뇌 아밀로이드 혈관병과 고혈압성 뇌출혈의 감별에 있어서 Apolipoprotein Eε4와 점상 출혈 분포의 유용성

김용범,이광호,이수주,나덕렬,조수진,정진상,이원용 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

CoFeSiB아몰퍼스리본의 자기감성기능

강재덕,임재근,신용진 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-

This thesis has studied the magnetic sensing function by using an amorphous magnetic ribbon which has a zero-magnetostrictive composition its magnetic properties through the annealing technique in the demagnetization were measured in the magnetic field. We used a sample of composition (Fe0.06Co0.94)79Si2B19 with a thickness, length and width were 12㎛, 5㎝ and 2.5㎜, As a result of measuring the hysteresis curve of the sample which was examined inducing the pinning site of magnetization filed, the sample which was carried out the two annealing step shows that the LBJ(Large Barkhausen Jump) effect was confirmed at the reversal magnetization field Hw of 0.5 Oe and observed by the variation of the magnetic domain with the process of magnetization. And the sample with was used in this experiment was confirmed to have a magnetic sensing function.

근거리 수치화상에 의한 정밀측정에서 자유망 번들조정의 효과

이진덕,최용진,장기태 金烏工科大學校 産業技術開發硏究院 1999 産業技術開發硏究 Vol.15 No.-

The vision metrology system employing still-video imagery for industrial measurement has the potential of automated measurement with high accuracy. This paper was focussed on ascertaining the impact of free-net technique in self-calibrating bundle adjustment. The practical measurement of a three dimensional test field was conducted using a vision metrology system which was composed of a high resolution still-video camera, a PC-based image mensuration algorithm and a self-calibrating bundle adjustment program. As a result, free-net technique, which does not require any control points with pre-known object space coordinates, went up about 12% in accuracy compared to traditional standard technique. Therefore free-net bundle adjustment is expected to be able to be used efficiently for industrial applications such as dimensional inspection, deformation monitoring and so on.

미만성 대형 B-세포 림프종에서의 예후인자에 관한 연구

김삼용,곽승근,박상은,윤환중,조덕연,김진만 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

미만성 대형 B-세포 림프종은 가장 흔한 악성 림프종의 한 종류로서 우리나라에서는 전체 비호지킨 림프종의 50%를 차지한다. 비호지킨 림프종에서 병기는 호지킨병과는 달리 예후 인자로서의 유용성이 적다. 따라서 병기만을 예후 인자로서 평가하는 한계를 극복하기 위해 국제예후지표(International Prognostic Index)가 도입되었다. 특정 환자에서 IPI 점수와 함께 그 환자의 림프종의 생물학적 특성을 분석한다면 예후 예측에서 정확도가 높아질 것이다. 본 연구에서는 미만성 대형 B-세포 림프종에서 국제예후지표의 유용성을 확인하고자 하였으며, 각종 생물학적 지표의 면역화학염색을 통하여 이들을 배세포 중심 아형(germinal center subgroup : 이하 GC양 아형으로 약함)과 활성화 B-세포 아형(post-germinal center subgroup; 이후 pGC양 아형으로 약함)으로 분류하고 이들의 예후 예측에 대한 적절성을 평가하였다. 결과는 다음과 같다. 1. 연령분포는 37세에서 69세로 중앙치는 56세이었으며, 남자는 17예(65.4%), 여자가 9예(34.6%)였다. 병기는 Ⅰ, Ⅱ, Ⅲ, Ⅳ기가 각각 2예(7.7%), 11예 (42.3%), 5예(19.2%), 8예(30.8%)였다. 'B'증상은 5예(19.2%)에서 양성이었다. 진단 당시 혈청 LDH치가 상승한 경우가 11예(42.3%)였고, 거대종양(직경이 10㎝이상)을 갖는 경우가 5예(19.2%)이었다. ECOG 수행등급은 0이 2예(7.7%), 1이 18예(69.2%), 2가 5예(19.2%), 3이 1예(3.8%)이었다. 2. 면역조직화학염색 상 bcl-2의 양성은 17예(65.4%), bcl-6의 양성이 20예(76.9%)이었다. CD10이 양성인 경우가 5예(19.2%)이었다. IRF-4가 양성인 경우는 8예(30.8%)였다. 26명의 환자에서 bcl-6, CD10과 IRF-4를 이용하여 GC양 아형과 pGC양 아형으로 분류 하였는데, GC양 아형은 14예(53.8%)이었고, pGC양 아형은 7예(26.9%), 분류가 되지 않는 경우가 5예(19.3%)이었다. 3. 평균 48개월 동안 추적한 결과 중앙생존기간은 44개월이었고 생존기간은 1~100+개월에 분포하였다. Kaplan-Meier법에 의한 5년 누적 생존률은 32%이었다. 4. 병기, 'B' 증상, 혈청 LDH 농도, ECOG 수행등급, 거대종양유무가 통계학적으로 의미있는 임상적 예후 인자였다. 5. 면연조직화학염색에서는 bcl-2만이 통계학적으로 유의한 예후인자였다. 6. GC양 아형은 pGC양 아형에 비해 생존기간은 좋았으나, 통계학적 유의성은 없었다. 7. 다변량 분석결과 bcl-2 발현과 혈청 LDH치만이 예후에 영향을 미쳤다. Clinical Significanceof Expression of Biomarkers in Patients with Diffuse Large B-cell Lymphoma Diffuse large B-cell lymphoma(DLBL) is the most common type of lymphoma in Korea, representing about 50% of non-Hodgkin's Lymphomas. Although DLBL is usually considered as a specific category, the diversity in clinical presentation, morphology, genetic and molecular alterations strongly suggest that these tumors represent a heterogeneous group of neoplasia rather than a single clinicopathological entity. Clinical prognostic systems, including the International Prognostic Index (IPI), although useful to assess overall prognosis, embraces patients with heterogeneous prognoses. It is likely that the prognostic assessment of patients with DLBL might be improved by using biological features. During the last decade, most studies dealing with the heterogeneity of DLBL have focused on individual protein expression and molecular alterations. The expression of individual antigens related to different stages of B-cell differentiation, including CD10, bcl-6, and IRF-4, may help to define groups of tumors with different clinical and pathological characteristics. To determine the clinical significance and prognostic value of individual biomarker expression and the biomarker expression patterns according to germinal center subgroup or post-germinal center subgroup of DLBL as defined by a relatively small number of single antigens, we studied 26 patients with de novo DLBL, whose archival pathology specimen were available for immunohistochemistry studies, atChungnam National University Hospital from September 1992 to December 2000. Archival specimens from each patient were immunostained with respective antibodies for CD10, bcl-6, IRF-4, bcl-2 antigens. Two immunophenotyping profiles were distinguished according to the pattern of differentiation; germinal center(GC;CD10/Bcl-6+/IRF-4-) subgroup or postgerminal center (pGC ; CD10/bcl-6/IRF4+) subgroup. The results are as follows; 1) Baseline characteristics of patients were ; median age of patients was 56(range ; 37-69). 17 patients(65.4%) were male. 5 patients(l9.2%) had 'B' symptoms. Stages were as follows ; stage Ⅰ2 patients(7.7%), stage Ⅱ 11 patients(42.3%), stage Ⅲ 5 patients(l9.2%), stage Ⅳ 8 patients(30.8%). 11 patients (42.3%) had elevated LDH levels. 25 patients(96.2%) had ECOG performance grade 0-Ⅱ and 1 patient had grade Ⅲ. 5 patients(l9.2%) bad bulky disease. 2) The results of immunohistochemical study were as follows ; positive bcl-2 staining in 17 patients(65.4%), positive bcl-6 in 20 patients(76.1%), positive CD10 in 5 patients(l9.2%), positive IRF-4 staining in 8 patients (30.8%). 3) After a median follow up duration of 48 months, the median survival duration was 44 months with a range of survival of 1-100+ months. 5-year overall survival rate was 32% by Kaplan-Meier method. 4) The clinical factors affecting survival were elevated serum LDH level, B symptoms, bulky disease, stage at diagnosis and ECOG performance status 5) Among the biomarkers, only bcl-2 expression affected survival of DLBL patients 6) The germinal center like subgroup had superior survival than post-germinal center like subgroup but had no statistical significance. 7) Multivariate analysis showed that bcl-2 and serum LDH level had siginificance on survival Conclusion In addition to the known clinical prognostic factors, immunohistochemically defined characteristics such as bcl-2 expressionin DLBL is important and subgroups(germinal center or post-germinal center subgroup) of DLBL may have importance in predicting prognosis of DLBL patients

GPS 상사관측 데이터를 이용한 금오공대 GPS 기준점 설치에 관한 연구

이진덕,최용진 금오공과대학교 2006 論文集 Vol.27 No.-

The objective of this study is to analyze the temporal pattern characteristics of rainfall in Korean national geographic information institute notified to select as a ellipsoid for new the GRS80 geodetic reference and to introduce 3D geocentric coordinate system which employs ITRF200 system as coordinate axes from Jan 1, 2007. In this study, the electronic control data of GPS ordinary observation stations were used to establish a few KIT GPS control points for the active utilization of GPS surveying. Accuracies of location determination were analyzed according to GPS data processing methods. The characteristics of the results according to baseline distance were compared in different processing methods. As a result, we derived the coordinates of KIT GPS control points in new geodetic reference system(GRS80, ITRF2000).

안검과 수정체 난시를 고려한 도난시 도수 결정

李原鎭,成德鏞,金在道 대구산업정보대학 1994 논문집 Vol.8 No.-

This study is investigated the subject refract examination about relation astigmatism power and axis with the eyelid and lens astigmatism. Astigmatism is generally accredited as being one of the major causes of ocular asthenopia. This may be due to the requirement for constant accommodation in an attempt to place the cicle of least confusion on the retina and to subsidiary actions such as contraction of the eyelids to secure stenopaic slit effect, the narrowing of the pupil aperture to reduce aberration. Frontal and temporal headaches, tearing, smarting and eye-strain are all common to astigmia. In particular, inverse astigmatism produced more asthenopia than direct astigmatism. Because the contraction of the eyelids to stenopaic slit effect and the axis of lens astigmatism are connected with astigmatism axis. Therefore, the astigmatism axis and power may be considered the eyelids and lens astigmatism axis.

소아 혈중 연농도에 관한 조사

이용환,이덕희,김진하,박인근,한태영,장세한 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

지리적 위치에 따라 소아들에 있어서 혈중 연농도에 차이가 있는지의 여부와 소아들의 혈중 연농도의 참고치 계산을 위한 기초자료를 얻기 위하여 6-8세의 도심지역 거주 소아 102명과 교외지역 거주 86명, 총 188명을 대상으로 조사하여 다음과 같은 결과를 얻었다. 1. 전체 소아들의 평균혈중 연농도는 산술평균이 7.24, 기하평균이 6.92 ㎍/100㎖이었으며 남자가 여자보다 통계적으로 유의하게 더 높았다(p<0.05). 2. 도심지역과 교외지역 거주 소아들의 혈중 연농도는 도심지역거주 소아가 남, 녀 모두에서 교외지역 거주 소아보다 통계적으로 유의하게 더 높았다(p<0.05). 3. 혈중 연농도에 따른 분포에서는 <5 ㎍/100㎖군에 조사대상자 188명의 17.02%가 분포되었고 도심지역(5.88%)보다 교외지역(30.23%)에서 더 많은 분포를 보였으며, 10 ㎍/100㎖이상 군에는 전체 소아의 12.23%가 분포하고 있었으며, 도심지역(20.59%)이 교외지역(2.33%)보다 더 많이 분포하고 있었다. 이상의 결과에서 볼 때 도심지역 거주 소아들에 대한 연폭로의 관리대책이 시급히 마련되어야 할 것으로 판단된다. The authors conducted this study to evaluate some differences in blood lead levels between inner-city and suburban children and obtain the basic data of the reference value of the blood lead concentrations in children. The subjects were composed of 102 children residing in inner-city and 86 children in suburban. Their age range were 6 to 8 years old and the obtained results were as follows; 1. The arithmetic means of the blood lead level in male and female, male, and female children were 7.24, 7.40, 7.08 ㎍/100㎖, and geometric means were 6.92, 7.08, 6.76㎍/100㎖, respectively. 2. The children residing in inner-city had the higher blood lead levels both male and female than suburban children with statistical significance(p<0.05) 3. Seventeen percent of the total subjects had lead concentrations < 5 ㎍/100㎖, and 5.88% of inner-city children and 30.23% of suburban children had this lead values. But in ≥10㎍/100㎖ group, the inner-city children(20.39%) were more distributed than suburban children(2.33%), and 12.33% of total subjects had this lead values.

Ni-Zn 페라이트의 透磁率과 磁氣抵抗에 미치는 添加物의 影響

강재덕,최희태,서강수,신용진 明知大學校 産業技術硏究所 1990 産業技術硏究所論文集 Vol.9 No.-

This paper is studied on the effects of additive of permeability and magnetic reluctance of Ni-Zn ferrites. Ni-Zn ferrites was composed of 20mo1% NiO, 30mo1% ZnO, 50mo1% Fe₂O₃, and 0.0025n1o1%, 0.005mo1%, 0.01 mol% ??, Bi₂O₃, ?? were used as minor additive Sintering was carried oui at 1100℃. As results from the experiments, the initial permeability was proportional inversely to magnetic reluctance. It was observed that the better magnetic properties of initial permeability anti magnetic reluctance could be achieved by the additive ??.

우리나라와 외국 안경사법의 비교 연구

李原鎭,成德鏞,金在道 대구산업정보대학 1994 논문집 Vol.8 No.-

In current, the Korea optician law includes a part of the eye test for fitting the glass power different from the optical dispensing law of foreign. The number of average population per a optometrist or a ophthalmologist are about 135 but those of the Korea are about 52,500. This shows the higher than the case of foreign. Besides, the optician in Korea takes charge of the eye test for the adjustment of the degree of glasses and all of the optical dispensing. Therefore, it takes the sufficient part of the national health of the eye. For making up for the weak point of Korea optician, a them of ophthalmic optics within junior college be required to project 4 terms to beyond 6 terms with a curriculum and practical training.

지역감정 해소를 위한 스포츠의 필요성에 관한 연구

조동진,안용덕,김갑수 조선대학교 스포츠과학연구소 1999 스포츠科學硏究 Vol.10 No.-

Though the pride of creating the regime by a region may offset the past material and economic alienation, the direction of national policy by new regime toward democratization directs to exterminate the regional emotion which is the absolute obstacle of national unity and reunify the South and North Koreas. Therefore this study investigates the cause of regional conflicts and regional emotion between west and east regions and examines the actual necessity of sports for the social unity before seeking the methods to exterminate the regional emotion with sports First, it grasps the type and cause of regional conflicts by examining and researching the existing research theses and literatures, carries out the questionnaire with the content, Can sports exterminate the regional emotion, with the university students in Pusan-Kyungnam region and Kwangju-Chonnam region and then obtains the following conclusions with the possibility to exterminate the regional emotion by sports. 1. The types of typical conflicts in Korea are labor-management conflict, income classes conflict, sexual conflict, generation conflict and regional conflict and the most serious social problem among these is the regional conflict. 2. The regional emotion means that the regional consciousness which is hope and desire for local community and a kind of condensed social energy shown in the relation to other regions are expressed to the people of other regions in exclusive and unfair way. 3. The use of sports can be the effective means to exterminate. In this case, the sports game of regular exchange type between amateurs not by pros can double its effects.