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Nam-youl Kim,Koon-Ja Lee 대한시과학회 2018 대한시과학회지 Vol.20 No.4
목적: 항균제 polyhexamethylene Biguanide(PHMB), epigallocatechin gallate(EGCG) 및 PHMB/EGCG 혼합물의 각막상피세포(primary human corneal epithelial cells, HCEpiCs)에 대한 급성독성을 평가하고자 하였다. 방법: 각막상피세포를 0.00001~0.005% PHMB, 0.001~5% EGCG 및 0.00005% PHMB/0.05% EGCG 혼합물이 각각 포함된 배양액에서 30분, 60분, 120분 및 240분 동안 배양하였다. 배양한 각막상피세포를 고정한 다음 Draq 5로 염색하고 공초점현미경과 ImageXpress UltraTM를 이용하여 세포형태를 관찰하여 세포 생존율과 세포자살(apoptosis)을 비교하였다. 결과: 배양된 각막상피세포는 0.00005% 이하의 PHMB 농도 및 0.05% 이하의 EGCG 농도에서는 세포 독성이 나타나지 않았다. 0.00005% PHMB/0.05% EGCG 혼합물이 포함된 배양액에서 급성 세포독성은 관찰되지 않았으나 240분 배양시킨 경우에는 손상된 각막상피세포 수가 증가하고 생존 세포의 수는 감소하였다. 결론: 항균 시너지 효과를 갖는다고 보고된 0.00005% PHMB/0.05% EGCG 혼합물의 경우 각막상피세포에 대한 급성독성은 없었으나 만성효과에 대해서는 추가적인 연구가 필요할 것으로 생각된다. Purpose : To evaluate the acute cytotoxic effect of polyhexamethylene biguanide (PHMB), epigallocatechin gallate (EGCG) and PHMB/EGCG mixture on the cultured human corneal epithelial cell (HCEpiC). Methods : HCEpiCs were cultured in the media of HCEpiC containing 0.00001~0.005% PHMB, 0.001~5% EGCG and 0.00005% PHMB/0.05% EGCG mixture respectively for 30, 60, 120 and 240 min. Cultured HCEpiCs were fixed and stained with Draq5 and cell viability and apoptosis were evaluated using confocal microscope and ImageXpress UltraTM. Results : Cultured HCEpiC did not show cytotoxic effect at below 0.00005% PHMB and below 0.05% EGCG concentration. In the media containing 0.00005% PHMB/0.05% EGCG, acute cytototoxic effect was not found, whereas damaged HCEpiCS were increased and survival cells were decreased in the media incubated for 240 min. Conclusion : The mixture of 0.00005% PHMB/0.05% EGCG showed non acute cytotoxic effect on the cultured HCEpiCs, however it is needed to investigate its chronic cytotoxic effect.
물과 백색폴리스티렌 팬텀에 의한 10 MV X-선 빔 선량계측
김종언(Jong-Eon Kim),차병열(Byung-Youl Cha),강상식(Sang-Sik Kang),박지군(Ji-Koon Park),신정욱(Jeong-Wook Sin),김소영(So-Yeong Kim),조성호(Seong-Ho Jo),손대웅(Dae-Woong Son),최치원(Chi-Won Choi),박창희(Chang-Hee Park),윤천실(Chun-Sil 대한방사선과학회(구 대한방사선기술학회) 2008 방사선기술과학 Vol.31 No.1
본 연구의 목적은 고체물등가팬텀을 사용하여 절대흡수선량을 측정할 때 물등가깊이에 비례되는 측정값을 보정하기 위한 보정인자를 구하는데 있다. 10MV X-선 빔에 대하여 백색폴리스티렌팬텀과 물팬텀에서 측정의 조건들은 선원 대 전리조 중심까지의 거리를 SAD 100cm로 고정하였고, 조사면 크기(field size)는 각각 10×10cm2, 20×20cm2를 사용하였으며, 깊이는 각각 2.3cm, 5cm, 10cm, 15cm를 사용한 것이다. 두개의 팬텀에 대하여 분당 400MU의 출력을 갖는 선형가속기로부터 100MU의 전달로 각각의 조사면 크기와 깊이들에서 3번 측정으로 취득된 전리의 평균값을 측정값으로 얻었다. 이 실험으로부터 보정인자와 TPR에서 퍼센트 편차는 각각 0.97%, 0.53% 이하를 얻었다. 따라서, 고체물등가팬텀을 사용한 절대흡수선량 측정 시에는 보정인자와 TPR에서 퍼센트 편차를 사용하여 보정을 행하면 높은 정확도를 얻을 수 있다. The purpose of this study is to get the correction factor to correct the measured values of the absolute absorbed dose proportional to the water equivalent depth. The measurement conditions in white polystyrene and water phantoms for 10MV X-ray beam are that the distance of source to center of ionization chamber is fixed at SAD 100cm, the field sizes are 10×10cm2, 20×20cm2 and the depths are 2.3cm, 5cm, 10cm, and 15cm, respectively. The mean value of ionization was obtained by three times measurements in each field size and depths after delivering 100MU from linear accelerator with output of 400MU per min to the two phantoms. The correction factor and the percentage deviation in were obtained below 0.97% and 0.53%, respectively. Therefore, we can get high accuracy by using the correction factor and the percentage deviation in in measuring the absolute absorbed dose with the solid water equivalent phantom.
Shim, Ji Sung,Kwon, Tae Gyun,Rha, Koon Ho,Lee, Young Goo,Lee, Ji Youl,Jeong, Byong Chang,Kim, Jae Yoon,Pyun, Jong Hyun,Kang, Sung Gu,Kang, Seok Ho KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.10
<P>The aim of our study was to evaluate intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns in a multicenter series of patients treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma (UC) of the bladder. Between 2007 and 2015, 346 patients underwent RARC at multiple tertiary referral centers in Korea. Descriptive statistics were used for demographics and perioperative variables. Survival and recurrence were estimated with Kaplan-Meier analysis. Logistic regression models were used to determine predictors of recurrence. Median follow-up was 33 months (interquartile range [IQR], 7–50). The numbers of patients with organ-confined and lymph node (LN)-positive disease were 237 (68.4%) and 68 (19.7%), respectively. LN density (1–20 vs. > 20) was 13.6% and 6.1%, with a median of 17 nodes removed (IQR, 9–23). In logistic regression analysis, type of LN dissection, and pathologic tumor stage were significant predictors of cancer recurrence and death from cancer. Local, distal recurrence and secondary UC occurred in 7 (2.0%), 53 (15.3%), and 4 (1.2%) patients, respectively. The 5-year overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were 78%, 84%, and 73%, respectively. At last follow-up, RFS for extended pelvic LN dissection vs. standard pelvic LN dissection was 70% and 47% (<I>P</I> = 0.038). In addition, at last follow-up, LN density (0 vs. 1–20 vs. over 20) was 67%, 41%, and 29%, respectively (<I>P</I> < 0.001). Patients undergoing RARC in this multi-institutional cohort demonstrated intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns that were not unusual.</P>
혈뇨 환자의 방광암 진단에서 UBC™ ( Urinary Bladder Cancer ) 검사의 유용성
길명철(Myung Cheol Gil),강도영(Do Young Kang),성열근(Youl Koon Seong),정세일(Se Il Jung),권헌영(Hyon Young Kwon),정경우(Gyung Woo Jung),김덕규(Duk Kyu Kim),노미숙(Mee Sook Roh),황태호(Tae Ho Hwang),윤진한(Jin Han Yoon) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3
N/A Purpose: Urinary cytology and cystoscopic exam are effective methods for diagnosis of transitional cell carcinoma(TCC). But the former shows drawbacks such as the need for a well-trained examiner, and wide imprecision related to the variability of microscopic exam the latter is an invasive method. UBC™ test detects the epitope on specific cytokeratin fragments released from epithelium of bladder cancer by immunoradiometric assay. We compared UBC™ test with urinary cytology for diagnosis of TCC to evaluate the utility of UBC™ test. Materials and Methods: Eighty-four patients with hematuria were included in our study. UBC™ tests (IDL Biotech, Sweden) were assayed in mid-stream urine according to the ordinary assay protocol. Nineteen patients were confirmed as TCC by cystoscopic examination and underwent transurethral resection (Group A). Other patients had various benign urinary tract conditions (Group B). Samples were considered positive as the UBC™ concentration was greater than 12 μg/L. Results: UBC levels were significantly different between group A (95.9±166.4 μg/L) and group B (19.2±85.6 μg/L) (p<0.001). Sensitivity for diagnosis of TCC was 89.5% (17/19) in UBC test and 47.4% (9/19) in cytology (p<0.05). Specificity for diagnosis of TCC was 81.5% (53/65) in UBC test and 100% (65/65) in cytology. UBC test was significantly more sensitive in stage Ta, T tumors (84.6 vs 38.5%, p<0.05) and in grade I (83.3% vs 16.7% p<0.05) than cytology. UBC test showed a tendency to be more sensitive as the grade was higher (83.3% in Grade 1.90% in Grade II and 100% in Grade III). Conclusion: UBC™ test could be a useful method in distinguishing TCC from other benign genitourinary diseases. Moreover, UBC™ test could be an especially valuable marker for diagnosis of TCC in patients with early TCC of low grade TCC compared to urinary cytology. Therefore, mbined use of UBC™ test in association with cytology is helpful to overcome the limited sensitivity of cytology. (Korean J Nucl Med 200135:192-197)
Hah, Yoon Soo,Lee, Kwang Suk,Choi, In Young,Lee, Ji Youl,Hong, Jun Hyuk,Kim, Choung-Soo,Lee, Hyun Moo,Hong, Sung Kyu,Byun, Seok-Soo,Lee, Seung Hwan,Rha, Koon Ho,Chung, Byung Ha,Koo, Kyo Chul Williams & Wilkins Co 2018 Medicine Vol.97 No.42
<P><B>Abstract</B></P><P>A multicenter Korean Prostate Cancer Database (K-CaP) has been established to provide information regarding Korean patients with prostate cancer (PCa). We used the K-CaP registry to investigate the value of age and comorbidity for predicting cancer-specific mortality (CSM) and other-cause mortality (OCM) according to risk grouping.</P><P>The K-CaP registry includes 2253 patients who underwent radical prostatectomy (RP) between May 2001 and April 2013 at 5 institutions. Preoperative clinicopathologic data were collected and stratified according to the National Comprehensive Cancer Network risk criteria. Survival was evaluated using Gray's modified log-rank test according to risk category, age (<70 years vs ≥70 years), and Charlson comorbidity index (CCI) (0 vs ≥1).</P><P>The median follow-up was 55.0 months (interquartile range: 42.0–70.0 months). Competing-risk regression analysis revealed that, independent of CCI, ≥70-year-old high-risk patients had significantly greater CSM than <70-year-old high-risk patients (<I>P</I> = .019). However, <70-year-old high-risk patients with a CCI of ≥1 had similar CSM relative to ≥70-year-old patients. Survival was not affected by age or CCI among low-risk or intermediate-risk patients. Multivariate analysis revealed that a CCI of ≥1 was independently associated with a higher risk of CSM (<I>P</I> = .003), while an age of ≥70 years was independently associated with a higher risk of OCM (<I>P</I> = .005).</P><P>Age and comorbidity were associated with survival after RP among patients with high-risk PCa, although these associations were not observed among low-risk or intermediate-risk patients. Therefore, older patients with high-risk diseases and greater comorbidity may require alternative multidisciplinary treatment.</P>
누룩(Rhizopus oryzae KSD-815)으로부터 분리한 지질화합물의 세포독성 및 항염증 활성
곽호영 ( Ho Young Kwak ),이상진 ( Sang Jin Lee ),이대영 ( Dae Young Lee ),배낙현 ( Nark Hyun Bae ),정낙훈 ( La Koon Jung ),홍성렬 ( Sung Youl Hong ),김계원 ( Gye Won Kim ),백남인 ( Nam In Baek ) 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.2
고해상도 방사선 영상을 위한 $Gd_2O_3:Eu^{3+}$ 나노 형광체 제조 및 광학적 특성
김소영,강상식,박지군,차병열,최치원,이형원,남상희,Kim, So-Yeong,Kang, Sang-Sik,Park, Ji-Koon,Cha, Byung-Youl,Choe, Chi-Won,Lee, Hyung-Won,Nam, Sang-Hee 대한의용생체공학회 2007 의공학회지 Vol.28 No.1
In this paper, we have synthesized $Gd_2O_3:Eu^{3+}$ nano phosphor particle using a low temperature solution-combustion method. We have investigated the structure and the luminescent characteristic as the sintering temperature and europium concentration. From XRD(X-ray diffraction) and SEM(scanning electron microscope) results, we have verified that the phosphor particle was fabricated a spherical shape with $30{\sim}40nm$ particle size. From the photoluminescence results, the strong peak exhibits at 611 um and the luminescent intensity depends on europium concentration. $Gd_2O_3:Eu$ fine phosphor particle has shown excellent luminescent efficiency at 5 wt% of europium concentration. The phosphors calcinated at $500^{\circ}C$ have possessed the x-ray peaks corresponding to the cubic phase of $Gd_2O_3$. As calcinations temperature increased to $700^{\circ}C$, the new monoclinic phase has identified except cubic patterns. From the luminescent decay time measurements, mean lifetimes were $2.3{\sim}2.6ms$ relatively higher than conventional bulk phosphors. These results indicate that $Gd_2O_3:Eu$ nano phosphor is possible for the operation at the low x-ray dose, therefore, the application as medical imaging detector.
형광체 기반 X선 광 변조기를 위한 비정질 셀레늄 필름 특성
강상식,박지군,조성호,차병열,신정욱,이건환,문치웅,남상희,Kang, Sang-Sik,Park, Ji-Koon,Cho, Sung-Ho,Cha, Byung-Youl,Shin, Jung-Wook,Lee, Kun-Hwan,Mun, Chi-Woong,Nam, Sang-Hee 대한의용생체공학회 2007 의공학회지 Vol.28 No.2
PXLM(Phosphor based x-ray light modulator) has a combined structure by phosphor, photoconductor, and liquid crystal and it can realize x-ray image of high resolution in clinical diagnosis area. In this study, we fabricated a photoconductor and investigated electrical and optical properties to confirm application possibility of radiator detector of PXLM structure. As photoconductor, amorphous selenium(a-Se), which is used most in DR(Digital radiography) of direct conversion method, was used and for formation of thin film, it was formed as $20{\mu}m-thick$ by using thermal vacuum evaporation system. For a produced a-Se film, through XRD(X-ray diffraction) and SEM(Scanning electron microscope), we investigated that amorphous structure was uniformly established and through optical measurement, for visible light of 40 $0\sim630nm$, it had absorption efficiency of 95 % and more. After fabricated a-Se film on the top of ITP substrate, hybrid structure was manufactured through forming $Gd_2O_3:Eu$ phosphor of $270{\mu}m-thick$ on the bottom of the substrate. As the result to confirm electrical property of the manufactured hybrid structure, in the case of appling $10V/{\mu}m$, leakage current of $2.5nA/cm^2$ and x-ray sensitivity of $7.31nC/cm^2/mR$ were investigated. Finally, we manufactured PXLM structure combined with hybrid structure and liquid crystal cell of TN(Twisted nematic) mode and then, investigated T-V(Transmission vs. voltage) curve of external light source for induced x-ray energy. PXLM structure showed a similar optical response with T-V curve that common TN mode liquid crystal cell showed according to electric field increase and in appling $50\sim100V$, it showed linear transmission efficiency of $12\sim18%$. This result suggested an application possibility of PXLM structure as radiation detector.