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Shujun Sun,Xinliang Pan,Limin Zhao,Jianming Zhou,Hongzeng Wang,Yonghong Sun 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.3
Objectives. We sought to identify the expression of CD68-tumor-associated macrophages (TAMs) and CD34-microvascular density (MVD) in laryngeal squamous cell carcinoma (LSCC), to study the relationship with clinical pathological parameters and to determine whether their expression is predictive of disease. Methods. Pathologically confirmed 45 LSCC tissue and 20 peritumoral non-tumor tissue were examined. Immunohistochemical studies were used to detect the expression of CD68-TAMs and CD34-MVD. Results. The positive expression rate of CD68 in LSCC tissue was 82% (37/45), which was higher than the 10% (2/20) expression rate of the peritumoral tissue (P<0.05). The CD34-MVD positive expression rate in the LSCC tissue was 26.5±6.4, which obviously higher than 12.2±4.0 expression rate of the peritumoral tissue (P<0.05). The positive expression rates of both CD68 and CD34-MVD were higher in the lymph node metastasis (LNM) positive group than in the LNM negative group. The expression of CD68 had positive correlation with CD34-MVD. The 5-year disease-free survival rate in the group with the low CD68 expression was significantly higher than that in the group with high CD68 expression (76% vs. 42%, respectively). Conclusion. The high expression of CD68-TAMs in LSCC and its positive correlation with CD34-MVD illustrates that both play an important role in promoting the metastasis and angiogenesis of this cancer. Their expression was also positively correlated with the prognoses of these patients, suggesting that they could be used as important prognostic markers for LSCC.
Yonghong Huang,Junjun Xu,Yukun Sun,Yuxiang Huang 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
A Dynamic Voltage Restorer (DVR) model is proposed to eliminate the short-term voltage disturbances that occur in the grid-connected mode, the switching between grid-connected mode and the stand-alone mode of a Microgrid. The proposed DVR structure is based on a conventional cascaded H-bridge multilevel inverter (MLI) topology; a novel composite control strategy is presented, which could ensure the compensation ability of voltage sag by the DVR. Moreover, the compensation to specified order of harmonic is added to implement effects that zerosteady error compensation to harmonic voltage in specified order of the presented control strategy; utilizing wind turbines-batteries units as DC energy storage components in the Microgrid, the operation cost of the DVR is reduced. When the Microgrid operates under stand-alone mode, the DVR can operate on microsource mode, which could ease the power supply from the main grid (distribution network) and consequently be favorable for energy saving and emission reduction. Simulation results validate the robustness and effective of the proposed DVR system.
Yangdong Sun,Qiao Ye,Min Wu,Yonghong Wu,Chenggang Zhang,Weiqun Yan 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-
This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the Tat tag increases expression. Escherichia coli superoxide dismutase (SOD) proteins, including SodA, SodB and SodC, were selected for analysis. As expected, the yields and the solubility of Tat-tagged proteins were higher than those of Tat-free proteins, and similar results were observed for the total SOD enzyme activity. Bacterial cells that overexpressed Tat-tagged proteins exhibited increased anti-paraquat activity compared with those expressing Tat-free proteins that manifested as SodA4SodC4SodB. When compared with an MG1655 wild-type strain, the growth of a ΔSodA mutant strain was found to be inhibited after paraquat treatment; the growth of ΔSodB and ΔSodC mutant strains was also slightly inhibited. The mRNA transcript level of genes encoding Tat-tagged proteins was higher than that of genes encoding Tat-free proteins. Furthermore, the α-helix and turn of Tat-tagged proteins were higher than those of Tat-free proteins, but the β-sheet and random coil content was lower. These results indicated that the incorporation of the Tat core peptide as a significant basic membrane transduction peptide in fusion proteins could increase mRNA transcripts and promote the high yield and soluble expression of heterologous proteins in E. coli.
Huang, Yonghong,Xu, Junjun,Sun, Yukun,Huang, Yuxiang The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
A Dynamic Voltage Restorer (DVR) model is proposed to eliminate the short-term voltage disturbances that occur in the grid-connected mode, the switching between grid-connected mode and the stand-alone mode of a Microgrid. The proposed DVR structure is based on a conventional cascaded H-bridge multilevel inverter (MLI) topology; a novel composite control strategy is presented, which could ensure the compensation ability of voltage sag by the DVR. Moreover, the compensation to specified order of harmonic is added to implement effects that zero-steady error compensation to harmonic voltage in specified order of the presented control strategy; utilizing wind turbines-batteries units as DC energy storage components in the Microgrid, the operation cost of the DVR is reduced. When the Microgrid operates under stand-alone mode, the DVR can operate on microsource mode, which could ease the power supply from the main grid (distribution network) and consequently be favorable for energy saving and emission reduction. Simulation results validate the robustness and effective of the proposed DVR system.
Yuan Ye,Huang Yonghong,Xiang Qianwen,Sun Yukun 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.5
With the increase of the production of energy from renewable, it becomes important to look at techniques to store this energy. Therefore, a single winding bearingless flywheel motor (SWBFM) specially for flywheel energy storage system is introduced. For the control system of SWBFM, coupling between the torque and the suspension subsystems exists inevitably. It is necessary to build a reasonable radial force mathematical model to precisely control SWBFM. However, SWBFM has twelve independently controlled windings which leads to high-order matrix transformation and complex differential calculation in the process of mathematical modeling based on virtual displacement method. In this frame, a Maxwell tensor modeling method which is no need the detailed derivation and complex theoretical computation is present. Moreover, it possesses advantages of universality, accuracy, and directness. The fringing magnetic path is improved from straight and circular lines to elliptical line and the rationality of elliptical line is verified by virtual displacement theory according to electromagnetic torque characteristics. A correction function is taken to increase the model accuracy based on finite element analysis. Simulation and experimental results show that the control system of SWBFM with radial force mathematical model based on Maxwell tensor method is feasible and has high precision.
Liuxin Xiang,Yuxian Xia,Ying-Fan Cai,Jijun Liu,Xiaohong He,Quan Sun,Xiaoyan Wang,Yuyin Fu,Yonghong Fan,Daiwen Dong,Guanfan Zhou,Jinjuan Shen,Yihua Liu 한국식물학회 2013 Journal of Plant Biology Vol.56 No.3
The first tuber mustard calmodulin-like (CML) gene BjAAR1 (Brassica juncea var. tumida Tsen et Lee Abiotic stress and Abscisic acid (ABA) Responsive gene 1) was cloned and characterized. The protein encoded by BjAAR1 contains four predicted Ca2+ binding sites (EF-hand motif) and its recombinant protein can bind Ca2+ in vitro. qRT-PCR showed that the expression level of BjAAR1 was rather high in non-swollen stem of tuber mustard and largely reduced in swollen stem. Expression of BjAAR1 enhanced ABA- and stress-induced gene expression in Arabidopsis (Arabidopsis thaliana). Transgenic plants also exhibited hypersensitivity to NaCl, mannitol, and ABA during the seed germination and post-germination stages. ABA biosynthesis inhibitor, norflurazon (NF), rescued hypersensitivity phenotype of transgenic plants to NaCl and mannitol, indicating that BjAAR1 functions in multiple abiotic stresses response through ABA-dependent process.