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이호왕,Lee, Ho-Wang 한국과학기술단체총연합회 1971 과학과 기술 Vol.4 No.2
1.유행성 출혈열이란 2.파나마 중미연구소 및 고가서 기업 연구소 3.미국 미육군 월타리-드 연구소 존스합킨스 대학원 4.일본 5.결론
한국산 가토에서의 Shope Fibroma Virus에 대한 항체증명과 섬유종 형성에 관한 연구
양현옥,박건우,류선자,우영대,주용규,이호왕,Yang, Hyun-Ok,Park, Kun-Koo,Ryu, Sun-Ja,Woo, Young-Dae,Joo, Yong-Kyu,Lee, Ho-Wang 대한미생물학회 1998 Journal of Bacteriology and Virology Vol.28 No.4
In our preliminary study to find antiviral or antitumor agents from Korean natural products, we found that the Shope fibroma virus (SFV) induced fibromas reaching maximum size at $5{\sim}6$ days with spontaneous disappearance at $15{\sim}20$ days after SFV intracutaneous inoculation into Korean domestic rabbits. However, the sizes of fibromas of rabbits at day 5 after virus inoculation were significantly different individually. Assuming that the variation of tumor size was due to either susceptibility or the preexisting antibodies against SFV in the Korean domestic rabbits, the rabbits were checked for the antibodies against SFV by IFAT using SFV infected RK13 cells. The antibody positive rate of normal Korean domestic rabbits was 32.8% and the sizes of the fibromas of the positive rabbits were significantly smaller than those of negative rabbits (p<0.0001). The fibroma sizes were dependent on the antibody titers of rabbits to SFV. The sizes of fibromas after inoculation of SFV into immunized rabbits were about one tenth of those by the first inoculation into normal rabbits. This is the first report on the antibody prevalence against SFV among normal Korean domestic rabbits and it suggest the existence of a wild fibroma virus or related virus in Korea.
주용규(Yong Gyu Joo),송대용(Dae Yong Song),구형모(Hyung Mo Goo),이호왕(Ho Wang Lee) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.3
Hantaan virus (HTNV), the etiologic agent of hemorrhagic fever with renal syndrome (HFRS), belongs to the genus Hantavirus, and has three single negative stranded RNA genome segments. HTNV strain Howang isolated from the blood of severe case of Korean HFRS is more virulent than HTNV 76/118 and the M and S genome segments' nucleotide sequence of Howang strain showed 93.5% and 94% homology to each segment of HTNV 76/118. We have obtained 6533 nucleotides long sequence of the L genome segment of Howang strain using reverse transcriptase in conjunction with PCR amplification and compared to other hantaviruses. The messenger sense of the L segment contains one long single long open reading frame of 2151 amino acids, which encodes a deduced RNA dependent RNA polymerase of 246.4 kDa caculated molecular weight protein. The nucleotide sequence of the L segment of Howang strain shows 93%, 74%, 66%, 65% homology to HTNV 76/118, Seoul virus 80/39, Puumala virus hallnas B1 and Sin Nombre virus, respectively. The amino acid sequence of the L segment of Howang strain shows 99%, 85%, 68%, 68% homology to HTNV 76/118, Seoul virus 80/39, Puumala virus Hallnas B1 and Sin Nombre virus, respectively.