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A pivotal role of GSK-3 in synaptic plasticity
Bradley, Clarrisa A.,Peineau, Sté,phane,Taghibiglou, Changiz,Nicolas, Celine S.,Whitcomb, Daniel J.,Bortolotto, Zuner A.,Kaang, Bong-Kiun,Cho, Kwangwook,Wang, Yu Tian,Collingridge, Graham L. Frontiers Media S.A. 2012 Frontiers in molecular neuroscience Vol.5 No.-
<P>Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.</P>