http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The SH2 domain is crucial for function of Fyn in neuronal migration and cortical lamination
( Xi Lu ),( Xin De Hu ),( Ling Zhen Song ),( Lei An ),( Ming Hui Duan ),( Shu Lin Chen ),( Shan Ting Zhao ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.2
Neurons in the developing brain form the cortical plate (CP) in an inside-out manner, in which the late-born neurons are located more superficially than the early-born neurons. Fyn, a member of the Src family kinases, plays an important role in neuronal migration by binding to many substrates. However, the role of the Src-homology 2 (SH2) domain in function of Fyn in neuronal migration remains poorly understood. Here, we demonstrate that the SH2 domain is essential for the action of Fyn in neuronal migration and cortical lamination. A point mutation in the Fyn SH2 domain (FynR176A) impaired neuronal migration and their final location in the cerebral cortex, by inducing neuronal aggregation and branching. Thus, we provide the first evidence of the Fyn SH2 domain contributing to neuronal migration and neuronal morphogenesis. [BMB Reports 2015; 48(2): 97-102]
Xi Hu,Yicheng Zhao,Yang Huang,Chen Zhu,Jun Yao,Nana Fang 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.11
In urban vehicular edge computing (VEC) environments, one edge server always serves many task requests in its coverage which results in the resource-constrained problem. To resolve the problem and improve system utilization, we first design a general hierarchical resource management framework based on typical VEC network structures. Following the framework, a specific interacting protocol is also designed for our decision algorithm. Secondly, a greedy bidding-based multi-hop task scheduling decision algorithm is proposed to realize effective task scheduling in resource-constrained VEC environments. In this algorithm, the goal of maximizing system utility is modeled as an optimization problem with the constraints of task deadlines and available computing resources. Then, an auction mechanism named greedy bidding is used to match task requests to edge servers in the case of multiple hops to maximize the system utility. Simulation results show that our proposal can maximize the number of tasks served in resource constrained VEC networks and improve the system utility.
Hu Xi,Tao Xinwei,Zhang Yueqiao,Niu Zhongfeng,Zhang Yong,Allmendinger Thomas,Kuang Yu,Chen Bin 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.11
Objective: To investigate the accuracy of the Agatston score obtained with the ultra-high-pitch (UHP) acquisition mode using tin-filter spectral shaping (Sn150 kVp) and a kVp-independent reconstruction algorithm to reduce the radiation dose. Materials and Methods: This prospective study included 114 patients (mean ± standard deviation, 60.3 ± 9.8 years; 74 male) who underwent a standard 120 kVp scan and an additional UHP Sn150 kVp scan for coronary artery calcification scoring (CACS). These two datasets were reconstructed using a standard reconstruction algorithm (120 kVp + Qr36d, protocol A; Sn150 kVp + Qr36d, protocol B). In addition, the Sn150 kVp dataset was reconstructed using a kVp-independent reconstruction algorithm (Sn150 kVp + Sa36d, protocol C). The Agatston scores for protocols A and B, as well as protocols A and C, were compared. The agreement between the scores was assessed using the intraclass correlation coefficient (ICC) and the Bland–Altman plot. The radiation doses for the 120 kVp and UHP Sn150 kVp acquisition modes were also compared. Results: No significant difference was observed in the Agatston score for protocols A (median, 63.05; interquartile range [IQR], 0–232.28) and C (median, 60.25; IQR, 0–195.20) (p = 0.060). The mean difference in the Agatston score for protocols A and C was relatively small (-7.82) and with the limits of agreement from -65.20 to 49.56 (ICC = 0.997). The Agatston score for protocol B (median, 34.85; IQR, 0–120.73) was significantly underestimated compared with that for protocol A (p < 0.001). The UHP Sn150 kVp mode facilitated an effective radiation dose reduction by approximately 30% (0.58 vs. 0.82 mSv, p < 0.001) from that associated with the standard 120 kVp mode. Conclusion: The Agatston scores for CACS with the UHP Sn150 kVp mode with a kVp-independent reconstruction algorithm and the standard 120 kVp demonstrated excellent agreement with a small mean difference and narrow agreement limits. The UHP Sn150 kVp mode allowed a significant reduction in the radiation dose.
Yong Chen,Xi Liu,Chengyue Jiang,Gaojian Liao,Bo Hu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.6
The dynamic response and damage behavior of aluminum honeycomb sandwich panels (HC/SPs) subjected to hypervelocity impact by volcanic rock projectiles were investigated by hypervelocity impact tests and hydrocode simulations. The experiments were conducted using a two stage light gas gun and the results showed that the failure modes in HC/SPs subjected to hypervelocity impact by volcanic rock projectiles mainly took forms of front-face denting and circular perforation, honeycomb core collapsing and rapture, rear-face petalling and perforation etc. A 3D discrete configuration of the porous volcanic rock projectiles was set up. The hypervelocity impact behavior of the HC/SPs was investigated through hydrocode modeling, within a Lagrange-SPH coupling method in LS-DYNA solver. It was found that the dynamic response and failure modes in the HC/SPs were significantly influenced by the impact location and the impact velocity of the volcanic rock projectile.
Ren Chen-Xi,Jin Xin,Xie Dan-Ping,Guo Xiao-Yu,Yu Li-Yun,Cui Yu-Dong,Kwon Taeho,Sun Hu-Nan 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.5
Idiopathic pulmonary fibrosis (IPF) is a serious and irreversible chronic lung disease. Bleomycin (BLM) is an anticancer drug, which can cause severe lung toxicity. The main target of oxidative stress-induced lung injury is alveolar epithelial cells, which lead to interstitial fibrosis. The present study investigated whether hispidin (HP), which has excellent antioxidant activity, attenuates bleomycin-induced pulmonary fibrosis via anti-oxidative effects in A549 cells. We found that hispidin reduced bleomycin-induced fibrosis of A549 cells by reducing reactive oxygen species (ROS) levels and inhibiting epithelial-mesenchymal transition. Taken together, our data suggest that hispidin has therapeutic potential in preventing bleomycin-induced pulmonary fibrosis.
Liu, Xi-Jun,Lin, Xiu-Tong,Yin, Yong,Chen, Jin-Hu,Xing, Li-Gang,Yu, Jin-Ming Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Objective: The aim of this study was to determine a method of dose prescription that minimizes normal tissue irradiation outside the planning target volume (PTV) during stereotactic body radiotherapy (SBRT) for patients with non-small cell lung cancer. Methods: Previous research and patients with typical T1 lung tumors with peripheral lesions in the lung were selected for analysis. A PTV and several organs at risk (OARs) were constructed for the dose calculated; six treatment plans employing intensity modulated radiotherapy (IMRT) were produced, in which the dose was prescribed to encompass the PTV, with the prescription isodose level (PIL) set at 50, 60, 70, 80, 90 or 95% of the isocenter dose. Additionally, four OARs around the PTV were constructed to evaluate the dose received in adjacent tissues. Results: The use of higher PILs for SBRT resulted in improved sparing of OARs, with the exception of the volume of lung treated with a lower dose. Conclusions: The use of lower PILs is likely to create significant inhomogeneity of the dose delivered to the target, which may be beneficial for the control of tumors with poor conformity indices.
( Bin Yin ),( Chen Xi Hu ),( Zheng Chen ),( Wen Jun Zhao ),( Li Rong Wei ),( Yan Wen Zheng ),( Chao He ),( Yan Zeng ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2
Vesicular Stomatitis Virus G Glycoprotein and ATRA EnhancedBystander Killing of Chemoresistant Leukemic Cells by HerpesSimplex Virus Thymidine Kinase/Ganciclovir
Li, An,Hu, Qian,Chen, Xi,Kim, Byoung Yoon,Shieh, William Optical Society of America 2014 Optics letters Vol.39 No.11
<P>We propose and demonstrate generation of Brillouin dynamic grating (BDG) in a few-mode fiber (FMF) with a Gaussian pulse pump and a counterpropagating continuous wave pump in LP01 mode. Brillouin optical time-domain analysis (BOTDA) is achieved by launching a third Gaussian pulse probe in LP11 mode. With coherent detection and time-domain analysis on the backreflected probe signal, the modal birefringence of the FMF is characterized via the distributed BDG with high spatial resolution and high accuracy.</P>
( Yan Qun Hu ),( Li Li Chen ),( Chuan Wang ),( Ya Feng Xie ),( Zhi Xi Chen ),( Liang Zhuan Liu ),( Ze Hong Su ),( Yi Mou Wu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.8
Chlamydophila psittaci is an important intracellular pathogen. Persistent infection is an important state of the host-parasite interaction in this chlamydial infection, which plays a significant role in spreading the organism within animal populations and in causing chronic chlamydiosis and serious sequelae. In this study, a C. psittaci persistent infection cell model was induced by penicillin G, and real-time quantitative PCR was used to study the transcriptional levels of 10 C. psittaci genes (dnaA, dnaK, ftsW, ftsY, grpE, rpsD, incC, omcB, CPSIT_0846, and CPSIT_0042) in acute and penicillin-G-induced persistent infection cultures. Compared with the acute cultures, the penicillin-G-treated cultures showed a reduced chlamydial inclusion size and a significantly decreased number of elementary body particles. Additionally, some enlarged aberrant reticulate body particles were present in the penicillin- G-treated cultures but not the acute ones. The expression levels of genes encoding products for cell division (FtsW, FtsY) and outer membrane protein E encoding gene (CPSIT_0042) were downregulated (p < 0.05) from 6 h post-infection onward in the persistent infection cultures. Also from 6 h post-infection, the expression levels of DnaA, DnaK, IncC, RpsD, GrpE, and CPSIT_0846 were upregulated (p < 0.05); however, the expression level of OmcB in the persistent infection was almost the same as that in the acute infection (p > 0.05). These results provide new insight regarding molecular activities that accompany persistence of C. psittaci, which may play important roles in the pathogenesis of C. psittaci infection.
Kun Yang,Mo-Xi Chen,최윤영,Zong-Guang Zhou,형우진,노성훈,Jian-Kun Hu 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.2
Purpose: This study aimed to investigate the effectiveness of postoperative chemotherapy in pT1bN0 and pT2N0 gastric cancerpatients with high risk factors. Materials and Methods: Clinicopathological data of gastric cancer patients, who had undergone gastrectomy in high volumecenters in Korea and China and were finally diagnosed with pT1bN0 and pT2N0 between 2006 and 2010, were analyzed retrospectively. Survival analyses stratified by risk factors and multivariable analyses were performed. Results: A total of 1509 patients were enrolled, with 41 (2.7%) patients receiving adjuvant chemotherapy after gastrectomy and1468 (97.3%) patients undergoing surgery alone. The adjuvant chemotherapy group showed higher percentages of tumor withmaximal diameter >3 cm (51.2% vs. 25.8%), poor differentiation (68.3% vs. 49.8%), and less harvested lymph nodes (17.1% vs. 5.2%) compared to the surgery alone group. The overall survival rates were 95.1% in the adjuvant chemotherapy group and 93.3%in the surgery alone group, without significant difference. In multivariable analysis, age was found to be an independent prognosticfactor. However, there were no difference in the overall survival between patients with risk factors and those without risk factors,even in terms of age. Meanwhile, patients with more than two risk factors who received chemotherapy showed better survivaltrend, especially for pT2N0 patients, compared to the surgery alone group, although no significant differences were observed. Conclusion: In pT1bN0 and pT2N0 patients, age was found to be an independent prognostic factor. However, adjuvant chemotherapyseemed to be unnecessary, while postoperative chemotherapy might offer survival benefits to pT2N0 patients with morethan two risk factors.