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Yulong Zheng,Eun-Hye Lee,Ji-Hyun Lee,So-Yeon Lee,Ga-Ryeong Kim,Il-Jun Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Previous studies have shown that Morus alba L. root 30% ethanol extract (MAR) can inhibit the accumulation and release of melanin in B16F10 melanoma cells. This study aimed to explore the mechanism of MAR involving the MAPK pathway to inhibit melanogenesis in B16F10 melanoma cells. We treated MAR with different concentrations and times in melanocytes and investigated the expression and phosphorylation of MAPK pathway-related proteins. Moreover, we have identified several potential anti-melanogenic active compounds in MAR by LC-MS/MS. MAR prevents the transient activation of ERK induced by melanogenesis in melanocytes within 2 h, but it does not affect JNK and p38 MAPK. However, MAR significantly reduced the phosphorylation of ERK, JNK, and p38 MAPK at 72 h. These results indicate that the anti-melanogenesis effects of MAR mainly involve the rapid suppression of the ERK signaling pathway in a short period, followed by inhibiting JNK and p38 MAPK in the MAPK pathway and finally down-regulating the expression level of MITF. In addition, several active compounds wtith anti-melanogenic effects have been identified in MAR, such as mulberroside A and oxyresveratrol.
Yulong Zheng,이재선,이은혜,인교,김종한,이미향,이옥환,강일준 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.3
Anti-obesity activities of Korean red ginseng saponin fraction (RGS) and/or Glycyrrhiza glabra L. extract (GG) were investigated in 3T3-L1 adipocytes and high-fat diet-induced C57BL/6J obese mice. RGS and GG extracts were mixed at a mass ratio of 3:1 (SG31), 1:1 (SG11), or 1:3 (SG13). SG31 showed the highest anti-obesity activity among the three different mass ratios of RGS and GG extracts. SG31 showed higher inhibition efficiency on triglyceride (TG) accumulation than either single extract in 3T3-L1 adipocytes and without any cytotoxicity. It also decreases the expression of adipogenic and lipogenic genes such as C/EBPα and SREBP-1c (sterol regulatory element-binding protein 1c). In the obese induced mouse model, SG31 significantly reduced white adipose tissue weight and body weight, attenuated dyslipidemia, and decreased serum TG levels. In some indices, the activity of SG31 was even higher compared with Garcinia Cambogia water extract, a positive control. The possible mechanism by which SG31 causes the above results was by activating the AMP-activated protein kinase (AMPK) pathway and stimulating the secretion of adiponectin in adipose tissue to regulate energy metabolism balance, inhibit TG formation, and promote β-oxidation of fatty acids. Therefore, SG31 may have efficacy as an anti-obesity functional food or raw material if the results can be confirmed in human studies.
Yulong Zhang,Changzhong Li,Wenhui Zhang,Xiangqin Zheng,Xiujuan Chen 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.4
Myo-inositol supplementation may reduce insulin resistance (IR) with few serious side effects in patients with polycystic ovary syndrome (PCOS). To explore the mechanism of this action in an animal model, a PCOS-IR rat model was generated. Enzyme-linked immunosorbent assay was used to assess changes in ovulation function during treatment with a myo-inositol supplement, and Western blotting, real-time polymerase chain reaction, and immunohistochemistry were performed to investigate the underlying molecular mechanisms. The results showed that the myo-inositol supplement decreased the homeostatic model assessment of insulin resistance (HOMA-IR) index and significantly decreased the serum levels of luteinizing hormone (LH), LH/follicle-stimulating hormone ratio, and testosterone, while increasing the serum level of estradiol. Upregulation of interleukin 6 (IL-6), phospho-STAT3 (p-STAT3), Mir-21, and Mir-155 and significant downregulation of PPAR-γ and GLUT4 were detected in the untreated PCOS-IR rat model. However, downregulation of IL-6, p-STAT3, miR-21, and miR-155 and significant upregulation of PPAR-γ and GLUT4 were detected with myo-inositol supplementation. Thus, myo-inositol supplementation may reduce Mir-21 and Mir-155 levels by downregulating IL-6 and p-STAT3 and, subsequently, reverse the expression of PPAR-γ and GLUT4, leading to a decreased HOMA-IR index. In conclusion, the identification of an IL-6/p-STAT3/Mir-155/Mir-21/PPAR-γ/GLUT4 system in the PCOS-IR rat model provides insight into the pathogenesis of PCOS and may indicate a possible therapeutic strategy. Amelioration of the basal serum glucose levels and of the HOMA/HOMA-IR index may be achieved by the reversal of the expression of PPAR-γ and GLUT4 through the downregulation of IL-6, p-STAT3, miR-21, and miR-155 with myo-inositol supplementation.
Hongpeng Zheng,Yulong Lei,Pengxiang Song 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.3
Hydraulic retarders are auxiliary braking devices that reduce the velocity of a vehicle, particularly when a vehicle is driven downhill. Such velocity reduction could reduce the potential risk caused by brake failure caused by the service brake working for a long time and the temperature of the brake shoe becomes extremely high. This paper introduces the construction of the hydraulic retarder and proposes two mathematical models for the hydraulic retarder. The first mathematical model is deduced by using fluid mechanics, which is used to analyze the mechanism of how braking torque is produced and the key factors that can influence the value of the braking torque. The second mathematical model is deduced by using thermodynamics, which is used to quantify the heat produced by the hydraulic retarder. This research emphasizes that the flow rate and the average velocity of the working fluid in the working chamber mainly determine the braking torque of the hydraulic retarder. The flow rate into and out of the working chamber determines the temperature rise of the working fluid. Computational fluid dynamics (CFD) simulations are conducted with the Reynolds-averaged Navier-Stokes (RANS) and Shear Stress Transport (SST) turbulent models. Experiments are carried out to justify the two mathematical models and the CFD simulations. The results show that the mathematical models are capable of describing the force analysis and energy conversion of the hydraulic retarder and SST is more accurate for CFD simulation and the error is within 6 %.
Yan Zhou,Zheng Ruan,Lili Zhou,Yuhui Yang,Shumei Mi,Ze-Yuan Deng,Yulong Yin 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.1
Chlorogenic acid (CGA), an abundant polyphenol compound in plants, exhibits anti-oxidant effects. The protective effect of CGA in the rat intestine with endotoxin infusion was evaluated. CGA administration ameliorated endotoxin-induced intestinal injury, and decreased the ratio of lactulose/ mannitol, the ileum pathological grade, the myeloperoxidase activity in the ileum, and the malondialdehyde content in the ileum and in ileum mitochondria. The small intestine weight, activities of alkaline phosphatase and superoxide dismutase in the ileum, and β-nicotinamide adenine dinucleotide reduce form (NADH) dehydrogenase and succinate dehydrogenase activities in ileum mitochondria were increased. Intestinal permeability was positively correlated with intestinal mitochondrial injury indicated as the level of malondialdehyde in ileum mitochondria, and negatively correlated with NADH dehydrogenase activity. Dietary administration of CGA protected against increased intestinal permeability caused by endotoxin infusion. The protective effect of CGA was probably associated with a decrease in mitochondrial lipid peroxidation levels and an increase in NADH dehydrogenase activity.
The Prebiotic Lactosucrose Modulates Gut Metabolites and Microbiota in Intestinal Inflammatory Rats
Xiaoli Zhou,Zheng Ruan,Xiaoliu Huang,Yan Zhou,Shiqiang Liu,Yulong Yin 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
The effect of lactosucrose on the short chainfatty acid (SCFA) content, the intestinal flora, the acidity,and the amino nitrogen (NH3-N) content of the intestine ininflammatory bowel disease (IBD) rats was investigated. Dietary lactosucose supplementation increased amounts ofbeneficial bacteria and diminished amounts of pathogenicbacteria. Lactosucrose decreased the NH3-N content in cecaland colonic digesta, compared to inflammatory rats. Lactosucrose increased the acidity in the intestinal lumen,and the acetic acid, propionic acid, and butyric acidcontents in cecal and colonic digesta, compared toinflammatory rats. The butyrate content in the lactosucrosegroup was higher than for the inflammatory, sulfasalazine,and normal groups. Lactosucrose promoted beneficialintestinal health and prevented intestinal inflammation.