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Gold nanoparticle-mediated photothermal therapy: current status and future perspective.
Hwang, Sekyu,Nam, Jutaek,Jung, Sungwook,Song, Jaejung,Doh, Hyunmi,Kim, Sungjee Future Medicine Ltd. 2014 Nanomedicine Vol. No.
<P>Gold nanoparticles (AuNPs) are attractive photothermal agents for cancer therapy because they show efficient local heating upon excitation of surface plasmon oscillations. The strong absorption, efficient heat conversion, high photostability, inherent low toxicity and well-defined surface chemistry of AuNPs contribute to the growing interest in their photothermal therapy (PTT) applications. The facile tunability of gold nanostructures enables engineering of AuNPs for superior near-infrared photothermal efficacy and target selectivity, which guarantee efficient and deep tissue-penetrating PTT with mitigated concerns regarding side effects by nonspecific distributions. This article discusses the current research findings with representative near-infrared-active AuNPs, which include nanoshell, nanorod, nanocage, nanostar, nanopopcorn and nanoparticle assembly systems. AuNPs successfully demonstrate potential for use in PTT, but several hurdles to clinical applications remain, including long-term toxicity and a need for sophisticated control over biodistribution and clearance. Future research directions are discussed, especially regarding the clinical translation of AuNP photosensitizers.</P>
Yang, Bo Yeun,Moon, Sung-Hyun,Seelam, Sudhakara Reddy,Jeon, Min Jeong,Lee, Yun-Sang,Lee, Dong Soo,Chung, June-Key,Kim, Young Il,Jeong, Jae Min Future Medicine Ltd 2015 Nanomedicine Vol.10 No.12
<P>We tried to develop a multimodal iron oxide nanoparticles (IO NP) imaging probe by an encapsulation method using specific amphiphiles for (68)Ga-labeling and lymph node-targeting.</P>
Park, Sung Young,Kang, Byung-Soo,Hong, Seunghun Future Medicine Ltd 2013 Nanomedicine Vol.8 No.5
<P>The authors aimed to investigate the effect of carbon nanotube (CNT)-based extracellular environments on the neural differentiation of human mesenchymal stem cells (hMSCs) when combined with chemical inducers.</P>
Lee, Eun Ju,Park, Hwan-Woo,Jeon, Hyo-Jin,Kim, Hyo-Soo,Chang, Mi-Sook Future Medicine 2013 Regenerative medicine Vol.8 No.3
<P>Human bone marrow-derived mesenchymal stem cells (hMSCs) are advantageous for cell-based therapy to treat ischemic diseases owing to their capacity to secrete various paracrine factors with potent angiogenic activity.</P>
Bain, Owen,Detela, Giulia,Kim, Hae-Won,Mason, Chris,Mathur, Anthony,Wall, Ivan B Future Medicine 2014 Regenerative medicine Vol.9 No.2
<P>It is very difficult to conserve critical cell characteristics during expansion in culture, particularly those of adult mesenchymal stromal cells (MSCs), whose characteristics can change rapidly even within a short period of expansion.</P>
Mehtala, Jonathan G,Torregrosa-Allen, Sandra,Elzey, Bennett D,Jeon, Mansik,Kim, Chulhong,Wei, Alexander Future Medicine Ltd 2014 Nanomedicine Vol. No.
<P>The synergistic effects of gold nanorod (GNR)-mediated mild hyperthermia (MHT; 42-43C) and cisplatin (CP) activity was evaluated against chemoresistant SKOV3 cells in vitro and with a tumor xenograft model.</P>