Responses of inflammatory cytokines following moderate intensity walking exercise in overweight or obese individuals

Yunsuk Koh,Kyung-Shin Park 한국운동재활학회 2017 JER Vol.13 No.4

Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes

Jarrett Walbolt,Yunsuk Koh 대한비만학회 2020 The Korean journal of obesity Vol.29 No.2

Evidence linking the excessive consumption of nutritive sweeteners (NS) to adverse metabolic health outcomes has led to an increase in consumption of non-nutritive sweeteners (NNS), particularly among the obese and individuals with diabetes. NNS are characterized by having zero-to-negligible caloric load, while also having a sweet taste. They are utilized as a replacement for traditional NS to reduce energy intake and to limit carbohydrate-related negative health outcomes. However, recent studies have suggested that NNS may actually contribute to the development or worsening of metabolic diseases, including metabolic syndrome, obesity, type 2 diabetes, and cardiovascular disease. Thus, it is imperative to understand the NNS efficacy and the relationship between NNS and metabolic diseases.

The Effects of Medium-Chain Triglyceride Oil Supplementation on Endurance Performance and Substrate Utilization in Healthy Populations: A Systematic Review

Tomas J. Chapman-Lopez,Yunsuk Koh 대한비만학회 2022 Journal of obesity & metabolic syndrome Vol.31 No.3

Background: The use of medium-chain triglyceride (MCT) oil has increased due to its potential for therapeutic and ergogenic properties. Although recent evidence has suggested that MCT oil supplementation may lead to an improvement in endurance and substrate utilization, contradicting studies have reported the ergogenic benefits of MCT oil toward exercise performance. Methods: An extensive systematic review was conducted to assess the role of MCT oil as an ergogenic aid in exercise performance. Moreover, this study examined any alterations in substrate utilization and various physiological components while using MCT oil. The databases searched in this review were PubMed, Embase, CINAHL, and the Cochrane Library. Results: Most studies reported that MCT oil did not improve exercise performance and had no effect on respiratory exchange ratio, glucose concentration, fat and carbohydrate oxidation, and lactate concentration. Although ketones were increased when supplementing with MCTs, most studies demonstrated that the body could not utilize the MCT oil-induced ketones as its primary energy source during an acute bout of endurance exercise. Thirty grams of MCTs seems to be the safe maximal dosage to minimize adverse reactions during or after exercise. Conclusion: MCT oil showed very little to no ergogenic effects on exercise performance and substrate utilization in healthy populations. Future research is needed to examine the effects of long-term intake of MCT oil alongside various diets, perhaps a ketogenic diet, on exercise performance within different sports/exercises in a variety of populations.

골막성 골육종의 무병 생존 13년 후 다른 부위에 발생한 전형적 골육종

공창배(Chang-Bae Kong),홍윤석(Yunsuk Hong),고재수(Jae-Soo Koh),전대근(Dae-Geun Jeon) 대한정형외과학회 2011 대한정형외과학회지 Vol.46 No.2

골막성 골육종은 골육종의 약 1-2%를 차지히는 드문 질환으로써, 국소 재발이나 전이는 3년 이내에 대부분 발생하고, 전이는 대부분 폐에서 일어나며 골전이는 드물다고 알려져 있다. 저자들은 근위 경골 골막성 골종양 성공적인 치료 후 13년 만에 상완골 근위부에 전형적인 골육종이 발생한 증례를 경험하여 이를 문헌 고찰과 함께 보고하는는 바이다. Periosteal osteosarcoma is a rare variant of osteosarcoma and has represented 1-2% of all osteosarcomas. Most local recurrences or progression to metastatic disease occurred within the first 3 years after presentation and lung metastasis is more common than bony metastasis. We describe a periosteal osteosarcoma of tibia patient who developed conventional osteosarcoma of proximal humerus after 13 years from the completion of treatment.

유방의 침윤성 관암종 환자에서 발생한 췌장 전이 1예

노진희 ( Jin-hee Noh ),고수진 ( Su-jin Koh ),최혜정 ( Hye Jeong Choi ),전희정 ( Hee-jeong Jeon ),안재성 ( Jae-sung Ahn ),최윤숙 ( Yunsuk Choi ),민영주 ( Young Joo Min ) 대한내과학회 2017 대한내과학회지 Vol.92 No.3

유방의 췌장 전이는 드물게 발생하는 질환으로 저자들은 유방의 침윤성 관암종으로 진단된 지 13년 후 췌장 전이가 발견된 예를 경험하고 보고하는 바이다. 유방암이 췌장으로 전이되는 경우는 매우 드물지만 주로 장시간이 지난 후 우연히 발견되는 경우가 대부분이므로 장기간의 추적 관찰 후에 발견되는 경우가 많고, 원발성 췌장암과의 감별진단이 필요하다. 또한 전이성 췌장암이 발견되었을 때 질환의 범위와 환자의 전신 상태를 고려하여 수술적 제거의 필요성을 판단해야 하며, 일부의 경우 증상과 질병의 조절에 도움이 될 수 있다. Pancreatic metastases from primary breast cancer are very rare. We report a case of pancreatic metastasis from invasive ductal carcinoma 13 years after the initial diagnosis of breast cancer. When the pancreatic mass was discovered, it was believed to be a primary pancreatic cancer due to the long interval from the initial diagnosis of breast cancer to metastasis. However, it was confirmed as metastatic breast cancer based on the pathology after surgical removal. Follow-up imaging has shown no recurrence. (Korean J Med 2017;92:308-311)

Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study

( Dong Won Baek ),( Dae Young Kim ),( Sang Kyun Sohn ),( Youngil Koh ),( Sung-hoon Jung ),( Ho-young Yhim ),( Yunsuk Choi ),( Joon Ho Moon ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.6

Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology. Methods: Data of 99 patients with newly diagnosed ALL, who were treated with the KALLA 1406/1407 protocol, were retrospectively analyzed. All patients equally received age-adjusted daunorubicin, vincristine, and prednisolone. L-asparaginase was additionally administered to Philadelphia (Ph)-negative patients according to age, whereas Ph-positive patients received 600 mg/day of imatinib. Results: A total of 99 patients were enrolled in this study, of whom 62 (62.6%) were diagnosed with Ph-negative ALL and 37 (37.3%) were diagnosed with Ph-positive ALL. The median age of patients in the Ph-negative ALL group was 46 years, and that of patients in the Ph-positive ALL group was 49 years. In patients with Ph-negative ALL, 57 (92%) patients achieved complete remission (CR) and CR with incomplete hematologic recovery (CRi). Disease-free survival (DFS) and overall survival (OS) rates at 2 years were estimated to be 42% and 63%, respectively. In patients with Ph-positive ALL, 32 (86%) patients achieved CR/CRi, and 2-year DFS and OS were 31.2% and 49.1%, respectively. Patients who were able to proceed to the allogeneic hematopoietic cell transplantation and younger patients showed significantly superior survival in both Ph-negative ALL and Ph-positive ALL. Neutropenic fever and bacterial infection were the most common and severe adverse events. Conclusions: The KALLA 1406/1407 protocol showed tolerable toxicities in adult ALL patients. Especially, younger patients had more survival benefits with KALLA 1406/1407 protocol.

Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells

Heo, Sook-Kyoung,Noh, Eui-Kyu,Kim, Jeong Yi,Jegal, SungHoo,Jeong, Yookyung,Cheon, Jaekyung,Koh, SuJin,Baek, Jin Ho,Min, Young Joo,Choi, Yunsuk,Jo, Jae-Cheol Elsevier 2018 Phytomedicine Vol.49 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid), a natural anthraquinone derivative, is a traditional Chinese herb that has been used as a medication in many Asian countries. It has been used as a laxative and stomach drug for a long time in both China and Korea. It is well-known to have many pharmacological activities, such as anti-cancer, anti-bacterial, anti-fungal, anti-oxidant, anti-atherogenic, anti-angiogenic, anti-fibrosis, anti-inflammatory, hepatoprotective, and nephroprotective properties. However, little is known about how rhein may affect the differentiation activities in acute promyelocytic leukemia (APL) cells.</P> <P><B>Purpose</B></P> <P>The present study was designed to examine the anti-leukemic effects of rhein against APL cells and to explore the underlying mechanism.</P> <P><B>Methods</B></P> <P>Cell viability was investigated by MTS assay. To examine the differentiation activities in APL cells, the cell surface molecules (CD11b, CD14, CCR1 and CCR2), phagocytosis, reactive oxygen species (ROS) were determined by flow cytometry. Also, induction of caspase-3 activity and reduction of mitochondrial membrane potential (MMP) were determined by flow cytometry. RNA and protein expressions were determined by qRT-PCR and western blotting, respectively.</P> <P><B>Results</B></P> <P>In this study we assessed the role of rhein in treating APL. Interestingly, rhein potentiated all-trans retinoic acid (ATRA)-induced macrophage differentiation in NB4 cells by inducing changes in morphology, expression of the differentiation markers CD11b and CD14, ROS production, phagocytic activity, and expression of CCR1 and CCR2. Signaling through CD11b was found to be dependent on ERK activation. Additionally, rhein induced APL cell death by activating apoptosis and suppressing the mTOR pathway.</P> <P><B>Conclusion</B></P> <P>Therefore, we suggest that a combination of rhein and ATRA carries strong therapeutic potential through the beneficial differentiation of APL cells. Moreover, rhein causes cell death via the activation of apoptosis and suppression of survival signals in APL cells. In combination with the ability of rhein to promote functional macrophage differentiation in APL, these properties suggest that a combined treatment of rhein and ATRA has great potential as an anti-leukemic therapy for APL.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A case of metastatic prostate cancer initially presenting as chylothorax

( Yu-jin Yang ),( Minjung Seo ),( Hee-jeong Jeon ),( Jin-hee Noh ),( Seol Hoon Park ),( Yunsuk Choi ),( Jae-cheol Jo ),( Jin Ho Baek ),( Su-jin Koh ),( Hawk Kim ),( Young Joo Min ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Chylothorax is caused by disruption or obstruction of the thoracic duct, which results in leakage of chyle in the pleural space. The most common etiologies are malignancy and trauma. Among the causative malignancies, lymphoma is the most common, followed by primary lung cancer, mediastinal tumors, and other metastatic malignancies. Conversely, prostate cancer has rarely been reported as the cause of chylothorax. We here report a case of metastatic prostate cancer initially presenting as chylothorax, and being disappeared pleural effusion after androgen deprivation therapy. We also discuss the various rare manifestations of metastatic prostate cancer.