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Novel severity quantitative analysis method for melasma
( Jaeyoung Kim ),( Geo Han ),( Onseok Lee ),( Seunghan Ha ),( Jaewoo Ahn ),( Chilhwan Oh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Melasma is a common pigmentary skin disease with patchy facial skin discoloration and typically appears on upper cheeks, upper lip, forehead, and chin. The most common severity assessment method of melasma is Melasma Area Severity Index(MASI)score. However,ordinary MASI scoring system has some downsides due to the observer``s subjective visual judgment. Objectives: This study aimed to develop a new advanced severity assessment method of melasma based on computerized optical imaging analysis system. Methods: We proposed a new analysis method for the quantitative assessing of melasma. In order toquantitatvely analyze the involvement area, we divided frontal, cheek and chin region in patients. The divided images were processed to define the melasma lesions by the multi-threshold method and gradient mask were apply to correct the curvature error of facial contour.Degree of darkness and homogenesis were measured based on intensity of gray level and difference of gray level in melasma lesions. Results: The proposed new quantitative assessment method for melasma is more objective and accurate than ordinary MASI method. also, our method is able to quantify a minute difference of pigmented pattern among melasma patients. Conclusion: We developed the quantitative assessment method for melasma using computerized optical imaging analysis.Based on the results, our new computerized optical imaging system could be used as valuable tools to assess the severity of various pigmentary skin diseases
Gd-DOTA Conjugate of RGD as a Potential Tumor-Targeting MRI Contrast Agent
Park, Ji-Ae,Lee, Jae-Jun,Jung, Jae-Chang,Yu, Dae-Yeul,Oh, Chilhwan,Ha, Seunghan,Kim, Tae-Jeong,Chang, Yongmin WILEY-VCH Verlag 2008 Chembiochem Vol.9 No.17
<B>Graphic Abstract</B> <P>Tumor recognition: Conjugation of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) with the cyclic pentapeptide c(RGDYK) and subsequent complexation with GdCl<SUB>3</SUB>⋅6 H<SUB>2</SUB>O afforded Gd-DOTA-RGD, which, although a single molecular entity, is an efficient, target-specific MRI contrast agent for the α<SUB>ν</SUB>β<SUB>3</SUB> receptors in hepatocellular carcinoma in H-ras12V transgenic mice. The compound displays very low cytotoxicity and might hence warrant further study for clinical usage. <img src='wiley_img/14394227-2008-9-17-CBIC200800529-content.gif' alt='wiley_img/14394227-2008-9-17-CBIC200800529-content'> </P>
Phase‐contrast hard X‐ray microscopy using synchrotron radiation for the diagnosis of onychomycosis
Lee, Onseok,Ha, Seunghan,Lee, Gunwoo,Kim, Jaeyoung,Huang, Jungyun,Jin, Kyeongsik,Oh, Chilhwan Wiley Subscription Services, Inc., A Wiley Company 2010 Microscopy research and technique Vol.73 No.12
<P><B>Abstract</B></P><P>Onychomycosis, or fungal infection of the nail, is a disease seen frequently in clinical settings. However, the rates of positive identification using potassium hydroxide preparations or fungal cultures are relatively low. Precise diagnosis is possible via histopathologic examination to monitor the existence of fungus and performance of a fungal culture for confirmation. Phase‐contrast hard X‐ray microscopy using synchrotron radiation provides 70‐nm spatial resolution and enables imaging of minute internal cellular structures. This study confirms the feasibility of diagnosing onychomycosis using a phase‐contrast hard X‐ray microscope developed at 1B2 beam line using a Pohang light source. Microsc. Res. Tech. 73:1110–1114, 2010. © 2010 Wiley‐Liss, Inc.</P>
A study of a method for distribution analysis of skin color
Ha, Seunghan,Lee, Minhee,Lee, Onseok,Lee, Gunwoo,Kim, Jeayoung,Moon, Jongsub,Kim, Mingi,Oh, Chilhwan Blackwell Publishing Ltd 2009 SKIN RESEARCH AND TECHNOLOGY Vol.15 No.2
<P>Background/aims</P><P>The objective and quantitative assessment of the skin is important in medical and cosmeceutical research. Assessment of color is an important element for analyzing the surface of the skin, which is usually determined subjectively by a doctor or using color analysis devices. These devices, however, cannot provide correct color information because color is construed from the mean value of the observation region, and analysis of color distribution is impossible. The purpose of this paper is to develop an objective analysis method to permit skin color measurement of each pixel unit of an image and analyze the distribution of skin surface color.</P><P>Methods</P><P>The Skin Color Distribution Analyzer (SCDA) is an analysis method newly developed at the Research Institute for Skin Image at Korea University. The SCDA system presented in this paper performed a novel form of quantitative and objective analysis of skin color distribution using each pixel color model parameter found in image wavelength information.</P><P>In this paper, distribution analysis was conducted on normal skin and skin lesions and skin affected by artificially induced irritant contact dermatitis and pigmented nevous. The method selected a grade using a color model parameter. Twenty healthy Korean males participated in this study. A comparative study of the eight anatomical areas was performed, including the exposure and non-exposure parts and the medial aspect and the lateral aspect of the forearm. A reliability test for the SCDA system was also conducted with a spectrometer (SPEC) using the color analysis method.</P><P>Results</P><P>Each skin lesion was precisely segmented by grade and each parameter hada different statistical significance for results of analysis of distribution in pigmented nevous and the artificially induced irritant contact dermatitis. Parameters <I>L</I><SUP>*</SUP>, <I>b</I><SUP>*</SUP>, <I>a</I><SUP>*</SUP>, and EI showed salient traits. Showed resemble measured result in the SCDA system and the SPEC of normal skin. The exposed site, in comparison with the non-exposed site, showed a notable difference in the <I>L</I><SUP>*</SUP> parameter and a significant statistical difference in the <I>x</I> and <I>z</I> parameters, except <I>b</I><SUP>*</SUP>. The comparison of the medial and lateral aspects of the forearm showed a notable difference in the <I>L</I><SUP>*</SUP> parameter and a significant statistical difference in the parameters except <I>y</I> and <I>b</I><SUP>*</SUP>. In the reliability test result using the SCDA system and the SPEC, the SCDA system was highly reliabile in terms of the CV value in all color model parameters.</P><P>Conclusions</P><P>The color distribution analysis method using the SCDA system has revealed an aspect that the existent method of medical research has not shown, and is considered to be more reliable than other methods. This method can provide better study findings because it can be applied to other fields in addition to the medical science field and the ripple effect is thought to be bigger in other science field too.</P>
Park, Gyuman,Yoon, Byung Sun,Moon, Jai-Hee,Kim, Bona,Jun, Eun Kyoung,Oh, Sejong,Kim, Hyunggee,Song, Hea Joon,Noh, Joo Young,Oh, ChilHwan,You, Seungkwon The Society for Investigative Dermatology, Inc 2008 The Journal of investigative dermatology Vol.128 No.10
Keloids are benign skin tumors characterized by collagen accumulation and hyperproliferation of fibroblasts. To find an effective therapy for keloids, we explored the pharmacological potential of (−)-epigallocatechin-3-gallate (EGCG), a widely investigated tumor-preventive agent. When applied to normal and keloid fibroblasts (KFs) in vitro, proliferation and migration of KFs were more strongly suppressed by EGCG than normal fibroblast proliferation and migration (IC<SUB>50</SUB>: 54.4 μM (keloid fibroblast (KF)) versus 63.0 μM (NF)). The level of Smad2/3, signal transducer and activator of transcription-3 (STAT3), and p38 phosphorylation is more enhanced in KFs, and EGCG inhibited phosphorylation of phosphatidylinositol-3-kinase (PI3K), extracellular signal-regulated protein kinase 1/2 (ERK1/2), and STAT3 (Tyr705 and Ser727). To evaluate the contribution of these pathways to keloid pathology, we treated KFs with specific inhibitors for PI3K, ERK1/2, or STAT3. Although a PI3K inhibitor significantly suppressed proliferation, PI3K and MEK/ERK inhibitors had a minor effect on migration and collagen production. However, a JAK2/STAT3 inhibitor and a STAT3 siRNA strongly suppressed proliferation, migration, and collagen production by KFs. We also found that treatment with EGCG suppressed growth and collagen production in the in vivo keloid model. This study demonstrates that EGCG suppresses the pathological characteristics of keloids through inhibition of the STAT3-signaling pathway. We propose that EGCG has potential in the treatment and prevention of keloids.Journal of Investigative Dermatology (2008) 128, 2429–2441; doi:10.1038/jid.2008.103; published online 8 May 2008