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Arluison, Vé,ronique,Hohng, Sungchul,Roy, Rahul,Pellegrini, Olivier,Ré,gnier, Philippe,Ha, Taekjip Oxford University Press 2007 Nucleic acids research Vol.35 No.3
<P>Hfq protein is vital for the function of many non-coding small (s)RNAs in bacteria but the mechanism by which Hfq facilitates the function of sRNA is still debated. We developed a fluorescence resonance energy transfer assay to probe how Hfq modulates the interaction between a sRNA, DsrA, and its regulatory target mRNA, <I>rpoS</I>. The relevant RNA fragments were labelled so that changes in intra- and intermolecular RNA structures can be monitored in real time. Our data show that Hfq promotes the strand exchange reaction in which the internal structure of <I>rpoS</I> is replaced by pairing with DsrA such that the Shine-Dalgarno sequence of the mRNA becomes exposed. Hfq appears to carry out strand exchange by inducing rapid association of DsrA and a premelted <I>rpoS</I> and by aiding in the slow disruption of the <I>rpoS</I> secondary structure. Unexpectedly, Hfq also disrupts a preformed complex between <I>rpoS</I> and DsrA. While it may not be a frequent event <I>in vivo</I>, this melting activity may have implications in the reversal of sRNA-based regulation. Overall, our data suggests that Hfq not only promotes strand exchange by binding rapidly to both DsrA and <I>rpoS</I> but also possesses RNA chaperoning properties that facilitates dynamic RNA–RNA interactions.</P>
A note on maximally repeated sub-patterns of a point set
Cortier, Vé,ronique,Goaoc, Xavier,Lee, Mira,Na, Hyeon-Suk Elsevier 2006 Discrete mathematics Vol.306 No.16
<P><B>Abstract</B></P><P>We answer a question raised by Brass on the number of maximally repeated sub-patterns in a set of <I>n</I> points in <SUP>Rd</SUP>. We show that this number, which was conjectured to be polynomial, is in fact Θ(<SUP>2n/2</SUP>) in the worst case, regardless of the dimension <I>d</I>.</P>
Hwang, Wonseok,Arluison, Vé,ronique,Hohng, Sungchul Oxford University Press 2011 Nucleic acids research Vol.39 No.12
<P>Hfq is a key regulator involved in multiple aspects of stress tolerance and virulence of bacteria. There has been an intriguing question as to how this RNA chaperone achieves two completely opposite functions—annealing and unwinding—for different RNA substrates. To address this question, we studied the Hfq-mediated interaction of fragments of a non-coding RNA, DsrA, with its mRNA target <I>rpoS</I> by using single-molecule fluorescence techniques. These experiments permitted us to observe the mechanistic steps of Hfq-mediated RNA annealing/unwinding at the single-molecule level, for the first time. Our real-time observations reveal that, even if the ring-shaped Hfq displays multiple binding sites for its interaction with RNA, the regulatory RNA and the mRNA compete for the same binding site. The competition makes the RNA-Hfq interaction dynamic and, surprisingly, increases the overall annealing efficiency by properly aligning the two RNAs. We furthermore reveal that when Hfq specifically binds to only one of the two RNAs, the unwinding process dominates over the annealing process, thus shedding a new light on the substrate selectivity for annealing or unwinding. Finally, our results demonstrate for the first time that a single Hfq hexamer is sufficient to facilitate sRNA–mRNA annealing.</P>
All natural cork composites with suberin-based polyester and lignocellulosic residue
De Oliveira, Hugo,Yoon, Bumyong,Michaud, Vé,ronique,Nam, Jae-Do,Suhr, Jonghwan Elsevier 2017 INDUSTRIAL CROPS AND PRODUCTS Vol.109 No.-
<P><B>Abstract</B></P> <P>Suberin is an aromatic-aliphatic cross-linked polyester structure which constitutes cell wall structures of cork. It is particularly interesting for its use of monomeric compounds towards renewable bio-based polymers. In this study, the extraction of suberin monomers was successfully done by green method using alkaline hydrolysis combined with mechanical grinding. As the mechanical grinding was applied along with hydrolysis process, the maximum yield of depolymerized suberin monomer (DSM) with relatively low energy and less time was acheived. The polarity and functionality of DSM extracted in this study also showed higher values compared to conventional reflux hydrolysis process. Polyesterification and curing behavior of DSM were examined with molecular weights and mechanical properties of the ensuing polyesters. Tensile properties of suberin-based polyesters are reported for the first time that the maximum strength was found to be 7.3MPa while Young‘s modulus was found to be 105MPa. Furthermore, all natural cork composites were fabricated which comprise suberin-based polyester as matrix and lignocellulosic residue as reinforcement, and also reported their significantly enhanced tensile properties showing the great potential as an alternative green polymer composites for various engineering applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Suberin extraction process has been developed in efficient way and showed high functionality of suberin monomers, not compromising the maximum yield of suberin monomer. </LI> <LI> The kinetics of polyesterification reaction of suberin monomers showed that the gel point of suberin monomers was estimated to be 3h in 170°C convection oven. </LI> <LI> Synthesis of suberin-based polyesters is optimized by reducing void formations inside the material. </LI> <LI> The maximum tensile strength was found to be 7.3MPa while Young‘s modulus was found to be 105MPa. </LI> <LI> Lignocellulosic residue obtained from extraction process has been incorporated into suberin-based polyester matrix to fabricate all cork-based composites. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>A green composite material was developed by environmentally friendly fabrication process from renewable natural cork, without compromising the mechanical properties of the resultant materials.</P> <P>[DISPLAY OMISSION]</P>
Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes
Grosse, Yann,Loomis, Dana,Guyton, Kathryn Z,Lauby-Secretan, Bé,atrice,El Ghissassi, Fatiha,Bouvard, Vé,ronique,Benbrahim-Tallaa, Lamia,Guha, Neela,Scoccianti, Chiara,Mattock, Heidi,Straif, Elsevier 2014 The Lancet. Oncology Vol.15 No.13
Schnekenburger, Michael,Goffin, Eric,Lee, Jin-Young,Jang, Jun Young,Mazumder, Aloran,Ji, Seungwon,Rogister, Bernard,Bouider, Nafila,Lefranc, Florence,Miklos, Walter,Mathieu, Vé,ronique,de Tullio American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.11
<P>A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. On the basis of computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea] which displays a potent anti.proliferative activity on various glioma cell types, assessed by quantitative videomicroscopy, eventually triggering senescence. The impact on normal glial cells was lower with a selectivity index of >10. Furthermore, human U373 and Hs683 glioblastoma cell lines served to demonstrate the inhibitory activity of 18 against histone deacetylase (HDAC) class III sirtuins 1 and 2 (SIRT1/2) by quantifying acetylation levels of histone and non-histone proteins. The translational potential of 18 was validated by an NCI-60 cell line screen and validation of growth inhibition of drug resistant cancer cell models. Eventually, the anticancer potential of 18 was validated- in 3D glioblastoma spheroids and in vivo by zebrafish xenografts. In summary, compound 18 is the first representative of a new class of SIRT inhibitors opening new perspectives in the medicinal chemistry of HDAC inhibitors.</P>
La question du genre et des TNIC au prisme du dialogue de la sociologie et de la sémiotique
Hélène Bourdeloie,Véronique Julliard 고려대학교 응용문화연구소 2013 에피스테메 Vol.0 No.9
This contribution studies the seniors’ practices in relation with Digital Information and Communication Technologies (DICT) and gendered identities that are built through these practices. We make the hypothesis that Sex is a determining factor and that Gender structures practices as well as representations. The authors congujate sociological and semiotic approaches upon two fields: firstly, two groups of persons over 60 years, which one has followed a training to DICT, secondly, the Social Networking Service (SNS) Quintonic. The study reveals that beyond gender divisions, the seniors’ practices make sense in the system of Gender-which distributes centers of interests between men and women-, participating in the construction of gendered identities. Furthermore, the SNS, because of their expressive dimensions, allow gender norms’ interpretations. These interpretations question gendered identities. Cette contribution étudie les pratiques des seniors liées aux technologies numériques de l’information et de la communication (TNIC) et les identités de genre qui s’élaborent via ces pratiques, l’hypothèse étant que le sexe est là un facteur déterminant et que le genre structure tant les pratiques que les représentations. Les auteures font ici dialoguer des approches sociologique et sémiotique sur deux terrains : deux groupes de seniors âgés de 60 ans, dont l’un a suivi une formation aux TNIC, et le réseau socionumérique (RSN) Quintonic. Il ressort de l’étude qu’au-delà de leur sexuation, les pratiques des seniors prennent sens dans le système du genre-qui distribue les centres d’intérêt entre les sexes-, et participent à la construction des identités de genre. Par ailleurs, certaines TNIC, telles qu’un RSN, de par leurs dimensions éditoriale et expressive, donnent lieu à des interprétations des normes de genre, interprétations susceptibles de redessiner les identités de genre traditionelles.
Relevant design parameters for a reactor used in P removal with ZVI-based materials
Pauline Lanet,Véronique Deluchat,Michel Baudu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
Phosphate (P) retention onto zero valent iron (ZVI) particles and on iron oxyhydroxides has been widelyinvestigated as a treatment process for domestic wastewater. Since such a process is less expensive andrequires less maintenance than typical biological and physicochemical methods, it could provide a viablepath to reaching high P removal capacities. This manuscript provides up-to-date information on P retentionmechanisms, with the main ones being adsorption, precipitation and co-precipitation. The majorexperimental parameters affecting these mechanisms and ZVI reactivity are summarized. Through areview of batch studies and continuous reactor experiments, the P retention capacities of ZVI-basedmaterials have been collated and compared according to test operating conditions, such as pH, initialadsorbate concentrations or hydrodynamic conditions. ZVI and its byproducts have already demonstratedhigh P retention capacities (up to 264 mg P/g ZVI). Methodological recommendations are providedto design reactor for phosphorus removal in wastewater treatment plants.