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From Single to Many-Objective PID Controller Design using Particle Swarm Optimization
Hélio Freire,P. B. Moura Oliveira,E. J. Solteiro Pires 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.2
Proportional, integrative and derivative (PID) controllers are among the most used in industrial controlapplications. Classical PID controller design methodologies can be significantly improved by incorporatingrecent computational intelligence techniques. Two techniques based on particle swarm optimization (PSO) algorithmsare proposed to design PI-PID controllers. Both control design methodologies are directed to optimizePI-PID controller gains using two degrees-of-freedom control configurations, subjected to frequency domain robustnessconstraints. The first technique proposes a single-objective PSO algorithm, to sequentially design a twodegrees-of-freedom control structure, considering the optimization of load disturbance rejection followed by setpointtracking optimization. The second technique proposes a many-objective PSO algorithm, to design a twodegrees-of-freedom control structure, considering simultaneously, the optimization of four different design criteria. In the many-objective case, the control engineer may select the most adequate solution among the resulting optimalPareto set. Simulation results are presented showing the effectiveness of the proposed PI-PID design techniques, incomparison with both classic and optimization based methods.
Juliana Semensato,Júlio Cesar Fernandes,Mohamed Benderdour,Vera Aparecida de Oliveira Tiera,Aline Margarete Furuyama Lima,Marcio José Tiera 한국고분자학회 2020 Macromolecular Research Vol.28 No.2
The improvement of biological properties of polycations is a fundamental step to overcome their limitations as non-viral gene carriers. This work studied the effect of phosphorylcholine (PC) groups on the physicochemical properties of poly(L-lysine) (PLL)/pDNA nanoparticles. Phosphorylcholine-grafted PLL derivatives (PLL-PC) containing increasing proportions of PC were obtained by the reductive amination reaction with phosphoryl glyceraldehyde and characterized by 1H NMR, FTIR, and GPC measurements. The PLL-PC derivatives were used to prepare polyplexes with pDNA and their properties were evaluated by fluorescence, gel electrophoresis and dynamic light scattering (DLS) measurements. The PLL-PC derivatives were able to interact with pDNA at low N/P ratios in physiological pH to form stable polyplexes having lower zeta potentials, as evidenced by the gel electrophoresis and zeta potentials measurements. A degree of grafting of 10% increased the in vitro transfection efficiency of PLL and a degree of 20 mol% of PC groups provided colloidal stability in physiological saline solution at neutral pH. Overall, the PC-PLL derivatives exhibited improved physicochemical properties and have significant potential for further studies as non-viral gene transfer agents.
Boron nitride nanotube-CREKA peptide as an effective target system to metastatic breast cancer
Ferreira Tiago Hilário,de Oliveira Freitas Luiza Baptista,Fernandes Renata Salgado,dos Santos Virgílio Mateus,Resende Jarbas Magalhães,Cardoso Valbert Nascimento,de Barros André Luís Branco,de Sousa E 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.5
Purpose The development of nanomaterials that are capable of recognizing disease-specific biomarkers with high sensitivity and specificity is related to several advances in the field of nanomedicine. Furthermore, the targeted delivery of anticancer agents to tumor tissues enhances their efficiency and reduces their toxic side effects. Boron nitride nanotubes (BNNTs) are nanostructured materials, analog to carbon nanotubes, which present good biocompatibility and morphology suitable for tumor cell internalization. CREKA is a pentapeptide that has a high affinity to fibrin, a protein found in the new tumor vessels in the early stages of metastasis and in thrombosis regions. Methods In this study BNNTs were chemically functionalized with the peptide CREKA, and this system was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), zeta potential, scanning electron microscopy, and transmission electron microscopy. Results After the mentioned chemical steps, the FTIR analysis shows an organic phase related to the CREKA, TGA indicates that about 10% of the peptide is firmly attached to BNNT surface. In addition, the radiolabeling process was successful, achieving the purity required for the biodistribution study. In vivo experiments showed that a considerable amount of BNNTCREKA was accumulated at the tumor and metastasis sites. Conclusion The present results indicate an effective targeting of the system to tumor and metastasis sites. Further studies can reveal potential applications of functionalized BNNTs in cancer treatment.
André Luís Gamino,Túlio Nogueira Bittencourt,José Luiz Antunes de Oliveira e Sousa 사단법인 한국계산역학회 2009 Computers and Concrete, An International Journal Vol.6 No.3
This paper focuses on the flexural behavior of RC beams externally strengthened with Carbon Fiber Reinforced Polymers (CFRP) fabric. A non-linear finite element (FE) analysis strategy is proposed to support the beam flexural behavior experimental analysis. A development system(QUEBRA2D/FEMOOP programs) has been used to accomplish the numerical simulation. Appropriate constitutive models for concrete, rebars, CFRP and bond-slip interfaces have been implemented and adjusted to represent the composite system behavior. Interface and truss finite elements have been implemented (discrete and embedded approaches) for the numerical representation of rebars, interfaces and composites.
Catiane S. Souza,Bruno M. Oliveira,Gustavo G. L. Costa,Albert Schriefer,Alessandra Selbach-Schnadelbach,Ana Paula T. Uetanabaro,Carlos P. Pirovani,Gonçalo A. G. Pereira,Alex G. Taranto,Júlio Cézar de 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
Chitin synthase (CHS) is a glucosyltransferase that converts UDP-N-acetylglucosamine into chitin, one of the main components of fungal cell wall. Class III chitin synthases act directly in the formation of the cell wall. They catalyze the conversion of the immediate precursor of chitin and are responsible for the majority of chitin synthesis in fungi. As such, they are highly specific molecular targets for drugs that can inhibit the growth and development of fungal pathogens. In this work, we have identified and characterized a chitin synthase gene of Moniliophthora perniciosa (Mopchs) by primer walking. The complete gene sequence is 3,443 bp, interrupted by 13 small introns, and comprises a cDNA with an ORF with 2,739 bp, whose terminal region was experimentally determined, encoding a protein with 913 aa that harbors all the motifs and domains typically found in class III chitin synthases. This is the first report on the characterization of a chitin synthase gene, its mature transcription product, and its putative protein in basidioma and secondary mycelium stages of M. perniciosa, a basidiomycotan fungus that causes witches’ broom disease of cacao.
Ana Flávia Seraine Custódio Viana,Hélio B Fernandes,Mariana H Chave,Daniel A Viana,Verlane G Santos,Ariadne C A Silva,Miriam T.P. Lopes,Rita de Cássia M Oliveira 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.3
Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae–Caesalpinioideae) is a medicinal plant traditionally used for treatment of gastric ulcer. This study evaluated the ulcer-healing activity of the hydroalcoholic fraction of C. macrophyllum Tul. var. acuminata Teles Freire leaves (Cm-FHA) and the tea of the leaves of C. macrophyllum (Cm-tea), as well as the possible action of Cm-FHA, through in vitro models. Leaves of C. macrophyllum were dried and powdered to obtain the Cm-FHA. Subsequently, the Cm-FHA was characterized phytochemically and biologically. Besides, Cm-tea was prepared. The gastric healing effects of Cm-tea and Cm-FHA were analyzed using the model of acetic acid-induced gastric ulcer in rats. The human gastric adenocarcinoma (AGS) cell line was employed as an in vitro model. Cm-tea promoted a protective effect against gastric ulcers induced by absolute ethanol. Cm-FHA or Cm-tea (100 mg/kg/7 days) exhibited a significant healing effect on ulcers induced by acetic acid. In the histological analysis, gastric mucosa treated with Cm-FHA or Cm-tea advanced restoration of the mucosal epithelium. In vitro, lower concentrations of Cm-FHA stimulated cell proliferation in the BrdU assay and cell migration. Cm-tea and Cm-FHA present a significant gastric healing effect in in vivo and in vitro models.
Discrete-time Analysis of a Robust Model Reference Adaptive Sliding Mode Control
Deise Maria Cirolini Milbradt,Guilherme Vieira Hollweg,Hilton Abílio Gründling,Paulo Jefferson Dias de Oliveira Evald 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5
In real-world applications, plants with parametric variations and unmodelled dynamics are very common, and, in most cases, fixed-gain controllers can not ensure global stability and hardly have high performance for large system variations. To overcome this challenge, this paper presents a Robust Model Reference Adaptive Sliding Mode Control, whose structure combines a Robust Model Reference Adaptive controller (RMRAC) and an adaptive first-order Sliding Mode controller (SMC). Its discrete-time robustness analysis and stability proofs by means of Lyapunov theory are provided. The mathematical analyses show that this hybrid adaptive controller is robust to parametric variations and unmodelled plant dynamics. Besides, it ensures that tracking error tends to a residual set in steady state, maintaining global stability. Simulation results are presented to show the controller effectiveness applied in a non-minimum phase unstable plant with unmodelled dynamics. Furthermore, a comparison with a Proportional-Resonant controller is also provided.
Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer
Brena Rodrigues Manzano,Natá,lia Garcia Santaella,Marco Auré,lio Oliveira,Cá,ssia Maria Fischer Rubira,Paulo Sé,rgio da Silva Santos 대한구강악안면외과학회 2019 대한구강악안면외과학회지 Vol.45 No.1
Objectives: Osteoradionecrosis (ORN) is one of the most severe complications resulting from radiotherapy (RT) in patients with head and neck cancer (HNC). It is characterized by persistent exposed and devitalized bone without proper healing for greater than 6 months after a high dose of radiation in the area. To describe the profile and dental management of ORN in HNC patients undergoing RT in an oncological clinical research center. Materials and Methods: A retrospective descriptive study was performed to analyze dental records from HNC patients with ORN treated at an oncological clinical research center from 2013 to 2017. A total of 158 dental records for HNC patients were selected from a total of 583 records. Afterwards, this number was distributed to three examiners for manual assessments. Each examiner was responsible for selecting dental records that contained an ORN description, resulting in 20 dental records. Results: Mean patient age was 60.3 years with males being the most affected sex (80.0%). The most affected area was the posterior region of the mandible (60.0%) followed by the anterior region of the mandible (20.0%) and the posterior region of the maxilla (10.0%). The factors most associated with ORN were dental conditions (70.0%) followed by isolated systemic factors (10.0%) and tumor resection (5.0%). There was total exposed bone closure in 50.0% of cases. The predominant treatment was curettage associated with chlorhexidine 0.12% irrigation (36.0%). Conclusion: Poor dental conditions were related to ORN occurrence. ORN management through less invasive therapies was effective for the closure of exposed bone areas and avoidance of infection.