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- 저자 : Yongxin Jiang (검색결과 6 건)
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Phase Only Pupil Filter Design Using Zernike Polynomials
Jiang Liu,Erlong Miao,Yongxin Sui,Huaijiang Yang 한국광학회 2016 Current Optics and Photonics Vol.20 No.1
A pupil filter is a useful technique for modifying the light intensity distribution near the focus of anoptical system to realize depth of field (DOF) extension and superresolution. In this paper, we proposeda new design of the phase only pupil filter by using Zernike polynomials. The effect of design parametersof the new filters on DOF extension and superresolution are discussed, such as defocus Strehl ratio (S.R.),superresolution factor (G) and relative first side lobe intensity (M). In comparison with the other two typesof pupil filters, the proposed filter presents its advantages on controlling both the axial and radial lightintensity distribution. Finally, defocused imaging simulations are carried out to further demonstrate theeffectiveness and superiority of the proposed pupil filter on DOF extension and superresolution in an opticalimaging system.
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Optimization of Wavefront Coding Phase Mask Applied to 5X-40X Micro-Objectives Simultaneously
Jiang Liu,Erlong Miao,Yongxin Sui,Jianghuai Yang 한국광학회 2015 Current Optics and Photonics Vol.19 No.5
A wavefront coding (WFC) technique provides an extension of the depth of field for a microscopyimaging system with slight loss of image spatial resolution. Through the analysis of the relationship betweenthe incidence angle of light at the phase mask and the system pupil function, a mixing symmetrical cubicphase mask (CPM) applied to 5X-40X micro-objectives is optimized simultaneously based on point-spreadfunction (PSF) invariance and nonzero mean values of the modulation transfer function (MTF) near thespatial cut-off frequency. Optimization results of the CPM show that the depth of field of thesemicro-objectives is extended 3-10 times respectively while keeping their resolution. Further imagingsimulations also prove its ability in enhancing the defocus imaging
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Shiyuan Luo,Yongxin Jiang,Sandrine Thuillier,Philippe Castany,Liangcai Zeng 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.2
A simplified 3D FE model based on McCormick’s model is developed to numerically predict the spatiotemporal behaviorsof the PLC effect in Ti-12Mo alloy tensile tests at 350 °C with strain rates from the order of 10–4 s−1 to 10–2 s−1. The materialparameter identification procedure is firstly presented in details, and the simulated results are highly consistent withexperimental ones, especially in terms of stress drop magnitudes and PLC band widths. The distribution of simulated stressdrop magnitudes at a constant tensile velocity (0.01 mm/s) follows a normal distribution and its peak value is in the range of26–28 MPa. Furthermore, the simulated band width slightly fluctuates with the increase of true strain and its average valueis about 1.5 mm. Besides, the staircase behavior of strain–time curves and the hopping propagation of the PLC band areobserved in Ti-12Mo alloy tensile process, which are related to the strain localization and stress drop magnitudes.
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Wu Na,Zhu Yingchuan,Jiang Wenhao,Song Yue,Yin Lan,Lu Yilu,Tao Dachang,Liu Yunqiang,Ma Yongxin 한국유전학회 2022 Genes & Genomics Vol.44 No.5
Background: NPHS2 is the causative gene of nephrotic syndrome type 2 (MIM 600995) which often clinically manifests as steroid-resistant nephrotic syndrome (SRNS). The NPHS2 gene encodes a slit diaphragm (SD) associated protein podocin. Objective: This study reported a novel disease-causing mutation of NPHS2 in a Chinese family with SRNS. We also investigated the pathogenic mechanism of the variants in this family. Method: A Chinese family with SRNS was recruited. Whole exome sequencing was performed to screen for disease-causing mutation. Sanger sequencing was used to confirm the results. In vitro functional experiments including immunoblotting, co-immunoprecipitation and double immunofluorescence staining were performed to explore the pathogenic mechanisms of mutations. Results: In this family, compound heterozygous mutations of NPHS2 (c.467dupT and c.865A > G) were identified and segregated with the disease. The maternal c.865A > G was a novel variant, leading to amino acid substitution (p.K289E). In vitro functional assays indicated that c.467dupT (p.L156FfsX11) mutant lost interaction with nephrin. Both K289E and L156FfsX11 mutants showed sharply diminished plasma membrane localization. Furthermore, abnormal distribution of podocin mutants also altered the cell membrane localization of nephrin. Conclusion: We reported a family with SRNS caused by compound heterozygous mutations of NPHS2 (c.467dupT and c.865A > G). c.865A > G (p.K289E) in NPHS2 was a novel causative variant associated with SRNS. Both variants in this family not only affected the normal cell membrane localization of podocin, but also altered the cell membrane localization of nephrin which is the major architectural protein of SD.
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Effects of Sulfur Introduction on the UV and the Visible Emission Properties of ZnO
Hongying Guo,Feihong Jiang,Run Yuan,Jun Zhang,Yuanping Sun,Yifan Liu,Yongxin Qiu,Taofei Zhou,Xionghui Zeng,Baoshun Zhang,Ke Xu,Hui Yang 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.4
Hexagonal ZnO particles have been synthesized by using the hydrothermal method with differentsulfur concentrations in the reaction solutions. Structural and optical characterizations have beenconducted to study the effects of the sulfur in the reaction solutions on the properties of thesynthesized ZnO in the ultraviolet (UV) and the visible (VIS) bands. The existance of sulfur inthe solutions can help to introduce compression strain along the a axis and an opposite trend forthe parameter c with strain inside the formed ZnO particles, which means the total strain in thesamples is presented along the c axis. The average size of the ZnO particles, as calculated fromSEM images, shows the same trend as the strain in the samples. The increasing incorporation ofsulfur causes an increase in the VIS luminescence band, which can be attributed to an increase inthe number of sulfur-induced defects.
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Lu Yan,Huiyuan Wang,Yifan Jiang,Jinhua Liu,Zhao Wang,Yongxin Yang,Shengwu Huang,Yongzhuo Huang 한국고분자학회 2013 Macromolecular Research Vol.21 No.4
Macromolecular drugs become an essential part in neuroprotective treatment. However, the nature of ineffective delivery crossing the blood brain barrier (BBB) renders those macromolecules undruggable for clinical practice. Recently, brain target via intranasal delivery have provided a promising solution to circumventing the BBB. Despite the direct route from nose to brain (i.e. olfactory pathway), there still are big challenges for large compounds like proteins to overcome the multiple delivery barriers such as nasal mucosa penetration, intracellular transport along the olfactory neuron, and diffusion across the heterogeneous brain compartments. Herein presented is an intranasal strategy mediated by cell-penetrating peptide modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the delivery of insulin to the brain, a potent therapeutic against Alzheimer’s disease. The results revealed that the cell-penetrating peptide can potentially deliver insulin into brain via the nasal route, showing a total brain delivery efficiency of 6%. It could serve as a potential treatment for neurodegenerative diseases.
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