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Lee, Byoung-Kwon,Kwon, Hyuck-Moon,Roh, Hyung-Woon,Cho, Min-Tae,Suh, Sang-Ho Biomedical Engineering Society for Circulation 2003 International Journal of Vascular Biomedical Engin Vol.1 No.1
Backgrounds: The present study in angulated coronary stenosis was to evaluate the influence of velocity and wall shear stress (WSS) on coronary atherosclerosis, the changes of hemodynamic indices following coronary stenting, as well as their effect of evolving in-stent restenosis using human in vivo hemodynamic parameters and computed simulation quantitatively and qualitatively. Methods: Initial and follow-up coronary angiographies in the patients with angulated coronary stenosis were performed (n=80). Optimal coronary stenting in angulated coronary stenosis had two models: < 50 % angle changed(model 1, n=43), > 50% angle changed group (model 2, n=37) according to percent change of vascular angle between pre- and post-intracoronary stenting. Flow-velocity wave obtained from in vivo intracoronary Doppler study data was used for in vitro numerical simulation. Spatial and temporal patterns of velocity vector and recirculation area were drawn throughout the selected segment of coronary models. WSS of pre/post-intracoronary stenting were calculated from three-dimensional computer simulation. Results: Follow-up coronary angiogram demonstrated significant difference in the percent of diameter stenosis between two groups (group 1: $40.3{\pm}30.2$ vs. group 2: $25.5{\pm}22.5%$, p<0.05). Negative WSS area on 3D simulation, which is consistent with re-circulation area of velocity vector, was noted on the inner wall of post-stenotic area before stenting. The negative WSS was disappeared after stenting. High spatial and temporal WSS before stenting fell into within physiologic WSS after stenting. This finding was prominent in Model 2 (p<0.01) Conclusions: The present study suggests that hemodynamic forces exerted by pulsatile coronary circulation termed as WSS might affect on the evolution of atherosclerosis within the angulated vascular curvature. Moreover, geometric change, such as angular difference between pre / post-intracoronary stenting might give proper information of optimal hemodynamic charateristics for vascular repair after stenting.
류마토이드 관절염 환자에 대한 Recombinant Interferon Gamma 의 임상시험
권기운(Ki Woon Kwon),변정원(Jung Won Byun),이오영(Oh Young Lee),전용철(Yong Chul Chun),박병권(Byoung Kwon Park),김성윤(Seoug Yoon Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.2
N/A To evaluate antirheumatic efficacies and possibilities on treatment of rheumatoid arthritis with recombinant interferon-gamma, 44 patients with rheumatoid arthritis were treated with IFN-γ for 20 days and were analysed from the standpoint of Ritchie index, patient's assessment, laboratory findings and sideffect. The observed results are as follows: 1) 44 patients were enrolled, 40 patients could be evaluated. Of these, 22 were responders (55%) according to the criteria for treatment success. 2) In 35 patients, stabilized therapy was continued concomittant with the IFN-γ and were no significant differences with respect to the results of treatment. 3) In responders, Ritchie index decreased from 28 on the day of recruitment into the study to 15 on day 20. 4) The patients evaluation of morning pain and change in mobility showed more improvements in responders than non-responders. 5) Monitering of laboratory parameters revealed no therapeutically relevant changes. Side-effects occurred in 14 out of 40 patients. In 10 of these patients, transient fever was recorded.
The Ballooning Time in Endoscopic Papillary Balloon Dilation for the Treatment of Bile Duct Stones
( Byoung Wook Bang ),( Seok Jeong ),( Don Haeng Lee ),( Jung Il Lee ),( Jin Woo Lee ),( Kye Sook Kwon ),( Hyung Gil Kim ),( Yong Woon Shin ),( Young Soo Kim ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.3
Background/Aims: Endoscopic papillary balloon dilation (EPBD) is a safe and effective method for the treatment of choledocholithiasis, but previous studies have rarely reported the appropriate ballooning time (BT). We prospectively evaluated the safety and efficacy of EPBD according to BT in patients undergoing bile duct stone removal. Methods: Seventy consecutive patients with bile duct stones were randomly assigned to receive EPBD with either conventional (n=35, 60 seconds) or short (n=35, 20 seconds) BT. Results: EPBD alone achieved complete bile duct clearance in 67 patients (long BT, n=33, 94.3%; short BT, n=34, 97.1%; p=0.808). We also found no significant difference in the rate of complete duct clearance, including procedures that used mechanical lithotripsy, between the long and short BT groups (97.1% vs. 100%; p=0.811). Mild pancreatitis was noted in four (11.4%) patients in the long BT group and two (5.7%) patients in the short BT group, but this incidence was not significantly different. Conclusions: The study showed that EPBD using both 20-sec and 60-sec BTs is safe and effective for the treatment of bile duct stones. Short and long BTs produced comparable outcomes. (Korean J Intern Med 2010;25:239-245)
난치성, 재발성 Clostridium difficile 감염에서 대변세균총이식: 9예의 임상증례보고
방병욱 ( Byoung Wook Bang ),박진석 ( Jin-seok Park ),김형길 ( Hyung Kil Kim ),신용운 ( Yong Woon Shin ),권계숙 ( Kye Sook Kwon ),권해윤 ( Hea Yoon Kwon ),백지현 ( Ji Hyeon Baek ),이진수 ( Jin-soo Lee ) 대한소화기학회 2017 대한소화기학회지 Vol.69 No.4
Background/Aims: Fecal microbiota transplantation (FMT) is a highly effective therapy for refractory and recurrent Clostridium difficile infection (CDI). Despite its excellent efficacy and recent widespread use, FMT has not been widely used in South Korea thus far. We describe our experience with FMT to treat refractory/recurrent CDI. Methods: We conducted a chart review of patients who underwent FMT for refractory/recurrent CDI at Inha University Hospital, between March 2014 and June 2016. The demographic information, treatment data, and adverse events were reviewed. FMT was administered via colonoscopy and/or duodenoscopy. All stool donors were rigorously screened to prevent infectious disease transmission. Results: FMT was performed in nine patients with refractory/recurrent CDI. All patients were dramatically cured. Bowel movement was normalized within one week after FMT. There were no procedure-related adverse events, except aspiration pneumonia in one patient. During the follow-up period (mean 11.4 months), recurrence of CDI was observed in one patient at one month after FMT due to antibiotics. Conclusions: FMT is a safe, well-tolerated and highly effective treatment for refractory/recurrent CDI. Although there are many barriers to using FMT, we expect that FMT will be widely used to treat refractory/recurrent CDI in South Korea. (Korean J Gastroenterol 2017;69:226-231)
Kim, Woon-Ki,Sul, Ok-Ju,Kwak, Jung-Sook,Hur, Hye-Young,Latour, Anne M.,Koller, Beverly H.,Kwon, Byoung-S.,Jeong, Choon-Soo Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.12
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2 gene expression, we studied the upstream region of the gene. Gel supershift assays revealed inducible binding of nuclear factor of activated T cells (NFAT) to a putative NFAT site within the TR2 promoter. Furthermore, cotransfection of a dominant negative NFAT construct, or siRNA for NFAT, resulted in increased expression of a TR2 reporter gene. Our findings demonstrate that NFAT negatively regulates TR2 expression in activated T cells.
CTTS의 비동기 절체 시 조속기 제어를 통한 과도 개선에 관한 연구
강병욱(Byoung-Wook Kang),채희석(Hui-Seok Chai),한운기(Woon-Ki Han),임현성(Hyun-Sung Lim),권승옥(Seung-Ok Kwon),김재철(Jae-Chul Kim) 한국조명·전기설비학회 2015 조명·전기설비학회논문지 Vol.29 No.11
This paper derives the problems that occur when asynchronous transfer in case of phase, frequency, voltage between the emergency generator and the grid and proposed the countermeasure to solve this problem when the transfer switch replace ATS(Automatic Transfer Switch) with CTTS(Closed Transition Transfer Switch) for the non-interrupting switching. In order to simulate above cases, modelling was used the transient analysis program PSCAD/EMTDC. By using this, the customer installed emergency generator and the grid was implemented. We compared three cases of asynchronous transition based on the basic case and proposed improvement by controlling the governor of emergency generator.
박병도 ( Byoung Do Park ),김형길 ( Hyung Gil Kim ),정현정 ( Hyun Jung Jung ),최용준 ( Yong Jun Choi ),김상구 ( Sang Gu Kim ),김수한 ( Soo Han Kim ),권계숙 ( Gye Sug Kwon ),신용운 ( Yong Woon Shin ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.1
Inflammatory bowel disease often involves extra-intestinal organs. Cerebral thrombosis, portal vein thrombosis and pulmonary thrombosis have been reported. Deep vein thrombosis and pulmonary thromboembolism are significant causes of mortality in patients with inflammatory bowel disease. A 48-year-old woman was diagnosed as inflammatory bowel disease on colonoscopy and histology. We used hydrocortisone and mesalazine for the treatment of disease. Nineteen days later, she complained of abrupt dyspnea. Pulmonary CT angiography revealed a thromboembolism in right pulmonary arteries. After the treatment of heparin therapy, follow-up pulmonary CT angiography showed significant improvement of previously thrombosed pulmonary arteries. (Korean J Gastroenterol 2009;53:48-52)