.