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Mycoplasma pneumoniae 肺炎의 臨床的 考察
孫槿贊,金順華,辛宗燦,李明益,鄭京恩 대한감염학회 1987 감염 Vol.19 No.1
A clinical study was made on 53 cases of mycoplasma pneumoniae pneumonia during the period of 2 years from July '84 to June '86. Those pneumonia patients were composed of 30 in-patients and 23 out-patients. 1) The high incidence was in the age of 3 to 6 years and female was more dominant over male patients in the ratio of 1.8:1. 2) Mean duration of hospitalization was 11.7 days in admitted patients. 3) Seasonal distribution showed increased incidence in autumn. 37 cases(69.8% of all patients) occurred from September to November. 4) Cough was the most common chief complaint(47 cases, 88.7%) and then followed by fever, dyspnea and convulsion. 5) Cough was the most common symptom and noted in all cases and then followed by fever(28 cases), sputum expectoration(16 cases) and chest pain etc. 6) The cases in which duration of coughing was more than 7 days on initial visit were 37 cases (68%) out of 50 cases. 7) Moist rales was the most common auscultatory finding of chest (37 cases, 69.8%) and then followed by wheezing (14 cases) and coarse breathing sound etc. 8) Leukocyte counts in peripheral blood were the most common in the range of 5,001-10,000/mm³(36 cases,67.9%) and then followed by 10,001-15,000/mm³(12 cases). 9) Neutrophil percentage in peripheral blood smear was the most common in the range of 61-70% (13 cases, 24.6%) and then followed by 51-60% (11 cases, 20.8%) etc. 10) The cases having more than 5% of eosinophiles in peripheral blood differential counts were 14 cases (26.4%) out of all cases. 11) Positive CRP cases were 14 cases(58.3%) out of 24 studied cases. 12) The cases in which ESR was higher than 10 mm/hr were 31 cases (71.7%) out of 49 studied cases and mean ESR value was 20.8 mm/hr. 13) Radiologic findings of pulmonary infiltration were the most common in Rt. lower lobe and perihilar region 19 cases (35.9%) in each, and then followed by left lower lung field 14 cases. 14) The cases which was improved within 7 days on chest radiography after adequate erythromycin treatment were 22 cases out of 34 cases. 15) Complications or associated findings were elevated serum transaminase (5 cases), skin rashes (5 cases), paranasal sinusitis (4 cases) and asthma attack (3 cases). 16) The cases treated initially with other than erythromycin were 38 cases (71.7%). 17) The cases in which indirect hemmagglutination test titer for mycoplasmal antibody was 1:40 or higher were 25 cases (75.9%) out of 29 cases.
Enhancement of Murine NK cell Activity in vitro by Red Ginseng Acidic Polysaccharide
Choi, Hye-Sook,Sohn, Eun-Wha,Rhee, Dong-Kwon,Pyo, Suh-Kneung The Korean Society of Ginseng 2009 Journal of Ginseng Research Vol.33 No.4
본 논문은 홍삼 산성 다당류 (RGAP)의 생체외 쥣과 NK 세포 활성 향상에 대한 내용으로 주요 내용은 다음과 같다. RGAP는 Yac-1 종양 세포에서 NK 세포 활성을 향상시켰다. 비장 세포에 16시간 동안 RGAP 10 및 $100{\mu}g$/ml을 처리한 결과, NK 활성이 239와 250% 증가 하였다. 인터페론 (IFN)-$\gamma$ 생성은 17-125% 증가하였고, 종양 괴사 인자 (TNF)-${\alpha}$ 생성도 15-100% 증가 하였다. NK 세포의 세포 독성 증가는 NK 세포가 생성하는 이 두 시토카인 증가가 원인이다. 따라서 RGAP는 NK 세포에 미치는 면역증진 효과가 있다는 내용이다. The in-vitro immunomodulatory function of the activity of murine natural-killer (NK) cells induced by redginseng acidic polysaccharide (RGAP) was examined. RGAP induced the significant enhancement of NK cell activity against the Yac-1 tumor cells. The treatment of splenocytes cultured with RGAP for 16 h resulted in a significant increase in NK activity at the E:T ratio of 100:1, and in a 239 and 250% increase at 10 and $100{\mu}g$/ml, respectively. We also demonstrate that RGAP treatment increased the production of interferon (IFN)-$\gamma$ (17-125%) and tumor necrosis factor (TNF)-${\alpha}$ (15-100%), suggesting that the increase in NK cell cytotoxicity could be due to the enhancement of the NK cell production of both cytokines. In addition, RGAP had a stimulating effect on lymphocyte proliferation in the presence of mitogens. Overall, these results suggest that RGAP has an immunopotentiating effect on NK cells, which can support the development of clinical studies on RGAP.
Mutations of ACADS Gene Associated with Short-Chain Acyl-Coenzyme A Dehydrogenase Deficiency.
Kim, Se Hwa,Park, Hyung-Doo,Sohn, Young Bae,Park, Sung Won,Cho, Sung Yoon,Ji, Suntae,Kim, Su Jin,Choi, Eun Wha,Kim, Chi Hwa,Ko, Ah-Ra,Yeau, Sunghee,Paik, Kyung-Hoon,Jin, Dong-Kyu Institute for Clinical Science] 2011 Annals of clinical and laboratory science Vol.41 No.1
<P>Short-chain acyl-coenzyme A dehydrogenase deficiency (SCADD) is an autosomal recessive disorder of mitochondrial fatty acid oxidation associated with mutations in the ACADS gene (Acyl-CoA Dehydrogenase, Short-chain, OMIM #606885). SCADD is a heterogeneous condition that has been associated with various clinical phenotypes ranging from fetal metabolic decompensation in infancy to asymptomatic individuals. Here, the first Korean neonate diagnosed with SCADD by biochemical and genetic findings is reported. The patient has remained asymptomatic by avoiding hypoglycemia. An increased concentration of butylcarnitine was detected on newborn screening. Subsequent urine organic acid analysis showed increased urinary excretion of ethylmalonic acid. To confirm the presence of the genetic abnormality, all the coding exons of the ACADS gene and flanking introns were amplified by the polymerase chain reaction (PCR). Sequence analysis of the ACADS gene revealed novel homozygous missence mutations, c. 1031A>G (p.E344G) in exon 9. In summary, the first Korean patient with confirmed SCADD by genetic analysis is reported with novel mutation.</P>
난소절제 쥐에서 칼슘섭취수준에 따른 망간의 보충이 골격상태 빛 칼슘평형에 미치는 영향
배윤정(Bae Yun-Jung),손은화(Sohn Eun-Wha),김병철(Kim Byung-Chul),서동완(Seo Dong-Wan),김미현(Kim Mi-Hyun) 韓國營養學會 2008 Journal of Nutrition and Health Vol.41 No.3
The purpose of this study was to investigate the effect of manganese (Mn) supplementation on bone status and calcium balance in ovariectomized rats according to the calcium intake levels. Total of 50 Sprague Dawley female rats (6 weeks) were divided into 5 groups and bred for 12 weeks: sham operated control group (SACa), OVX Ca deficiency group (OLCa) with Ca deficiency diet (0.1% Ca modified AIN-93N diet), OVX Ca deficiency & Mn supplement group (OLCaMn), OVX adequate Ca group (OACa; 0.5% Ca AIN-93N diet) and OVX adequate Ca & Mn supplement group (OACaMn). BMD (bone mineral density) of the femur was increased by Mn supplementation in OVX adequate Ca group. However, BMDs of spine, femur and tibia were lowered in OLCa compared to the OLCaMn group. Bone strength of tibia in OLCaMn group was significantly lower than OLCa group. Serum ALP (alkaline phos-phatase) and CTx (C-telopeptide of collagen cross-links) levels were significantly higher in ovariectomized rats than those in the sham group, but they were not changed by Mn supplementation. Ca retention rate and Ca absorption rate did not differ among the experimental groups. Urinary Ca excretion was increased by Mn supplementation in Ca deficiency rats. In summary, Mn supplementation resulted in positive effects on bone mineral density ovariectomized rats with which intake adequate Ca. However, Mn supplementation on Ca deficiency ovariectomized rats resulted in decrement of BMD and bone strength by increasing Ca excretion. Therefore, it is encouraged to consider calcium in-take levels in supplementation of manganese in order to prevent postmenopausal osteoporosis and to keep bone healthy. (Korean J Nutr2008; 41(3): 206~215)
Lee, Hye-Rim,Do, Hang,Lee, Sung-Ryul,Sohn, Eun-Soo,Pyo, Suhk-Neung,Son, Eun-Wha The Korean Society of Food Science and Nutrition 2007 Preventive Nutrition and Food Science Vol.12 No.2
Fucoidan, that is high-molecular-weight sulfated polysaccharides extracted from brown seaweeds has been shown to elicit various biological activities. Here, we investigated the effects of fucoidan on cell proliferation and nitric oxide (NO) production in neuronal blastoma cell (SH-SY5Y). In the present study, we demonstrated that fucoidan treatment resulted in increase of cell proliferation and NO production. When cells were treated with amyloid-${\beta}$ (A${\beta}$) in the absence or presence of fucoidan, fucoidan recovered the cell viability decreased by A${\beta}$ peptides. To further determine whether nitric oxide synthase (NOS) is involved in proliferative effect of fucoidan, cells were treated with NOS inhibitors in the absence or presence of fucoidan. Selective constitutive nitric oxide synthase (cNOS) inhibitor, diphenylene iodonium chloride (DPI), caused a decrease of cell viability, whereas cell viability was increased by specific inducible nitric oxide synthase (iNOS) inhibitor, S-methylisothiourea (SMT), in the fucoidan-untreated cells. Treatment with fucoidan inhibited the cell viability decreased in DPI-exposed cells. In contrast, fucoidan had no effect on cell growth in SMT-treated cells, indicating that cNOS may not play a role in the proliferation of fucoidan-treated cells. The present data suggest that fucoidan has proliferative and neuroprotective effects and these effects may be associated with iNOS.