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Epigenetic Regulation of Axon Regeneration after Neural Injury
Shin, Jung Eun,Cho, Yongcheol Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.1
When peripheral axons are damaged, neuronal injury signaling pathways induce transcriptional changes that support axon regeneration and consequent functional recovery. The recent development of bioinformatics techniques has allowed for the identification of many of the regeneration-associated genes that are regulated by neural injury, yet it remains unclear how global changes in transcriptome are coordinated. In this article, we review recent studies on the epigenetic mechanisms orchestrating changes in gene expression in response to nerve injury. We highlight the importance of epigenetic mechanisms in discriminating efficient axon regeneration in the peripheral nervous system and very limited axon regrowth in the central nervous system and discuss the therapeutic potential of targeting epigenetic regulators to improve neural recovery.
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury
Shin, Jung Eun,Ha, Hongseok,Kim, Yoon Ki,Cho, Yongcheol,DiAntonio, Aaron Elsevier 2019 Neurobiology of disease Vol.127 No.-
<P><B>Abstract</B></P> <P>Following damage to a peripheral nerve, injury signaling pathways converge in the cell body to generate transcriptional changes that support axon regeneration. Here, we demonstrate that dual leucine zipper kinase (DLK), a central regulator of injury responses including axon regeneration and neuronal apoptosis, is required for the induction of the pro-regenerative transcriptional program in response to peripheral nerve injury. Using a sensory neuron-conditional DLK knockout mouse model, we show a time course for the dependency of gene expression changes on the DLK pathway after sciatic nerve injury. Gene ontology analysis reveals that DLK-dependent gene sets are enriched for specific functional annotations such as ion transport and immune response. A series of comparative analyses shows that the DLK-dependent transcriptional program is distinct from that promoted by the importin-dependent retrograde signaling pathway, while it is partially shared between PNS and CNS injury responses. We suggest that DLK-dependency might provide a selective filter for regeneration-associated genes among the injury-responsive transcriptome.</P> <P><B>Highlights</B></P> <P> <UL> <LI> DLK is required for injury-induced transcriptional regulation in the PNS. </LI> <LI> DLK regulates baseline transcription in dorsal root ganglion neurons. </LI> <LI> DLK-dependent injury-responsive genes are enriched for particular functions. </LI> <LI> DLK regulates a distinct pro-regenerative retrograde signaling pathway. </LI> </UL> </P>
신용철 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1
I studied the oriental psychotherapy and reached the following conclusions. 1. In Oriental medicine, the internal organs considered in relation to mental reaction, and thought concerned with the mental disease. From the ancient times, treated mental disease by the theory of the Five Elements(五行). 2. The purpose of oriental psychotherapy is the life cultivation through training of True essesse, Vital force, Sprit by disciplining body and breathing and mind. 3. The oriental psychotherapy made body and mind relaxed it conduces to the precaution of disease, the promotion of health, the therapy of psycosomatic disorder, neurosis, etc.
Design of the Ontology Based Retrieval Engine for Managing the Public Control Points
Seonghyun Shin,Yulan Cui,Myunggil Park,Hyunsuk Hwang,Yongcheol Suh,Changsoo Kim 한국멀티미디어학회 2008 한국멀티미디어학회 국제학술대회 Vol.2008 No.-
The spatial information is being more widely used with the development of ubiquitous society and the effective management of control points which are basis of the spatial information is required. The existing management system supports key words and categorized search. However, the ontology-based retrieval system is not only dealing with complex queries but also increasing effective business and convenience. Therefore, this paper proposes the design of the ontology-based retrieval engine including the function of intelligent and personalized search. Our searching engine is able to be applied to current management systems of control points and PDA and Web-based information systems related with control points.