Clinical Evaluation of the Traditional Chinese Prescription Chi-Ju-Di-Huang-Wan for Dry Eye

Yung-Hsien Chang,Hui-Ju Lin,Wei-Chu Li 한의병리학회 2006 대한동의병리학회 학술대회논문집 Vol.2006 No.9

SACADA and HuREX: Part 1. the use of SACADA and HuREX systems to collect human reliability data

Yung Hsien James Chang,김요찬,박진균,Lawrence Criscione 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.5

As a part of probabilistic risk (or safety) assessment (PRA or PSA) of nuclear power plants (NPPs), theprimary role of human reliability analysis (HRA) is to provide credible estimations of the human errorprobabilities (HEPs) of safety-critical tasks. Accordingly, HRA community has emphasized the accumulation of HRA data to support HRA practitioners for many decades. To this end, it is critical to resolvepractical problems including (but not limited to): (1) how to collect HRA data from available informationsources, and (2) how to inform HRA practitioners with the collected HRA data. In this regard, the U.S. Nuclear Regulatory Commission (NRC) and Korea Atomic Energy Research Institute (KAERI) independently initiated two large projects to accumulate HRA data by using full-scale simulators (i.e., simulatordata). In terms of resolving the first practical problem, the NRC and KAERI developed two dedicated HRAdata collection systems, SACADA (Scenario Authoring, Characterization, And Debriefing Application) andHuREX (Human Reliability data EXtraction), respectively. In addition, to inform HRA practitioners, theNRC and KAERI proposed several ideas to extract useful information from simulator data. This paper isthe first of two papers to discuss the technical underpinnings of the development of the SACADA andHuREX systems

Effects of Acupuncture at Pai-Hui on the Deficit of Memory

Chang, Yung-Hsien,Hsieh, Ming-Tsuen,Wu, Chi-Rei 경희대학교 2001 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.2001 No.1

Acupuncture has been introduced as one of the complementary therapies in traditional Chinese medicine. In addition to the analgesic effect, acupuncture also has anti-inflammatory, anti-allergic and immunomodulatory effects. Activation of the Bai-Hui by acupuncture was further shown to correct loss of consciousness, as well as to relieve mental abstraction, sluggish speech and hysteria. In this study, we investigated the attenuating effect of Pal-Hui acupuncture on scopolamine (SCOP)-induced or cycloheximide (CXM)-induced impairment of the passive avoidance response in rats. Our preliminary results indicated that acupuncture at Pal-Hui before or immediately after the training trial could significantly attenuate SCOP-induced impairment in rats. The effects were better than those treated before the right-room retention trial. Interestingly, the identical procedure could also significantly attenuate the CXM-induced impairment, but not those treated before the retention trial. The correction effect of acupuncture on CXM-induced impairment was equivalent to that of piracetam treatment. Acupunctures at Pal-Hui 15,30 or 60 min before the training trial could he all effective to attenuate CXM-induced impairment, and its efficacy paralleled acupuncture duration. Furthermore, we demonstrated the mechanism of the attenuating effects of acupuncture at Pal-Hui on CXM-induced memory consolidation deficits by combined with SCOP or p-chloroamphetamine(PCA). The attenuating effects of acupuncture at Pal-Hui was significantly antagonized by PCA but not SCOP. These results suggest acupuncture at Pal-Hui might mainly affect the memory storage process and had preventive and immediate therapeutic effects on the CXM-induced impairment and its efficacy paralleled acupuncture duration. The preventive effect of acupuncture at Pal-Hui on CXM-induced impairment is significantly reduced by serotonergic 5-HT releaser. However, the detailed mechanism of acupuncture on memory function and the differential mechanism of acupuncture on memory function an analgesia must be further investigated.

Intra-Arterial Treatment in Patients with Acute Massive Gastrointestinal Bleeding after Endoscopic Failure: Comparisons between Positive versus Negative Contrast Extravasation Groups

Wei-Chou Chang,Chang-Hsien Liu,Hsian-He Hsu,Guo-Shu Huang,Ho-Jui Tung,Tsai-Yuan Hsieh,Shih-Hung Tsai,Chung-Bao Hsieh,Chih-Yung Yu 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.5

Objective: To determine whether treatment outcome is associated with visualization of contrast extravasation in patients with acute massive gastrointestinal bleeding after endoscopic failure. Materials and Methods: From January 2007 to December 2009, patients that experienced a first attack of acute gastrointestinal bleeding after failure of initial endoscopy were referred to our interventional department for intra-arterial treatment. We enrolled 79 patients and divided them into two groups: positive and negative extravasation. For positive extravasation, patients were treated by coil embolization; and in negative extravasation, patients were treated with intra-arterial vasopressin infusion. The two groups were compared for clinical parameters, hemodynamics, laboratory findings, endoscopic characteristics, and mortality rates. Results: Forty-eight patients had detectable contrast extravasation (positive extravasation), while 31 patients did not (negative extravasation). Fifty-six patients survived from this bleeding episode (overall clinical success rate, 71%). An elevation of hemoglobin level was observed in the both two groups; significantly greater in the positive extravasation group compared to the negative extravasation group. Although these patients were all at high risk of dying, the 90-day mortality rate was significantly lower in the positive extravasation than in the negative extravasation (20% versus 42%, p < 0.05). A multivariate analysis suggested that successful hemostasis (odds ratio [OR] = 28.66) is the most important predictor affecting the mortality in the two groups of patients. Conclusion: Visualization of contrast extravasation on angiography usually can target the bleeding artery directly, resulting in a higher success rate to control of hemorrhage. Objective: To determine whether treatment outcome is associated with visualization of contrast extravasation in patients with acute massive gastrointestinal bleeding after endoscopic failure. Materials and Methods: From January 2007 to December 2009, patients that experienced a first attack of acute gastrointestinal bleeding after failure of initial endoscopy were referred to our interventional department for intra-arterial treatment. We enrolled 79 patients and divided them into two groups: positive and negative extravasation. For positive extravasation, patients were treated by coil embolization; and in negative extravasation, patients were treated with intra-arterial vasopressin infusion. The two groups were compared for clinical parameters, hemodynamics, laboratory findings, endoscopic characteristics, and mortality rates. Results: Forty-eight patients had detectable contrast extravasation (positive extravasation), while 31 patients did not (negative extravasation). Fifty-six patients survived from this bleeding episode (overall clinical success rate, 71%). An elevation of hemoglobin level was observed in the both two groups; significantly greater in the positive extravasation group compared to the negative extravasation group. Although these patients were all at high risk of dying, the 90-day mortality rate was significantly lower in the positive extravasation than in the negative extravasation (20% versus 42%, p < 0.05). A multivariate analysis suggested that successful hemostasis (odds ratio [OR] = 28.66) is the most important predictor affecting the mortality in the two groups of patients. Conclusion: Visualization of contrast extravasation on angiography usually can target the bleeding artery directly, resulting in a higher success rate to control of hemorrhage.

The simple and easy way to manufacture counter electrode for dye-sensitized solar cells

Jo-Lin Lan,Yung-Yun Wang,Chi-Chao Wan,Tzu-Chien Wei,Hsien-Ping Feng,Chao Peng,Hai-Peng Cheng,Ya-Huei Chang,Wen-Chi Hsu 한국물리학회 2010 Current Applied Physics Vol.10 No.2

We previously developed poly-N-vinyl-2-pyrrolidone (PVP)-capped Pt nanoclusters on ITO glass via a simple ‘‘2-step dip coating process” as counter electrode for DSSC. This new counter electrode was examined by transmission electron microscopy (TEM), inductively coupled plasma-atomic emission spectroscopy (ICP-AES), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and current–voltage curve (I–V curve). The TEM results revealed that PVP-capped Pt nanoclusters’ size is about 3 nm, and the amount of Pt deposited on ITO glass is about 5 ㎍/㎠. Comparing with sputtered Pt and Solaronix thermal cluster Pt-catalyst T/SP, the PVP-capped Pt counter electrode has lower amount of Pt deposited on TCO glass,more positive potential of tri-iodide reduction, and better performance for the charge-transfer resistance (RCT) and the cell efficiency (g).

Grey Neural Network-Based Forecasting System for Vision-Guided Robot Trajectory Tracking

Shih-Hung Yang,Chung-Hsien Chou,Chen-Fang Chung,Wen-Pang Pai,Tse-Han Liu,Yung-Sheng Chang,Jung-Che Li,Huan-Chan Ting,Yon-Ping Chen 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10

This paper presents a grey neural network-based forecasting system (GNNFS) in solving the prediction problem. GNNFS adopts a grey model to predict the signal and a neural network (NN) to forecast the prediction error of the grey model. A sequential batch learning (SBL) is developed to adjust the weights of the NN. The proposed GNNFS is applied to a binocular robot, called an Eye-Robot, for human-robot interaction which involved predicting the trajectory of a participant’s hand and tracking the hand. By applying the SBL, the GNNFS can gradually learn to predict the trajectory of the hand and track it well. The experimental results show that the GNNFS can carry out the SBL in real-time for vision-guided robot trajectory tracking.

Grasping the Pseudo-Cleft in the Case of a Small, Severely Tethered Posterior Mitral Leaflet

Ching-Wei Lee,Shih-Hsien Sung,Ting-Yung Chang,I-Lin Tsai,Chih-Po Hsu,Chun-Che Shih 대한심장학회 2017 Korean Circulation Journal Vol.47 No.4

Using Multidetector-Row CT for the Diagnosis of Afferent Loop Syndrome Following Gastroenterostomy Reconstruction

Yu-Hsiu Juan,Wei-Chou Chang,Chih-Yung Yu,Hsian-He Hsu,Guo-Shu Huang,De-Chuan Chan,Chang-Hsien Liu,Ho-Jui Tung 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.4

Purpose: To assess the clinical manifestations and multidetector-row computed tomography (MDCT) findings of afferent loop syndrome (ALS) and to determine the role of MDCT on treatment decisions. Materials and Methods: From January 2004 to December 2008, 1,100 patients had undergone gastroenterostomy reconstruction in our institution. Of these, 22 (2%) patients were diagnosed as ALS after surgery that included Roux-en-Y gastroenterotomy (n=9), Billroth-II gastrojejunostomy (n=7), and Whipple’s operation (n=6). Clinical manifestations and MDCT features of these patients were recorded and statistically analyzed. The presumed etiologies of obstruction shown on the MDCT were correlated with clinical information and confirmed by surgery or endoscopic biopsy. Results: The most common clinical symptom was acute abdominal pain, presenting in 18 patients (82%). We found that a fluid-filled C-shaped afferent loop in combination with valvulae conniventes projecting into the lumen was the most common MDCT features of ALS. Malignant causes of ALS, such as local recurrence and carcinomatosis, are the most common etiologies of obstruction. These etiologies and associated complications can be predicted 100% by MDCT. Conclusion: Our results suggest that MDCT is a reliable modality for assessing the etiologies of ALS and guiding treatment decisions.

Clinical Features and Computed Tomography Characteristics of Non-Klebsiella pneumoniae Liver Abscesses in Elderly (>65 Years) and Nonelderly Patients

Chih-Weim Hsiang,Wei-Chou Chang,Chang-Hsien Liu,Hsiu-Lung Fan,Kai-Hsiung Ko,Chih-Yung Yu,Hong-Hau Wang,Wen-I Liao,Hsian-He Hsu 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2

Purpose: To compare the clinical and computed tomography (CT) appearances of liver abscesses caused by non-Klebsiella pneumoniae bacterial pathogens in elderly and nonelderly patients. Materials and Methods: Eighty patients with confirmed non-Klebsiella pneumoniae liver abscesses (non-KPLAs) were enrolled and dividedinto two age groups: elderly (age ≥65 years, n=42) and nonelderly (age <65 years, n=38). Diagnosis of non-KPLA was established by pus and/or blood culture. We compared clinical presentations, outcomes, and CT characteristics of the two groups, and performed multivariate analysis for significant variables and receiver-operating-characteristic analysis to determine the cutoff value of abscess diameter for predicting non-KPLA. Results: Elderly patients with non-KPLA were associatedwith a longer hospital stay (p<0.01). Regarding etiology, biliary sources had a strong association in the elderly group (p<0.01), and chronic liver diseases were relatedto the nonelderly group (p<0.01). Non-KPLAs (52.5%) tended to show a large, multiloculated appearance in the elderly group and were associated with bile duct dilatation (p<0.01), compared with the nonelderly group. The abscess diameter (cutoff value, 5.2 cm; area under the curve, 0.78) between the two groups was predicted. In multivariate analysis, underlying biliary tract disease [odds ratio (OR), 3.58, p<0.05], abscess diameter (OR, 2.40, p<0.05), and multiloculated abscess (OR, 1.19, p<0.01) independently predicted elderly patients with non-KPLA. Conclusion:In the elderly patients with non-KPLA, a large, multiloculated abscess with a diameter greater than 5.2 cm was the predominant imaging feature.

Efficacy and Safety Comparison of a Fixed Triple Combination vs Hydroquinone 4% Cream in Asian Patients with Moderate to Severe Melasma

( Kyoung Chan Park ),( Mu Hyoung Lee ),( Eun So Lee ),( Sung Eun Chang ),( Roy Chan ),( Yung Hian Leow ),( Yong Kwang Tay ),( Filomena Legarda Montinola ),( Ren Yeu Tsai ),( Tsung Hsien Tsai ),( Saman 대한피부과학회 2007 대한피부과학회 학술발표대회집 Vol.59 No.2