APPLICATION OF THE SEGUE STELLAR PARAMETER PIPELINE TO LAMOST STELLAR SPECTRA

Lee, Young Sun,Beers, Timothy C.,Carlin, Jeffrey L.,Newberg, Heidi J.,Hou, Yonghui,Li, Guangwei,Luo, A.-Li,Wu, Yue,Yang, Ming,Zhang, Haotong,Zhang, Wei,Zhang, Yong IOP Publishing 2015 The Astronomical journal Vol.150 No.6

Fundamental impedance‑based digital synchronous rectification scheme for bidirectional CLLC resonant converters

Guopeng Zhang,Xindi Sun,Hao Wang,Yonghui Liu,Haijun Tao,Lulu Huang 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.1

Synchronous rectification (SR) is an effective way to improve the efficiency of CLLC resonant converters. The soft switching of SR is affected by the parasitic capacitance and the zero-crossing point of the current of the secondary inductance. Therefore, based on uncontrolled rectification on the secondary of the converter, the effective range of soft switching for SR under different operating modes is analyzed. A fundamental impedance model is established to obtain the discharge time of the parasitic capacitance and the zero-crossing point of the current of the secondary in the upper resonant frequency mode. The relationship between the SR signals and primary driving signals in different operating modes is summarized, which can improve the operating range of the SR while ensuring soft-switching. This in turn, ensures the operating efficiency of the converter. The calculation method of the turn-ON and turn-OFF times of the SR in different modes is improved. In addition, the proposed SR method can be used in bidirectional CLLC resonant converters that do not have SR functionality. To accomplish this, only the control program needs to be updated. Experimental results on a 200 V 500 W prototype are given to verify the effectiveness of the SR method.

Effect of blended protein nutritional support on reducing burn-induced inflammation and organ injury

Yu Yonghui,Zhang Jingjie,Wang Jing,Wang Jing,Chai Jiake 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.5

BACKGROUND/OBJECTIVES Previous studies have reported that protein supplementation contributes to the attenuation of inflammation. Serious trauma such as burn injury usually results in the excessive release of inflammatory factors and organs dysfunction. However, a few reports continued to focus on the function of protein ingestion in regulating burn-induced inflammation and organ dysfunction. MATERIALS/METHODS This study established the rat model of 30% total body surface area burn injury, and evaluated the function of blended protein (mixture of whey and soybean proteins). Blood routine examination, inflammatory factors, blood biochemistry, and immunohistochemical assays were employed to analyze the samples from different treatment groups. RESULTS Our results indicated a decrease in the numbers of white blood cells, monocytes, and neutrophils in the burn injury group administered with the blended protein nutritional support (Burn+BP), as compared to the burn injury group administered normal saline supplementation (Burn+S). Expressions of the pro-inflammatory factors (tumor necrosis factor-α and interleukin-6 [IL-6]) and chemokines (macrophage chemoattractant protein-1, regulated upon activation normal T cell expressed and secreted factor, and C-C motif chemokine 11) were dramatically decreased, whereas anti-inflammatory factors (IL-4, IL-10, and IL-13) were significantly increased in the Burn+BP group. Kidney function related markers blood urea nitrogen and serum creatinine, and the liver function related markers alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase were remarkably reduced, whereas albumin levels were elevated in the Burn+BP group as compared to levels obtained in the Burn+S group. Furthermore, inflammatory cells infiltration of the kidney and liver was also attenuated after burn injury administered with blended protein supplementation. CONCLUSIONS In summary, nutritional support with blended proteins dramatically attenuates the burn-induced inflammatory reaction and protects organ functions. We believe this is a new insight into a potential therapeutic strategy for nutritional support of burn patients.

Enhanced charge collection with passivation of the tin oxide layer in planar perovskite solar cells

Lee, Yonghui,Paek, Sanghyun,Cho, Kyung Taek,Oveisi, Emad,Gao, Peng,Lee, Seunghwan,Park, Jin-Seong,Zhang, Yi,Humphry-Baker, Robin,Asiri, Abdullah M.,Nazeeruddin, Mohammad Khaja Royal Society of Chemistry 2017 Journal of Materials Chemistry A Vol.5 No.25

<P>Tin oxide is an excellent candidate to replace mesoporous TiO2electron transport layers (ETLs) in perovskite solar cells. Here, we introduced a SnO2layer by a low-temperature solution process, and investigated its morphology, opto-physical and electrical properties affecting the device performance. We reveal that low-temperature processed SnO2is self-passivating in nature, which leads to a high efficiency. To further enhance the blocking effect, we combined a compact TiO2underlayer with the SnO2contact layer, and found that the bi-layered ETL is superior compared to single layers. The best device shows photovoltaic values in a planar structure with a short-circuit current density (<I>J</I>sc) of 22.58 mA cm<SUP>−2</SUP>, an open-circuit voltage (<I>V</I>oc) of 1.13 V, a fill factor (FF) of 0.78, and a power conversion efficiency (PCE) of 19.80% under 1 sunlight illumination.</P>

Common Correlated Effects Estimation of Unbalanced Panel Data Models with Cross-Sectional Dependence

Qiankun Zhou,Yonghui Zhang 한국계량경제학회 2016 계량경제학보 Vol.27 No.4

We consider the estimation and inference of unbalanced panel data models with cross-sectional dependence with a large number of individual units in a relatively short time period. By following the common correlated effects (CCE) approach of Pesaran (2006), we propose a CCE estimator for unbalanced panels (CCE-UB). The asymptotics of the CCE-UB estimator is developed in the paper. Small scale Monte Carlo simulation is conducted to examine the finite sample properties of the proposed estimator.

Stress field interference of hydraulic fractures in layered formation

Zhu, Haiyan,Zhang, Xudong,Guo, Jianchun,Xu, Yaqin,Chen, Li,Yuan, Shuhang,Wang, Yonghui,Huang, Jingya Techno-Press 2015 Geomechanics & engineering Vol.9 No.5

Single treatment and staged treatments in vertical wells are widely applied in sandstone and mudstone thin interbedded (SMTI) reservoir to stimulate the reservoir. The keys and difficulties of stimulating this category of formations are to avoid hydraulic fracture propagating through the interface between shale and sand as well as control the fracture height. In this paper, the cohesive zone method was utilized to build the 3-dimensional fracture dynamic propagation model in shale and sand interbedded formation based on the cohesive damage element. Staged treatments and single treatment were simulated by single fracture propagation model and double fractures propagation model respectively. Study on the changes of fracture vicinity stress field during propagation is to compare and analyze the parameters which influence the interfacial induced stresses between two different fracturing methods. As a result, we can prejudge how difficult it is that the fracture propagates along its height direction. The induced stress increases as the pumping rate increasing and it changes as a parabolic function of the fluid viscosity. The optimized pump rate is $4.8m^3/min$ and fluid viscosity is $0.1Pa{\cdot}s$ to avoid the over extending of hydraulic fracture in height direction. The simulation outcomes were applied in the field to optimize the treatment parameters and the staged treatments was suggested to get a better production than single treatment.

Effect of leading edge boundary layer thickness on dimple flow structure and separation control

Jibing Lan,Yonghui Xie,Di Zhang 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.12

This paper concerns the effect of leading edge boundary layer thickness on dimple flow structure and separation control. A flat plate with adverse pressure gradient sufficient for separation was designed. Large eddy simulation (LES) with dynamic Smagorinsky subgrid model was validated. Dimples with R=0.378, 0.994, 1.453 (R is the ratio of leading edge boundary layer thickness to dimple depth) were investigated. The results show that the horseshoe vortex dominates the dimple flow structure. As R increases, the head of the horseshoe vortex rises further away from the wall and moves downstream. Hairpin vortices in the dimple wake are productions of the horseshoe vortex. Both the horseshoe vortex and the hairpin vortices energize the boundary layer by mixing with the free-stream fluid. As R increases,the separation control effectiveness decreases.

Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response

Wang, Lijun,Liu, Haiyan,Zhang, Ligong,Wang, Gongming,Zhang, Mengyuan,Yu, Yonghui The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.4

Dexmedetomidine is an ${\alpha}2$-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action and potential mechanisms of dexmedetomidine against ischemia-reperfusion induced cerebral injury. Transient focal cerebral ischemia-reperfusion injury was induced in Sprague-Dawley rats by middle cerebral artery occlusion. After the ischemic insult, animals then received intravenous dexmedetomidine of $1{\mu}g/kg$ load dose, followed by $0.05{\mu}g/kg/min$ infusion for 2 h. After 24 h of reperfusion, neurological function, brain edema, and the morphology of the hippocampal CA1 region were evaluated. The levels and mRNA expressions of interleukin-$1{\beta}$, interleukin-6 and tumor nevrosis factor-${\alpha}$ as well as the protein expression of inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-${\kappa}Bp65$, inhibitor of ${\kappa}B{\alpha}$ and phosphorylated of ${\kappa}B{\alpha}$ in hippocampus were assessed. We found that dexmedetomidine reduced focal cerebral ischemia-reperfusion injury in rats by inhibiting the expression and release of inflammatory cytokines and mediators. Inhibition of the nuclear factor-${\kappa}B$ pathway may be a mechanism underlying the neuroprotective action of dexmedetomidine against focal cerebral I/R injury.

CFD study on the radial distribution of coolants in the inlet section of rod-baffle-multi-tubular reactor

Cheng Liu,Lei Zhang,Yekun Xu,Yonghui Li 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.3

CFD method was employed to investigate the radial distribution of coolants in the inlet section of rod baffle multi-tubular reactor. It was found that the reactor had poor distribution of coolants. In view of this problem, the detailed structures of incident channel, shape of baffle ring and distance between tube plate and the first rod baffle were discussed to study their effect on the radial distribution. The simulation results showed that incident channels 0#, 1#, 3#, 5# and 6# could improve radial distribution of coolants significantly, and the effect of incident channels 2# and 4# was relatively limited. The zigzag baffle ring was proved to prevent short pass near the shell wall. In addition, the radial distribution of coolants was also improved with distance between tube plate and the first rod baffle increasing from 85 mm to 242mm. The simulation results can provide guidance for designing multi-tubular reactor with rod baffles.

Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/ PKA/CREB signaling pathway in the trigeminal ganglion in rats

QingLing Zhai,KaiXin Wang,Defu Zhang,Jinbo Chen,XiaoMeng Dong,Yonghui Pan 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.3

Background: Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study was to investigate whether perampanel could exert an antimigraine effect. Methods: Nitroglycerin (NTG) was used to induce a migraine model in rats, and the model animals were pretreatment with 50 μg/kg and 100 μg/kg perampanel. The expression of pituitary adenylate-cyclase-activating polypeptide (PACAP) was quantified by western blot and quantitative real-time PCR in the trigeminal ganglion, and rat-specific enzyme-linked immunosorbent assay in serum. Western blot was also conducted to explore the effects of perampanel treatment on the phospholipase C (PLC)/protein kinase C (PKC) and protein kinase A (PKA)/ cAMP-responsive-element-binding protein (CREB) signaling pathways. Moreover, the cAMP/PKA/CREB-dependent mechanism was evaluated via in vitro stimulation of hippocampal neurons. The cells were treated with perampanel, antagonists and agonists for 24 hours and cell lysates were prepared for western blot analysis. Results: Perampanel treatment notably increased the mechanical withdrawal threshold and decreased head grooming and light-aversive behaviors in NTG-treated rats. It also decreased PACAP expression and affected cAMP/ PKA/CREB signaling pathway. However, PLC/PKC signaling pathway may not be involved in this treatment. In in vitro studies, perampanel notably decreased PACAP expression by inhibiting cAMP/PKA/CREB signaling pathway. Conclusions: This study shows that perampanel inhibits the migraine-like pain response and that this beneficial effect might be attributable to regulation of the cAMP/PKA/CREB signaling pathway.