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표준시장단가 및 BIM 라이브러리 연계 활용에 관한 기초연구
김정훈 ( Jin Zheng-xun ),백승호 ( Baek Seung-ho ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.1
With the recent emergence of the 4th Industrial Revolution, the government is promoting the development of smart construction technology and institutional improvement through various policies to induce cutting-edge and technological innovation in the construction industry. As part of such smart construction technology, the application of BIM is being activated, and related regulations and guidelines are constantly being supplemented. In relation to BIM, there are many studies on the fields of library, design standards etc., but research on specific unit price utilization and unit price DB construction for calculating construction cost is insufficient. Therefore, in this study, a basic study was conducted on the linkage of the construction standard market unit price and the BIM library. Based on the basic research conducted in the future, we intend to establish specific standards for calculating BIM-based construction costs.
김정훈 ( Jin Zheng-xun ),백승호 ( Baek Seung-ho ) 한국건축시공학회 2022 한국건축시공학회 학술발표대회 논문집 Vol.22 No.1
Recently, the application of BIM has been continuously expanded according to various government policies, and the application performance is being analyzed in BIM projects such as roads and railways. In line with this trend, the government is making additional efforts to introduce full-scale design BIM. The BIM design in the public sector is directly related to the estimated price. However, looking at the current status of BIM introduction, there is no support system in place for calculating the estimated price. Therefore, this study intends to analyze the priority activity that is easy to develop BIM unit price among the construction standard unit Price of construction work. In this study, in order to derive the BIM-based priority activity, BIM application statements and application guidelines were analyzed. As a result of the analysis, cast-in-place concrete construction (civil engineering) and reinforced concrete construction (architecture) were deduced as suitable construction activities for the preferential application of BIM. Since the results presented in this study are a rough analysis, it is judged that additional detailed analysis is necessary for the future.
Jin, Yong-Xun,Zheng, Zhong,Yu, Xian-Feng,Zhang, Jia-Bao,Namgoong, Suk,Cui, Xiang-Shun,Hyun, Sang-Hwan,Kim, Nam-Hyung Cambridge University Press 2016 Zygote Vol.24 No.1
<B>Summary</B><P>The mitochondrial genome is maternally inherited in animals, despite the fact that paternal mitochondria enter oocytes during fertilization. Autophagy and ubiquitin-mediated degradation are responsible for the elimination of paternal mitochondria in <I>Caenorhabditis elegans</I>; however, the involvement of these two processes in the degradation of paternal mitochondria in mammals is not well understood. We investigated the localization patterns of light chain 3 (LC3) and ubiquitin in mouse and porcine embryos during preimplantation development. We found that LC3 and ubiquitin localized to the spermatozoon midpiece at 3 h post-fertilization, and that both proteins were colocalized with paternal mitochondria and removed upon fertilization during the 4-cell stage in mouse and the zygote stage in porcine embryos. Sporadic paternal mitochondria were present beyond the morula stage in the mouse, and paternal mitochondria were restricted to one blastomere of 4-cell embryos. An autophagy inhibitor, 3-methyladenine (3-MA), did not affect the distribution of paternal mitochondria compared with the positive control, while an autophagy inducer, rapamycin, accelerated the removal of paternal mitochondria compared with the control. After the intracytoplasmic injection of intact spermatozoon into mouse oocytes, LC3 and ubiquitin localized to the spermatozoon midpiece, but remnants of undegraded paternal mitochondria were retained until the blastocyst stage. Our results show that paternal mitochondria colocalize with autophagy receptors and ubiquitin and are removed after <I>in vitro</I> fertilization, but some remnants of sperm mitochondrial sheath may persist up to morula stage after intracytoplasmic spermatozoon injection (ICSI).</P>
Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro
Jin, Yong-Xun,Zhao, Ming-Hui,Zheng, Zhong,Kwon, Jung-Suk,Lee, Seul-Ki,Cui, Xiang-Shun,Kim, Nam-Hyung CSIRO Publishing 2014 Reproduction, fertility, and development Vol.26 No.6
<P> Previous studies show that porcine oocyte aging resulting from asynchronised IVM impairs embryo developmental competence. In the present study we investigated whether trichostatin A (TSA; an inhibitor of histone deacetylation) prolongs the maturation time and prevents the aging of oocytes. Porcine oocytes were cultured in medium containing increasing concentrations of TSA (300 nM) for 24, 44 or 64 h. The percentage of oocytes that underwent germinal vesicle breakdown was significantly lower in the TSA-treated group (300 nM) than in the control group. TSA did not affect oocyte quality at MII based on levels of maturation-promoting factor, the phosphorylation status of mitogen-activated protein kinase or histone H3K9 acetylation analysis. We also compared the preimplantation developmental competence and the viability of pathenogenetic embryos treated with 100 nM TSA for 24 h and then continuously cultured for another 24 h in TSA free condition. No significant differences were observed for either parameter between the TSA-treated and control groups. These results indicate that TSA prolongs the IVM of porcine oocytes but that oocyte quality and aging are not affected. These findings provide a feasible option by which to adjust the initiation time of downstream experiments based on porcine matured oocytes. </P>
Jin Xun,Guo Xingle,Chen Jian,Li Jiasheng,Zhang Shufei,Zheng Sixu,Wang Yunpeng,Peng Ying,Zhang Kun,Liu Yifan,Liu Bingjian 한국유전학회 2023 Genes & Genomics Vol.45 No.3
Background In this study, the complete mitogenome of Hemigrapsus sinensis was the first identified and analyzed. Objective The complete mitochondrial genome of Hemigrapsus sinensis (Brachyura, Grapsoidea, Varunidae) and its phylogenetic position within Grapsoidea. Methods The sample of Hemigrapsus sinensis was collected and DNA was extracted. After sequencing, NOVOPlasty was used for sequence assembly. Annotate sequences with MITOS WebServer, tRNAscan-SE2.0, and NCBI database. MEGA was used for sequence analysis and Phylosuite was used for phylogenetic tree construction. DnaSP was used to calculate Ka/Ks. Results This mitochondrial genome shows that it was 15,900 bp and encoded 13 PCGs, 22 tRNA genes, two rRNA genes, and one control region. The genome composition tends to A + T (74.34%) and presents a negative GC-skew (− 0.22) and AT-skew (− 0.03). The PCGs initiation codon was the typical ATN and termination codon was the typical TAN, incomplete T or missing. The ML and BI trees showed that H. sinensis was most closely related to Hemigrapsus and clustered together with the Varunidae. And our phylogenetic trees provide proof that Ocypodoidea and Grapsoidea may be of common origin. Meanwhile, in the phylogenetic tree, parallel mixing of Chiromantes and Orisarma raised doubts over the traditional classification system. Besides, Incomplete Lineage sorting (ILS) was observed in Varunidae. In the subsequent analysis of evolution rate, we found that all of the PCGs (NAD4 was not calculated) had undergone negative selections, indicating the conservation of mitochondrial genes of H. sinensis during the evolution. Conclusion Therefore, researching the complete mitogenome of H. sinensis would be contributing to molecular taxonomy, phylogenetic relationship, and breeding optimization within the Grapsoidea superfamily.
고건호 ( Go Gun-ho ),김정훈 ( Jin Zheng-xun ),김현주 ( Kim Hyun-joo ),현창택 ( Hyun Chang-taek ) 한국건축시공학회 2018 한국건축시공학회 학술발표대회 논문집 Vol.18 No.1
Recently, CM at Risk delivery system(CM@R) that could solve the problems of Design Bid Build delivery(DBB) system has been emerging. In the CM@R delivery system, the contractor negotiates for a maximum guaranteed price(GMP) with the client at the design stage, and the contractor carries out the construction within the GMP. In CM @ R, the construction company with expertise in construction participates from the design stage to reflects the construction know-how in the design. On the other hand, the modification design frequently occurs due to the change of the construction cost when negotiating the GMP. In addition, uncertainties are inherent in the GMP calculation because the calculation is based on unfinished drawings and documents. This study proposes a probabilistic GMP estimation method applying MCS to the BIM - based cost prediction model, in order to extract the accurate quantity information when estimating the GMP and to cope with the change of the construction cost inherent in uncertainty.
박진호,김정훈,현창택,김현주,권석현,Park, Jin-Ho,Jin, Zheng-xun,Hyun, Chang-taek,Kim, Hyun-joo,Kwon, Suk-hyun 한국건설관리학회 2018 건설관리 : 한국건설관리학회 학회지 Vol.19 No.5
발주자, 건설사업관리자, 설계자, 시공자, VE 전문가 등 참여자 역량에 의해 성패가 좌우되는 VE 프로젝트에서는 체계적인 절차를 따르는 것이 중요하다. 하지만, 실제 VE 업무에서는 개략평가만을 실시하거나, 개략평가와 상세평가를 통합하여 수행하는 경우가 있다. 이러한 경우, 중요한 대안일지라도 리스크에 대하여 평가하는 것이 어렵다. 이에 따라, 선행단계에서 제안된 대안이 후행단계에서 다시 기존안으로 돌아가는 회귀제안(returning alternatives)이 발생하여, 해당 대안에 대한 반복작업으로 인해 VE 업무효율이 저하되는 경우가 종종 발생한다.이에 본 연구에서는 VE 대안을 구체적으로 분석하고 체계적으로 평가하여 회귀제안 발생을 최소화하기 위해, VE 대안의 리스크 평가절차(risk assessment process for VE alternatives)를 제안하였다. 이는 VE 대안을 구체적이고 체계적으로 평가하여 회귀제안을 최소화하기 위한 평가절차로서 의의가 있으며, 회귀제안에 대한 반복업무를 줄임으로써 VE 업무의 효율을 높일 수 있을 것으로 예상된다. Since the success or failure of VE projects depends on the capabilities of participants, including owners, construction managers, architects, general contractors and VE experts, it is important to follow systematic procedures. However, it is often the case that only a rough evaluation is performed, or the rough and detailed evaluations are integrated in actual VE tasks. In this case, it is difficult to analyze and evaluate the alternatives in terms of risk, even for the important alternatives. This in turn leads to the so-called returning alternatives where the alternatives proposed in the preceding stage are returned to the original plans in the following stage, and thus the repetitive work for the alternatives often decreases the efficiency of the VE task. In this regard, this study proposed a risk assessment process for VE alternatives in order to minimize the occurrence of returning alternatives based on the systematic analysis and evaluation of VE alternatives. It will increase the efficiency of VE tasks by reduces the number of regression alternatives.