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류마티스 관절염에서 제 2형 콜라겐에 대한 T림프구 증식반응과 염증지표 및 관절손상과의 관계
최진정 ( Jin Jung Choi ),김완욱 ( Wan Uk Kim ),조미라 ( Mi La Cho ),이명수 ( Myeung Su Lee ),서영일 ( Young Il Seo ),민도준 ( Do June Min ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ),김기준 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.2
Objective: To investigate the role of T cell responses to type II collagen (CII) in disease progression in rheumatoid arthritis (RA). Methods: T cell proliferative responses to bovine CII by peripheral blood mononuclear cells (PBMC) from early RA patients (duration <5 years) were assayed by mixed lymphocyte culture. Clinical and laboratory variables including erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) were examined at the time of sampling. Radiographic damage on hand X-rays was evaluated by the method of Steinbrocker and Sharp. Results: In a cross-sectional study, patients (n=22) with positive T cell responses (stimulation index: SI≥2) had higher levels of CRP and ESR than those (n=21) not showing T cell responses. The number of damaged joints (by Steinbrocker`s method) and damaged joint scores (by Sharp`s method) were significantly higher in patients with positive T cell responses than in those without. The joint space narrowing scores correlated well with T cell responsiveness to CII. Patients (n=15) with both positive T cell responses and RA-susceptible allotypes, HLA-DR1 or DR4, had greater damaged joint scores than the rest of patients (n=24). Conclusion: T cell proliferative responses to CII are associated with inflammatory activity and radiographic severity in RA. Our data suggest that CII reactive T cells may play an important role in the pathogenic process of joint damage.
Streptozotocin 에 의해 유도된 당뇨병성 통증시 Nitric Oxide 의 역할
최진정(Jin Jung Choi),전병화(Byeong Hwa Joen),윤석화(Seok Hwa Yoon),이영호(Young Ho Lee),김무강(Moo Gang Kim),김광진(Kwang Jin Kim) 대한통증학회 2001 The Korean Journal of Pain Vol.14 No.1
N/A Background: It is controversial whether the change in nitric oxide (NO) expression in the dorsal root ganglia (DRG) may be responsible for developtment and/or maintenance of painful diabetic neuropathy. The aim of this study was to clarify the role of NO in the pathogenesis of painful diabetic neuropathy. Methods: The effect of L-nitroargine methylester (L-NAME) or sodium nitroprusside (SNP) on allodynia was measured in streptozotocin (STZ)-induced diabetic rats. NO concentration was measured in the cerebrospinal fluid (CSF) and plasma of the diabetic rats. NADPH-diaphorase (NADPH-d) histochemistry was performed on the DRG and spinal cords of the STZ-induced diabetic rats. Results: L-NAME, an inhibitor of nitric oxide synthase, alleviated allodynia, while SNP, a nitric oxide donor, aggravated allodynia in diabetic rats. Plasma NO level in the diabetic rats was significantly de- creased compared with control rats. NO level in the CSF of diabetic rats did not differ from that of the control rats. NADPH-d positive cells were decreased in the DRG of diabetic rats. However, NADPH-d histochemistry in the diabetic spinal cord was not different from that of the control rats. Conclusions: Downregulation of NO expression in the diabetic rats may not be causally related to the development and/or maintenance of painful diabetic neuropathy.
전신홍반루푸스에 동반된 항인지질항체 증후군 환자에서 괴저농피증 양상으로 발현된 족부 궤양
허기훈 ( Ki Hoon Hur ),곽승기 ( Seung Ki Kwok ),박윤정 ( Yoon Jung Park ),최진정 ( Jin Jung Choi ),조철수 ( Chul Soo Cho ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.2
Antiphospholipid syndrome (APS) is characterized by vascular thrombosis in association with elevated titers of antiphospholipid antibodies. Leg ulcers are a considered to be a cutaneous manifestation of APS due to thrombosis of small to medium sized vessels. We report a case of necrotic non-healing, ankle ulcers mimicking pyoderma gangrenosum associated with APS in 50-year-old man. He had a past history of autoimmune thrombocytopenia and cerebral infarction. Laboratory findings showed a circulating lupus anticoagulant, positive anticardiolipin antibodies as well as anti-dsDNA and anti-Sm antibodies. Skin biopsy of ulcer lesions showed thrombotic vasculopathy of medium sized vessels with minimal leukocyte infiltration. Ulcers were successfully treated with surgical debridement and subsequent skin graft along with anticoagulation therapy.
분류 불능형 면역 결핍증(Common Variable Immunodeficiency)과 병발된 쇼그렌 증후군
강산하 ( San Ha Kang ),조혜정 ( Hye Jeong Cho ),홍희진 ( Hee Jin Hong ),홍소담 ( So Dam Hong ),김보혜 ( Bo Hye Kim ),정상윤 ( Sang Yoon Jung ),최진정 ( Jin Jung Choi ) 대한내과학회 2015 대한내과학회지 Vol.89 No.2
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immune deficiencies in adults characterized by hypogammaglobulinemia, recurrent bacterial infections, and a higher incidence of autoimmune diseases. More than 25% of CVID patients also have autoimmune diseases such as autoimmune hemolytic anemia, immune thrombocytopenic purpura, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathogenesis of autoimmunity in CVID remains obscure. We report a 56-year-old woman with CVID and Sjogren`s syndrome. In addition to a long history of recurrent upper respiratory infections, acute gastroenteritis, and cellulitis, she has also suffered from persistent xerostomia and xerophthalmia for the past 10 years. Serologic studies revealed hypogammaglobulinemia (low levels of IgG, IgA, and IgM in serum) and the presence of anti-Ro antibodies, and salivary scintigraphy indicated salivary gland involvement. These findings led to a diagnosis of CVID and Sjogren`s syndrome, which was treated by monthly intravenous immunoglobulin therapy. (Korean J Med 2015,89:254-258)
류마티스 활막세포에서 비스테로이드성 항염제에 의한 Vascular Endothelial Growth Factor 생성의 억제
김용주 ( Yong Ju Kim ),박종서 ( Jong Seo Park ),최진정 ( Jin Jung Choi ),민소연 ( So Youn Min ),조미라 ( Mi La Cho ),김완욱 ( Wan Uk Kim ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Objective: Vascular endothelial growth factor (VEGF), a potent angiogenic, permeability-enhancing cytokine plays an important role in chronic inflammatory process of rheumatoid arthritis (RA). Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs for the treatment of RA. However, the effect of NSAIDs on angiogenesis in rheumatoid synovium is unclear. In this study, we investigated the effects of NSAIDs such as indomethacin (IDC) on TGF-β-induced VEGF production in rheumatoid synoviocytes. Methods: Fibroblast-like synoviocytes (FLS) from RA were stimulated with TGF-β (10 ng/ml) for 24hr in the presence of the various concentrations of IDC. The levels of VEGF were measured in culture supernatant by ELISA. In addition, COX-2 and VEGF mRNA expression of cultured FLS were evaluated by RT-PCR. Results: VEGF production from FLS was significantly increased in the presence of TGF-β. IDC exerted a dose-dependent inhibitory effect on the production of VEGF induced by TGF-β. RT-PCR analysis showed that IDC also inhibited TGF-β-induced COX-2 and VEGF mRNA expression in cultured FLS by a dose-dependent manner. Conclusion: Our results demonstrate that NSAIDs inhibit VEGF production and the expression of its mRNA and COX-2 mRNA in synovial cells of RA patients. These findings suggest that NSAIDs may suppress progression and perpetuation of rheumatoid synovitis by anti-angiogenic activity.
항인지질 항체 증후군 환자의 혈청 내 Monocyte Chemoattractant Protein-1의 증가
박종서 ( Jong Seo Park ),박경수 ( Kyung Su Park ),최진정 ( Jin Jung Choi ),윤종현 ( Jong Hyeon Yoon ),김용주 ( Yong Ju Kim ),김완욱 ( Wan Uk Kim ),민도준 ( Do Jun Min ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.4
Objective: To determine the association of serum monocyte chemoattractant protein-1 (MCP-1) concentration and clinical variables of antiphospholipid syndrome (APS). Methods: We investigated the serum concentration of MCP-1 in systemic lupus erythematosus (SLE) patients by ELISA. The clinical features of APS were evaluated in SLE patients, and anticardiolipin antibody (aCL) was determined at the time of blood sampling. Results: Serum MCP-1 levels (median [range]) in 76 SLE patients were significantly higher than those in 99 healthy controls (192 pg/ml [116, 560] versus 91 pg/ml [26~251], p<0.001). Patients with APS had higher levels of serum MCP-1 than those without (p=0.013). Seum MCP-1 levels were significantly higher in patients with thrombosis and recurrent fetal loss than those without. Among APS patients, patients with longer disease duration (>3 years) had higher levels of MCP-1 than those without (263 pg/ml [166,534] versus 196 pg/ml [116,322], P=0.023). Furthermore, serum MCP-1 levels correlated well with IgG aCL titers (r=0.62, p<0.001). Conclusion: Serum MCP-1 levels were elevated in SLE patients, particularly in those with APS, and correlated well with titers of IgG aCL and thrombosis. Our data suggest that increased MCP-1 may play a critical role in the development of APS in SLE patients.
이두용(Doo Yong Lee),김병모(Byung Mo Kim),서용희(Yong Hei Suhr),최진정(Jin Jung Choi),한승수(Seung Soo Han),김광희(Kwang Hoi Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.6
N/A The present study was performed to evaluate the serum rGtp activity on ear1y detection and prevention of alcohol induced liver injury in 4184 persons with negative HBsAg, who live their common life. Prior to test we measured normal value of rGtp activity as contrast group among totals with numbers of 2226 (male 735, female 1491) which were HBsAg negative and no other LFT abnormality. In series of auther's test on teetotal group with cases of 2501 and habitual drinking group with cases of 1863 which were divided to 5 to 6 subgroups depending on daily amount, weekly frequency and total period in alcohol drinking respectively, we anlayzed comparatively the mean value and percentage of abnormality in rGtp, SGOT, SGPT and s-ALP in order to evaluate the efficacy of rGtp activity among each groups and teetoatla group and tested the influencing factor on rGtp. The results are summarized follows; 1) The mean values of rGtp activity in a normal contrast group were 17.9±11.0(SD) in male, 11.7±6.7 in female and 13.7±12.1 in total. 2) The total mean values of rGtp, SGOT, SGPT and s-ALP were 15.9±16.1, 17.25±7.8, and 54.2±25.6 in tee-total group and 33.6±43.0, 19.4±11.2, 22.4±18.5 and 55. 1±29.6 in habitual drinking group respectively, so the elevated rGtp, SGOT, SGPT and s-ALP in habitual drinking group compared to the teetotal group were obrained and statistically significant (p<0.05). Among each group of alcohol drinking the value of rGtp, SGOT and SGPT were increased tendency depending on increase in daily amount weekly frequency and toal period. 4) The rGtp activity was influenced by either of daily amount or weekly frequency or total period in alcohol drinking and we obtained by multiple regression test that most striking influencing factor on rGtp was weekly frequency of drinking. We concluded that rGtp is more sensitive than other liver function test in detection of alcohol-induced liver injury in a man who lives his common life and considered to be required to follow up rGtp activity as objective index to clearfy how to be influenced by abstinence of alcohol.
윤종현 ( Chong Hyeon Yoon ),박경수 ( Kyung Soo Park ),최진정 ( Jin Jung Choi ),조미라 ( Mi La Cho ),민소연 ( So Youn Min ),김완욱 ( Wan Uk Kim ),민도준 ( Do June Min ),민준기 ( Jun Ki Min ),홍연식 ( Yeon Sik Hong ),박성환 ( Sung H 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.2
Objective: Infiltrating T cells and monocytes have been implicated in the pathogenesis of lupus nephritis (LN). Chemokines may play a key role in the recruitment of these cells. We investigated whether RANTES (regulated on activation normal T cell expressed and secreted), one of the CC chemokine family, may be involved in the pathogenesis of LN. Methods: We measured the levels of RANTES in sera and urine from 87 systemic lupus erythematosus (SLE) patients and 78 healthy controls using ELISA. Clinical and laboratory assessment including SLE disease activity index (SLEDAI) were performed at the time of sampling. Results: Serum RANTES levels were significantly higher in the patients with SLE than in healthy controls (115.0±5.6 vs. 91.5±4.0 pg/ml, p=0.001, mean±SEM). Serum RANTES levels correlated well with anti-dsDNA antibody titer (r=0.29, p<0.05) and inversely with serum complement C4 level (r=-0.28, p<0.05). Urinary RANTES/creatinine ratios were significantly higher in patients with nephritis than those without (3.4±0.4 vs. 2.2±0.3, p=0.004), while serum RANTES level was not different between patients with nephritis and those without. Moreover, urinary RANTES/creatinine ratio positively correlated with urine protein/creatinine ratio (r=0.41, p<0.001). Conclusions: Our results demonstrate that serum RANTES was elevated in patients with SLE and urinary excretion of RANTES was strongly associated with presence of nephritis. These data suggest that RANTES may be expressed in renal inflammatory sites and may participate in the pathogenesis of LN possibly by augmenting the recruitment of T cells and monocytes.
전신흥반루푸스 환자에서 혈청 Osteoprotegerin 증가
신용주 ( Yong Ju Shin ),홍경희 ( Kyung Hee Hong ),유승아 ( Seung Ah Yoo ),최진정 ( Jin Jung Choi ),김완욱 ( Wan Uk Kim ),조철수 ( Chul Soo Cho ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.3
Objective: To determine the serum levels of soluble osteoprotegerin (OPG), decoy receptor of receptor activator of nuclear factor kB ligand (RANKL), in patients with systemic lupus erythematosus (SLE) and to assess the its relationships with certain clinical manifestations. Methods: Serum levels of OPG in 60 patients with SLE and 30 healthy controls were determined by enzyme-linked immunosorbent assay. At the time of serum sampling, clinical manifestations and lupus disease activity index (SLEDAI) were assessed. Results: Serum levels of OPG in 60 patients with SLE were significantly higher than in 30 healthy controls (1,058±699 versus 806±113 pg/mL, p=0.008). Patients with active disease had higher levels of OPG levels than those with inactive disease (1,355±837 versus 760±113 pg/mL, p<0.001). Serum OPG levels correlated with SLEDAI (γ=0.588, p<0.0001), anti-dsDNA antibody titers (γ=0.337, p=0.009) and serum MCP-1 levels (γ=0.485, P<0.0001). In particular, serum OPG levels were found to be significantly increased in patients with neurological manifestation compared to those without (1,504±1,152 versus 918±376 pg/mL, p=0.004). Conclusion: The results of this study suggest that serum OPG levels are increased in patients with SLE. Serum OPG has a role as marker for disease activity and its increased levels reflect the involvement of neurological manifestation.