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New Geldanamycin Analogs from Streptomyces hygroscopicus
( Cheng Zhu Wu ),( Jae Hyuk Jang ),( Jong Seog Ahn ),( Young Soo Hong ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.11
Geldanamycin (GM) and its analogs are important anticancer agents that inhibit heat shock protein (Hsp) 90, which is a major chaperone protein in cancer cells. Accordingly, based on interest in obtaining novel natural GM derivatives, the potential of Streptomyces hygroscopicus JCM4427, a GM producer, was explored for novel natural GM derivative(s), resulting in the discovery of new GM analogs as a biosynthetic shunt product and intermediates from its fermentation broth. In this study, the fermentation, isolation, structure determination, and biological activity of the compounds, two new tetracyclic thiazinogeldanamycin (1) and 19-hydroxy-4,5-dihydrogeldanamycin (3), together with the three known 4,5-dihydrothiazinogeldanamycin (2), reblastatin (4), and 17-demethoxy-reblastatin (5), are described.
New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus
Wu, Cheng-Zhu,Moon, An Na,Jang, Jae-Hyuk,Lee, Dongho,Kang, Sun-Young,Park, Joon-Tae,Ahn, Jong Seog,Hwang, Bang Yeon,Kim, Young Ho,Lee, Hong-Sub,Hong, Young-Soo Springer Science and Business Media LLC 2011 The Journal of Antibiotics Vol.64 No.6
6-Alkylsalicylic Acid Analogues Inhibit In Vitro ATPase Activity of Heat Shock Protein 90
Cheng-Zhu Wu,An Na Moon,Oksik Choi,Sun-Young Kang,Jung Joon Lee,황방연,김영호,Hong-Sub Lee,홍영수,이동호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.12
The molecular chaperone heat shock protein 90 (Hsp90) is responsible for maintaining the correct folding and stability of many signaling proteins. It is a promising target of cancer therapeutics and several other diseases, including neurodegenerative disease, nerve injuries, inflammation, and infection. In an effort to identify new Hsp90 inhibitors from natural sources using an in vitro ATPase inhibition assay, two 6-alkylsalicylic acid analogues, salaceyin A and B were identified from the culture extract of Streptomyces. Salaceyin A and B exhibited moderate ATPase inhibitory activities with IC50 values of 68.3 and 65.2 μM, respectively. Binding of salaceyins to human Hsp90α was examined by competition binding experiments with ATPSepharose beads. However, the compounds exhibited no degradation activity of Hsp90 client proteins, Her2, c-Raf, or Akt.
( Cheng Wu ),( Lijie Liu ),( Peng Zhao ),( Dan Tang ),( Dingkang Yao ),( Liang Zhu ),( Zhiqiang Wang ) 대한소화기학회 2015 Gut and Liver Vol.9 No.5
Background/Aims: To screen for serum protein/peptide biomarkers of hepatitis B virus (HBV)-associated chronic hepatic lesions in an attempt to profile the progression of HBV-associated chronic hepatic lesions using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) techniques. Methods: Using SELDI-TOF MS, serum protein/peptide profiles on the CM10 ProteinChip arrays were obtained from a training group including 26 HBV-associated hepatocellular carcinoma patients with liver cirrhosis (LC), 30 HBV-associated LC patients, 85 patients at different stages of liver fibrosis, and 30 asymptomatic HBV carriers. The most valuable SELDI peak for predicting the progression to LC in HBV-infected patients was identified. Results: A SELDI peak of M/Z 5805 with value for predicting LC in HBV-infected patients was found and was identified as a peptide of the C-terminal fraction of the fibrinogen a-chain precursor, isoform 1. Conclusions: The peptide of the C-terminal fraction of the fibrinogen α-chain precursor, isoform 1 with M/Z 5805, may be a serological biomarker for progression to LC in HBV-infected patients. (Gut Liver 2015;9:665-671)
Cheng Zhou,Shemin Zhu,Xiuming Wu,Bo Jiang,Tao Cen,Shubao Shen 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.3
Penicillin acylase (PA) is known to regulate the microenvironment of nanospores. In this study, nanopores containing chemically-modified macromolecules co-assembled with immobilized PA were constructed. We also investigated the various types of functionalized mesocellular siliceous foams (MCFs) commonly used for the immobilization of PA by measuring the catalytic performance and stability of each PA preparation. Amino-MCF activated by p-benzoquinone was chosen as the optimum support for PA immobilization. Successful modification of macromolecules was verified by FT-IR and ultraviolet (UV)spectroscopy. The specific activity of PA co-assembled with dextran 10 k was 99.1 U/mg, which was 1.5-fold that of pristine immobilized PA, while the optimum pH was shifted to neutral. Compared to pristine immobilized and free PA, the optimum temperatures for the modified PA were 5 and 10oC higher, respectively. The residual activity of the ficoll derivative of PA after treatment at 50oC for 6 h was 70%, and this was later increased to 214.5% compared to that of pristine immobilized PA. The dextran 10 k derivative of PA exhibited 90.2% residual activity after 25times of continuous use. The results show that chemicallymodified macromolecules co-assembled with PA in amino-MCF provided a suitable microenvironment for enzyme stability.
Bencheng Wu,Jianhua Zhu,Xiaohui Li,Yanzhao Huang,Hui Cheng 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.6
Acidic species were extracted from heavy crude oil by alcohol-alkali solution and ion exchange resin. Theacidic species in the obtained extracts and extracted crude oil were characterized by negative-ion ESI FT-ICR MS. Theanalytical results indicated that some class species, O2, O1, N1, N1O1, N1O2, N1S1 and O2S1 etc., were identified in thenegative-ion spectrum, in which O2, O1 and N1 class showed much higher abundance than others. Compared to O1 andN1 class, O2 class could be extracted from heavy crude oil by using the two methods more efficiently, which meansthat a great majority of O2 class can be extracted; meanwhile, almost half of O1 and N1 class still remained in residualphase. Detailed analysis demonstrated that alcohol-alkali method was effective for extracting O2, O1 and N1 class withlower molecular weight; ion exchange method, however, was helpful to extract higher molecular weight O1 and N1class and showed almost equal extraction selectivity to all kind of O2 class.
Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene
Xiaoqian Wu,Zhendong Tan,Linyuan Shen,Qiong Yang,Xiao Cheng,Kun Liao,Lin Bai,Surong Shuai,Mingzhou Li,Xuewei Li,Shunhua Zhang,Li Zhu 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.7
Objective: Qingyu pig, a Chinese indigenous pig breed, exhibits two types of coat colour phenotypes, including pure black and white with black spotting respectively. Melanocortin receptor 1 (MC1R) and agouti signaling protein (ASIP) are two widely reported pivotal genes that significantly affect the regulation of coat colour. The objectives of this study were to investigate whether the polymorphisms of these two genes are associated with coat colour and analyze the molecular mechanism of the coat colour separation in Qingyu pig. Methods: We studied the phenotype segregation and used polymerase chain reaction amplification and Sanger sequencing to investigate the polymorphism of MC1R and ASIP in 121 Qingyu pigs, consisting of 115 black and 6 white with black spotted pigs. Results: Coat colour of Qingyu pig is associated with the polymorphisms of MC1R but not ASIP. We only found 2 haplotypes, EQY and Eqy, based on the 13 observed mutations from MC1R gene. Among which, Eqy presented a recessive inheritance mode in black spotted Qingyu pigs. Further analysis revealed a g.462-463CC insertion that caused a frameshift mutation and a premature stop codon, thus changed the first transmembrane domain completely and lost the remaining six transmembrane domains. Altogether, our results strongly support that the variety of Qingyu pig’s coat colour is related to MC1R. Conclusion: Our findings indicated that black coat colour in Qingyu pig was dominant to white with black spotted phenotype and MC1R gene polymorphism was associated with coat colour separation in Qingyu pig.
Zihan Zhu,Hu Zhou,Xiangshao Kong,Fang Liu,Yongqiang Zhang,Cheng Zheng,Weiguo Wu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.12
This study is devoted to reveal the influence of weaving architectures and impact locations on the ballistic resistance of UHMWPE (ultrahigh high molecular weight polyethylene) fabrics. Firstly, a mesoscopic model of UHMWPE fabric is established and the accuracy of the numerical method is verified. Subsequently, the models with different weaving architectures are further established, and the impact resistance performances are evaluated. Finally, the influence factors on the fabric ballistic resistance is explored. It is proved that the ballistic resistance of UHMWPE fabric mainly dominated by the tensile strength of yarn under highvelocity impact. The plain fabric shows best anti-ballistic performance, while basket and woven fabric are slightly inferior. The damage pattern of fabrics with different weaving architectures changes greatly. In addition, this study proposes a residual impact velocity correction model for projectile based on the probability distribution of impact positions, which can better characterize the protective ability of fiber fabrics.
Xin Cheng,Jinpeng Zhu,Zhijie Chen,Zhihao Wu,Fuqiang Zhang,Cai-e Wu,Gong-Jian Fan 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.10
To evaluate the storage stability of anthocyanin in stirred yoghurt, mulberry juice and different starter cultures (S) were added into milk to investigate the color stability and degradation kinetics of anthocyanin. The result showed that the redness value decreased, while the brightness value increased, and the anthocyanin content decreased significantly from 1.47 ~ 1.86 to 1.01 ~ 1.19 mg/g. The degradation kinetics followed a first-order reaction. Principal component analysis showed that S2 and S6 were correlated with anthocyanins, S8 and S4 were correlated with a*. At the later stage, S4, S8 were correlated with a*, while S2, S4, S6 were correlated with anthocyanins. At 28th day, the anthocyanin content of S4 was 1.14 mg/g, which was not the highest, but the total score was the highest. Therefore, S4 was the best choice when the storage period is 28 days. This study provided technical support for the selection of a better starter for stirring yoghurt.
Effects of a chitosan nanoparticles encapsulation on the properties of litchi polyphenols
Xingan Cheng,Qiwen Zou,Hanhui Zhang,Jianwei Zhu,Murtaza Hasan,Fangyun Dong,Xin Liu,Junjie Li,Yuehua Wu,Xiaojing Lv,Keqiang Wang,Xiangling Deng,Zhanmei Liu,Xuhong Jiang 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.13
Litchi polyphenols have very specific biological activities. Nevertheless, the low and inconsistent oral bioavailability and instability hinder the further application of litchi polyphenols in food systems. This work prepared litchi polyphenols loaded chitosan nanoparticles (LP-CSNPs) by ionic gelation method to enhance the encapsulation on the properties of litchi polyphenols. The optimum conditions of formation via single factors and the Box–Behnken design were chitosan (CS) concentration 1.065 mg/mL, sodium tripolyphosphate (TPP) concentration 0.975 mg/mL, and the mass ratios of polyphenols and CS 1:1 with encapsulation efficiency (EE%) of 45.53%. LP-CSNPs presented the nanosized range of particle size (mean 170 nm), excellent polydispersity index (PDI) (0.156 ± 0.025), and zeta potential values (+ 35.44 ± 0.59). The in vitro release in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 6.8) during 100 h was 58.34% and 81.68%, respectively. LP-CSNPs could effectively improve the storage stability and had great antibacterial activity compared with unencapsulated litchi polyphenols.