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Lin, Guang-Xun,Quillo-Olvera, Javier,Jo, Hyun-Jin,Lee, Hyeong-Jin,Covarrubias-Rosas, Claudia Angelica,Jin, Chengzhen,Kim, Jin-Sung Elsevier 2017 World neurosurgery Vol.106 No.-
<P><B>Objective</B></P> <P>To compare the outcomes between patients older and younger than 65 years who underwent single-level minimally invasive transforaminal interbody fusion (MI-TLIF) surgery.</P> <P><B>Methods</B></P> <P>This study is a retrospective analysis of 76 patients who underwent MI-TLIF between April 2012 and June 2016. Group A consisted of 35 patients (<65 years) and group B consisted of 41 patients (≥65 years). Intraoperative data were recorded. The evaluation of clinical outcomes was based on the visual analog scale for back and leg pain and the Oswestry Disability Index. Radiologic outcomes including cage subsidence, end plate cyst formation, and fusion rate were assessed.</P> <P><B>Results</B></P> <P>The mean age of the study subjects was 65.3 years, and the mean duration of follow-up was 18.98 months. Group B had a higher rate of comorbidities compared with group A (90.24% vs. 57.14%, respectively; <I>P</I> < 0.05). There was no statistically significant difference in the rate of complications between the groups (group A, 14.29%; group B, 17.07%). Clinical outcomes significantly improved in both groups postoperatively (<I>P</I> < 0.05). Although bony fusion in group A was slightly higher than that in group B, the fusion rate was not statistically different according to age. There were no statistically significant differences in the rates of cage subsidence or positive cyst sign between the groups.</P> <P><B>Conclusions</B></P> <P>MI-TLIF presented similar safeness and acceptable outcomes and complication rate in both groups. Cyst formation may be aggravated by cage subsidence, because cage subsidence was a useful potential predictor of cyst formation.</P>
Jin, Xun,Beck, Samuel,Sohn, Young-Woo,Kim, Jun-Kyum,Kim, Sung-Hak,Yin, Jinlong,Pian, Xumin,Kim, Sung-Chan,Choi, Yun-Jaie,Kim, Hyung-Gee Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.8
Although human telomerase catalytic subunit (TERT) has several cellular functions including telomere homeostasis, genomic stability, cell proliferation, and tumorigenesis, the molecular mechanism underlying anti-apoptosis regulated by TERT remains to be elucidated. Here, we show that ectopic expression of TERT in spontaneously immortalized human fetal fibroblast (HFFS) cells, which are a telomerase- and p53-positive, leads to increases of cell proliferation and transformation, as well as a resistance to DNA damage response and inactivation of p53 function. We found that TERT and a mutant TERT (no telomerase activity) induce expression of basic fibroblast growth factor (bFGF), and ectopic expression of bFGF also allows cells to be resistant to DNA-damaging response and to suppress activation of p53 function under DNA-damaging induction. Furthermore, loss of TERT or bFGF markedly increases a p53 activity and DNA-damage sensitivity in HFFS, HeLa and U87MG cells. Therefore, our findings indicate that a novel TERT-bFGF axis accelerates the inactivation of p53 and consequent increase of resistance to DNA-damage response.
Chromatin, microtubule and microfilament configurations in the canine oocyte
Jin, Yong-Xun,Lee, Hyo-Sang,Yin, Xi-Jun,Cui, Xiang-Shun,Kong, Il-Keun,Kim, Nam-Hyung CSIRO Publishing 2006 Reproduction, fertility, and development Vol.18 No.8
<P>In the present study, we observed chromatin, microtubule and microfilament distribution in canine oocytes. The germinal vesicle (GV) chromatin of canine oocytes was classified into four configurations (GV-I, -II, -III and -IV) based on the degree of chromatin separation and condensation. Oocytes recovered from follicular phase ovaries had a greater amount (68%, P < 0.05) of GV-III or GV-IV chromatin than did those from non-follicular phase ovaries (35%). The majority (86.7%) of in vivo ovulated oocytes were at GV-IV. The rates of development to GV breakdown/metaphase I/metaphase II were higher in oocytes recovered from follicular ovaries than from non-follicular ovaries. Immunostaining results revealed cytoplasmic microtubules present in all GV-stage oocytes. Following GV breakdown, microtubular asters were produced from condensed chromatin. The asters appeared to be elongated, and encompassed condensed chromatin particles to form meiotic metaphase chromatin. Microfilaments were located in the cortex and around the GV. During meiotic maturation, a microfilament-rich area, in which the chromatin is allocated, was observed in the oocyte. Our results indicate that oocytes recovered from follicular ovaries were in an advanced stage of GV, and were more competent to complete maturation compared to those from non-follicular phase ovaries. Both microtubules and microfilaments are closely associated with reconstruction of chromatin during meiotic maturation in canine oocytes.</P>
Cat fertilization by mouse sperm injection
Jin, Yong-Xun,Cui, Xiang-Shun,Yu, Xian-Feng,Lee, Sung-Hyun,Wang, Qing-Ling,Gao, Wei-Wei,Xu, Yong-Nan,Sun, Shao-Chen,Kong, IL-Keun,Kim, Nam-Hyung Cambridge University Press 2012 Zygote Vol.20 No.4
<B>Summary</B><P>Interspecies intracytoplasmic sperm injection has been carried out to understand species-specific differences in oocyte environments and sperm components during fertilization. While sperm aster organization during cat fertilization requires a paternally derived centriole, mouse and hamster fertilization occur within the maternal centrosomal components. To address the questions of where sperm aster assembly occurs and whether complete fertilization is achieved in cat oocytes by interspecies sperm, we studied the fertilization processes of cat oocytes following the injection of cat, mouse, or hamster sperm. Male and female pronuclear formations were not different in the cat oocytes at 6 h following cat, mouse or hamster sperm injection. Microtubule asters were seen in all oocytes following intracytoplasmic injection of cat, mouse or hamster sperm. Immunocytochemical staining with a histone H3-m2K9 antibody revealed that mouse sperm chromatin is incorporated normally with cat egg chromatin, and that the cat eggs fertilized with mouse sperm enter metaphase and become normal 2-cell stage embryos. These results suggest that sperm aster formation is maternally dependent, and that fertilization processes and cleavage occur in a non-species specific manner in cat oocytes.</P>
( Xun Jin ),( Jongweon Kim ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.7
In this paper, we propose a robust blind watermarking scheme for high-definition video. In the embedding process, luminance component of each frame is transformed by 2-dimensional fast Fourier transform (2D FFT). A secret key is used to generate a matrix of random numbers for the security of watermark information. The matrix is transformed by inverse steerable pyramid transform (SPT). We embed the watermark into the low and mid-frequency of 2D FFT coefficients with the transformed matrix. In the extraction process, the 2D FFT coefficients of each frame and the transformed matrix are transformed by SPT respectively, to produce two oriented sub-bands. We extract the watermark from each frame by cross-correlating two oriented sub-bands. If a video is degraded by some attacks, the watermarks of frames contain some errors. Thus, we use an ensemble position-based error correcting algorithm to estimate the errors and correct them. The experimental results show that the proposed watermarking algorithm is imperceptible and moreover is robust against various attacks. After embedding 64 bits of watermark into each frame, the average peak signal-to-noise ratio between original frames and embedded frames is 45.7 dB.