자궁선근증의 고찰

조환성,이해혁,정성윤,김성욱,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: This study was designed to estimate the frequency and risk factor for edenomyosis Methods: The clinical records of 623 women undergoing hysterectomy were retrieved in the Department of Obstetrics and Gynecology, Soonchunhyang University Hospital, during 5 years, from Jan. 1995 to Dec. 1999. Results: The following result were obtained. 1. Adenomyosis was found in 247 of 623 patients(39.6%) 2. The highest incidence was 40-49 years of age group, an incidence of 46.6% and mean age was 44.7 years. 3. Adenomyosis was more frequently observed in parous women than non-parous women, such as 93.1% and 6.9%, respectively. 4. Dysmenorrhea, metrorrhagia, pelvic pain and vaginal bleeding were common symptom of adenomyosis, an incidence of 28.7%, 19.0%, 18.2% and 16.2%, respectively. 5. Myoma was the most combined disease in adenomyosis, showing the incidence of 54.7%. 6. Grossly, the size of uterus was enlarged more than 10 weeks gestational size in adenomyosis, an incidence of 61.9%. 7. Preoperative diagnostic accuracy of adenomyosis was 6.9%. Conclusion: The results show that deeply understanding of the common symptoms and epidemiology of adenomyosis improve the preoperative diagnostic accuracy.

석면이 흰쥐폐의 섬유모세포 증식에 미치는 영향

이동원,김경아,임 영,윤임중 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3

Asbestosis is chronic inflammatory disorder of lower respiratory tract in which alveolar wall are progressively thickened by a fibrotic process. Fibrotic process characterized by an expansion of fibroblast and collagenous extracellular matrix secreted from this fibroblast. Alveolar macrophage is believed to be a primary target cell and major participant in the evolution of lung fibrosis after asbestos inhalation. Alveolar macrophage are known to release a variety of substance that induce tissue damage and stimulate inflammatory cells and fibroblast. Macrophage also release a variety of metabolite of arachidonic acid. Of these, PGE₂is known to suppress fibroblast proliferation. Asbestos may be a very effective stimulus for fibroblasts without triggering the release of PGE₂. To assess the fibrogenic properties of asbestos according to kind and dosage of asbestos and the ability of PGE₂to suppress the proliferation of fibroblast, alveolar macrophages cultured with crocidolite, amosite and chrysotile in presence or absence of PGE₂10-5M. At 24 hours after alveolar macrophage cultured with various stimuli, the released fibronectin and TNF-α was measured. Viability of alveolar macrophages was observed and growth promoting activity of macrophage supernatant to fibroblasts was quantified. The results were as follows; 1. The viability of alveolar macrophages stimulated with asbestos fiber was markedly decreased compared with control group except chrysotile 10 μg group. Crocidolite and amosite were more cytotoxic than chrysotile. 2. All of asbestos augmented fibronectin production in concentration dependent fashion. 3. There was a significant positive correlation between TNF-α production in supernatant and fiber concentration. 4. Supernatant from alveolar macrophages cultured with asbestos were inducible a significant increase in fibroblast proliferation. 5. Incubation of alveolar macrophages with asbestos in the presence of PGE₂resulted in significant decrease of TNF-α production in supernant. 6. Supernatant from alveolar macrophages cultured with asbestos were inducible a significant decrease in fibroblast proliferation when PGE₂was added. The result of this study strongly suggested that crocidolite and amosite were more cytotoxic and fibrogenic and exogenous PGE₂suppressed fibroblast proliferation following exposed to asbestos.

수유 요인에 따른 유치열의 치면별 우식패턴

임경욱,이광희,라지영,안소연,김윤희 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

연구목적은 모유 또는 분유 섭취 시 나타나는 유치열의 치면별 우식패턴에 차이가 없으며 수유기간에 따른 차이도 없다는 가설을 검증하는 것이었다. 익산시, 청주시, 울산광역시의 36-71 개 월 어린이 815명을 대상으로 구강검사로 치면별 우식경험도를 조사하고, 보호자들을 대상으로 설문지 조사법으로 모유와 분유 중에서 생후 1년간 주로 수유한 것과 수유 기간을 조사하였다. 모유군과 분유군 간 우식경험유치면수(dmf)의 차이는 유의하지 않았다. 모유군에서 분유군보다 우식경험도가 더 높았던 유치군은 상악 유전치이었고, 유치면군은 상악 유전치 협설면과 인접면이었으며, 유치는 상악 유절치와 상하악 제2유구치이었고, 유치면은 상악 유중절치의 협면과 원섬면, 상악 유측절치의 협설면, 인접면, 상악 제2유구치의 설면, 인접면, 교합면, 하악 제2유구치의 협면, 원심면이었다. 모유군에서 수유기간이 증가함에 따라 우식경험유치면수가 증가한 유치군은 상악 유전치와 상악 유구치이었고, 유치면군은 상악 유전치의 인접면, 상악 유구치의 협설면, 인접면, 교합면, 하악 유구치의 인접면이었으며, 유치는 상악 유전치, 상악 유구치, 하악 제 2유구치이었고, 유치면에서는 상악 유전치의 인접면, 상악 제 1유구치의 협설면, 인접면, 교합면, 상악 제 2유구치의 협면, 하악 제 2유구치의 근심면이었다. 분유군에서는 수유기간 3년 이상에서 우식경험유치면수가 증가하였으나 차이가 유의하지 않았다. 수유와 관련되어 발생하는 상악 유절치의 중증 유아기 우식증은 분유를 수유하는 경우보다 모유를 수유하는 경우에 더 많이 발생하였다. 모유 수유를 2년 이상 하는 경우에는 상악 유절치의 우식 예방을 위한 조치가 필요하다. The purpose of this study was to investigate the tooth surface caries patterns in the primary dentition according to breast or bottle feeding. The subjects of study were 815 children, 36 to 71 months old, in Iksan, Cheongju and Ulsan cities. The caregivers of the children were asked which they fed between the breast milk and the infant formula during the 1st year after birth and the duration of feeding. There was no significant difference in dmfs between the breast milk group and the infant formula group(significance level 0.05, same below). Tooth groups, tooth surface groups, teeth, and tooth surfaces which had significantly higher dmfs in the breast milk group than in the infant formula group were upper anterior teethttooth groups), upper incisors' buccal and proximal surfacesttooth surface groups), upper incisors and upper second molars (teeth), upper central incisors' buccal and distal surfaces, upper lateral incisors' buccolingual and proximal surfaces, upper 2nd molars' lingual. proximal. and occlusal surfaces, and lower 2nd molars' buccal and distal surfaces. In the breast milk group, tooth groups, tooth surface groups, teeth, and tooth surfaces which dmfs significantly increased as the duration of the feeding increased were upper anterior teeth and upper molars (tooth groups), upper anterior teeth's proximal surfaces, upper molars' buccolingual, proximal, and occlusal surfaces, lower molars' proximal surfacesttooth surface groups), upper anterior teeth, upper molars, lower 2nd molars (teeth), upper anterior teeth's proximal surfaces, upper 1st molars' buccolingual, proximal. and occlusal surfaces, upper 2nd molars' buccal surfaces, and lower 2nd molars' mesial surfaces (tooth surfaces). In the infant formula group, dmfs increased after 3 years of feeding, but the difference was not significant. Caries prevention is necessary in case of breastfeeding more than two years.

우리나라 어린이와 청소년의 구강건강을 위한 공공서비스의 현황과 전망

이광희,김지영,송지현,김윤희,임경욱,정승열 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

소아치과학이 목표로 하는 어린이와 청소년의 구강건강을 달성하기 위하여는 민간 치과의료기관에서 내원 환자를 대상으로 하는 진료만으로는 한계가 있으며 공공서비스(公共service)의 역할이 필요하다. 학교구강보건설이 설치된 초등학교는 전체의 7.2%이었고,초등학교 중에서 불소용액양치사업을 수행한 비율은 57.5%, 급식 후 집단잇솔질을 한 비율은 46.9%이었으며,초등학생 중에서 구강보건교육을 받은 비율은 48.0%, 치아홈메우기를 받은 비율은 12.4%이었다(2006년). 0∼6세 영유아의 약 42%가 지난 1년간 구강검진,불소도포,치면세마,치아홈메우기 중 하나 이상의 예방적 치과진료를 받았으며,받은 장소는 교육시설이 약 18%, 보건소가 약 1%이었다(2005년). 불소농도가 조정된 수돗물을 마시는 인구 비율은 전국 평균이 5.7%이었다(2006년). 학교구강보건사업의 발전을 위해서 행정의 일원화,보건교사에 대한 교육,구강보건교사제도의 도입,순회 학교치과의사와 학교치과병원을 통한 포괄적 진료서비스의 제공 등을 고려할 수 있을 것이다. 또한 아동·청소년 주치의제의 도입으로 민간기관을 통해 공공서비스를 강화하는 방안이 검토되고 있다. To achieve the dental health of children and adolescents which is the objective of the pediatric dentistry, the role of the public service should be increased. The basis of the public service is established by many laws of which the Dental Health Law is most important. The percentages of primary schools that had the school dental health clinic, that implemented the fluoride rinsing program, and that implemented the group toothbrushing after lunch were 7.2%, 57.5%, and 46.9%, respectively, and the percentages of primary school children that received the dental health education and that received the fissure sealing were 48.0% and 12.4%, respective1y(2006). About 42% of infants and preschool children from 0 to 6 years received preventive dental care in the last one year, at the nursery or kindergarten(18%) or at the health center(1%)(2005). The percentage of the health centers that implemented water fluohdation was 11.3%, and the percentage of the population who drank the fluoridated water was 5.7 %(2006). It was suggested that the school dental health administration should be unified, that dental health teachers should be employed, and that the comprehensive dental health care should be supplied to all the children and adolescents through the circuit school dentists and the school dental hospitals in the long term. Also, the dentist in charge system for the children and adolescent was suggested.

Sprague Dawley 수컷 랏트에서 Bisphenol A Diglycidyl Ether의 경구 투여에 의한 급성 독성

임재언,양윤정,이태진,홍연표 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

목적: 본 연구는 BADGE의 경구 투여에 의한 급성 독성학적 연구를 수행하여 기존의 연구 결과를 확인하고 추후 내분비계 장애 연구에 필요한 기초자료를 얻고자 하였다. 방법: 수컷 SD 랏트에 0, 1000, 2000, 4000과 8000 mg/kg/day의 BADGE와 DES 0.37 mg/kg/day의 농도를 단회 경구로 투여한 후 14일간 일반 증상 등을 관찰하였고 14일 후 부검하였다. 결과: BADGE를 투여한 모든 군에서 투여 후 3일째에 설사와 다른 일반 증상들이 관찰되었고 체중도 감소하는 경향을 보였다. 특히 8000 mg/kg/day의BADGE를 투여한 랏트에서 투여 후 3일째에 대조군에 비해 유의한 수준으로 체중이 감소하는 것을 관찰할 수 있었다. 일부 BADGE 투여군에서 대조군에 비해 심장(1000, 2000과 4000 mg/kg/day), 간(1000, 2000, 4000과 8000 mg/kg/day)과 전립샘(4000 mg/kg/day)의 무게의 감소가 관찰되었다. BADGE 투여군의 간(1000과 4000 mg/kg/day)과 전립샘(8000 mg/kg/day) 의 상대 무게가 대조군과 차이를 보였다. 고환을 제외한 모든 장기에서 조직학적인 변화는 관찰되지 않았으며 고환에서는 세 정관에서 정자세포의 감소가 관찰되었다. 고환과 부고환의 sperm head 수를 보면, 고환에서만 감소하는 경향을 보였으며 정자의 운동성과 기형은 대조군과 차이가 없었다. 혈장 에스트로겐과 테스토스테론 농도는 대조군과 모든 투여군 간의 유의한 차이가 없었다. 결론: BADGE를 랏트에 경구 투여 하였을 때 1000 mg/kg/day의 수준에서도 일반 독성 및 생식독성을 유발시킬 수 있음을 보여준다. Objectives: Bisphenol A Di Glycidyl Ether (BADGE) is the major component in commercial liquid epoxy resins, which are manufactured by co-reacting bisphenol A with epichlorohydrin. The authors investigated the acute toxicity of BADGE. Methods: BADGE was administered by a gavage to 8 week old SPF Sprague Dawley rats in a single dose of 0 (negative control), 0.37 (Diethylstilbesterol, DES), 1000, 2000, 4000, and 8000 mg/kg/day of BADGE. Each treatment group contained 7 rats. The general status and weight of the rats were observed for 14 days. The rats were anesthetized by ether at 14 days, and the changes in morphology, organ weight, sperm count and motility, and hormone level were measured. Results: All the rats treated with BADGE had diarrhea on the 1st day. The rats administered BADGE at 1000, 2000, and 4000 mg/kg/day showed a soiled perineal region and soft stools with diarrhea until the 3rd day. The 8000 mg/kg/day BADGE rats had diarrhea for two days followed by emaciation, soiled fur, a soiled perineal region, staining around the mouth and were moribund for three to eight days. No weight gain was observed after the 1st day in the 2000, 4000, and 8000 mg/kg/day BADGE rats and after the 7th day in all the treatment groups compared with the control groups. Some treatment groups were observed to have a decrease in the weight of the heart (BADGE 1000, 2000 and 4000 mg/kg/day), liver (BADGE 1000, 2000, 4000 and 8000 mg/kg/day) and prostate (BADGE 4000 mg/kg/day) compared with control group. The weight of the liver was significantly lower in all treatment groups compared with the control group. The relative weight of the liver (BADGE 1000 and 4000 mg/kg/day) was significant lower than the control. No pathological changes were observed in the brain, liver, thyroid, heart, spleen, kidney, lung and prostate. The number of spermatid in the seminiferous tubule in the testes was lower in all treatment groups than the control. The sperm motility tended to decrease with increasing concentration but the sperm count was similar in all treatment groups. The plasma Estrogen and testosterone level were similar in the control and treatment groups. Conclusions: These results suggest that BADGE induces general, hepatic and reproductive toxicity at 1000 mg/kg/day.

반응성 애착장애아와 발달성 언어장애아의 의사소통 의도 비교 연구

이경숙,이호분,신정현,노경선,임연화 대한소아ㆍ청소년정신의학회 1997 소아청소년정신의학 Vol.8 No.2

카톨릭의과대학 부속산업재해병원

유병국,윤임중,이승한 가톨릭대학산업의학센타 산업의학연구소 1979 韓國의 産業醫學 Vol.18 No.1

For the purpose of obtaining reference materials which may be applied to diagnosis of lead poisoning and absorption by D-penicillamine chelation technique, 4-hour fractionated urinary lead excretion was determined under various dosage schedule on 90 lead workers who were either heavily exposed to or intoxicated with lead. The observation groups consisted of nine groups of ten persons and each group was administered 200㎎, 300㎎ or 400㎎ of oral D-penicillamine, either once daily, twice daily at 12-hour intervals or thrice daily at 6-hour intervals. The resulls were as follows: 1. 24-hour urinary lead excretion increased by 2.3 to 6.0 times after daily oral D-penicillamine of 200∼1,200㎎ as compared with initial excretion. 2. 4-hour fractionated urinary lead excretion reached plateau usually within 0-4 hours after each dose of D-penicillamine, though frequently plateau was observed in 4-8 hour period with single doses of D-PCA. 3. 4-hour fractionated urinary lead excretion showed close association showed close association with initial lead excretion only when three doses of 400㎎ D-penicillamine were administered at 6-hour intervals. No association was noted with initial blood lead, urinary coproporphyrin or δ-amino-levulinic acid levels. 4. Determination of lead in third period 4-hour fractionated urine after 2 doses of 400㎎ D-penicillamine given at 6-hour intervals seems most helpful for diagnosis of lead poisoning and absorption.

반복성 단늑골 다지 증후군 1예

방성윤,최규연,박은희,강미경,김미경,이정재,이임순 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Short-rib polydactyly syndromes(SRPS) comprise a group of rare, generally lethal skeletal dysplasias. This group is manifested by short-limb short stature, short ribs with thorasic hypoplasia, and polydactyly. This heterogenous group of recessively inherited disorder has distinct imaging findings and ancillary findings on both pre-and postnatal assessments may enable individual cases to be classified into one of four subtypes : SRPS Ⅰ(Saldino-Noonan); SRPS Ⅱ (Majewski); SRPS Ⅲ (Verma-Naumoff); and SRPS Ⅳ (Beemer-Langer)1,2,3). All forms of the SRPS described to date are thought to be inherited in an autosomal recessive manner. There are difficulties in the clssification of these disorders because of the frequent overlap. We experienced one case of recurrent short-rib polydactyly syndrome and presented with review of literature.

규폐결핵 3례의 임상 및 병리학적 소견의 비교 검토

김상호,이수영,윤임중,이승한,조규상,김영제 카톨릭대학산업의학센타 산업의학연구소 1972 韓國의 産業醫學 Vol.11 No.3

Among the pneumoconiosis, the silicosis is an occupational lung disease, ordinally due to prolonged inhalation of air containing free silicon dioxide. We had chance to perform autopsy of three cases of silicotuberculosis. Both lungs with hard and contracted appearance, were showed massive fibrous adhesion to pleura and also revealed gritty appearance on cut sectioning, and the cut surfaces were shown dark greenish to black pigmentation. Characteristically, many dense black or grey colored silicotic nodules measuring upto 1-4 mm in diameter, with anthracotic pigments distributed throughout both lung parenchyma especially along the peribronchial regions in all three cases, commonly. Microscopically, the nodules were noted as the mass of concentrically laminated dense fibrotic tissue. In addition to those findings, the pulmonary parenchymas were replaced by wide areas of fibrosis and also accompanied with exudative and productive form of tuberculosis (common in all three cases), bronchopneumonia (except case-1) and also compensating emphysema, atelectatic lesions. At the peripheral areas of the silicotic nodules, focal accumulation of the plasma cells, lymphocytes and many foci of endarteritis were shown in three cases, commonly. The silica was confirmed by polarizing microscopy as birefringent, white colored crystals.

제왕절개술의 전신마취 유도중 전완고립술과 Bispectral Indes를 이용한 마취깊이의 평가

김계민,이윤석,연준흠,임윤희,홍기혁,최원주,김정원 대한정맥마취학회 2000 정맥마취 Vol.4 No.3