http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Dong Churl Suh ),( Yeong Seok Kim ),( Hyeong Min Kim ),( Ji Eun Ro ),( Seong Wan Cho ),( Gyiae Yun ),( Sung Up Choi ),( Jae Hwi Lee ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.1
The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed using Franz diffusion cells along with rat dorsal skin, and the effect of drug concentration and the addition of pectin on skin deposition profiles of RP was observed. The skin distribution of RP increased in a concentration dependent manner and the formulations containing 0.5 and 1 mg of pectin demonstrated significantly increased RP distributions in the epidermis. Furthermore, it was found that skin distribution of RP could be further improved by combined use of pectin and ascorbyl palmitate (AP), due largely to their anti-oxidative effect. These results clearly demonstrate that the skin deposition properties of RP can be improved by stabilizing RP with pectin. Therefore, it is strongly suggested that pectin could be used in the pharmaceutical and cosmetic formulations as an efficient stabilizing agent and as skin penetration modulator.
장기철(Ki Churl Chang),손동렬(Dong-Ryul Sohn),정원석(Won Seog Chong),정수연(Soo Youn Chung),이영수(Young Soo Lee),김시환(Si Hwan Kim),노홍기(Hong Kee Noh),서정서(Joung Seo Suh),다까자와(Satoko Takizawa),가라끼(Hideaki Karaki) 대한약리학회 1991 대한약리학잡지 Vol.27 No.1
The inhibitory effects of GS354 and GS389 on cytosolic Ca<sup>2+</sup> level ([Ca<sup>2+</sup>]<sub>1</sub>; measured with fura-2 fluorescence) and muscle tension in vascular smooth muscle of rat thoracic aorta were investigated. Both GS354 and GS389 inhibited the contractions induced by high K<sup>+</sup> or by norepinephrine. The vasodilator effect of GS354 was accompanied by a decrease in [Ca<sup>2+</sup>]<sub>1</sub>. The inhibitory effect on high K<sup>+</sup>-stimulated [Ca<sup>2+</sup>]<sub>1</sub> was antagonized by a Ca<sup>2+</sup> channel activator, Bay K8644. However, the inhibitory effect on muscle tension was not antagonized by Bay K8644. These results suggest that GS354 inhibits Ca<sup>2+</sup> channels to decrease [Ca<sup>2+</sup>]<sub>1</sub> and also decreases Ca<sup>2+</sup> sensitivity of contractile elements. The inhibitory effects of GS389 was accompanied by the increase in tissue fluorescence. This increment was not due to fura-2 fluorescence but to endogeneous pyridine nucleotides, suggesting that GS389 has an effect to inhibit mitochondrial function. Because of this interference, effects of GS389 on [Ca<sup>2+</sup>]<sub>1</sub> was obscured. However, since sequential addition of Bay K8644 in the presence of GS389 further increased the fluorescence but not muscle tension, this compound seems to have the effects to inhibit Ca<sup>2+</sup> channels and to decrease Ca<sup>2+</sup> sensitivity of contractile elements. GS354와 GS389의 세포내 칼슘{[Ca<sup>2+</sup>]<sub>1</sub>: Fura-2의 형광으로 측정}과 근장력 변화에 대하여 백서의 흉부동맥을 사용하여 검토하였다. GS354와 GS389 모두 고농도의 포타슘과 노어에피네프린에 의한 수축을 억제시켰다. GS354의 헐관이완은 [Ca<sup>2+</sup>]<sub>1</sub>의 감소가 동반되었고 고농도의 포타슘에 의한 [Ca<sup>2+</sup>]<sub>1</sub>증가억제 현상도 칼슘통로 활성제인 Bay K8644에 의하여 길항되었다. 그러나 혈관이완 작용은 Bay K8644에 의해 억제 되지 않았다. 이러한 사실은 GS354는 칼슘통로를 차단하여 [Ca<sup>2+</sup>]<sub>1</sub>을 감소시키며 또한 수축기구에 대한 칼슘의 감수성을 낮추는 것을 암시하는 결과이다. 한편 GS389는 세포내 형광성을 증가시켰으나 이것은 Fura-2에 의한 형광이 아니라 내인성 피리딘 뉴클레오타이드에 의한 것으로서 나타났다. 이것은 미토콘드리아 기능을 억제하는 것을 의미하며 이러한 현상때문에 GS389에 대한 [Ca<sup>2+</sup>]<sub>1</sub>의 측정이 곤란하였으나 계속하여 Bay K8644를 첨가하여 본 결과 형광은 더욱 증가 되었으나 혈관이완은 역전되지 않았다. 이러한 사실은 GS389가 칼슘통로를 억제하며 아울러 수축기구에 대한 칼슘의 감수성을 낮추는 것을 암시하는 결과로 사료된다.
Jang, Byeong-Churl,Lim, Ki-Jo,Choi, In-Hak,Suh, Min-Ho,Park, Jong-Gu,Mun, Kyo-Chul,Bae, Jae-Hoon,Shin, Dong-Hoon,Suh, Seong-Il D.A. Spandidos 2007 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.19 No.5
<P>The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role in the innate immunity. We have previously demonstrated that IL-1beta induced HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), or phosphatidylinositol-3-kinase (PI3K). In this study, we investigated effects of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells. Triptolide inhibited IL-1beta-induced HBD-2 mRNA expression in a dose-dependent manner. Addition of triptolide did not suppress activation of p38 MAPK, JNK, or PI3K in response to IL-1beta. Triptolide inhibited IL-1beta-induced MAPK phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK, explaining the little effect of triptolide on IL-1beta-induced phosphorylation of these kinases. Although triptolide partially suppressed IL-1beta-mediated degradation of IkappaB-alpha and nuclear translocation of p65 NF-kappaB, triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells. These results collectively suggest that the inhibitory effect of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells seems to be at least in part mediated through nuclear inhibition of NF-kappaB transcriptional activity, but not inhibition of p38 MAPK, JNK, or PI3K. This inhibition may explain the ability of triptolide to diminish innate immune response.</P>
Kang-Bo Shim,Churl-Whan Kang,Jae-Duck Seong,Chung-Dong Hwang,Duck-Yong Suh 韓國作物學會 2006 Korean journal of crop science Vol.51 No.4
Multiple linear regression analysis was conducted to interpretate the relationship between sesame grain yield and its components under early sowing cropping condition. The t test showed that stem length, number of capsules per plant, 1000 seeds weight and seed weight per plant gave significant contribution to sesame grain yield, therefore those variables were assumed to mostly influenced components to grain yield of sesame. In the stepwise regression analysis, the predicted equation for sesame grain yield per square meter (Y) was Y = -7.900 + 0.150X1 + 0.461X5 + 15.553X6 + 8.543X7. Meanwhile, F value showed that stem length, number of capsules per plant and seed weight per plant gave significant contribution to sesame grain yield, while 1000 seeds weight did not significantly show. Based on the results, it is reasonable to assume that high yield. potential of sesame under early sowing cropping condition would be obtained by selecting breeding lines with long stem length, number of capsules per plant, and seed weight per plant, which was different result at the late sowing cropping condition in which days to flowering and maturity were assumed to be more affected factors to the sesame grain yield.
A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield
Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5
A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.
Shim Kang-Bo,Kang Churl-Whan,Seong Jae-Duck,Hwang Chung-Dong,Suh Duck-Yong The Korean Society of Crop Science 2006 Korean journal of crop science Vol.51 No.4
Multiple linear regression analysis was conducted to interpretate the relationship between sesame grain yield and its components under early sowing cropping condition. The t test showed that stem length, number of capsules per plant, 1000 seeds weight and seed weight per plant gave significant contribution to sesame grain yield, therefore those variables were assumed to mostly influenced components to grain yield of sesame. In the stepwise regression analysis, the predicted equation for sesame grain yield per square meter (Y) was Y = -7.900 + 0.150X1 + 0.461X5 + 15.553X6 + 8.543X7. Meanwhile, F value showed that stem length, number of capsules per plant and seed weight per plant gave significant contribution to sesame grain yield, while 1000 seeds weight did not significantly show. Based on the results, it is reasonable to assume that high yield. potential of sesame under early sowing cropping condition would be obtained by selecting breeding lines with long stem length, number of capsules per plant, and seed weight per plant, which was different result at the late sowing cropping condition in which days to flowering and maturity were assumed to be more affected factors to the sesame grain yield.
Soon Jong Kweon,Jong Nae Hyun,Jong Min Ko,Dong Soo Park,Shin Churl Bae,Duck Yong Suh,Huhn Pal Moon,Dal Ung Kim 한국육종학회 2003 한국육종학회지 Vol.35 No.1
To analyze the effect of 1RS chromosome segment on anther culture efficiency in wheat, 44 cultivars released from several countries were evaluated. The cultivars applied for this investigation came from several regions and it was necessary to confirm cult