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Yong Su,Zhiwei Pan,Yongpei Peng,Shenghong Huang,Qingchuan Zhang 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.6
In nuclear fusion reactors, the key structural component (i.e., the plasma-facing component) undergoes high heat flux cyclic loading. To ensure the safety of fusion reactors, an experimental study on the temperature-induced creep of stainless steel under heat flux cyclic loading was performed in the present work. The strains were measured using a stereo digital image correlation technique (3D-DIC). The influence of the heat haze was eliminated, owing to the use of a vacuum environment. The specimen underwent heat flux cycles (500°C-1000°C) with different mechanical preloads (0 kN, 10 kN, 30 kN, and 50 kN). The results revealed that, for a relatively large preload (for example, 50 kN), a single temperature cycle can induce a residual strain of up to 15000
Yang Sheng,Xie JiaJun,Pan ZhiJie,Guan HongMei,Tu YueSheng,Ye YuanJian,Huang ShouBin,Fu ShiQiang,Li KangXian,Huang ZhiWei,Li XiaoQi,Shi ZhanJun,Li Le,Zhang Yang 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee osteoarthritis (KOA), and meniscal calcification is associated with alterations in biomechanical properties. Meniscal calcification originates from a biochemical process similar to vascular calcification. Advanced glycation end products (AGEs) and their receptors (RAGEs) reportedly play critical roles in vascular calcification. Herein, we investigated whether targeting AGE-RAGE is a potential treatment for meniscal calcification. In our study, we demonstrated that AGE-RAGE promotes the osteogenesis of meniscal cells and exacerbates meniscal calcification. Mechanistically, AGE-RAGE activates mTOR and simultaneously promotes ATF4 accumulation, thereby facilitating the ATF4-mTOR positive feedback loop that enhances the osteogenic capacity of meniscal cells. In this regard, mTOR inhibits ATF4 degradation by reducing its ubiquitination, while ATF4 activates mTOR by increasing arginine uptake. Our findings substantiate the unique role of AGE-RAGE in the meniscus and reveal the role of the ATF4-mTOR positive feedback loop during the osteogenesis of meniscal cells; these results provide potential therapeutic targets for KOA.
One-Step Synthesis of Nitrogen and Chlorine Co-Doped Carbon Quantum Dots for Detection of Fe3+
Yin Zhong,Qi Chen,Junjian Li,Xihao Pan,Zhiwei Han,Wei Dong 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.11
An environment friendly, economic and maneuverable hydrothermal method was proposed for fabrication of nitrogen and chlorine co-doped carbon quantum dots (N,Cl-CQDs). D-Glucosamine hydrochloride as the only precursor offered source of carbon, nitrogen and chlorine. As a consequent N,Cl-CQDs can emit blue luminescence and detect Fe3+ by fluorescence response with high selectivity and sensitivity. There is a linear semilogarithmic correlation between the quenching efficiency F0 /F and the concentration of Fe3+ with a detection limit of 0.167 μM. The N,Cl-CQDs exhibit a high quantum yield of 16.8% along with the fluorescence lifetime of 2.2 ns. It is worth noting that the prepared N,Cl-CQDs show excellent biocompatibility and they are promising materials for sensing and biology.
Zhang, Jinglan,Shi, Xiaomin,Li, Yehua,Kim, Beom-Jun,Jia, Junling,Huang, Zhiwei,Yang, Tao,Fu, Xiaoyong,Jung, Sung Yun,Wang, Yi,Zhang, Pumin,Kim, Seong-Tae,Pan, Xuewen,Qin, Jun Elsevier 2008 Molecular cell Vol.31 No.1
<P><B>Summary</B></P><P>Sister chromatid cohesion is normally established in S phase in a process that depends on the cohesion establishment factor Eco1, a conserved acetyltransferase. However, due to the lack of known in vivo substrates, how Eco1 regulates cohesion is not understood. Here we report that yeast Eco1 and its human ortholog, ESCO1, both acetylate Smc3, a component of the cohesin complex that physically holds the sister chromatid together, at two conserved lysine residues. Mutating these lysine residues to a nonacetylatable form leads to increased loss of sister chromatid cohesion and genome instability in both yeast and human. In addition, we clarified that the acetyltransferase activity of Eco1 is essential for its function. Our study thus identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion.</P>