THE DECADE TRENDS AND POLICY ISSUES FOR RURAL SCHOOL CLOSURE AND CONSOLIDATION IN CHINA

Zhi-hui WU 한국교육행정학회 2011 한국교육행정학회 학술연구발표회논문집 Vol.2011 No.2

Earthquake-related Crush Injury versus Non-Earthquake Injury in Abdominal Trauma Patients on Emergency Multidetector Computed Tomography: A Comparative Study

Tian-wu Chen,Zhi-gang Yang,Zhi-hui Dong,Zhi-gang Chu,Si-shi Tang,Wen Deng 대한의학회 2011 Journal of Korean medical science Vol.26 No.3

The aim of this study was to investigate features of abdominal earthquake-related crush traumas in comparison with non-earthquake injury. A cross sectional survey was conducted with 51 survivors with abdominal crush injury in the 2008 Sichuan earthquake, and 41with abdominal non-earthquake injury, undergoing non-enhanced computed tomography (CT) scans, serving as earthquake trauma and control group, respectively. Data were analyzed between groups focusing on CT appearance. We found that injury of abdominalwall soft tissue and fractures of lumbar vertebrae were more common in earthquake trauma group than in control group (28 vs 13 victims, and 24 vs 9, respectively; all P <0.05); and fractures were predominantly in transverse process of 1-2 vertebrae among L1-3 vertebrae. Retroperitoneal injury in the kidney occurred more frequently in earthquake trauma group than in control group (29 vs 14 victims, P < 0.05). Abdominal injury in combination with thoracic and pelvic injury occurred more frequently in earthquake trauma group than in control group (43 vs 29 victims, P < 0.05). In conclusion, abdominal earthquake-related crush injury might be characteristic of high incidence in injury of abdominal-wall soft tissue, fractures of lumbar vertebrae in transverse process of 1-2 vertebrae among L1-3 vertebrae, retroperitoneal injury in the kidney, and in combination with injury in the thorax and pelvis.

The role of ginsenoside Rb1, a potential natural glutathione reductase agonist, in preventing oxidative stress-induced apoptosis of H9C2 cells

Hui-Jie Fan,Zhang-Bin Tan,Yu-Ting Wu,Xiao-Reng Feng,Yi-Ming Bi,Ling-Peng Xie,Wen-Tong Zhang,Zhi Ming,Bin Liu,Ying-Chun Zhou 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2

Background: Oxidative stress-induced cardiomyocytes apoptosis is a key pathological process inischemic heart disease. Glutathione reductase (GR) reduces glutathione disulfide to glutathione (GSH) toalleviate oxidative stress. Ginsenoside Rb1 (GRb1) prevents the apoptosis of cardiomyocytes; however,the role of GR in this process is unclear. Therefore, the effects of GRb1 on GR were investigated in thisstudy. Methods: The antiapoptotic effects of GRb1 were evaluated in H9C2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, annexin V/propidium iodide staining, and Western blotting. Theantioxidative effects were measured by a reactive oxygen species assay, and GSH levels and GR activitywere examined in the presence and absence of the GR inhibitor 1,3-bis-(2-chloroethyl)-1-nitrosourea. Molecular docking and molecular dynamics simulations were used to investigate the binding of GRb1 toGR. The direct influence of GRb1 on GR was confirmed by recombinant human GR protein. Results: GRb1 pretreatment caused dose-dependent inhibition of tert-butyl hydroperoxide-induced cellapoptosis, at a level comparable to that of the positive control N-acetyl-L-cysteine. The binding energybetween GRb1 and GR was positive ( 6.426 kcal/mol), and the binding was stable. GRb1 significantlyreduced reactive oxygen species production and increased GSH level and GR activity without altering GRprotein expression in H9C2 cells. Moreover, GRb1 enhanced the recombinant human GR protein activityin vitro, with a half-maximal effective concentration of z2.317 mM. Conversely, 1,3-bis-(2-chloroethyl)-1-nitrosourea co-treatment significantly abolished the GRb1’s apoptotic and antioxidative effects of GRb1in H9C2 cells. Conclusion: GRb1 is a potential natural GR agonist that protects against oxidative stresseinducedapoptosis of H9C2 cells.

Overexpression of a Thellungiella halophila CBL9 Homolog, ThCBL9, Confers Salt and Osmotic Tolerances in Transgenic Arabidopsis thaliana

( Zhi Bin Sun ),( Xing Yun Qi ),( Ping Hua Li ),( Chun Xia Wu ),( Yan Xiu Zhao ),( Hui Zhang ),( Zeng Lan Wang ) 한국식물학회 2008 Journal of Plant Biology Vol.51 No.1

Two new records of genus Nudaria Haworth, 1809 (Lepidoptera, Erebidae, Arctiinae, Lithosiini) from China

Zhi-Guang Wu,Hui Lin HAN 국립중앙과학관 2015 Journal of Asia-Pacific Biodiversity Vol.8 No.3

Two species of genus Nudaria Haworth, N. fasciata Moore, 1878 and N. phallustortens Holloway, 2001, are reported for the first time from China. The adult and genital characters of the two species are briefly redescribed, with illustrations and distributional data given.

A phase I dose-finding trial of hyperthermic intraperitoneal docetaxel combined with cisplatin in patients with advanced-stage ovarian cancer

Zhi-yao You,Hui Li,Miao-fang Wu,Yanfang Ye,Li-juan Wang,Zhongqiu Lin,Jing Li 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1

Objective: To identif y the maximum tolerated dose (MTD) of docetaxel combined with afixed dose of cisplatin (75 mg/m2) delivered as hyperthermic intraperitoneal chemotherapy(HIPEC) in patients with ovarian cancer. Methods: In this phase I trial, a time-to-event Bayesian optimal inter val design was used. Docetaxel was given at a starting dose of 60 mg/m2 and was increased in 5 mg/m2 incrementsuntil the MTD was determined or the maximum dose level of 75 mg/m2 was reached. The dose-limiting toxicity (DLT) rate was set at 25%, with a total sample size of 30 patients. HIPEC wasdelivered immediately following debulking surger y at a target temperature of 43°C for 90 minutes. Results: From August 2022 to November 2022, 30 patients were enrolled. Among thepatients who received a dose of docetaxel ≤65 mg/m2, no DLT was reported. DLTs wereobser ved in one patient who received 70 mg/m2 docetaxel (grade 3 anaemia) and in threepatients who received 75 mg/m2 docetaxel (one case of grade 3 anaemia, one case of grade3 hepatic impairment and one case of grade 4 thrombocytopenia). Patients treated withdocetaxel 75 mg/m2 in combination with cisplatin 75 mg/m2 had an estimated DLT rate of25%, which was the closest to the target DLT rate and was therefore chosen as the MTD. Conclusion: Docetaxel, in combination with a fixed dose of cisplatin (75 mg/m2), can be usedsafely at intraperitoneal doses of 75 mg/m2 in ovarian cancer patients who received HIPEC(43°C, 90 minutes) following debulking surger y. Trial Registration: ClinicalTrials.gov Identifier: NCT05410483

Feasibility, accuracy and acceptability of self-sampled human papillomavirus testing using careHPV in Cambodia: a cross-sectional study

Zhi-yao You,Jing Li,Miao-fang Wu,Hui Li,Yanfang Ye,Li-juan Wang,Zhongqiu Lin 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1

Objective: Self-sampled human papillomavirus (HPV) testing is a potential option forcer vical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility,accuracy, and acceptability of self-sampled HPV testing using careHPV. Methods: A cross-sectional study including women aged 20–49 years attending 2 nationalhospitals in the capital city was conducted. Women under went both self-sampling andclinician-sampling of specimens, and were then asked to complete an acceptabilityquestionnaire. The paired samples were analyzed for high-risk HPV by careHPV andgenotyped by polymerase chain reaction (PCR). Results: A total of 375 women were eligible for inclusion. Based on PCR, 78.9% were negativefor HPV in both self and clinician-samples, 9.9% had a complete HPV type match, and 6.1%had all HPV types in clinician-samples also detected in self-samples. In 5.1%, one or more HPVtypes identified in the clinician-samples were missed in self-samples. When using careHPV,the overall agreement between the 2 sampling methods was 95.7% (95% confidence inter val[CI]=95.8–95.6) with good concordance (κ=0.66, 95% CI=0.56–0.76). Nearly 90% of the womenpreferred clinician-sampling over self-sampling, citing greater comfort, ease, and speed. Conclusion: Self-sampled HPV testing using careHPV could be an option for cer vical cancerscreening in Cambodia; however, it requires periodic quality control of handling procedures. In addition, women’s health education regarding the accuracy of self-sampled HPV testingand the importance of follow-up in cases of positive results is needed.

Nomogram for predicting overall survival in children with neuroblastoma based on SEER database

Song-Wu Liang,Gang Chen,Yi-Ge Luo,Peng Chen,Jin-Han Gu,Qiong-Qian Xu,Yi-Wu Dang,Li-Ting Qin,Hui-Ping Lu,Wen-Ting Huang,Zhi-Guang Huang,Li Gao,Jia-Bo Chen 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.2

Purpose: This study was performed to establish and validate a nomogram for predicting the overall survival in children with neuroblastoma. Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and End Results (SEER) database was extracted from 2000 to 2016. The cases included were randomly divided into training and validation cohorts. The survival curves were drawn with a Kaplan-Meier estimator to investigate the influences of certain single factors on overall survival. Also, least absolute shrinkage and selection operator regression was applied to further select the prognostic variables for neuroblastoma. Additionally, receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the accuracy of the nomogram. Results: In total, 1,262 patients were collected and 8 independent prognostic factors were achieved, including patients’ age, sex, race, tumor grade, radiotherapy, chemotherapy, tumor site, and tumor size. Then we constructed a nomogram by using the data of the training cohort with 886 cases. Subsequently, the nomogram was validated internally and externally with 886 and 376 cases, respectively. The internal validation revealed that the area under the curves (AUC) of ROC curves of 1-, 3-, and 5-year overall survival were 0.69, 0.78, and 0.81, respectively. Accordingly, the external validation also showed that the AUC of 1-, 3-, and 5-year overall survival were all ≥0.69. Both methods of validation demonstrated that the predictive calibration curves were consistent with standard curves. Conclusion: The nomogram possess the potential to be a new tool in predicting the survival rate of neuroblastoma patients.

Effect of Ultrasonic Vibration Tensile on the Mechanical Properties of High-Volume Fraction SiCp/Al Composite

Dao-Hui Xiang,Zhi-Meng Zhang,Bang-Fu Wu,Hao-Ren Feng,Zhan-Li Shi,Bo Zhao 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.11

Silicon carbide particle-reinforced aluminum matrix composite has been widely used in the military and aerospace industry due to its special performance; however, there remain many problems in processing. The present paper introduces an ultrasonic vibration tensile device with a view to investigating an ultrasonic vibration tensile specimen. The results show that there are three major stages in the change in stress of the material under ultrasonic vibration: the ultrasonic stress superposition effect, softening effect, and Hall–Petch strengthening effect, these three effects occupy different proportions in different tensile stages. In addition, increasing the frequency of ultrasonic vibration increased the degree of stress reduction. Increasing the ultrasonic vibration amplitude reduced the fracture strength of the material. Comparison of the fracture morphology shows that the conventional condition was mainly interfacial peeling of SiC particles, and cleavage of the fracture occurred under ultrasonic vibration conditions.

Reliability-based assessment of American and European specifications for square CFT stub columns

Zhao-Hui Lu,Yan-gang Zhao,Zhi-wu Yu,Cheng Chen 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.19 No.4

This paper presents a probabilistic investigation of American and European specifications (i.e., AISC and Eurocode 4) for square concrete-filled steel tubular (CFT) stub columns. The study is based on experimental results of 100 axially loaded square CFT stub columns from the literature. By comparing experimental results for ultimate loads with code-predicted column resistances, the uncertainty of resistance models is analyzed and it is found that the modeling uncertainty parameter can be described using random variables of lognormal distribution. Reliability analyses were then performed with/without considering the modeling uncertainty parameter and the safety level of the specifications is evaluated in terms of sufficient and uniform reliability criteria. Results show that: (1) The AISC design code provided slightly conservative results of square CFT stub columns with reliability indices larger than 3.25 and the uniformness of reliability indices is no better because of the quality of the resistance model; (2) The uniformness of reliability indices for the Eurocode 4 was better than that of AISC, but the reliability indices of columns designed following the Eurocode 4 were found to be quite below the target reliability level of Eurocode 4.