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      • KCI등재

        Research on the Technology of Alternative Continuous Wide Spectral Spatial Heterodyne Spectrometer

        Wenli Zhang,Fengchun Tian,Zhenzhen Zhao,An Song,Li Zhang 한국광학회 2017 Current Optics and Photonics Vol.1 No.4

        An innovative system for the alternative continuous wide spectral spatial heterodyne spectrometer (ACWSSHS)is proposed. The relationship between the ACWS-SHS and the wide spectral spatial heterodynespectrometer (WS-SHS) at the resolution limit, the spectral range, the grating diffraction efficiency and theinterference fringes contrast ratio has been analyzed theoretically. Through the comparison of the theoreticalanalysis and simulation results, it is found that the two systems for the WS-SHS and the ACWS-SHShave the same resolution limit and spectral range, which are  and , while in the ACWS-SHS systemthe critical diffraction efficiency of echelle grating is 68.39% and the critical contrast ratio of interferencefringes is 0.4135, which is much better than the performance of the WS-SHS system. Therefore, the ACWSSHSreduces the high requirements for the precision of equipment and expands the application field ofSHS effectively.

      • AUTONOMOUS LAND VEHICLE PATH PLANNING USING TERRAIN DATABASE

        Bin, Zhang Shi,Wei, Tang Guo,Yue, Ma,Wen, Zhang Tian,Xiong, Zhang Shi 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1

        We describe a new path planning system using terrain database. The system is adapt to the navigation of autonomous land vehicle under known environment such as road network without unknown moving obstacles. We discuss the terrain database structure, terrain representation, global path planning, local path planning under the direction of global path planning.

      • Rapid assessment of suspension bridge deformation under concentrated live load considering main beam stiffness: An analytical method

        Wen-ming Zhang,Jia-qi Chang,Xing-hang Shen,Xiao-fan Lu,Tian-cheng Liu 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.1

        With the gradual implementation of long-span suspension bridges into high-speed railway operations, the main beam’s bending stiffness contribution to the live load response permanently grows. Since another critical control parameter of railway suspension bridges is the beam-end rotation angle, it should not be ignored by treating the main beam deflection as the only deformation response. To this end, the current study refines the existing method of the main cable shape and simply supported beam bending moment analogy. The bending stiffness of the main beam is considered, and the main beam’s analytical expressions of deflection and rotation angle in the whole span are obtained using the cable-beam deformation coordination relationship. Taking a railway suspension bridge as an example, the effectiveness and accuracy of the proposed analytical method are verified by the finite element method (FEM). Comparison of the results by FEM and the analytical method ignoring the main beam stiffness revealed that the bending stiffness of the main beam strongly contributed to the live load response. Under the same live load, as the main beam stiffness increases, the overall deformation of the structure decreases, and the reduction is particularly noticeable at locations with original larger deformations. When the main beam stiffness is increased to a certain extent, the stiffening effect is no longer pronounced.

      • Antifibrotic Effect of Curcumin in TGF-β1-Induced Myofibroblasts from Human Oral Mucosa

        Zhang, Shan-Shan,Gong, Zhao-Jian,Li, Wen-Hui,Wang, Xiao,Ling, Tian-You Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

        Background: Myofibroblasts play an important role in the development of oral submucous fibrosis (OSF). In the current study, we investigate the effect of curcumin on growth and apoptosis of myofibroblasts derived from human oral mucosa. Methods: Myofibroblasts were generated by incubating fibroblasts, obtained from human oral mucosa, with transforming growth factor-${\beta}1$ (TGF-${\beta}1$). MTT, PI staining, and FACS assays were used to investigate curcumin's effect on proliferation and cell cycle of fibroblasts and myofibroblasts. Annexin V/PI binding and FACS assays were used to examine apoptosis of myofibroblasts, Western blotting to determine the levels of Bcl-2 and Bax, and enzyme-linked immunosorbant assay was employed to examine the levels of collagen type I and III in the supernatants of myofibroblasts. Results: Curcumin inhibits proliferation of fibroblasts and myofibroblasts; it also disturbs the cell cycle, induces apoptosis and decreases the generation of collagen type I and III in myofibroblasts, which are more sensitive to its effects than fibroblasts. Curcumin induces apoptosis in myofibroblasts by down-regulating the Bcl-2/ Bax ratio. Conclusion: Our results demonstrate the antifibrotic effect of curcumin in vitro. It may therefore be a candidate for the treatment of OSF.

      • SCIESCOPUSKCI등재

        Antioxidant Enzymes and Photosynthetic Responses to Drought Stress of Three Canna edulis Cultivars

        Zhang, Wen-E,Wang, Fei,Pan, Xue-Jun,Tian, Zhi-Guo,Zhao, Xiu-Ming Korean Society of Horticultural Science 2013 원예과학기술지 Vol.31 No.6

        Edible canna is a productive starch source in some tropical and semitropical regions. In these regions, water deficit stress is one of factors that limit the crop yield. In the present study, we investigated seven physiological indexes and photosynthetic responses of three edible canna (Canna edulis Ker.) cultivars ('PLRF', 'Xingyu-1', and 'Xingyu-2') under 35 days drought stress. Our results indicated that drought treatment caused visible wilting symptoms in all cultivars, especially in 'Xingyu-1'. Coupled with the increase of wilting symptoms, relative water content (RWC) and chlorophyll content decreased progressively, malondialdehyde (MDA) content gradually increased, and key antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) activities increased first and then decreased in all three cultivars. The effect of water stress was more pronounced in 'Xingyu-1' than in 'PLRF' and 'Xingyu-2', and in lower leaves than in upper leaves. In addition, 35 days drought stress also significantly reduced the photosynthetic capacity. Consistent with antioxidant parameters, photosynthetic changes of 'Xingyu-2' were less than those of the other cultivars under water deficit stress. Drought stress caused a significant increase of water use efficiency (WUE) in 'Xingyu-2', but little in 'PLRF', and obvious decrease in 'Xingyu-1'. These results indicated that 'Xingyu-2' was more tolerant to drought stress than 'PLRF' and 'Xingyu-1' by maintaining lower lipid peroxidation and higher antioxidant enzyme activities.

      • KCI등재

        Genotoxicity and effect on early stage proliferation of osteoprogenitor cells on amino-group functionalized titanium implant surface: an in vitro test

        Tian-qi Guo,Yi-di Zhang,Wen-jing Luo,Xue Li,Yan-min Zhou,Jing-hui Zhao,Jing-hui Zhao 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.2

        Genotoxicity and effect on early stage proliferation of osteoprogenitor cells of titanium surfaces modified by heptylamine functionalization through Plasma Enhanced Chemical Vapor Deposition (PECVD) were evaluated in current study. Mouse embryo osteoprogenitor MC3T3-E1 cells were grown on titanium surfaces of all the groups. The CCK-8 assay showed the growths of MC3T3-E1 cells on treated titanium disks were not inhibited compared with those on pure titanium groups. Result of Single Cell Gel Electrophoresis (SCGE) test indicated the treated groups showed no significant differences in tail length, tail DNA%, and tail moment compared with pure titanium group. Rate of micronucleus, nucleoplamic buds and nuclear blebs showed no significant differences between treated groups and pure titanium group. Our research exhibited that: The amino-group functionalized titanium surface has neither genotoxicity nor detrimental effects on early-stage proliferation towards osteoprogenitor cells in vitro, thus offer a theoretic support for the clinical use of such functionalized titanium as implant surface.

      • Complex Regulatory Network of MicroRNAs, Transcription Factors, Gene Alterations in Adrenocortical Cancer

        Zhang, Bo,Xu, Zhi-Wen,Wang, Kun-Hao,Lu, Tian-Cheng,Du, Ye Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

        Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.

      • KCI등재

        Analytical methods for determining the cable configuration and construction parameters of a suspension bridge

        Wen-Ming Zhang,Gen-min Tian,Chao-yu Yang,Zhao Liu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.71 No.6

        Main cable configurations under final dead load and in the unloaded state and critical construction parameters (e.g. unstrained cable length, unstrained hanger lengths, and pre-offsets for tower saddles and splay saddles) are the core considerations in the design and construction control of a suspension bridge. For the purpose of accurate calculations, it is necessary to take into account the effects of cable strands over the anchor spans, arc-shaped saddle top, and tower top pre-uplift. In this paper, a method for calculating the cable configuration under final dead load over a main span, two side spans, and two anchor spans, coordinates of tangent points, and unstrained cable length are firstly developed using conditions for mechanical equilibrium and geometric relationships. Hanger tensile forces and unstrained hanger lengths are calculated by iteratively solving the equations governing hanger tensile forces and the cable configuration, which gives careful consideration to the effect of hanger weight. Next, equations for calculating the cable configuration in the unloaded state and pre-offsets of saddles are derived from the cable configuration under final dead load and the conditions for unstrained cable length to be conserved. The equations for the main span, two side spans and two anchor spans are then solved simultaneously. In the proposed methods, coupled nonlinear equations are solved by turning them into an unconstrained optimization problem, making the procedure simplified. The feasibility and validity of the proposed methods are demonstrated through a numerical example.

      • Efficiency Analysis on the Shandong Service Industry based on DEA Method (Data Envelopment Analysis)

        Zhang Dong sheng,Zhai Wen xiu,Lv Tian ying 한국유통과학회 2017 KODISA ICBE (International Conference on Business Vol.2017 No.-

        In recent years, the development of service industries is oriented on marketing, industrialization and internationalization and maintains productive service industry and life of service industry simultaneously and modern and traditional services simultaneously, promoting the development of service industry and increasing the proportion and the level, which has become the consensus of the people. However, the service industry in Shandong and even around the whole country is still not developed in the whole economic and social development. In this context, using of data envelopment analysis (DEA) to empirically analyze Shandong services from the efficiency of the whole to the industry has great significance in finding out the reasons for the existence inconsistence between the total amount of services and the quality status in Shandong and reasons for over investment on elements of service industry, breaking out the dilemma of the undeveloped status, building the upgrade servicing, realizing the words of president Xi to Shandong "rebirth of phoenix, removing the birds from the cage optimizing the industrial structure; continuing to play a leading role".

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