Investigation on fixture design and precision stability of new-type double collect chuck for machining of long ladder shaft gear

Zhipeng Liang,Chunju Zhao,Huawei Zhou,Yihong Zhou 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1

To solve the problems of poor positioning accuracy and non-automatic processing seen in the machining of long ladder shaft gears, a fixture structure scheme with a new type of double collect chuck (DCC) is proposed. The design rationality, clamping stability, and repeat clamping positioning accuracy of the proposed DCC were analyzed and investigated based on theory calculation, simulation analysis, and engineering application tests. First, the clamping performance of DCC was investigated through theory calculation and simulation analysis. The test results showed that the structure of DCC maintained effective clamping and the repeat clamping positioning accuracy was steadily controlled within 0.008 mm. Meanwhile, efficiently automated machining of long ladder shaft gear was realized based on extended design and engineering application of automatic up and down mechanism when the structure of DCC was applied. Furthermore, the machining accuracy of the gear was steadily controlled within DIN8 (DIN5480-2 standard). Additionally, based on extended design and engineering tests, the automatic up and down machining improves production efficiency and machining accuracy. Thus, the novel fixture structure scheme provides a new approach for automatic up and down machining of long ladder shaft gear.

Investigation on shaping machining method for deep hole keyway based on on-line symmetry detection and compensation

Chunhua Zhao,Zhipeng Liang,Huawei Zhou,Hongling Qin 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.3

Machining of deep hole keyway often suffers from low processing accuracy, low processing symmetry degree between keyway and the reference plane and is difficult to control. In order to enhance the processing quality, a mathematical model of space symmetry error was established based on space projection, orthogonal combination and linear fitting methods so as to study rotatable and shift-able space objects. The space symmetry error was separated into included angle error and displacement error between the fitting straight line and the benchmark line. Through included angle rotation and location measurement along with quantitative translation, the space symmetry error compensation was realized. On the basis of the proposed methods, a Double combined manual self-centering fixture (DCMSF) was designed to realize the radial self-centering and axial location for effective clamping of deep hole keyway, and the reference plane of builtin straight slot was derived out to make it detectable and controllable. Meanwhile, an Online multi-degree of freedom symmetry detection device (OMFSDD) and corresponding Numerical control (NC) programs were also designed for automatic detection and control of symmetry error. Subsequently, mass production of high symmetric deep hole keyway were realized by means of NC gear shaper servo control of rotating shaft angle compensation and bi-directional cutter back-off amount translation compensation, and combination of NC control of fixed angle processing. Deep hole keyway processing experiments indicate that the proposed method can steadily keep the symmetry within 0.03 mm. Thus, the rationality and accuracy of the proposed method was validated which provides a novel approach to high precision deep hole keyway processing.

Protective strategy for the caudate lobe bile duct during left hemihepatectomy based on imaging data analysis

Zhengyi Wu*,Liang Sun*,Ke Ning,Zhendong Chen,Zhipeng Wu,Hanqing Yang,Jinlong Yan*,Xiangbao Yin* 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.6

Purpose: This study was performed to analyze the rule of confluence of the caudate lobe bile duct (CLD) into the left hepatic duct (LHD) and to discuss the protective strategy during left hemihepatectomy. Methods: MRI of 400 patients and T-tube angiography images of 100 patients were collected, and the imaging rules of the confluence of the CLD into the LHD were summarized. The clinical data of 33 patients who underwent left hemihepatectomy using the protective strategy were analyzed. Results: MRI and T-tube angiography images showed that the length from the confluence point of the CLD into the LHD to the confluence of the left and right hepatic ducts was 1.19 ± 0.40 cm and 1.26 ± 0.39 cm, respectively. The average angle between the longitudinal axis of the 2 bile ducts was 68.27° ± 22.59° and 66.58 ± 22.88°, respectively. Coronal and cross-sectional images showed that inflow from the foot side to the cranial side was noted in 79.8% and 82.0% of patients, respectively, and inflow from the dorsal to the ventral side was observed in 84.5% and 88.0%, respectively. Based on these imaging rules, the safe transection length and plane were summarized, and the CLD was effectively protected in 33 cases of left hemihepatectomy. Conclusion: In left hemihepatectomy, the LHD should be transected at least 1.5 cm away from the confluence of the left and right hepatic ducts, and the plane of transection should be oblique to the dorsal side at an angle of 45° with the LHD, these parameters represent an effective strategy to protect the CLD.

Upregulating miR-637 aggravates endoplasmic reticulum stress-induced apoptosis in gastric cancer cells by suppressing Calreticulin

Kong Qingli,Zhang Zhisheng,Liang Zhipeng 한국통합생물학회 2020 Animal cells and systems Vol.24 No.5

Gastric cancer is a leading cause of cancer death worldwide. Endoplasmic reticulum (ER) stressinduced apoptosis has been confirmed to be important in the treatment of gastric cancer. MiR- 637 has recently been found to exert inhibitory effects on gastric cancer, and this study aimed to investigate whether miR-637 could regulate apoptosis through ER stress. The results showed that tunicamycin (TM) induced downregulation of miR-637 in gastric cancer cells (AGS) and increase of apoptosis and ER stress. Overexpression of miR-637 promoted TM-induced apoptosis and expression of ER stress associated proteins (GRP78 and CHOP), but inhibited expression of Calreticulin. MiR-637 could bind with the 3ʹ-UTR of CALR, and negatively regulated the expression of CALR. The co-transfection of miR-637 and CALR in AGS cells show that, CALR overexpression could reverse the pro-apoptosis effects of miR-637 in TM-treated cells. In conclusion, the present study suggests that miR-637 participates in ER stress-induced apoptosis in gastric cancer cells by suppressing CALR expression. miR-637 or CALR may be a future potential target for gastric cancer treatment.

Method and application of spatial positioning for valid temperature-measuring optical fibers in concrete dams

Huawei Zhou,Chunju Zhao,Zhipeng Liang,Yihong Zhou,Fang Wang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8

Spatial positioning of Valid Temperature-measuring Optical Fiber (VTOF) is of great significancefor accurately grasping the real temperature distribution of a concrete dam. However, there is barely an effective way to accurately locate the measuring points of optical fiber in concrete dams. A comprehensive data symmetry analysis technique is presented for determining the optimal spatial positioning of valid temperature-measuring optical fibers (VTOFs) in concrete dams. This approach includes a mathematical model to confirm the center of symmetry in monitoring data, which is required to reconstruct the real spatial temperature distribution. This process can identify VTOF locations and verify the reliability of temperature predictions. Experimental validation was conducted using findings from research on a new mathematical model, site measurements from a concrete dam, and corresponding data from distributed optical fibers. These results were successfully applied to the construction of the Baihetan dam; the concrete temperature from 405 pouring blocks in 5 typical dam monoliths was accurately monitored, and the temperature-measuring points of VTOFs were more than 24711. Meanwhile, the optical fiber temperature measurement and temperature field analysis system of Baihetan dam located in southwest China was developed based on accurately acquired temperature measurement data, which provides data basis and engineering application platform support for temperature evolution and temperature field analysis and precise temperature control management of pouring blocks.

Temperature Field Reconstruction of Concrete Dams based on Distributed Optical Fiber Monitoring Data

Huawei Zhou,Zhiguo Pan,Zhipeng Liang,Chunju Zhao,Yihong Zhou,Fang Wang 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.5

Mastering the real temperature distribution of the concrete dam is the basis for solving the problem of temperature control and crack prevention. In this paper, Distributed Temperature Sensing (DTS) technology was applied to temperature monitoring of a higharch dam under construction in southwest China. In order to obtain a more comprehensive temperature distribution of the dam, optical fiber layout principles for arch dams were studied, and horizontal and vertical optical fiber layout schemes were first proposed according to these principles. The real temperature variation processes of the dam were obtained in real time with a line temperature measurement pattern instead of a point temperature measurement pattern. Additionally, a framework of distributed optical fiber data acquisition and remote transmission was proposed. Interconnection of multiple DTS hosts and remote transmission of temperature data were realized. Then, two-dimensional temperature fields of a typical dam block in different ages and longitudinal profiles of dam blocks with embedded fibers were reconstructed based on large amounts of temperature monitoring data and the Kriging difference algorithm. Temperature field reconstruction results showed that the temperature distribution law of the concrete arch dam was in accordance with the actual situation.

Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP

Hong, Audrey W,Meng, Zhipeng,Yuan, Hai‐,Xin,Plouffe, Steven W,Moon, Sungho,Kim, Wantae,Jho, Eek‐,hoon,Guan, Kun‐,Liang EMBO 2017 EMBO reports Vol.18 No.1

<P>YAP is the major downstream effector of the Hippo pathway, which controls cell growth, tissue homeostasis, and organ size. Aberrant YAP activation, resulting from dysregulation of the Hippo pathway, is frequently observed in human cancers. YAP is a transcription co-activator, and the key mechanism of YAP regulation is its nuclear and cytoplasmic translocation. The Hippo pathway component, LATS, inhibits YAP by phosphorylating YAP at Ser127, leading to 14-3-3 binding and cytoplasmic retention of YAP. Here, we report that osmotic stress stimulates transient YAP nuclear localization and increases YAP activity even when YAP Ser127 is phosphorylated. Osmotic stress acts via the NLK kinase to induce YAP Ser128 phosphorylation. Phosphorylation of YAP at Ser128 interferes with its ability to bind to 14-3-3, resulting in YAP nuclear accumulation and induction of downstream target gene expression. This osmotic stress-induced YAP activation enhances cellular stress adaptation. Our findings reveal a critical role for NLK-mediated Ser128 phosphorylation in YAP regulation and a crosstalk between osmotic stress and the Hippo pathway.</P>

Transmission Line Modeling and Algorithm Analysis Considering Parameter Asymmetry and Transient High-frequency Components

Mo Shixun,Lv Zhipeng,Han Kunlun,Yuan Rongji,Yang Hao,Jiang Kunping,Liang Zhenshen 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.2

When the power system is disturbed or the operation mode is changed, the electromagnetic transient process will occur, which will lead to the high frequency transient component and aff ect the protection and control of the power system. Therefore, attention should be paid to the analysis of high-frequency transient components when modeling and analyzing the system model. In view of the fact that the symmetrical-component theory is not suitable for asymmetric transmission lines and the phasor method is not suitable for transient analysis and calculation, this paper uses the phase coordinate approach and Laplace transform to derive the node voltage equation of three-phase π type transmission lines in frequency domain, which can be used to calculate the transient response of transmission lines caused by the change of operation mode or disturbance. And vectorized NILT is used to calculate the time domain solution, which greatly improves the calculation speed. The calculated results are basically consistent with those of ATP-EMTP, and can fully refl ect the transient characteristics. This method lays a foundation for analyzing the infl uence of high frequency transient components on power system and fault analysis considering transient process.

Feedback Design of Temperature Control Measures for Concrete Dams Based on Real-Time Temperature Monitoring and Construction Process Simulation

Huawei Zhou,Yihong Zhou,Chunju Zhao,Fang Wang,Zhipeng Liang 대한토목학회 2018 KSCE Journal of Civil Engineering Vol.22 No.5

Crack prevention is a significant issue in the construction process of concrete dams. The vast majority of concrete cracks arerelated to temperature variations, and hence, temperature control is a primary method used to prevent cracks. This paper presents anew integrated concept, named Feedback Design (FD) of temperature control measures, which incorporates real-time temperaturemonitoring, temperature field simulation and construction process simulation in a large system to optimize a temperature controlscheme for concrete dams. We used a fiber-optic Distributed Temperature Sensing (DTS) system to monitor the temperaturevariation process of typical dam monoliths in real time. By incorporating a genetic algorithm, neural network algorithm, and finiteelement theory, we proposed an intelligent inversion method to obtain thermal parameters of concrete dams based on the temperaturemonitoring data. Meanwhile, we built a simulation model of a concrete dam’s construction process based on a cycling networktechnique to obtain accurate construction environmental parameters. Finally, we simulated the temperature field of a typical dammonolith based on initial temperature control measures, inversion thermal parameters, and accurate construction environmentalparameters. Temperature variance lines of typical points in the model obtained from the finite element method (FEM) accord wellwith the measured values obtained from the DTS system. We applied the FD approach to the Xiluodu arch dam located in southwestChina to forecast the temperature fields and optimize the temperature control scheme of the dam blocks planned for pouring. The FDapproach has been proven reliable and efficacious.

Economic Optimization Operation Approach of Integrated Energy System Considering Wind Power Consumption and Flexible Load Regulation

Meng Qinglin,Xu Jing,Ge Leijiao,Wang Zhongguan,Wang Jianxiao,Xu Liang,Tang Zhipeng 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1

Due to the fuctuation of wind power output and the "heat to power" mode in the heating period, the wind abandonment phenomenon in coastal areas in winter is increasingly serious. From the perspective of integrated energy system in coastal areas, this paper frst builds an optimal operation model of integrated energy system in coastal areas with the minimum daily total operating cost and the minimum amount of abandoned wind, and constrains the output condition of the corresponding equipment. Then, the mechanism of the adjustable characteristics of seawater desalination load is analyzed, the adjustment range of seawater desalination load is calculated, and the integrated energy system optimization operation method in coastal areas is designed considering the desalination load. Finally, the winter scene of a coastal area in northern China is taken as an example to conduct simulation verifcation. The results show that the total daily operation cost of the system is reduced by 4.6% and the wind power consumption rate is increased by 2.87% after considering the load regulation efect of seawater desalination, which efectively verifes that the integrated energy system operation strategy designed plays a signifcant role in improving the system operation economy and promoting the consumption of new energy.