Cancer Registration in the Peoples Republic of China

Wei, Kuang-Rong,Chen, Wan-Qing,Zhang, Si-Wei,Liang, Zhi-Heng,Zheng, Rong-Shou,Ou, Zhi-Xiong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

The current situation of cancer registration in China was systematically reviewed. So far, cancer registration in China has been making a great progress in the following aspects: the number of cancer registries and covered population have increased dramatically; a registration network has been established and completed gradually; regulations and rules improved remarkably; more attention is being paid by every level of government; a lot of registration software has been created and financial support ensured. However, we are still facing some problems and challenges, such as no stable groups of registrars, shortage of training opportunities, poor data quality, insufficient utilization and lack of multidisciplinary mechanisms, so that the cancer registration system still needs to be enhanced and improved. Along with the development of economy, science and information technology, methods and patterns of cancer registration is changing. It is to be expected that cancer registration will be automatic, nationwide and integrated with community healthcare in the near future.

The Phytotoxic Effects of Selenium–Mercury Interactions on Root Growth in Brassica rapa (LvLing)

Zhi-Wei Bian,Jian Chen,Hui Li,Dan-Dan Liu,Li-Fei Yang,Yue-Lin Zhu,Wen-Li Zhu,Wei Liu,Zheng-Zheng Ying 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.3

Rapid industrial and agricultural development has dramatically increased the emission of selenium (Se) and mercury (Hg) into the environment. Combined soil pollution by Se and Hg poses a potential threat to crop production. However, no toxic effects of Hg–Se interactions on plants have been reported previously. In this study, we investigated the effects of Hg–Se interactions on biochemical and physiological indices in the roots of Brassica rapa (LvLing). Seedlings were treated hydroponically with solutions of mercury chloride (1 μM), sodium selenite (4 μM), or a combination of the two. Combined Hg+Se treatment significantly inhibited root growth, reduced root biomass, and enhanced reactive oxygen species (ROS) and malondialdehyde accumulation and led to a loss of plasma membrane integrity. The combined treatment increased glutathione peroxidase, glutathione S-transferase, and peroxidase activity, reduced superoxide dismutase activity, and had no effect on catalase activity. In addition, we detected increased glutathione concentrations in root tips and reduced ascorbic acid concentrations in the presence of Hg+Se relative to individual treatments with these elements. Thus, Hg–Se interactions enhanced oxidative injury, cell death, and phytotoxicity in B. rapa roots.

Multi-layer Feed-forward Neural Network Deep Learning Control with Hybrid Position and Virtual-force Algorithm for Mobile Robot Obstacle Avoidance

Wei Zheng,Hong-Bin Wang,Zhi-Ming Zhang,Ning Li,Peng-Heng Yin 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.4

This paper addresses the trajectory tracking and obstacle avoidance control problems for a class ofmobile robot systems. Two classes of controllers are designed for the mobile robot system in the free motion,respectively. A new hybrid position virtual-force controller is designed to adjust the distance between the mobilerobot and the obstacles. Since the uncertainties between the mobile robot dynamics model and obstacles degradethe performance of the obstacle avoidance system, a multi-layer feed-forward neural networks (NNs) deep learningmethod with hybrid position and virtual-force is proposed, such that the distance between the mobile robot andthe obstacles converges to an adjustable bounded region. It is shown that the proposed controller in this paperis smooth, effective, and only uses the system output. The control design conditions are relaxed because of thedeveloped multi-layer feed-forward NNs deep learning compensator. The simulation results and obstacle avoidancecases are performed to show the effectiveness of the proposed method.

Adaptive Dynamic Output-feedback Control for Chemical Continuous Stirred Tank Reactor System with Nonlinear Uncertainties and Multiple Time-delays

Wei Zheng,Hong-Bin Wang,Shu-Huan Wen,Hong-Rui Wang,Zhi-Ming Zhang 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4

This paper addresses the dynamic-output-feedback control problem for a class of nonlinear system with nonlinear uncertainties and multiple time-delays. Compared with the previous work, the time delay parameters of the system are both multiple and time-varying, and the results are further extended to the chemical continuous stirred tank reactor (CSTR) case. First, the system is decomposed into two subsystems based on the output and input matrix. Secondly, a dynamic compensator is designed for the first subsystem, and the output feedback controller is further employed based on the second subsystem and the compensator. Moreover, by using the introduced LyapunovKrasovskii functional, it can be seen that the solutions of the resultant closed-loop system converge to an adjustable bounded region. In this paper, the uncertainties are in the nonlinear form and bounded by nonlinear functions with unknown gains. And the control design conditions are relaxed because of the developed dynamic compensator. Finally, the simulations for a chemical (CSTR) case are performed to show the effectiveness of the main results.

Stability Analysis and Dynamic Output Feedback Control for Nonlinear T-S Fuzzy System with Multiple Subsystems and Normalized Membership Functions

Wei Zheng,Zhi-Ming Zhang,Hong-Bin Wang,Hong-Rui Wang,Peng-Heng Yin 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.6

This paper addresses the stability analysis and dynamic output-feedback control problems for a class of nonlinear Takagi-Sugeno (T-S) fuzzy systems with multiple subsystems and normalized membership functions. First, the switching control law of the membership function is proposed based on the membership function for the nonlinear T-S fuzzy subsystems. Secondly, the relaxation parameter is introduced into this switching control law to guarantee a minimal dwell time between two consecutive switching. Then, based on the proposed switching control law of the membership function and relaxation parameter, the dynamic output feedback controller with the estimate algorithm is designed to estimate the attraction domain. By introducing the new switched Lyapunov-Krasovskii functional, it can be seen that the solutions of the resultant closed-loop system converge to an adjustable bounded region. Compared with the previous works, the developed controller in this paper is flexible and smooth, which only uses the system output. And the results are further extended to the mobile robot case and the chemical process case. Finally, two simulation examples are performed to show the effectiveness of the theoretical results.

Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice

Wei Wang,Ai-Lei Xu,Zheng-Chao Li,Yi Li,Shun-Fu Xu,Hua-Chao Sang,Fachao Zhi 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.2

Background: Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men. Methods: Probiotics with lipid-lowering function were screened from the fecal microbiota of healthy adults. Polysaccharide from different sources was screened for improving insulin resistance. The combination of probiotics and Salvia miltiorrhiza polysaccharide (LBM) was investigated for alleviating hepatic steatosis. Results: First, Bifidobacterium bifidum V (BbV) and Lactobacillus plantarum X (LpX) were obtained from the fecal microbiota of healthy adults. Second, to improve insulin resistance, a Salvia miltiorrhiza Bunge polysaccharide showing good performance in reducing insulin resistance was obtained. The liver total cholesterol (TC) and total triglyceride (TG) levels and the serum levels of free fatty acid, alanine transaminase, aspartate transaminase, low density lipoprotein cholesterol, TG, and TC can be significantly reduced through supplementation with LpX-BbV (LB) in NAFLD mice. Interestingly, the function of the probiotic LB can be enhanced by S. miltiorrhiza Bunge polysaccharide. Furthermore, the gut microbiota was modulated by LpX-BbV+S. miltiorrhiza Bunge polysaccharide (LBM). The lipopolysaccharide concentration of the LBM group was decreased by 73.6% compared to the NAFLD group. Ultimately, the mRNA concentrations of the proinflammatory cytokines (tumor necrosis factor α, interleukin 1β [IL-1β], and IL-6) decreased with LB and LBM treatment. Conclusion: The results of this this study indicate that the LBM combination can be used as a therapeutic for ameliorating NAFLD via modulating the gut microbiota and improving insulin resistance.

Impact of cable sag on the efficiency of an inertial mass damper in controlling stay cable vibrations

Zhi-hao Wang,Hui Gao,Yan-wei Xu,Zheng-qing Chen,Hao Wang 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.1

Passive negative stiffness dampers (NSDs) that possess superior energy dissipation abilities, have been proved to be more efficient than commonly adopted passive viscous dampers in controlling stay cable vibrations. Recently, inertial mass dampers (IMDs) have attracted extensive attentions since their properties are similar to NSDs. It has been theoretically predicted that superior supplemental damping can be generated for a taut cable with an IMD. This paper aims to theoretically investigate the impact of the cable sag on the efficiency of an IMD in controlling stay cable vibrations, and experimentally validate superior vibration mitigation performance of the IMD. Both the numerical and asymptotic solutions were obtained for an inclined sag cable with an IMD installed close to the cable end. Based on the asymptotic solution, the cable attainable maximum modal damping ratio and the corresponding optimal damping coefficient of the IMD were derived for a given inertial mass. An electromagnetic IMD (EIMD) with adjustable inertial mass was developed to investigate the effects of inertial mass and cable sag on the vibration mitigation performance of two model cables with different sags through series of first modal free vibration tests. The results show that the sag generally reduces the attainable first modal damping ratio of the cable with a passive viscous damper, while tends to increase the cable maximum attainable modal damping ratio provided by the IMD. The cable sag also decreases the optimum damping coefficient of the IMD when the inertial mass is less than its optimal value. The theoretically predicted first modal damping ratio of the cable with an IMD, taking into account the sag generally, agrees well with that identified from experimental results, while it will be significantly overestimated with a taut-cable model, especially for the cable with large sag.

Characterization of two novel γ-gliadin genes encoded by K genome of Crithopsis delileana and evolution analysis with those from Triticeae

Zhi-Fu Guo,Li-Jun Zhang,Ming Zhong,Yu-Ming Wei,Li Zhang,Hui Ma,Hao-Ge Li,Li-Jing Chen,Jing-Wei Lin,You-Liang Zheng 한국유전학회 2010 Genes & Genomics Vol.32 No.3

By acid polyacrylamide gel electrophoresis (A-PAGE) analysis,it was indicated that the electrophoresis mobility of gliadins from Crithopsis delileana (Schult) Roshev (2n=2x=14,KK) had obvious difference with those from common wheat in α, γ and ω region. Using homologous primers, two γ-gliadin genes (gli-Kr1 and gli-Kr2) were isolated from C. delileana,which had been deposited in the GenBank under accession numbers EU283818 and EU283821, respectively. Two γ-gliadin genes of C. delileana had the similar primary structures to the corresponding gene sequences from other wheat related species. The differences were mainly resulted from substitutions,insertions and deletions involving single amino acid residues or motifs of γ-gliadins. The repetitive domains of gli-Kr1 and gli-Kr2 from C. delileana are shorter than most of other sequences. By the alignment of γ-gliadin genes from A, B, D, Am, Au, S, Sl, Ssh, Ss and Sb genomes of Triticum and Aegilops, R genome of Secale (γ-secalin), Ee genome of Lophopyrum and K genome of Crithopsis in Triticeae, phylogenetic analysis indicated that two γ-gliadin genes of C. delileana could be clustered together with a γ-gliadin genefrom Ssh genome of Aegilops by an interior paralleled branch. It was the first time that the γ-gliadin genes encoded by K genome of C. delileana were characterized. These could offer precious information for better understanding the qualities associated with gliadins, the response in coeliac disease and studying the evolutionary relationship of gliadins in Triticeae.

Research Articles : Molecular Cloning and Characterization of a Muscle-Specific Lipase from the Bumblebee Bombus ignitus

( Zhi Gang Hu ),( Dong Wang ),( Wei Lu ),( Zheng Cui ),( Jing Ming Jia ),( Hyung Joo Yoon ),( Hung Dae Sohn ),( Doh Hoon Kim ),( Byung Rae Jin ) 한국잠사학회 2008 International Journal of Industrial Entomology Vol.17 No.1

A muscle-specific lipase gene of the bumblebee Bombus ignitus was cloned and characterized. This gene, which we named Bi-Lipase, consists of seven exons encoding 317 amino acid residues. Bi-Lipase possesses all the features of lipases, including GXSXG consensus motif and Ser-Asp-His catalytic triad. Expressed as a 37-kDa polypeptide in baculovirus-infected insect Sf9 cells, recombinant Bi-Lipase showed an optimal pH of 9.0 and exhibited its highest catalytic activity at 40℃. Furthermore, through the addition of tunicamycin to the recombinant virus-infected Sf9 cells, recombinant Bi-Lipase was found to be N-glycosylated. Northern and western blot analyses indicated that Bi-Lipase was expressed in the wing, thorax, and leg muscles. These results show that Bi-Lipase is a muscle-specific lipase, suggesting a possible role of Bi-Lipase in the utilization of lipids for muscular activity in B. ignitus.

Analysis of the Relationship between Breaking Stress and Whiteness in a New Hair Bleaching Method

Wei Wang,Qing-hui Mao,Yu Zhang,Jian-gang Qu,Zhi-jie Liang,Jia Yu,Lin-juan Zheng,Li Zhang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12

In order to investigate the relationship between breaking stress and whiteness in a bleaching treatment withlaccase, hair samples from three biogeographically distinct populations were characterized by various chemical and physicaltechniques. Factors affecting whiteness and breaking stress were investigated by attenuated total reflection infraredspectroscopy, atomic absorption spectroscopy, X-ray diffraction and scanning electron microscopy. The results reveal thatwhiteness and breaking stress after bleaching are primarily influenced by the diversity of concentration of metal ions andfunctional groups in the hair. The hair samples with lower content of metal ions obtain better whiteness and higher stressretention. The presence of OH functional group increases the final whiteness of the hair sample, while lack of that not onlydecreases the whiteness but also leads to more stress loss. In addition, the presence of the C=C functional group alsodecreases the whiteness.