해외물류거점확보를 통한 국제물류시스템 구축방안에 관한 연구 : 동북아지역권의 항만인프라시설을 중심으로 With reference to Northeast Asian Ports

고용기,김승철 한국유통정보학회 2001 유통정보학회지 Vol.4 No.1

This study is to develop intra regional international logistics strategies between ports and its annex industrial complex in Northeast. It begins with a description of the needs of and prospects for trade between Korea, Japan, China, and North Korea following explanation of the current economic status of these countries as well as trade and investment trends in the region. The following viewpoints are suggested for intra regional development strategies based on the current circumstances. First cooperation strategies and economic investment for promoting the mutual concerns and interests of these countries were developed. Second, a practical way of utilising the port development plans was devised to stimulate industrial and investment cooperation. Third, a method of building a network among major ports in Northeast was developed. Fourth, and international logistics system that makes connection between sea, land and air easier through logistics standardisation was suggested in preparation for the changing environment of logistics and production control. Finally, methods of improving neighboring feeder port facilities are suggested.

운송화물의 최적배분을 통한 대구권 섬유산업의 물류관리 개선방안에 관한 연구

고용기,이종학,이명호 한국물류학회 2004 물류학회지 Vol.14 No.3

최근 기업물류의 혁신적인 변화에도 불구하고 대구지역 섬유산업의 중소기 업들은 물류개선을 통한 경쟁력 강화 시도가 절대 적으로 부족한 실정이다. 물론 물류관리의 개선에는 중소기업으로 부담하기 어려운 추가적 비용의 지출이 필요하고, 이러한 물류관리 개선노력이 가시적 성과로 이어지는 데는 상당한 시간이 걸릴 수도 있다. 그런데 최근 이러한 대구권 섬유산업의 경쟁력 강화를 위한 노력의 일환으로서 지역섬유산업의 통합물류관리전략을 제시하기 위한 일련의 연구들이 진행되어 왔다는 사실은 지역 섬유산업의 발전을 위해 긍정적으로 평가할만한 일이다. 본 논문에서는 대구권 섬유산업의 통합물류관리의 중요한 연구 대상인 지역섬유제품의 육상운송의 수송경로와 수송관리실태를 조사한 자료를 바탕으로, 수리적 모형을 통해 이를 분석하여 효율적 수송관리전략을 제시해 보고자 하였다. 대구권 섬유산업의 효율적 제품수송을 도출할 수 있는 수리모형을 제시하였고, 이에 따른 섬유제품의 현실적 수송관리전략을 제시하는데 있었다. 특히 수리모형을 이용하여 최적안을 도출할 수 있는 해법과 현실적용 가능성을 검토하고자 하였다. This paper attempts to develop a realistic model for establishing a new transportation network system in Daegu region. The model is constructed to identify the most effective traffic allocation plan for the industry in textile-industry-hub-oriented region and to evaluate the freight transportation routes between the manufacture process regions and the destination. The solution method of model gives birth to the determination of the optimal sizes of traffic allocation as well as the optimal cargo flows through transport networks. The linear programming method, particularly transportation model, is applied to derive the optimal allocation of traffic movements. Finally, utilizing the model and actual data, this study intends to construct real transportation network system for the region. It is expected that the present paper provides a pilot study for the strategies and schemes on establishing a new transportation network system for the region's industry.

연령의 증가에 따른 남성의 골밀도와 골교체율의 생화학적 표지자의 변화

민용기,안규정,정재훈,고은미,이명식,이문규,김광원,이종헌 대한골대사학회 1995 대한골대사학회지 Vol.2 No.2

방사선 조사선량에 따른 백서 악하선의 caspase-3 발현양상

권기정,최용석,황의환,이상래,고광준 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To investigate the caspase-3 expression in the acinar and ductal cells of rat submandibular glands after the irradiation of various doses. Materials and Methods: The male Sprague-Dawley rats weighing approximately 250 gm were used for this study. The experimental group was irradiated with a single absorbed dose of 2, 5, 10, and 15 Gy on the head and neck region. The rats were sacrificed on the 1st, 3rd, 7th, 14th, 21st, and 28th day after irradiation. The specimens including the submandibular gland were sectioned and observed using histopathological and immunohistochemical methods. Results : The local destruction of the acinar and ductal cells and the karyopyknotic nuclei of the acinar cells were observed in the 2 Gy and 5 Gy irradiation groups later than in the 10 Gy and 15 Gy irradiation groups. And the expression of caspase-3 was prominent only in the ductal cells in the 2 Gy and 5 Gy irradiation groups. Conclusion : This experiment suggests that radiation-induced apoptosis in the ductal cells of rat submandibular glands was induced by a low dose radiation associated with the activation of caspase-3 and radiation-induced necrosis was induced by a high dose radiation. (Korean J Oral Maxillofac Radiol 2006; 36 : 7-15)

MC3T3-E1 조골세포주의 osteonectin과 bone sialoprotein mRNA 발현에 미치는 방사선의 영향

하쌍용,강기현,이상래,권기정,고광준 대한구강악안면방사선학회 2004 Imaging Science in Dentistry Vol.34 No.2

Purpose : To investigate the effects of irradiation on the phenotypic expression of the MC3T3-E1 osteoblastic cell line, especially on the osteonectin and bone sialoprotein. Materials and Methods : Cells were irradiated with a single dose of 0.5, 1, 4 and 8 Gy at a dose rate of 5.38 Gy/min using Cs-137 irradiator. After specimens were harvested, total RNA was extracted on the 3rd, 7th, 14th, 21st day after irradiation. The total RNA was reverse-transcribed and the resulting cDNAs were subjected to amplification by PCR with a pair of primers. Results : The irradiated cells showed a dose-dependent increase in osteonectin mRNA expression when compared with the unirradiated control group. The irradiated cells showed no difference in bone sialoprotein mRNA expression when compared with the unirradiated control group. In accordance with the duration of culture period after irradiation, the level of osteonectin mRNA expression showed no difference, but it increased a little at the 21st day in the 4 and 8 Gy exposure groups. In the case of bone sialoprotein, however, the level of mRNA expression increased significantly at the 3rd and 7th day after irradiation, but it showed no difference at the 14th and 21st day when compared with the control group. Conclusion : These results showed that each single dose of 0.5, 1, 4 and 8 Gy influenced the mRNA expression of osteonectin and bone sialoprotein at the calcification stage of osteoblastic cells, suggesting that single dose of irradiation affected the osteoblastic bone formation at the cell level.

Multiple giant keratoacanthoma treated with acitretin

( Eun Sun Kwon ),( Byoung Yong Koh ),( Kyung Geun Lee ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Giant keratoacanthoma is an uncommon variant of keratoacanthoma, which may attain the diameter of several centimeters. Although keratoacanthoma usually undergo spontaneous resolution, giant keratoacanthoma can be invasive and destructive. A 49-year-old man presented with a 5-year history of multiple large hyperkeratotic and crusted plaques and nodules on the sun exposed areas such as face, ear, hand and forearm. Some lesions were involuted spontaneoulsy, whereas other lesions were rather enlarged. The biopsy specimen revealed horn-filled crater formation, epidermal extending like a buttress and eosinophilic glassy appearance in kertinocytic cytoplasm. In immunohistochemical stain, the Ki-67 staining was restricted to the basal layer. And p16 staining occurred more diffuse pattern. We treated them with acitretin and the lesions were almost cleared after 13 weeks. Herein we describe a case of multiple giant keratoacanthoma treated with acitretin.

Bowen`s disease originated from verruca

( Eun Sun Kwon ),( Byoung Yong Koh ),( Ki Bum Myung ),( Seung ),( Hyun Cheong ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Bowen’s disease is a precancerous condition that has the potential to progress to squamous cell carcinoma. The human papillomavirus(HPV) infection is associated with bowen’s disease. And recently HPV DNA has been detected to up to 30% on the extragenital bowen’s disease lesions. A 49-year-old woman presented solitary erythematous plaque with verrucous central region on the right calf. At first the lesion was just small verrucous papule, but gradually enlarged and became erythematous. The biopsy specimen from verrucous central region showed hyperkeratosis, parakeratotic tier within the stratum corneum, acanthosis and papillomatosis with inward bending of rete ridges. These findings were appropriate for verruca. But the specimen also revealed the features of bowen’s disease. Numerous atypical and pleomorphic cells showed mitotic figures and loss of polarity throughout stratum malpighi. The upper dermis was infiltrated by inflammatory cells. And specimen was stained weakly positive for p53 and strongly positive for p16 and Ki-67. Based on the clinical and histopathologic findings, the skin lesion simultaneously had the features of bowen’s disease and verruca. Therefore we suggest that the bowen’s disease may resulted from verruca and be associated with HPV infection. Here, we present a case of bowen’s disease originated from verruca.

A case of cellular fibrous histiocytoma on the palm

( Eun Sun Kwon ),( Byoung Yong Koh ),( Kyong Geun Lee ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Dermatofibroma is a common benign skin tumor that usually occurs as small, firm and red to brown solitary or multiple nodules on the lower extremities. In addition to the lower extremities, it can be observed anywhere. But the involvement of palm or sole is rare. Dermatofibroma has various histologic variants. In these variants, cellular fibrous histiocyma is relatively rare and histopathologically exhibits the densely cellular tumor with a fascicular to storiform growth pattern. A 40-year-old man presented with a solitary firm and reddish nodule on the left palm. The biopsy specimen revealed a nodular tumor that composed of spindle cells, histiocytes and collagen bundles. Immunohistochemical stain showed negative for CD 34, S-100 and CK, diffused positive for vimentin and weakly positive for CD68. Also Ki-67 staining showed less than 5% positive reactivity. Herein we describe a case of cellular fibrous histiocytoma on the palm.

[P349] A case of squamous cell carcinoma arising from epidermal cyst on buttock

( Won Choi ),( Kyoung Geun Lee ),( Byoung Yong Koh ),( Ki Bum Myung ),( Seung Hyun Cheong ),( Hyung Jin Hahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Epidermal cysts are common benign tumor of the skin. They are slow growing, round, firm intradermal or subcutaneous tumor and occur most commonly on the trunk, face and scalp. Interestingly, when an epidermal cyst ruptures and its contents are released into the dermis, foreign body reaction occurs. As a result, multinucleated giant cells may form a keratin granuloma and lead to a pseudocarcinomatous hyperplasia, which is thought to be a stimulant of squamous cell carcinoma (SCC) formation. From a review of the literature, malignant transformation of epidermal cysts is very rare and its incidence rate is known to be 0.011 -0.045%. An 82-year-old woman presented with painful, 2cm-sized subcutaneous nodule on left buttock for two years. Excisional biopsy specimens were taken from the skin lesion on buttock. In microscopic view, numerous keratinous materials were released from ruptured cysts. The specimen was consisted of well-differentiated squamous cells with atypical nucleus and mitotic figures. In mid dermis, horn pearl and the numerous multinucleated giant cells were also seen. On immunohistochemical staining, CK5/6 were positive. Also, Ki-67 and p53 were largely confined to basal portion of epithelium. The patient was diagnosed with a rare case of SCC arising from epidermal cyst based on histological finding and was later treated with complete excisional biopsy. Herein we report a rare case of SCC arising from epidermal cyst.

[P350] A case of adenoid type basal cell carcinoma on philtrum : Very rare histopathological variant

( Won Choi ),( Kyoung Geun Lee ),( Byoung Yong Koh ),( Ki Bum Myung ),( Seung Hyun Cheong ),( Hyung Jin Hahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Basal cell carcinoma (BCC) has been described as the most common malignant skin tumor usually seen in head and neck region. It has various histological variants and constitues about 65% of epithelial tumors. Known variants of BCC include as cystic, nodular, adenoid, morpheaform and miscellaneous forms. Of these, adenoid type BCC is regarded as a low grade malignancy compared to other types. A recent study reported the adenoid BCC incidence of 1.3%. Adenoid type of BCC has no site predilection and have been reported at various sites including forehead, inner canthus of eye, chin, trunk and extremities. A 78-year-old woman presented with a slow growing, pigmented, 0.8cm sized nodule located on the philtrum for seven years, along with an ulcerative hemorrhagic erosion lesion and rolled up edges. Skin biopsy specimens were taken by punch biopsy. Multiple cyst-like structures with strands of basaloid cells presenting with lacelike pattern, and mucoid-patterned stroma were seen. On immunohistochemical staining, SMA, CK19, C-kit were found negative while CD 10, CK5/6, p63 and p53 were positive. Also, Ki-67 was 70 %. After 18 days, excisional biopsy with skin-fat composite graft was taken from philtrum and left side of cheek. Thereafter, patient was diagnosed with adenoid BCC based on histological finding and was treated with wide biopsy with skin-fat composite graft for cosmetic aspect. Herein we report a rare case of adenoid BCC.