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Yeo, Young K .,Kim, Jong S .,Lee, Jong R .,Lee, Ji Y .,Chung, Sang W .,Kim, Hyo J .,Horrocks, Lloyd A .,Park, Young S . 생화학분자생물학회 2001 BMB Reports Vol.33 No.6
The level of long-chain n-3 fatty acids in chicken and pork can be increased by changing the diet of the animals. Increased levels of these essential fatty acids improve cardiovascular health in humans. The purpose of this study was to study the effects of the consumption of pork and chicken enriched in docosahexaenoic acid (DHA) on plasma lipids. The consumption of these products decreased the levels of two cardiovascular risk factors, LDL-cholesterol and triacylglycerols, in the plasma of female college students. The effect on LDL-cholesterol differed from that of fish oil, which does not affect the level of LDL-cholesterol. The proportions of DHA in the triacylglycerols and the glycerophospholipids were increased markedly The greatest changes in the glycerophospholipids were in the ether types of the ethanolamine glycerophospholipids. Dietary DHA appears to be incorporated preferentially into the plasma ethanolamine plasmalogens, which can act as antioxidants. This agrees with our hypothesis that DHA stimulated the transcription of the genes for peroxisomal enzymes that are required for plasmalogen synthesis.
충청지역에서 발생한 Rickettsia 감염 40 예에 대한 임상적고찰
이종민(Jong Min Lee),강진형(Jin Hyoung Kang),박석영(Suk Young Park),김석영(Suk Young Kim),박준철(Jun Chul Park),임계순(Kae Soon Im),백남종(Nam Jong Baeg),김영우(Young Woo Kim),정희영(Hee Young Chung),주용구(Young Kyu Chu),이호왕(Ho W 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A In Korea, there has been an increasing concern on rickettsiosis as a possible cause of unknown febrile illness since Tsutsugamushi disease among Koreans were first reported m 1986. We experienced 40cases of rickettsiosis occuring in Choong-chung-do area during the period October-November, 1986. 30cases were confirmed as Tsutsugmushi disease by indirect immunofluorescent antibody test. 10cases were positive to Weil-Felix test but negative to indirect immunofluorescent antibody test. The clinical illness was chracferized by abrupt onset of fever, chill and skin rash. Lymphadenopathy, headache and myalgia were not uncommon. Eschar was also detected in several cases and intersitial pneumonitis, pulmonary edema were appeared in 3cases, In our study, Tsutsugamushi disease was an mild to moderate febrile illness of 2 to 3 weeks duration.
Bo Yeon Kim,Kwang Sik Lee,Young Moo Choo,So Dong Woo,Yeon Ho Je,Byung Rae Jin 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10
Pseudorabies virus (PRV), a member of the Alphaherpesviridae, is the causative agent of Aujeszky’s disease in pigs. Glycoprotein B (gB) of PRV, a major constituent of the viral envelope, consists of 916 amino acids. We continuously combined three gB epitopes, E1 (aa 62-129), E2 (aa 217-282), and E3 (aa 543-737). The DNA fragment containing the PRV gB epitopes was fused with polyhedrin gene in order to generate recombinant baculovirus that expresses the recombinant polyhedra with PRV gB epitopes under the control of the Bombyx mori nucleopolyhedrovirus polyhedrin promoter. Recombinant baculoviruses were injected into fifth-instar B. mori larvae. SDS-PAGE and Western blot analyses revealed that recombinant polyhedra constitute polyhedrin and PRV gB epitopes, and that the recombinant PRV gB epitopes showed cross-reactivity against antiserum of PRV gB produced from pig. To examine the immunogenicity of recombinant PRV gB epitopes, we injected into mice as model animals. ELISA results indicated that antibody production is increased in a similar manner in the injection of recombinant polyhedra with PRV gB epitopes, either injected recombinant polyhedra as a granule form antigen without adjuvant or injected recombinant polyhedrin as a soluble form antigen with adjuvant. Taken together, these data show that PRV gB epitopes were produced as a granule form antigen by fusing recombinant polyhedra in baculovirus-infected silkworm larvae and displayed the immunogenicity in mice, indicating the efficacy of the granule form antigen as a PRV gB vaccine.
말기 신부전 환자에서 부갑상선 기능항진증으로 외과적 부갑상선 절제술을 시행 받은 환자의 임상적 경과
한승혁(Seung Hyeok Han),이상철(Sang Cheol Lee),강이화(E . Hwa Kang),구영석(Young Suk Goo),박형천(Hyung Chun Park),노현정(Hyun Jeong Roh),노현진(Hyun Jin Noh),윤수영(Soo Young Yoon),윤도식(Do Sik Yun),최소래(So Rye Choi),강신욱(Shin W 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.1
배 경 : 말기 신부전 환자의 내과적 치료에 교정되지 않는 중증 이차성 부갑상선 기능항진증시 외과적 부갑상선 절제술이 시행되어져 왔다. 부갑상선 절제술 시행 후 추적결과에 대한 보고가 드물어 본 연구를 시행하였다. 방 법 : 1990년부터 1999년까지 신촌세브란스병원에서 중증 이차성 부갑상선 기능항진증으로 외과적 부갑상선 절제술을 시행 받은 24 명을 대상으로 후향적으로 분석하였다. 결 과 : 술후 병리소견으로 미만성 17예, 결절성 6예, 선종이 1예였다. 임상증상으로 골통 또는 관절통은 19명(79.2%), 근육통은 17명(70.8%), 신체 불쾌감은 10명(41.7%), 소양증은 13명 (54.2%)였고, 술후 임상증상의 호전을 보였다. 술후 혈청 칼슘, 혈청 인, intact PTH는 각각 7.3±1.4 ㎎/dL, 4.0±1.3 ㎎/dL, 89.3±146.1 pg/mL로 술전과 비교하여 감소하였고(p<0.01), 혈청 alkaline phosphatase는 술후 738.8±935.1 IU/L로 술전 보다 증가하였다(p<0.01). 재발 5예 중 결절성 과증식형이 4예로 미만성 과증식형에 비해 높은 빈도를 보였고(p=0.006), 비재발군에 비해 수술 전후의 intact PT H의 감소차가 적었다(945.3±374.6 v s 1,385.8±481.8, p=0.036). 결 론 : 중증 이차성 부갑상선 기능항진증에서 외과적 부갑상선 절제술은 증상완화나 술후 intact PTH의 감소 등 좋은 결과를 기대할 수 있다. 병리학적 유형과 술후 intact PTH 감소 정도가 재발을 예측할 수 있는 인자로 생각된다. Backg round : Medical treatments such as restriction of phosphate, phosphate binder use, and active vitamine D therapy have been widely used for hyperparathyroidism in ESRD patients, and surgical parathyroidectomy should be considered in patients with uncontrolled hyperparathyroidism. Methods : A retrospective study w as performed in 24 ESRD patients with severe and uncontrolled hyperparathyroidism despite of medical treatment who undertook surgical parathyroidectomy in Severance hospital from 1990 to 1999. Results : Sixteen patients had total parathyroidectomy with immediate autotransplant, 7 patients had subtotal parathyroidectomy and only 1 patient had minimally invasive parathyroidectomy. An excellent short-term control of hyperparathyroidism was achieved in all patients after parathyroidectomy. Preoperative bone and joint pain improved in 16 of 19 patients. Muscle weakness and pain improved in 11 of 17 patiens, malaise improved in 8 of 10 patients and pruritus improved in 10 of 13 patients. In addition, clinical laboratory finding improved after parathyroidectomy. No clinical differences were seen between 16 patients who undertook total parathyroidectomy with immediate autotransplant and 7 patients who undertook subtotal parathyroidectomy. Recurrence of hyperparathyroidism ocurred in 5 of 24 patients with 4 nodular hyperplasia and 1 diffuse hyperplasia in pathologic finding . T he less degree of attenuated response of intact PTH levels immediately after operation w as observed in 5 recurrent cases. Conclusion : Good results were obtained after parathyroidectomy. We believe that histologic subtype and the attenuated response of intact PTH after surgical parathyroidectomy could be possible predictors of the recurrent hyperparathyroidism.