ECG PVC Classification Algorithm based on Fusion SVM and Wavelet Transform

Huang Dong,Liao Zhengquan,Li Changbin,Li Dan,Huang Wendong 보안공학연구지원센터(IJSIP) 2015 International Journal of Signal Processing, Image Vol.8 No.1

In the process of ventricular premature beat (PVC) and normal sinus rhythm (NSR) identification base on electrocardiogram (ECG), there exists problems like negative effect from ECG rhythm and low recognition rate. This paper proposes the electrocardiogram PVC classification algorithm based on support vector machine (SVM) and wavelet algorithm. The algorithm uses the wavelet transform to analyze ECG beating model, which is not influenced by the change of ECG waveform. The two feature sets respectively compose of statistical parameters of the wavelet coefficients and the selected wavelet coefficients. PVC and NSR are analyzed by using SVM. The experimental results show that this method improves the recognition rate of ECG.

Gallstones, Cholecystectomy and the Risk of Hepatobiliary and Pancreatic Cancer: A Nationwide Population-based Cohort Study in Korea

Dan Huang,Joonki Lee,Nan Song,조수영,Sunho Choe,신애선 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.3

Several epidemiological studies suggest a potential association between gallstones or cholecystectomy and hepatobiliary and pancreatic cancers (HBPCs). The aim of this study was to evaluate the risk of HBPCs in patients with gallstones or patients who underwent cholecystectomy in the Korean population. A retrospective cohort was constructed using the National Health Insurance Service-National Sample Cohort (NHIS-NSC). Gallstones and cholecystectomy were defined by diagnosis and procedure codes and treated as time-varying covariates. Hazard ratios (HRs) in relation to the risk of HBPCs were estimated by Cox proportional hazard models. Among the 704,437 individuals who were included in the final analysis, the gallstone prevalence was 2.4%, and 1.4% of individuals underwent cholecystectomy. Between 2002 and 2015, 487 and 189 individuals developed HBPCs in the gallstone and cholecystectomy groups, respectively. A significant association was observed between gallstones and all HBPCs (HR 2.16; 95% CI 1.92-2.42) and cholecystectomy and all HBPCs (HR 2.03; 95% CI 1.72-2.39). However, when 1-, 3-, and 5-year lag periods were applied, the HBPC and subsites risk approached zero. A significant association was observed between cholecystectomy and intrahepatic bile duct cancer (IBDC) (HR 2.68; 95% CI 1.63-4.40). When 1-, 3- and 5-year lag periods were applied, the IBDC risk after cholecystectomy was 2.86-fold (95% CI 1.68-4.85), 2.92-fold (95% CI 1.51-5.64), and 4.08-fold (95% CI 1.94-8.61) higher, respectively, than that in the comparison group. In conclusion, gallstone diagnosis and cholecystectomy seem to correlate with HBPCs, especially cholecystectomy and IBDC.

Damage Evolution and Integrity Assessment of Jointed Rock Mass Based on Synthetic Rock Mass Approach

Dan Huang,Xiaoqing Li,Wen-chao Song 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5

The integrity coefficient Kv of bed rock is one of the important approaches to evaluate the stability of engineering rock mass, but this parameter is difficult in frequent field tests. The integrity coefficient is the quantitative index for evaluating the complete deformation of rock mass, while the damage variable represents the level of damage of the jointed rock mass, and both have similar physical meanings and represent the degree of deterioration of surrounding rock. Damage variables and damage constitutive models were constructed based on Weibull distribution damage model and Synthetic Rock Mass (SRM) model. The relationship between damage variables and numerical calculation and damage constitutive curves of different weathered granite rocks in Hongtuzhang tunnel was calculated. A new method for evaluating integrity coefficient of rock mass is proposed.

Mean Square Consensus of Multi-agent systems with multiplicative noises and time delays under directed fixed topologies

Dan Huang,Lei Song,Sing Kiong Nguang,Shan Fu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1

This paper investigates the mean square consensus problem of multi-agent systems impacted by thecombined uncertainty of multiplicative noises and time delays. Considering general network under directed fixedtopologies, we propose consensus protocol that take into account both the multiplicative noises and time delays. Using tools from stochastic differential delay equation (SDDE), martingale theory and stochastic inequality, weestablish sufficient conditions and obtain the explicit consensus gain and delay upper bounds under which theproposed protocol leads to mean square consensus. In addition, we compare the impact of multiplicative andadditive noise and reach the conclusion that multiplicative noises have the property of stabilizing effect. Simulationsdemonstrate the theoretical results.

Dynamic Output Feedback Control for Uncertain Networked Control Systems with Random Network-induced Delays

Dan Huang,Sing Kiong Nguang 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.5

This paper investigates the stabilization problem for a class of uncertain networked control systems (NCSs) with random communication network-induced delays. A dynamic output feedback controller is designed for the uncertain NCSs in the presence of network effects, i.e., network-induced delays and packet dropouts in both the sensor-controller and controller-actuator channels. Based on the Lyapunov-Razumikhin method, the existence of such controller is given in terms of the solvability of bilinear matrix inequalities. An iterative algorithm is proposed to change this non-convex problem into quasi-convex optimization problems, which can be solved effectively by available mathematical tools. The effectiveness of the proposed design methodology is verified by a numerical example.

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

Dan Xiao,Kaisen Huang,Qingyong Chen,Baotao Huang,Wei Liu,Yong Peng,Mao Chen,Dejia Huang,Tong Zou,Jiefu Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.7

Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.

Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis

Dan Huang,Hyundeok Joo,Nan Song,Sooyoung Cho,Woosung Kim,Aesun Shin 한국역학회 2021 Epidemiology and Health Vol.43 No.-

OBJECTIVES: Biliary tract cancers (BTCs) are rare but highly fatal. Although the etiology of BTC is poorly understood, gallstones are proposed to be a major risk factor. We conducted a systematic review and meta-analysis to examine the associations between gallstone characteristics and BTC risk. METHODS: We searched the MEDLINE, Embase, and Cochrane Central databases and systematically reviewed cohort and case-control studies published before April 9, 2018. All the included studies reported appropriate risk estimates and confidence intervals (CIs) for associations between the presence, size, number, or duration of gallstones and the risk of BTC, including gallbladder cancer (GBC), extrahepatic bile duct cancer (EBDC), and ampulla of Vater cancer (AOVC). Summary odds ratios (ORs) and their 95% CIs were calculated using a random-effects model in the meta-analysis. Subgroup analyses were conducted to inspect sources of potential heterogeneity, and the Egger test was performed to assess publication bias. RESULTS: Seven cohort studies and 23 case-control studies in Asian, European, and American populations were included. The presence of gallstones was associated with an increased risk of BTC (OR, 4.38; 95% CI, 3.23 to 5.93; I2=91.2%), GBC (OR, 7.26; 95% CI, 4.33 to 12.18), EBDC (OR, 3.17; 95% CI, 2.24 to 4.50), and AOVC (OR, 3.28; 95% CI, 1.33 to 8.11). Gallstone size (>1 vs. <1 cm; OR, 1.88; 95% CI, 1.10 to 3.22) was significantly associated with the risk of GBC. CONCLUSIONS: Gallstone characteristics, such as presence, size, and number, are associated with an increased risk of BTC. However, significantly high heterogeneity in the meta-analyses is a limitation of this study.

Chigger Mite (Acari: Trombiculidae) Survey of Rodents in Shandong Province, Northern China

Xiao-Dan Huang,Peng Cheng,Yu-Qiang Zhao,Wen-Juan Li,Jiu-Xu Zhao,Hong-Mei Liu,Jing-Xuan Kou,Mao-Qing Gong 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.5

Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells

Huang, Yin-Jiu,Zhang, Yu-Yuan,Liu, Gang,Tang, Jie,Hu, Jian-Guo,Feng, Zhen-Zhong,Liu, Fang,Wang, Qi-Yi,Li, Dan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time- and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.

Development and Evaluation of a Duplex Real-Time PCR Assay With a Novel Internal Standard for Precise Quantification of Plasma DNA

Dan Chen,Shi-yang Pan,Erfu Xie,Li Gao,Huaguo Xu,Wenying Xia,Ting Xu,Peijun Huang 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.1

Background: Circulating levels of cell-free DNA increase in many pathologic conditions. However, notable discrepancies in the quantitative analysis of cell-free DNA from a large number of laboratories have become a considerable pitfall, hampering its clinical application. Methods: We designed a novel recombinant DNA fragment that could be applied as an internal standard in a newly developed and validated duplex real-time PCR assay for the quantitative analysis of total cell-free plasma DNA, which was tested in 5,442 healthy adults and 200 trauma patients. Results: Compared with two traditional methods, this novel assay showed a lower detection limit of 0.1 ng/mL, lower intra- and inter-assay CVs, and higher accuracy in the recovery test. The median plasma DNA concentration of healthy males (20.3 ng/mL, n=3,092) was significantly higher than that of healthy females (16.1 ng/mL, n=2,350) (Mann-Whitney two-sample rank sum test, P<0.0001). The reference intervals of plasma DNA concentration were 0-45.8 ng/mL and 0-52.5 ng/mL for healthy females and males, respectively. The plasma DNA concentrations of the majority of trauma patients (96%) were higher than the upper normal cutoff values and were closely related to the corresponding injury severity scores (R2=0.916, P<0.0001). Conclusions: This duplex real-time PCR assay with a new internal standard could eliminate variation and allow for more sensitive, repeatable, accurate, and stable quantitative measurements of plasma DNA, showing promising application in clinical diagnosis.