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Chunxiao Li,Lu Chen,Min Song,Zhirui Fang,Lusha Zhang,Joel Wake Coffie,Liyuan Zhang,Lulu Ma,Qianyi Wang,Wenjie Yang,Leyu Fang,Shaoxia Wang,Xiumei Gao,Hong Wang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
Acute myocardial infarction (AMI) resultsin irreversible cardiac cell damage or death because ofdecreased blood fl ow to the heart. Apoptosis plays an importantrole in the process of tissue damage after myocardialinfarction (MI), which has pathological and therapeuticimplications. Ferulic acid (FA) is a phenolic acid endowedwith strong antioxidative and cytoprotective activities. Thepresent study aimed to investigate whether FA protectscardiomyocytes from apoptosis by regulating autophagy,which is a cellular self-digestion process, and one of thefi rst lines of defense against oxidative stress. Apoptosis wasinduced by TNF-α (10 ng/mL) and cycloheximide (CHX,5 μg/mL) in rat H9c2 cardiomyocytes. FA-inhibited TNF-α/CHX-induced apoptosis was determined by the quantifi cationof TUNEL-positive cells, and the eff ect was associatedwith decreased ROS production and inhibited caspase3activation. FA treatment enhanced autophagy and increasedautophagy-associated protein expression, leading to an inhibitionof mTOR signaling. When co-treated with 3-methyladenine(3-MA), an autophagy inhibitor, the anti-apoptoticeff ect of FA was attenuated. In an in vivo mouse MI model,FA treatment decreased the apoptotic cell number, reducedinfarct size, and improved cardiac performance, as determinedby histological and echocardiographic assessments. Taken collectively, these results suggest that FA could protectcardiomyocytes from apoptosis by enhancing autophagy.
Mitsuhiro Okayasu,Zhirui Wang 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.10
To better understand the effect of an asperity on crack closure behavior, K-CMOD relations were examined using artificial asperity/wedge, inserted into the fatigue crack in a three point bending specimen made of a hardened medium carbon steel. Experimental results revealed that the unloading phase of the K vs. CMOD curve exhibited a concave shape if soft artificial asperity (Al alloy) was inserted,signifying acceleration in the CMOD decrease at zero applied load. This was mainly related to elastic and plastic deformation in the wedge material during the unloading process. On the contrary, the linear unloading portion of K vs. CMOD was obtained as hard asperity (high carbon steel) was employed, which specified deceleration in the CMOD decrease at zero applied load, where the only elastic deformation in the asperity was affected. From their unloading curves, the severity of crack closure or ?Keff value was found to be related to the strength of the asperity material. The values of ?Keff were examined in two different ways, e.g., (i) the remote displacement method and (ii) the adjusted compliance ratio method (ACR). The ?Keff value, measured using both approaches, decreases with increasing wedge strength, such as hardness and yield strength. The rate of reduction in <Keff was, however, changed depending on the manner of ?Keff examination, in which the ?Keff decreased at a higher rate for the compliance ratio method and at a lower rate for the remote displacement method. The reason for this is discussed in the present work.
Zhao Jujun,Wang Zhirui 부경대학교 글로벌지역학연구소 2019 Journal of Global and Area Studies(JGA) Vol.3 No.2
As the region with the most serious air pollution in China, Hebei Province, which is close to Beijing, is facing stringent environmental regulation. In face of the continuous pressure from the central government, most areas in Hebei Province, represented by Handan City, have carried out high-intensity campaign-style environmental governance. However, Chengde City, which is also in Hebei Province, adopted different strategies. In order to explain the differences, this paper constructs a resource mobilization framework for the campaign-style governance, namely “control-incentive-negotiation” framework. The framework is tested by taking the air pollution regulation in Handan and Chengde in 2017-2018 as examples. The study found that despite the unprecedentedly strengthened authority of the central government since the 18th CCP National Congress, under the combined effect of theater politics, differentiated incentives and implicit negotiation, if a region faces too many political tasks, the local government will choose the operations and policies that are the most beneficial for itself. The research results is helpful to understand the campaign-style environmental governance in China, as well as the vertical intergovernmental relations.
( Fangmin Xu ),( Pengkai Zou ),( Haiquan Wang ),( Haiyan Cao ),( Xin Fang ),( Zhirui Hu ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.12
In a device-to-device (D2D) underlaid cellular network, there exist two types of co-channel interference. One type is inter-layer interference caused by spectrum reuse between D2D transmitters and cellular users (CUEs). Another type is intra-layer interference caused by spectrum sharing among D2D pairs. To mitigate the inter-layer interference, we first derive the interference limited area (ILA) to protect the coverage probability of cellular users by modeling D2D users’ location as a Poisson point process, where a D2D transmitter is allowed to reuse the spectrum of the CUE only if the D2D transmitter is outside the ILA of the CUE. To coordinate the intra-layer interference, the spectrum sharing criterion of D2D pairs is derived based on the (signal-to-interference ratio) SIR requirement of D2D communication. Based on this criterion, D2D pairs are allowed to share the spectrum when one D2D pair is far from another sufficiently. Furthermore, to maximize the energy efficiency of the system, a resource allocation scheme is proposed according to weighted graph coloring theory and the proposed ILA restriction. Simulation results show that our proposed scheme provides significant performance gains over the conventional scheme and the random allocation scheme.
3D field phase-space control in tokamak plasmas
Park, Jong-Kyu,Jeon, YoungMu,In, Yongkyoon,Ahn, Joon-Wook,Nazikian, Raffi,Park, Gunyoung,Kim, Jaehyun,Lee, HyungHo,Ko, WonHa,Kim, Hyun-Seok,Logan, Nikolas C.,Wang, Zhirui,Feibush, Eliot A.,Menard, Jon NATURE PUBLISHING GROUP 2018 NATURE PHYSICS Vol.14 No.12