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Kui-Ye Yang,Myung-Dong Kim,Jin-Sook Ju,Min-Ji Kim,Dong-Kuk Ahn KOREAN ACADAMY OF ORAL BIOLOGY 2014 International Journal of Oral Biology Vol.39 No.1
We investigated the role of central P2X receptors in inflammatory pain transmission in the orofacial area in rats. Experiments were carried out using male Sprague-Dawley rats weighing 230-280g. Complete Freund's adjuvant (CFA, 40 μL) was applied subcutaneously to the vibrissa pad to produce inflammatory pain. The intracisternal administration of iso-PPADS tetrasodium salt, a non-selective P2X receptor antagonist, A317491 sodium salt hydrate, a P2X2/3 receptor antagonist, 5-BDBD, a P2X4 receptor antagonist, or A438079 hydrochloride, a P2X7 receptor antagonist, was performed 5 days after CFA injection. Subcutaneous injections of CFA produced increases in thermal hypersensitivity. Intracisternal injections of iso-PPADS (25 μg) or A438079 (25 or 50 μg) produced significant anti-hyperalgesic effects against thermal stimuli compared to the vehicle group. A317491 or 5-BDBD did not affect the head withdrawal latency times in rats showing an inflammatory response. Subcutaneous injections of CFA resulted in the up-regulation of OX-42, a microglia marker, and GFAP, an astrocyte marker, in the medullary dorsal horn. The intracisternal administration of A438079 reduced the numbers of activated microglia and astrocytes in the medullary dorsal horn. These results suggest that a blockade of the central P2X7 receptor produces antinociceptive effects, mediated by inhibition of glial cell function in the medullary dorsal horn. These data also indicate that central P2X7 receptors are potential targets for future therapeutic approaches to inflammatory pain in the orofacial area.
Kui-Ye Yang,Min-Su Kim,Eun-Kyung Kim,Mi-Sun Kong,Jong-Soo Ahn,Jong-Hun Lee,Jin-Sook Ju,Dong-Kuk Ahn KOREAN ACADAMY OF ORAL BIOLOGY 2013 International Journal of Oral Biology Vol.38 No.4
The present study investigated the effects of QX-314 on inflammatory pain of the temporomandibular joint (TMJ). Experiments were carried out on male Sprague-Dawley rats weighing 220-280 g. Under anesthesia, the TMJ of each animal was injected with 50 μL of formalin (5%). The number of noxious behavioral responses, including rubbing or scratching of the facial region including the TMJ area, was recorded over 9 sequential 5 min intervals for each animal. Although 2.5% QX-314 did not affect formalin-induced nociceptive behavior, administration of 5% QX-314 with formalin significantly decreased the number of scratches produced by the formalin injection. Co-administration of capsaicin, a TRPV1 agonist, with 2.5% QX-314 produced significant anti-nociceptive effects whereas 2.5% QX-314 alone did not. However, the co-administration of capsaicin did not enhance the anti-nociceptive effects in the 5% QX-314-treated rats. Moreover, the co-administration of capsazepine, a TRPV1 antagonist, did not attenuate anti-nociceptive effects in the 5% QX-314-treated rats. These findings suggest that TRPV1 is effective in the transport of low but not high doses of QX-314. Moreover, a high dose of QX-314, which is not mediated by peripheral TRPV1 activity, may be viable therapeutic strategy for inflammatory pain in the TMJ.
남자 고등학생의 구강건강관련 자기효능감이 구강건강관련 삶의 질에 미치는 영향
양귀예 ( Kui-ye Yang ),장지언 ( Ji-eon Jang ) 대한예방치과·구강보건학회 2020 大韓口腔保健學會誌 Vol.44 No.1
Objectives: To evaluate the association between oral health-related quality of life and oral healthrelated self-efficacy in high school students. Methods: A questionnaire-based survey was conducted among high school students in Daegu, South Korea from November to December 2015, and the final data of 432 students were analyzed. Results: Analysis of oral health-related self-efficacy in terms of general characteristics showed that both grade and income were significant factors (P<0.01). Furthermore, analysis of oral health-related quality of life in terms of general characteristics showed that academic achievement, father’s educational level, and academic stress were significant factors (P<0.05). Correlation analyses of oral health-related quality of life with oral health-related self-efficacy revealed positive correlations with tooth brushing and ordinary oral health behavior. Regression analysis of oral health-related quality of life showed that father’s educational level, oral health-related self-efficacy, academic stress, and academic achievement were influencing factors. Conclusions: These results indicate that oral health-related self-efficacy may play a significant role in oral health-related quality of life.
고등학생의 구강건강 관련 삶의 질이 학교생활 만족도에 미치는 영향
양귀예 ( Kui-ye Yang ),장지언 ( Ji-eon Jang ) 한국치위생과학회 2016 치위생과학회지 Vol.16 No.2
이번 연구는 고등학생의 구강건강 관련 삶의 질을 측정하여 학교생활 만족도와 상관관계를 알아보고, 청소년의 구강건강 관련 삶의 질이 학교생활 만족도에 미치는 영향을 분석하기 위해 실시하였다. 2015년 11월 30일부터 12월 7일까지 대구에 위치한 1개 고등학교 학생을 대상으로 편의표본추출법에 의한 자기기입 방식으로 설문조사를 실시하여 다음과 같은 결과를 얻었다. 고등학생의 구강건강 관련 삶의 질 중 기능적 삶이 3.51로 가장 높았으며, 학교생활 만족도 중에서는 대인관계 만족도가 3.75로 가장 높았다. 그리고 구강건강 관련 삶의 질에 유의한 영향을 주는 일반적 특성은 학업성적, 학업 스트레스(p<0.05)였으며, 학교생활 만족도에 유의한 영향을 주는 일반적 특성은 학업성적(p<0.001)이었다. 구강건강 관련 삶의 질은 학교생활 만족도의 하위요인 중 대인관계, 교육환경, 사회적 지지와 정(+)의 상관관계를 보였으며, 학교생활 만족도에 영향을 주는 요인으로는 학업성적과 구강건강 안녕 삶의 질이 유의한 영향을 나타내었다. 이상의 연구결과를 종합해보면, 고등학생의 구강건강 관련 삶의 질은 청소년의 학교생활 만족도와 관련되는 다양한 요인에 영향을 미치고 있다는 것을 알 수 있다. 따라서 청소년들이 올바른 구강건강 관리습관을 형성할 수 있도록 정기적인 구강보건교육 프로그램을 개발하여 효과적으로 실행할 수 있는 제도를 마련해야 하며, 학생 및 학교, 그리고 관련 부서에서 구강건강의 중요성을 인식하고 예방 및 조기치료, 구강건강 증진을 위해 노력해야 한다. The purpose of this study was to evaluate the association between oral health-related quality of life and school life satisfaction in high school students. A questionnaire-based survey was conducted on high school students in Daegu, South Korea from November to December, 2015, and final data from 432 students was analyzed. Analysis of oral health-related quality of life in terms of general characteristics showed that both academic achievement and stress were significant factors (p<0.05). With respect to school life satisfaction, academic achievement was found to be a highly significant influencing factor (p<0.01). Correlation analyses of oral health-related quality of life with various factors of school life satisfaction showed positive correlations with personal relationships, educational learning environment, social support. Regression analysis of school life satisfaction showed that academic achievement and oral health-related quality of life were influencing factors. These results indicate that oral health-related quality of life may play a significant role in school life satisfaction.
Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer
Li Ye,Chen Zhuo-Kun,Duan Xu,Zhang He-Jing,Xiao Bo-Lin,Wang Kui-Ming,Chen Gang 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover, due to their delivery of critical molecules that react to chemotherapy and immunotherapy, TDEs also contribute to tumor drug resistance and impede the effective response of antitumor immunotherapy, thereby leading to poor clinical outcomes. There is a pressing need for the inhibition or removal of TDEs to facilitate the treatment and prognosis of cancer patients. Here, in the present review, we systematically overviewed the current strategies for TDE inhibition and clearance, providing novel insights for future tumor interventions in translational medicine. Moreover, existing challenges and potential prospects for TDE-targeted cancer therapy are also discussed to bridge the gaps between progress and promising applications.
Zhang, Yu-Ping,Ye, Xiong-Wen,Tian, Meng-Kui,Qu, Ling-Bo,Choi, Seong-Ho,Gopalan, Anantha Iyengar,Lee, Kwang-Pill Elsevier 2008 Journal of chromatography A Vol.1188 No.1
<P><B>Abstract</B></P><P>Microwave irradiation can provide a viable alternative to the traditional means such as ultraviolet light and thermal initiation for the preparation of monolithic capillary columns. Polystyrene-based monolithic stationary phases were prepared <I>in situ</I> in fused-silica capillaries and simultaneously in vials. The column permeability, electrophoretic and chromatographic behavior were evaluated using pressure-assisted capillary electrochromatography (pCEC), capillary electrochromatography (CEC) and low pressure liquid chromatography (LPLC). With an optimal monolithic material, the largest theoretical plates for preparing the column could be close to 18,000 plates/m for thiourea in the mode of pCEC. Furthermore, the influence of the composition of the porogenic solvents (toluene/isooctane) on the morphology of organic-based monoliths [poly(styrene-divinylbenzene-methacrylic acid)] was systematically studied with mercury intrusion porosimetry and scanning electron microscopy. The monoliths which were prepared with a high content of isooctane had a bigger pore size and better permeability, and hence resulted in a faster separation.</P>