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Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations
Yuqi Guo,조선욱,Deepak Saxena,Xin Li 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.1
Since the identification of succinate’s receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate’s pro-inflammatory role. Takenwith the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discusswhether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especiallythe gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the criticalroles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatialmanner are also required.
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Competency-based Education: Evidence fromSocial Work Postgraduates fromFive Universities in China
Yu Guo,Chien-Chung Huang,Shuang Lu,Yuqi Wang 한국사회복지학회 2016 Asian Social Work and Policy Review Vol.10 No.3
Social work education in China has undergone rapid development during last two decades. However, methods to define, measure, and evaluate social work students’ competency remain largely unexplored. In this study, we evaluated competency in graduate social work students in China and examined factors that impacted competency, based on learning theory. Findings indicated that knowledge and skills learned in class, field placement, and social context all have effects on competency. How students think about individual development and the social work profession has the most significant effect. These findings carry implications for social work education in the Chinese context. The rapid development of social work education in China requires the effective measurement and evaluation of students’ core competencies.
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Qiuling Ma,Huixuan Zhang,Yuqi Cui,Xiaoyong Deng,Ruonan Guo,Xiuwen Cheng,Mingzheng Xie,Qingfeng Cheng 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-
Cu2O decorated TiO2 nano-tube arrays (Cu2O/TiO2 NTAs) photoelectrode was fabricated throughelectrodeposition strategy. Meanwhile, physicochemical properties of the resulting photoelectrode weresystematically studied by series of measurements. Results indicated that Cu2O/TiO2 NTAs photoelectrodeperformed a significantly enhanced light absorbance in the visible region between 400 and 800 nm,transient photocurrent density of 0.162 mA Cm 2, photogenerated charge separation efficiency and 99.9%of photoelectrocatalytic efficiency for decomposition of 2,4,6-trichlorophenol within 120 min Xenonillumination with the help of +1.0 V (vs. SCE) potential. Furthermore, the enhanced visible lightresponsible photoelectrocatalytic mechanism was proposed and discussed.
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Wenbo Zhou,Huiyan Wang,Yuqi Yang,Fang Guo,Bin Yu,Zhaoliang Su 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.5
Trophoblasts, important functional cells in the placenta, play a critical role in maintaining placental function. The heterogeneity of trophoblasts has been reported, but little is known about the trophoblast subtypes and distinctive functions during preeclampsia (PE). In this study, we aimed to gain insight into the cell type-specific transcriptomic changes by performing unbiased single-cell RNA sequencing (scRNA-seq) of placental tissue samples, including those of patients diagnosed with PE and matched healthy controls. A total of 29,006 cells were identified in 11 cell types, including trophoblasts and immune cells, and the functions of the trophoblast subtypes in the PE group and the control group were also analyzed. As an important trophoblast subtype, extravillous trophoblasts (EVTs) were further divided into 4 subgroups, and their functions were preliminarily analyzed. We found that some biological processes related to pregnancy, hormone secretion and immunity changed in the PE group. We also identified and analyzed the regulatory network of transcription factors (TFs) identified in the EVTs, among which 3 modules were decreased in the PE group. Then, through in vitro cell experiments, we found that in one of the modules, CEBPB and GTF2B may be involved in EVT dysfunction in PE. In conclusion, our study showed the different transcriptional profiles and regulatory modules in trophoblasts between placentas in the control and PE groups at the single-cell level; these changes may be involved in the pathological process of PE, providing a new molecular theoretical basis for preeclamptic trophoblast dysfunction.
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