모체 Thyroxine 투여가 태아알코올효과를 가진 흰쥐 대뇌겉질 및 해마에서 NPY함유 신경세포의 생후 발달에 미치는 영향

김복,박상기,박영란,김종중,문정석,김주수,문영민,현영식,천관영,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: Maternal alcohol abuse is considered to be one of the most prominent cause of neurobiological malformations in the postnatal and adult life of the offspring. In this study, we investigated the effects of maternal alcohol drinking on the postnatal development of NPY-containing neuron, and, the influence of thyroxine treatment on the cerebral cortex and hippocampus of pups of alcohol abused mother. Materials and Method: Time-pregnant rats were divided into three groups. Alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day 6; control pair-fed group B was fed a liquid diet in dextrin replaced alcohol isocalorically: alcohol + T4 group C received 35 calories liquid alcohol diet and exogenous thyroxine subcutaneously. Results: Group C showed prominent NPY immunoreactivity in the cerebral cortex compared to group A and B at P7. In group C, NPY-containing neurons were widely distributed in the all layers of cerebral cortex after P14. Besides, numerical decrease of NPY-containing neuron as age increases was not found in group C. However, the decrease of NPY-containing neuron was clearly observed in group A compared to group C after P14. In hippocampus, group Band C were appeared similar patterns after P7. Additionally, in group C, NPY immunoreactivity was prominently appeared in CA2 and CA3 at P14 as compared to group B. Conclusions: The present results showed the increase of intensity and number of NPY-containing neurons in cerebral cortex and hippocampus of pups of exogenous T₄ supplemented alcohol-exposed dams as compared to control pair-fed and alcohol-exposed pups at P7. It presumably suggest that NPY-containing neurons might be regulated by the early postnatal growth stimulatory effect of the exogenously supplemented T₄. Therefore, the increase of NPY synthesis caused by maternal administration of exogenous thyroxine may ameliorate fetal alcohol effect, one of the ill effects as a result of the dysthyroid state following maternal alcohol abuse.

척수를 손상시킨 후 꼬리정맥에 주입한 사람탯줄혈액세포가 뇌줄기에 미치는 영향

김종중,정윤영,박영란,문영민,현영식,정영욱,문정석 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Background and Objectives: Stem cells are a valuable resource for treatment of many disease, but limited access to stem cells in some organs such as brain restricts their utility. Many approaches have been attempted to restore the function following brain stem injury (BSI) and spinal cord injury (SCI). The use of the human umbilical cord blood cells (hUCB) - a rich source of nonembryonic or adult stem cells - has recently been reported to ameliorate the behavioral consequences of stroke. Mateiials and Methods: Forty rats were divided into 8 groups: (1) SCI l+hUCB (infused 1 day post injury); (2) SCI 2+hUCB (infused 2 days post injury); (3) SCI 3+hUCB (infused 3 days post injury); (4) SCI 4+hUCB (infused 4 days post injury); (5) SCI 5+hUCB (mfusedt 5 days post injury); (6) SCI 6+hUCB (infused 6 days post injury); (7) LO+hUCB (laminectomy+hUCB); and (8) LO (laminectomy only). SCI was produced by compressing the spinal cord for one minute with an aneurysm clip calibrated to a closing pressure of 50 g. We report here that immunhistotochemical identification of fluorescent hUCB positive cells in the brain stem after compressed spinal cord injury using mouse anti-human mitochondria monoclonal antibody (MAB1273). Results: All SCI+hUCB (1-8) groups contained fluorescent hUCB positive cells in the all area of the brain stem. But especially a large number of fluorescent hUCB positive cells were observed in the whole area of the brain stem of the experimental 5 (SCI 5+hUCB) and 6 (SCI 6+hUCB)groups. No hUCB positive cells were found in the brain stem of group with non-injured spinal cord of these animals and group with laminectomy only. Conclusion: These results suggest that hUCB are potentially useful as a vector for treating a variety of the central nervous system disorders, and we are sure that continuous of stem cell study will give an best opportunity to treat the uncurable disorders in the future.

폐색 혈전혈관염의 특징적인 혈관조영 소견

박상규,최창식,황우철,박충기,노준영 대한혈관외과학회 1992 Vascular Specialist International Vol.8 No.1

The authors wished to introduce detailed angiographjc findings that were reviewed from 11 patients with clinically and pathologically diagnosed as thromboangiitis obliterans(TAO) who were selected young-adult(under the age of 35) male without having history of diabetes mellitus or hyperlipidemia. Total 18 angiograms(16 femoral and 2 brachial) were analized. Follow-up angiographies were performed in 6 patients; 2 times in 5 patients and 3 times in 1 patient. There were 3l occluded arteries and 2 diffusely narrowed arteries. The sites of involvement were posterior tibial arteries in 8 cases, anterior tibial arteries in 6 cases, peroneal arteries in 4 cases, superficial fomoral arteries in 3 cases, popliteal arteries in 3 cases, radial arteries in 3 cases, ulnar arteries in 2 cases, common femorotibial trunk and interosseous arteries in each one case. Eleven arteries were segmentally occluded including one case of multisegmental involvement, and remaining 22 arteries were totally occluded. The shape of interfaces of the occlusion were smooth tapering appearance in 14 arteries, round appearance in 9 arteries, triangular appearance in 4 arteries, nipple shape in 3 arteries. There is no case of rat-tail appear- ance or round filling defect. The opacified arteries before occlusion were mostly normal(in 22 cases), but characteristic signs of corrugate appearance(in 6 cases), wave appearance(in 3 cases) and diffuse narrowing(in 2 cases) were often detected. The corrugate and the wave appearances were nearly symmetrical and constant. There are no case of plaque, calcification or post-stenotic dilatation. Corkscrew appearance of collaterals were observed in 8 cases. They looked as a tree-root or spider-legs. In 3 cases, there was no collaterals at all. In six patients available for follow-up, angiograms revealed gradually bidirectional extension of the occlusions regardless of receiving lumbar sympathectomy or lumbar sympathectomy with bypass graft. Conclusively, TAO is an apparently distinctive disease characterized by progressive and segmental occlusion in small to medium sized arteries with several characteristic signs.

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

축방향 그루브형 히트파이프의 형상에 따른 성능특성

서정세,박영준,권운식 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-

In this study, analysis is made for the effects of groove shape on the thermal performance of a axial groove heat pipe. The mathematical models of two-phase flow in grooved heat pipe are presented for the capillary limitation as steady state. Generally, the heat pipe performance depends on the capillary pressure and liquid flow. The friction force of liquid flow through the groove increases with the groove width decreased, and then the capillary pressure is improved in the gas-liquid interface of groove. Therefore, the optimal groove width shape exists for the maximum thermal performance of heat pipe. In this paper, the optimal groove shape and scale are presented by considering both capillary pressure and liquid flow.

Acute Myocardial Infarction in a Young Adult during Vigorous Physical Activity

Young Youp Koh,Young Jae Ki,Sung Soo Kim,Hyun Wook Kim,Keun Ho Park,Dong Hyun Choi,Joong Wha Jeong,Kyoung Sig Chang 조선대학교 의학연구원 2017 The Medical Journal of Chosun University Vol.42 No.4

Acute myocardial infarction (AMI) as an acute form and a catastrophic manifestation of coronary artery disease (CAD) is the major cause of morbidity and mortality worldwide. The prevalence and incidence of myocardial infarction can be influenced by demographic, biological and psychosocial factors, and it is rare in childhood and adolescent years. Contrary to the elderly, where cardiac attack is mainly caused by CAD, exercise-induced cardiac attack is relatively more prevalent in a young adult. We report here on a case of ST-segment elevation myocardial infarction (STEMI) in a young adult during vigorous physical activity and we review the relevant literatures.

Assay on Antioxidation Activity in Loquat (Eriobotrya japonica lindl.) Germplasm

Moon-young Park,Youn-seop Jo,Jae-ok Park,Hye-sung Cho,Seong-sig Hong,Jang-hyun Park,Young-seo Park,Gab-cheon Koh 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

모바일 환경에서의 XML을 이용한 실시간 주차정보시스템

김영돈,전현식,박현주 한밭대학교 2003 한밭대학교 논문집 Vol.20 No.-

Nowadays, parking lot causes a big problem. Cars are increased in geometrical progression, but parking lots that takes in cars are relatively limited. Often we spend a lot of time to look for a parking lot because of limited parking lot. To solve this problem, we can use real time parking lot information system provided from mobile vehicles. In this paper, we will tell you how to deliver the parking lot information in real time by construction wireless network environment to be provided real time information and making XML data that is easy to share and to exchange data between applications.

유아용 교재 ․ 교구 인증에 관한 유아교육현장 인식 및 요구에 대한 연구

강영식(Kang, Young-Sig),박정환(Park, Jung-Hwan) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.2

본 연구는 유아용 교재․교구 인증에 관한 유아교육현장 인식 및 요구를 알아보는데 목적을 갖고, 대전광역시 소재 유치원과 어린이집에 종사하고 있는 교사와 원장 350명을 대상으로 2013년 9월 21일부터 30일까지 설문조사 하 였다. 분석결과 첫째, 유아용 교재?교구 평가인증에 대한 인식을 분석한 결과 먼저 전체 59.4%가 유아용 교재?교구 평 가인증이 필요하며, 32.9%는 교육현장 인식도가 높다고 생각하는 것으로 나타났다. 또한 전체 39.4%가 교육현장 요 구도가 높다고 하였으며, 45.1%가 유아용 교재?교구 평가인증에 대한 제도의 도입 시 기대효과가 높은 것으로 나타났 다. 둘째, 전반적인 유아용 교재?교구 평가인증 요구도를 분석한 결과 교육적 측면, 기능적 측면, 영역적 측면 순으로 요구도가 나타났다. 또한 각 영역별로 교육적 측면에 있어서는 사회적 발달 중점, 기능적 측면에 있어서는 안전성 중 점, 영역적 측면에 있어서는 언어발달 중점이 가장 높게 나타났다. 이같은 결과는 유아용 교재?교구의 다양성으로 인 해 교육적 측면과 기능적 측면에서 사회적 발달촉진과 안전성 측면에서 평가인증된 교재?교구를 사용함으로써 유아들 의 쌓기놀이, 읽기자료, 조작자료, 만들기 도구 등 실험관찰 도구의 사용이 높아지면서 품질보증이 가능한 교재?교구 에 대한 높은 평가인증이 요구됨을 실증해 준 것으로 평가할 수 있다. The purpose of this study is to analyze the perception and need of the early childhood education field on authentication of teaching materials and implements for young children. To achieve this, a survey was carried out on 350 teachers and directors in Daejeon-based kindergartens and child-care centers from September 21 to September 30, 2013. The results of the analysis are as follows. First, 59.4% of them thought that it needed the evaluation authentication of teaching materials and implements for young children. 32.9% of them had a high perception of the early childhood education field. 39.4% of them had high need of the early childhood education field. And 45.1% of them expected a high effect of introducing the evaluation authentication system of teaching materials and implements for young children. Second, most of them had the highest need of the evaluation authentication of teaching materials and implements for young children in terms of education, followed by function and field. And most of them placed the highest emphasis on social development, safety and language in terms of education, function and field, respectively. Consequently, the use of teaching materials and implements, which the social development and safety in terms of education and function are respectively evaluated and authenticated by the diversity of teaching materials and implements for young children, has need of the high evaluation and authentication of teaching materials and implements that can guarantee the quality when young children use a lot of experiment and observation implements such as block play, reading materials, manipulating materials, making implements.

생태체험 프로그램 활동이 유아의 정서지능 향상에 미치는 영향

강영식(Kang, Young-Sig),박정환(Park, Jung-Hwan) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.10

본 연구는 생태체험 프로그램 활동을 실시함으로써 유아들에게 기쁨과 추억을 만들어 주고 스스로 정서지능 에 대한 변화를 알아보는데 목적이 있다. 연구대상은 충청도에 소재하는 어린이집 만 5세반 중 두 학급의 어린이 40 명을 대상으로 실험집단과 통제집단으로 나누어 남, 녀 각각 20명씩으로 구성하였으며, 연구대상인 실험집단 유아들 은 생태체험활동의 프로그램을 따라 정한 요일에 5명씩 그룹을 나눠서 관찰하고, 체험하며 실험을 진행하였다. 분석결과 생태체험 프로그램 활동은 전반적인 유아정서지능과 하위요인별 자기정서의 이용, 타인정서의 인식 및 배 려, 자기정서의 인식 및 표현, 감정의 조절 및 충동억제, 교사와의 관계, 또래와의 관계에 있어 통제집단에 비해 실험 집단의 경우 상대적으로 높은 증가효과를 나타내었다. 이는 자연과의 유기적인 관계형성과 생태 중심의 체험 탐구수 업이 실내교육에서 느낄 수 없는 자연 세계의 이해와 자연친화적 태도, 생태위기 인식, 사회적 협력과 더불어 함께 생활하는 태도 기반 형성을 제공한다는 점에서 유아들의 정서지능 향상에서 유용한 프로그램임을 입증시켜 준 것이 라 할 수 있다. The purpose of this study is to inquire into the changes to the emotional intelligence of young children by giving them pleasure and memory through the program of ecological experience. A survey was made on 40 young children in two classes out of 5-year-old children`s classes in nurseries located at Chungcheong-do. They were divided into the experiment group and control group to consist of 20 persons, respectively. For young children of the experiment group, the experiment was conducted while observing and experiencing through the division of the group into 5 persons on fixed days according to the program of ecological experience. Analysis showed that the program of ecological experience in the experiment group relatively higher effect of increase for the emotional intelligence of young children, and the use of self emotion, the cognition and consideration of other's emotion, the cognition and expression of self emotion, the regulation and impulse control of emotion, the relationship with teacher and the relationship with peer by sub-factors than that in the control group. In other words, close relationships with nature and inquiry instruction of ecological experience have provided the attitude-based formation living together with the understanding of natural world and eco-friendly attitude, the cognition of ecological crisis and social cooperation that couldn't feel in indoor education. Consequently, the program of ecological experience should prove useful for the emotional intelligence of young children.