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Tatjana P. Stanojković,Aleksandra Konic´-Ristic,Zorica D. Juranic,Katarina S ˇ avikin,Zorica D. Juranic,Katarina S ˇ avikin,Gordana Zdunic,Nebojsˇa Menkovic,Milka Jadranin 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
In recent times interest has increased in the complementary medicine of cancer patients. Two herbal mixtures were prepared from 17 and 12 plants, respectively. The goal of this study was to examine the in vitro cytotoxic and cell cycle effects of the aqueous-ethanol extracts (Extract 1 and Extract 2) obtained by maceration of the mixtures. The two extracts investigated exhibited significant antiproliferative activity toward two human breast cancer cell lines (MDA-MB-361 and MDA-MB-453) and a human cervix carcinoma cell line (HeLa) with 50% inhibitory concentration (IC50) values ranging from 9.92 to 17.38μL/mL. The extracts did not exert any significant cytotoxicity toward healthy human peripheral blood mononuclear cells. In vitro antitumor activites were accompanied by an important apoptotic fraction of all cell lines after treatment with the extracts. The amount of total phenols was similar in both extracts, whereas the concentration of total tannins was significantly higher in Extract 1. Extract 1 was also found to be a stronger free radical scavenger, with an IC50 value of 13.4μg/mL. Both extracts contained rosmarinic acid, while ursolic acid was identified in Extract 2.
Tatjana Stević,Katarina Savikin,Gordana Zdunic,Tatjana Stanojkovic´,Zorica Juranic,Teodora Jankovic,Nebojsˇa Menkovic 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Antioxidant, cytotoxic, and antimicrobial activities of leaves, bark, and cone extracts of Alnus incana (L.) Moench ssp. incana and endemic species A. viridis (Chaix) DC ssp. viridis were evaluated. All extracts were found to be strong 1,1-diphenyl-2-picrylhydrazyl free radical scavengers, exhibiting 50% inhibitory concentration (IC50) values of 3.3–18.9μg/mL, and also showed activity in inhibition of lipid peroxidation with IC50 values ranging from 38.5 to 157.4μg/mL. A. incana and A. viridis extracts exhibited significant cytotoxic effects toward HeLa cells, with IC50 values ranging from 26.02 to 68.5μg/mL. The most active extract of A. incana bark also contained great amounts of total phenolics (316.2mg of gallic acid equivalents/g). In our experiment all extracts were virtually nontoxic on brine shrimps. Extracts were screened for activity against 15 microorganisms, and all extracts investigated showed antimicrobial activity. The most active were dry extracts of cones of A. incana and A. viridis with minimum inhibitory concentration values ranging from 0.117 to 0.129mg/mL.
Rade Surudzic,Ana Jankovic,Miodrag Mitric,Ivana Matic,Zorica D. Juranic,Ljiljana Zivkovic,Vesna Miskovic-Stankovic,이경엽,박수진,David Hui 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.34 No.-
Poly(vinyl alcohol)/graphene (PVA/Gr) nanocomposite was synthesized with the aim of developing anovel improved material. The PVA/Gr nanocomposite was characterized by UV–visible spectroscopy,cyclic voltammetry, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, andX-ray photoelectron spectroscopy analyses, and the interaction of PVA molecules with graphene wasexamined. Introduction of Gr led to improved mechanical and thermal properties of the PVA/Grnanocomposite compared to pure PVA, as well as strong antibacterial activity against the bacterial strainStaphylococcus aureus. The PVA/Gr nanocomposite was non-cytotoxic against healthy peripheral bloodmononuclear cells by MTT assay, indicating its high potential for biomedical applications.
Ivana Matić,Zeljko Zizak,Mladen Simonovic,Branislav Simonovic,Dejan God-evac,Katarina Savikin,Zorica Juranic 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Red and white wine polyphenols have been reported to provide substantial health benefits. In this study, the cytotoxic activity of red and white wine polyphenolic extracts and of resveratrol was evaluated against different cancer cell lines—human cervix adenocarcinoma HeLa, human breast adenocarcinoma MDA-MB-361, and human breast carcinoma MDA-MB-453—and normal human peripheral blood mononuclear cells (PBMCs). Qualitative and quantitative compositions of wine polyphenolic extracts obtained by fractional vacuum distillation of corresponding wines were determined using spectrophotometric methods and high-performance liquid chromatography with diode array detection and liquid chromatography with electrospray ionization-time of flight mass spectrometry analysis. It was demonstrated that wine polyphenolic extracts and resveratrol exerted higher cytotoxic activity against HeLa and MDA-MB-453cells in comparison to MDA-MB-361cells and unstimulated and stimulated PBMCs. Furthermore, white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract. The presence of condensed or fragmented nuclei in HeLa cells, pretreated with extract of white wine and stained with a mixture of acridine orange and ethidium bromide, pointed to the morphological signs of apoptosis. In addition, HeLa cells in late stages of apoptosis or secondary necrosis were also observed. Results from our study suggest that polyphenolic extracts from red and white wine may have anticarcinogenic potential.