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관상동맥 풍선성형술 후 발생한 관상동맥 박리의 초기 조영술적 고찰
고영엽,강지인,장재혁,강민정,정중화,장경식,홍순표 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Background and Objectives: Percutaneous coronary intervention (PCI) is widely utilized in the treatment of symptomatic coronary artery disease (CAD). Althouth it has numerous benefits, intimal tear or dissection, serious and potentially life-threatening complications of plain old balloon angioplasty (POBA) can occur. The aim of this study was to assess the implications of coronary dissections after ballon angioplasty. Methods: 78 consecutive patients (age, 62 +/- 11 years; 46 men, 32 women) identified to two groups as having with or without dissection (dissection (D) group or non-dissection (ND) grouP) underwent balloon angioplsty for CAD were studied. All patients with dissection could be managed by successful stent implantation to rescue the artery. The morbidity of ischemic complication and mortality were evaluated for 30days after PCI. Results: Coronary dissection developed 44 lesions (38%) in 31 patients out of 117 lesions in 78 patients after POBA and a good final angiographic result was obtained in all patients with dissection, Significant correlates of a development of dissection were the lesion morphology of ACC/AHA type B and C (P<0.05). There were no significant correlations of clinical pictures, whether POBA in single vessel disease or in multivessel disease, diameter stenosis before POBA, and balloon/coronary artery diameter ratio. Morphologic feature of dissection was type A in 15 (34%), type B in 13(30%), type C in 12 (27%), and type D in 4 (9%). After PCI, there was no ischemic complication or death related coronary dissection during follow-up period for 30days. Conclusions: Coronary dissection after angioplasty occurred in 44 lesions (38%) out of 117 lesions of 78 consecutive patients underwent POBA. Coronary dissection after POBA significantly correlated with the severity of lesion morphology. Coronary stenting is effective in the management of acute coronary dissections after angioplasty.
간경변 환자의 문맥압 항진증을 평가하는데 있어 도플러 초음파 검사와 간정맥 압력차 측정의 비교
정필호,백순구,최윤종,박동훈,김문영,김현수,이동기,권상옥,김영주,박중화,김남동 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.3
목적: 도플러 초음파 검사는 간경변증 환자에서 문맥압 항진증의 정도 판정이나 문맥압을 떨어뜨 리는 약물의 효과를 알아보는데 사용되어 왔으나, 실제 문맥압 측정을 대변할 수 있는지에 대해서는 논란이 많다. 이에 본 연구자들은 도플러 초음파 검사가 문맥압 항진증의 진단 및 약물의 효과를 판정하는데 간정맥 압력차를 대신할 수 있는지 알아보고자 하였다. 대상과 방법: 간경변 환자 105 예에서 도플러 초음파를 이용하여 간문맥과 비장정 맥의 혈류속도, 혈류량 그리고 간동맥, 비장동맥 및 신장동맥의 박동지수와 저항지수를 산출하여 간정맥 압력차와의 상관관계를 구하였다. 이 중 31 예를 대상으로 terlipressin 투여 전, 후 간정맥 압력차와 간문맥 혈류속도를 같이 측정하여 간정맥 압력차와 간문맥 혈류속도의 변화를 비교하였다. Terlipressin 투여 후 간정맥 압력차가 기저값보다 20% 이상 감소한 경우를 약물의 반응군으로, 그렇지 못한 경우에 비반응군으로 정의하였다. 결 과: 간문맥 혈류속도는 간정맥 압력차가 증가할수록 감소하는 경향을 보였으나 통계학적 의의는 없었다(p>0.05). 비장정맥 혈류속도 또한 간정맥 압력차와 유의한 관계는 없었다(p>0.05). 간동맥과 비장동맥 그리고 신장동맥의 저항 및 박동지수는 간정맥 압력차와 의미있는 상관관계를 보이지 않았다. Terlipressin 투여 후 간정맥 압력차의 감소율은 평균 28.3± 3.9% 였고, 간문맥 혈류속도의 감소율은 31.2± 2.2% 였다. 그러나 간문맥 혈류속도 는 약물 반응군과 비반응군 모두에서 기저값에 비해 각각 31.7± 2.4%, 29.5± 6.1%가 감소하였다. 결론: 도플러 초음파 검사는 문맥압 항진증의 진단과 약물에 대한 반응을 평가하는데 있어 간정 맥 압력차의 측정을 대신할 수 없다. Background/Aims: This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to drug reducing portal pressure. Methods: The HVPG and the parameters of Doppler ultrasonography including portal venous velocity (PVV) and splenic venous velocity, the pulsatility and resistive index of hepatic, splenic and renal arteries were measured in 105 patients with liver cirrhosis. In 31 patients the changes of hepatic venous pressure gradient and portal venous velocity after administration of terlipressin were evaluated. The patients who showed a reduction in HVPG of more than 20% of the baseline were defined as responders to terlipressin. Results: Any Doppler ultrasonographc parameters did not correlate with HVPG. Both HVPG and PVV showed a highly significant reduction after the administration of terlipressin(-28.3± 3.9%, -31.2± 2.2% respectively). However, PVV decreased significantly not only in responders(31.7± 2.4%) but also in nonresponders(29.5± 6.1%). Conclusion: Doppler ultrasonography can not be representative of HVPG in assessing the severity of portal hypertension and response to drug reducing portal pressure in liver cirrhosis. (Korean J Hepatol 2002;8:264-270)
Joong-Keun Shin,Wha Young Kim,Haeun Rim,Jeong-Hoon Kim 대한생리학회-대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.1
Phosphorylation levels of glycogen synthase kinase 3β (GSK3β) negatively correlated with psychomotor stimulant-induced locomotor activity. Locomotor sensitization induced by psychomotor stimulants was previously shown to selectively accompany the decrease of GSK3β phosphorylation in the nucleus accumbens (NAcc) core, suggesting that intact GSK3β activity in this region is necessary for psychomotor stimulants to produce locomotor sensitization. Similarly, GSK3β in the NAcc was also implicated in mediating the conditioned effects formed by the associations of psychomotor stimulants. However, it remains undetermined whether GSK3β plays a differential role in the two sub-regions (core and shell) of the NAcc in the expression of drug-conditioned behaviors. In the present study, we found that GSK3β phosphorylation was significantly lower in the NAcc shell obtained from rats expressing amphetamine (AMPH)-induced conditioned locomotor activity. Further, we demonstrated that these effects were normalized by treatment with lithium chloride, a GSK3β inhibitor. These results suggest that the behavior produced by AMPH itself and a conditioned behavior formed by associations with AMPH are differentially mediated by the two sub-regions of the NAcc.
Kim, Won Joong,Kang, Hyun,Kim, Jung Eun,Choi, Geun Joo,Shin, Hwa Yong,Baek, Chong Wha,Jung, Yong Hun,Woo, Young Choel,Kim, Su Hyun,Lee, Jeong Hyuk The Korean Society of Food Science and Nutrition 2014 Journal of medicinal food Vol.17 No.6
The aim of this study was to assess the antinociceptive activity of ginseng total saponins (GTS) on hyperalgesia induced by repeated intramuscular injections of acidic saline in rats and to examine the mechanisms involved. Rats were injected intraperitoneally with a 0.9% saline vehicle or various doses of GTS after the development of hyperalgesia. Rats were then injected with N-methyl-D-aspartate (NMDA) or naloxone 10 min before GTS injection. The mechanical withdrawal threshold (MWT) was assessed with von Frey filaments. The MWT was significantly increased after intraperitoneal injection of 100 mg/kg and 200 mg/kg of GTS when compared with the MWT after the development of hyperalgesia. Injection of GTS with NMDA showed a significant decrease in the MWT when compared with GTS injection. GTS showed an antinociceptive activity against chronic muscle-induced pain, and the effect of GTS may be mediated by NMDA.
Kanghyug Choi,Hee Yoon Jang,Joong Mo Ahn,Sung Ho Hwang,Jung Wha Chung,Yun Suk Choi,Jin-Wook Kim,Eun Sun Jang,Gwang Hyeon Choi,Sook-Hyang Jeong 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Background/Aims: The role of serum myokine levels in sarcopenia and the outcome of hepatocellular carcinoma (HCC) patients are not clear. This study investigated the serum levels of myostatin, follistatin, and interleukin-6 (IL-6) in HCC patients and their association with sarcopenia and survival. Methods: Using prospectively collected pretreatment samples from 238 HCC patients in a hospital from 2012 to 2015, the serum levels of 3 myokines were determined and compared to 50 samples from age and sex-matched healthy controls. Sarcopenia was evaluated using the psoas muscle index (PMI) measured at the third lumbar level in the computed tomography, and clinical data were collected until 2017. Results: The median levels of the 3 myokines for the male and female HCC patients were as follow: myostatin (3,979.3 and 2,976.3 pg/mL), follistatin (2,118.5 and 2,174.6 pg/mL), and IL-6 (2.5 and 2.7 pg/mL), respectively. Those in the HCC patients were all significantly higher than in the healthy controls. In the HCC patient, the median PMI was 4.43 (males) and 2.17 cm2/m2 (females) with a sarcopenic prevalence of 56.4%. The serum levels of myostatin, IL-6 and follistatin in the HCC patients showed a positive, negative, and no correlation with PMI, respectively. The serum follistatin level was an independent factor for poor survival in HCC patients. Conclusions: The serum levels of myostatin, follistatin, and IL-6 and their correlation with sarcopenia and survival were presented in HCC patients for the first time. The role of the serum follistatin level as a poor prognostic biomarker warrants further study.
Jin Woo Jun,Sib Sankar Giri,Hyoun Joong Kim,Sae kil Yun,Cheng Chi,Sang Guen Kim,Sang Wha Kim,Jeong Woo Kang,Se Jin Han,Jun Kwon,Woo Taek Oh,Dal sang Jeong,Se Chang Park 한국예방수의학회 2018 예방수의학회지 Vol.42 No.3
In the current study, a total of 102 common Todarodes pacificus squid caught in the East Sea were investigated for parasitological research. The results revealed that 33 (32.35%) out of 102 squid were infected by Nybelinia surmenicola, the mean intensity was 5.58 parasites per squid, and the maximum abundance was 11. Morphological analysis using a field emission scanning electron microscope showed the characteristic features of N. surmenicola. Molecular identification based on the 28S rRNA gene confirmed the isolated parasite as N. surmenicola, while phylogenetic analysis revealed that N.surmenicola isolated in this study was clustered with N. surmenicola isolated from Japan. This is the first report of phylogenetic characterization of N. surmenicola isolated from Korea.
Influence of Nicorandil on Catecholamine Release in the Perfused Rat Adrenal Medulla
Young-Youp Koh,Eun-Sook Lee,Hae-Jeong No,Seong-Chang Woo,Joong-Wha Chung,Yoo-Seung Seoh,Dong-Yoon Lim 대한생리학회-대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.3
The present study was attempted to investigate the effect of nicorandil, which is an ATP-sensitive potassium (KATP) channel opener, on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal glands. The perfusion of nicorandil (0.3∼3.0 mM) into an adrenal vein for 90 min produced relatively dose-and time-dependent inhibition in CA secretion evoked by ACh (5.32 mM), high K<SUP>+</SUP> (a direct membrane depolarizer, 56 mM), DMPP (a selective neuronal nicotinic receptor agonist, 100μM for 2 min), McN-A-343 (a selective muscarinic M1 receptor agonist, 100μM for 4 min), Bay-K-8644 (an activator of L-type dihydropyridine Ca<SUP>2</SUP> channels, 10μM for 4 min) and cyclopiazonic acid (an activator of cytoplasmic Ca<SUP>2</SUP>-ATPase, 10μM for 4 min). In adrenal glands simultaneously preloaded with nicorandil (1.0 mM) and glibenclamide (a nonspecific KATP-channel blocker, 1.0 mM), the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were recovered to the considerable extent of the control release in comparison with that of nicorandil-treatment only. Taken together, the present study demonstrates that nicorandil inhibits the adrenal CA secretion in response to stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization from the isolated perfused rat adrenal glands. It seems that this inhibitory effect of nicorandil may be mediated by inhibiting both Ca<SUP>2</SUP> influx and the Ca<SUP>2</SUP> release from intracellular store through activation of KATP channels in the rat adrenomedullary chromaffin cells. These results suggest that nico</SUP>randil-sensitive KATP channels may play an inhibitory role in the regulation of the rat adrenomedullary CA secretion.