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Park, Pojeong,Volianskis, Arturas,Sanderson, Thomas M.,Bortolotto, Zuner A.,Jane, David E.,Zhuo, Min,Kaang, Bong-Kiun,Collingridge, Graham L. The Royal Society 2014 Philosophical transactions. Biological sciences Vol.369 No.1633
<P><I>N</I>-methyl-<SMALL>D</SMALL>-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) is extensively studied since it is believed to use the same molecular mechanisms that are required for many forms of learning and memory. Unfortunately, many controversies exist, not least the seemingly simple issue concerning the locus of expression of LTP. Here, we review our recent work and some of the extensive literature on this topic and present new data that collectively suggest that LTP can be explained, during its first few hours, by the coexistence of at least three mechanistically distinct processes that are all triggered by the synaptic activation of NMDARs.</P>
Park, Pojeong,Volianskis, Arturas,Sanderson, Thomas M.,Bortolotto, Zuner A.,Jane, David E.,Zhuo, Min,Kaang, Bong-Kiun,Collingridge, Graham L. Royal Society of London 2014 Philosophical transactions. Biological sciences Vol.369 No.1633
N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) is extensively studied since it is believed to use the same molecular mechanisms that are required for many forms of learning and memory. Unfortunately, many controversies exist, not least the seemingly simple issue concerning the locus of expression of LTP. Here, we review our recent work and some of the extensive literature on this topic and present new data that collectively suggest that LTP can be explained, during its first few hours, by the coexistence of at least three mechanistically distinct processes that are all triggered by the synaptic activation of NMDARs.
( Franciane Cabral Pinheiro ),( Vandreza Cardoso Bortolotto ),( Stifani Machado Araujo ),( Marcia Rosula Poetini ),( Carla Pohl Sehn ),( Jose S. S. Neto ),( Gilson Zeni ),( Marina Prigol ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.7
This study aimed to evaluate the antimicrobial activity of 2-phenylethynyl-butyltellurium (PEBT) in Escherichia coli and the relation to its pro-oxidant effect. For this, we carried out the disk diffusion test, minimum inhibitory concentration (MIC) assay, and survival curve analysis. We also measured the level of extracellular reactive oxygen species (ROS), activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and level of nonprotein thiols (NPSH). PEBT at 1.28 and 0.128 mg/disk exhibited antimicrobial capability in the disk diffusion test, with an MIC value of 1.92 mg/ml, whereas PEBT at 0.96, 1.92, and 3.84 mg/ml inhibited bacterial growth after a 9-h exposure. PEBT at 3.84, 1.92, and 0.96 mg/ml increased extracellular ROS production, decreased the intracellular NPSH level, and reduced the SOD and CAT activities. Glutathione or ascorbic acid in the medium protected the bacterial cells from the antimicrobial effect of PEBT. In conclusion, PEBT exhibited antimicrobial activity against E. coli, involving the generation of ROS, oxidation of NPSH, and reduction of the antioxidant defenses in the bacterial cells.
Park, Pojeong,Sanderson, Thomas M.,Amici, Mascia,Choi, Sun-Lim,Bortolotto, Zuner A.,Zhuo, Min,Kaang, Bong-Kiun,Collingridge, Graham L. Society for Neuroscience 2016 The Journal of neuroscience Vol.36 No.2
<P>Two forms of NM DA receptor (NMDAR)-dependent long-term potentiation (LIP) at hippocampal CAI synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA). The PKA-dependent form requires multiple episodes of high-frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between episodes in the order of minutes. To investigate the mechanism by which spaced episodes induce the PKA-dependent form of LIP, we have compared, in interleaved experiments, spaced (s) and compressed (c) TBS protocols in the rat CAI synapses. We find that LIP induced by sTBS, but not that induced by cTBS, involves the insertion of calcium-permeable (CP) AMPARs, as assessed using pharmacological and electrophysiological criteria. Furthermore, a single TBS when paired with rolipram [4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one], to activate PKA, generates an LTP that also involves the insertion of CP-AMPARs. These data demonstrate that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is associated specifically with the PKA-dependent form of LIP.</P>
A pivotal role of GSK-3 in synaptic plasticity
Bradley, Clarrisa A.,Peineau, Sté,phane,Taghibiglou, Changiz,Nicolas, Celine S.,Whitcomb, Daniel J.,Bortolotto, Zuner A.,Kaang, Bong-Kiun,Cho, Kwangwook,Wang, Yu Tian,Collingridge, Graham L. Frontiers Media S.A. 2012 Frontiers in molecular neuroscience Vol.5 No.-
<P>Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.</P>