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( Seok Jae Huh ),( Su Ee Lee ),( Ji Hyun Lee ),( Hyun Hwa Yoon ),( Sung Yong Oh ),( Sung Hyun Kim ),( Hyuk Chan Kwon ),( Hyo Jin Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Objective: Abnormal hemostasis in cancer patients has previously been studied. The principal objective of this study is to determine whether preoperative coagulation factors are related with the clinicopathologic characteristics and to clarify which coagulation factors have prognostic significance in operable colorectal cancer patients. Patients and Methods: This study evaluated 170 patients who underwent curative surgery for colorectal carcinoma. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer, fibrinogen degradation product (FDP). The clinicopathological variables including age, gender, tumor location (rectum/colon), preoperative carcinoembryonic antigen (CEA), tumor size (≥5cm vs. <5cm), depth of tumor invasion, lymph node metastasis, stage, lymphovascular invasion, and histologic differentiation were analyzed. Progression-free survival and overall survival were analyzed by Kaplan-Meier analysis. Results: The median age of analyzed patients was 63 years (range; 28~84). Male to female ratio was 62:38. The median follow-up duration was 21.05 months (range; 0.30-56.30). Higher plasma fibrinogen, PT and PLT levels were associated with larger tumor size (p<0.001, p=0.005, and p=0.004, respectively). Higher plasma fibrinogen level was significantly associated with depth of tumor invasion and stage (p=0.014 and p=0.036, respectively). Median progression-free survival was 10.2 month. Overall survival was not reached on median value. However, serum plasma fibrinogen showed no significant factor in predicting progression-free survival and overall survival. Conclusion: Preoperative plasma fibrinogen level is significantly associated with tumor size and depth of tumor invasion. Thus, plasma fibrinogen level might suggest increased early tumor burden. However, plasma fibrinogen did not show a prognostic value.
An Evaluation of Changes in the Allergenicity of Kochujang upon Preparation Using Aloe Extract
Bo-Kyung Son,Yoon-Ee Huh,Jung-Yun Kim,Geon-Woong Noh,Sang-Sun Lee 한국영양학회 2006 Nutritional Sciences Vol.9 No.4
??Soybeans are well-known as allergenic foods. Koreans consume large amounts of soybean foods, such as kochujang, which have gone through the fermentation process. To lower the allergenicity of these foods, we prepared hypoallergenic kochujang with aloe extract (AK). A sensory evaluation was conducted along with a clinical evaluation that used a double-blind, placebo-controlled food challenge (DBPCFC) test. These tests were designed to evaluate the acceptability of the fermented foods. In comparison to normal kochujang (NK), AK elicited a higher sensory test score, and the rate of positive reactions in atopic dermatitis patients during the DBPCFC test was reduced. Methods of protein extraction, protein quantitation with sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), and protein identification using two-dimensional (2D) gel electrophoresis were performed for both NK and AK to compare the functional factors. We found a reduction in the levels of high molecular proteins even though the bands of the proteins had not entirely disappeared, indicating that the boiling and fermentation process changed the soybean protein patterns. The rate of the reduction of high molecular proteins was more effective in the AK. In conclusion, AK can be recognized as a food with hypoallergenic effect.
An Evaluation of Changes in the Allergenicity of Kochujang upon Preparation Using Aloe Extract
Son, Bo-Kyung,Huh, Yoon-Ee,Kim, Jung-Yun,Noh, Geon-Woong,Lee, Sang-Sun The Korean Nutrition Society 2006 Nutritional Sciences Vol.9 No.4
Soybeans are well-known as allergenic foods. Koreans consume large amounts of soybean foods, such as kochujang, which have gone through the fermentation process. To lower the allergenicity of these foods, we prepared hypo allergenic kochujang with aloe extract (AK). A sensory evaluation was conducted along with a clinical evaluation that used a double-blind, placebo-controlled food challenge (DBPCFC) test These tests were designed to evaluate the acceptability of the fermented foods. In comparison to normal kochujang (NK), AK elicited a higher sensory test score, and the rate of positive reactions in atopic dermatitis patients during the DBPCFC test was reduced. Methods of protein extraction, protein quantitation with sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), and protein identification using two-dimensional (2D) gel electrophoresis were performed for both NK and AK to compare the functional factors. We found a reduction in the levels of high molecular proteins even though the bands of the proteins had not entirely disappeared, indicating that the boiling and fermentation process changed the soybean protein patterns. The rate of the reduction of high molecular proteins was more effective in the AK. In conclusion, AK can be recognized as a food with hypoallergenic effect.
Development of Proteomics and Applications of Proteomics in Toxicology
Jung, Woon-Won,Huh, Yoon-Ee,Ryu, Jae-Chun,Lee, Eun-Il,Sul, Dong-Geun The Korean Society of Toxicogenomics and Toxicopro 2005 Molecular & cellular toxicology Vol.1 No.1
Proteomics has recently received intense scientific interest after the completion of the Human Genome Project, because this genome-based high technology allows to search new drug targets or diagnostic markers. Many proteome projects including Human plasma proteome projects (HPPP), Human liver proteome projects (HLPP), Human brain proteome projects (HBPP), and Mouse and Rat Proteome Project (MRPP) have been carried out and proteomic analytical techniques have been developed in second dimensional electrophoresis (2-DE) and LC/MS system. This powerful method has been applied in toxicology producing a new term "Toxicoproteomics". In this review, recent proteome projects, proteomic technologies, and toxicoproteomics will be discussed.