선천성 일측성 폐정맥 폐쇄증 1 예

김철호,이계영,심영수,김건열,한용철,한성구,정희순,임정기,박재형 대한내과학회 1988 대한내과학회지 Vol.35 No.3

Unilateral pulmonary vein atresia is a rare congenital disease and is frequently associated with intracardiac anomalies. It is usually diagnosed in childhood and is very rarely diagnosed in adulthood. A case of unilateral pulmonary vein atresia in a 20-year old female is de- scribed. The relevant findings were symptoms of exertional dyspnea, roentgenographic evidence of decreased lung volume, increased interstitial infiltration with septal lines in the involved side (right), and aoscence of blood flow in a radionuclide perfusion scan. Pulmonary angiography showed an extremely small right pulmonary artery and thining of the peripheral branches, and nonvisualization of the draining pulmonary veins. Bronchial arteriography showed rommunication between the bronchial artery and the right pulmonary artery and it was drained to the left pulmonary artery. Cardiac catheterization showed no intracardiac anomaly. The right bronchography was normal; pulmonary function studies showed a pure restrictive pattern and markedly in creased physiologic dead space. MRI showed no visible right pulmonary vein.

만성폐쇄성폐질환의 중증도와 폐고혈압 및 폐성심으로 진행과의 상관관계

김형호,박철진,이준,장광표,하성일,이재록,하재화,권세훈,권용운,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background: From many previous studies, Pulmonary hypertension is the known independent predictive factor of the mortality in COPD. Also pulmonary hypertension is the major cardiovascular complication of COPD and is associated with the progression to cor pulmonale and poor prognosis. Author want to analyze the correlation between pulmonary hypertension and the severity of COPD which are classified by forced expiratory volume in one second, and the extent of progression to corpulmonale. Methods: Retrospectively we investigated the medical records of 118 patients with COPD who had pulmonary function test and echocardiogaphy more than one times during one-year follow-up (from June, 2005 to May, 2006) at respiratory division in chosun university hospital, and then 50 patients were enrolled in this study. We classified the severity from FEVl in pulmonary function test based on the GOLD guideline, also this was comparably analyzed with RVSP, RVIDd, Visual Grading from echocardiography. Results: 16 patients out of 50 were classified as moderate severity, 25 patients were severe, and 9 patients were very severe group. RVSP was higher in more severe groups than less severe groups but when it comes to pulmonary hypertension that RVSP is over 35 mmHg, there was no valid difference lies in those groups. As FEVl decreases RVSP and RVIDd increases, and observed relationship between RVSP which was classified as below 35 mm and above 35 mm groups and visual grading which was classified as normal and dilatated groups revealed valid correlation, Conclusion: As pulmonary function decreases, progression to pulmonary hypertension and cor pulmonale increases but there was no remarkable difference of prevalence in above moderate severity groups. 연구배경 폐고혈압은 이전의 많은 연구에서 만성폐쇄성폐질환에서 독립적인 사망의 예측인자로 알려져 있다. 또한 폐고혈압은 만성폐쇄성폐질환의 주요한 심혈관계 합병증이며, 폐성심으로의 진행 및 불량한 예후와도 관련되어 있다. 이에 저자는 폐고혈압과 1초간 노력성호기량으로 분류되는 만성폐쇄성폐질환의 중증도 및 폐성심으로의 진행 정도를 비교 분석하여 이들의 상관관계를 밝혀보고자 한다. 방법 2005년 6월부터 2006년 5월까지 1년 동안 본 병원 호흡기 내과에서 폐기능검사와 심장초음파 검사를 각각 1회 이상 시행한 적이 있는 118명에 한하여 의무기록을 후향적으로 조사하여 이 중에서 50명을 대상으로 하였다. 폐기능검사 시행 결과 얻은 1초간 노력성호기량을 바탕으로 GOLD guideline에 따라 중증도를 분류하였으며 이를 심초음파 시행 결과 얻은 우심실수축기압, 확장기말 우심실내부간격, 시각등급과 비교분석하였다. 결과 대상 환자 50명중 16명은 중등증, 25명은 중증, 9명은 최고중증 그룹으로 분류되었다. 우심실수축기압은 중증도가 높은 그룹에서 낮은 그룹에 비해 더 높게 나타났으나 폐고혈압에 해당하는 우심실수축기압이 35 mmHg이상인 환자에 있어사는 각 그룹간에 유의한 차이를 보이지 않았으며, 확장기말 우심실내부간격, 시각등급 또한 중증도와 유의한 차이를 보이지 안항ㅆ다. 1초간 노력성호기량이 감소함에 따라서는 우심실수축기압, 시각등급은 증가하였으며 우심실수축기압을 35mmHg 미만과 이상인 그룹으로, 시각등급을 정상과 확장이 있는 그룹으로 분류하여 비교한 결과에서는 유의한 상관관계를 나타냈다. 결론 폐기능이 감소할수록 페고혈압 및 폐성심으로의 진행이 증가하였으나 폐기능검사에서 중등도 이상의 그룹에서 유병률의 차이는 크지 않았다.

사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복

김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.

宇垣一成의 朝鮮統治觀과 '農村振興運動'

金容徹 조선대학교 전통문화연구소 1999 전통문화연구 Vol.6 No.-

窒素 및 加里 施肥水準이 飼料作物의 生育 및 乾物收量에 미치는 影響

黃鏞哲,金武成 경희대학교 부설 식량자원개발연구소 1984 硏究論文集 Vol.5 No.-

This study was conducted to investigate the effect of nitrogen and potassium fertilizers applied to forage crops grown alone and in mixture with grass and legumes of forage crops, on the yield of dry matter. The results are summarized as follows; 1. Nitrogen fertilizers for the yield of dry matter showed highly effective to orchardgrass in case of grown alone and were also effect of grown in mixture alfalfa and grasses, but potassium fertilizers did not show any significance on the dry matter yield increases compared with control. 2. In nitrogen fertilizer plots. alone and mixed sowings showed the total yields of dry matter in decreasing order of tallfescue>orchardgrass>alfalfa and alfalfa+orchardgrass (5:5)>alfalfa+orchardgrass(3:7)>alfalfa+orchardgrass(7:3)>alfalfa+tallfescue(3:7)>alfalfa+tallfescue (7:3)>alfalfa+tallfescue (5:5), respectively. 3. With nitrogen fertilizers for the yield of dry matter was highest effective with the application level of 20㎏/10a throughout the plots. except the with nitrogen plot of grown alone of alfalfa and orchardgrass. 4. In case of grown in mixture with grass and legume increasing total yields of dry matter with nitrogen and potassium fertilizers was ascribed to increase grasses. but botanical composition of alfalfa was decreased.

窒素 및 加里 施肥水準이 飼料作物의 生育 및 乾物收量에 미치는 影響

黃鏞哲,金武成 慶熙大學校 1984 論文集 Vol.13 No.-

This study was conducted to investigate the effect of nitrogen and potassium fertilizers applied to forage crops grown alone and in mixture with grass and legumes of forage crops, on the yield of dry matter. The results are summarized as follows; 1. Nitrogen fertilizers for the yield of dry matter showed highly effective to orchardgrass in case of grown alone and were also effect of grown in mixture alfalfa and grasses, but potassium fertilizers did not show any significance on the dry matter yield increases compared with control. 2. In nitrogen fertilizer plots, alone and mixed sowings showed the total yields of dry matter in decreasing order of tallfescue > orchardgrass > alfalfa and alfalfa + orchardgrass (5:5) > alfalfa + orchardgrass (3:7) > alfalfa + orchardgrass (7:3) > alfalfa + tallfescue (3:7) > alfalfa + tallfescue (7:3) > alfalfa + tallfescue (5:5), respectively. 3. With nitrogen fertilizers for the yield of dry matter was highest effective with the application level of 20㎏/10a throughout the plots, except the with nitrogen plot of grown alone of alfalfa and orchardgrass. 4. In case of grown in mixture with grass and legume increasing total yields of dry matter with nitrogen and potassium fertilizers was ascribed to increase grasses, but botanical composition of alfalfa was decreased.

제 2형 당뇨병 환자에서 대사증후군의 유병률 및 관련요인의 특징

박철진,박거운,박일구,신지혜,김진화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Background: People with insulin resistance has a higher risk of developing cardiovascular disease. This leads to the importance in diagnosing metabolic syndrome. The incidence of metabolic syndrome has increased significantly in korea because of an increased population of obese people and also the incidence of DM. There have been many studies done on the incidence of metabolic syndrome in the general population. Therefore, the authors have designed this study to identify the incidence of metabolic syndrome in patients with type 2 DM and also the associated characteristics in that population. Methods: The study included 169 adults over the age of 20 (84 males and 85 females) admitted to the endocrinology department of Chosun University between Jan, 1st 2005 and May, 31st 2006. Out of the people diagnosed with type 2 DM people were excluded when any of the physical measurements (height, weight, blood pressure, abdominal circumference) and blood measurements (TG, HDL-cholesterol, fasting blood sugar) were insufficient and when the patient was taking any drugs other than anti-hy-pertensive agents and oral anti-diabetic agents. Obesity and the other risk factors were defined by the Asian-Pacific guideline and 2001 ATP III of NCEP, respectively. Result: The each prevalence according to the metabolic syndrome criteria of the type 2 DM patients showed low HDL cholesterolemia with the highest incidence of 57.4% followed by hypertng1yceridemia(52.0%), obesity(40.9%) and hypertension(33.0%). The each incidence of diagnostic criteria in metabolic syndrome according to sex was different, In males, hypertriglyceridemia was the highest with the incidence of 57.7% followed by low HDL-cho1estero1emia(49.5%), obesity(40.9%) and hypertension (30.0%). In women, the incidence were low HDL-cho1estero1emia(64.8%), hyperthg1yceridemia(47.6%), obesity(45.0%) and hypertension(36.0%), in a descending order. The analysis between the diagnosis of metabolic syndrome in type 2 DM patients and the criteria showed that hyperthglyceridemia (correlative value 0.575) had the highest correlation followed by low HDL-cholesterolemia (correlative value 0.446), obesity (correlative value 0.350) and hypertension (correlative value 0.410). All the correlations were statistically significant with a p-value less than 0.01. Conclusions: Type 2 DM is a important factor of metabolic syndrome based on insulin resistance. The control of blood glucose with prevention and early diagnosis of the other factors related to metabolic syndrome in type 2 DM is important for preventing cardiovascular complications.

Mushroom堆肥의 飼料化에 關한 硏究 : 第1報 Mushroom 堆肥腐熟過程中 몇가지 有機成分과 腐植化度 Amino酸 및 酵素活性의 經時的 變化 THE VARIATION OF GENERAL ORGANIC COMPOSITION, DEGREE OF HUMIFICATION, FREE AMINO ACID AND ACTIVITY OF AMYLASE IN THE COMPOST BEFOR CULTIVATION OF MUSHROOM AND IN MUSHROOM COMPOST

李殷喆,金銅淵,金容植,金廣植 全南大學校 農漁村開發硏究所 1966 農業科學技術硏究 Vol.4 No.-

In order to use mushroom compost as feedstuffs to exeriments were carried out to determin the variation of general organic composition, degree of htunification, free amino acid and activity of amylase in the compost before cultivation of mushroom and mushroom compost. The results obtained were summarized as follows; 1. Contents of crude protein and soluble protein of the compost for mushroom cultivation were increased. In the mushroom compost crude protein contents were 10.9% and soluble proteins were 1.95%. The contents of nitrogen free extract were decrcased in both compost. Crude fiber contents were increased during fermentation but in mushroom compost contents of crude fiber were markedly decreased from 23.7% to 12.4%. 2. Degree of humification during fermentation was increased but in mushroom compost was decreased. 3. The free amino acid which were extrated with alfohol in mushroom compost were identified. that is cysteine, Serine, glycine, threonine. alanine, tynosine, methionine and isoleusine. 4. The value of amylase activity from mushroom compost was about two tims higher than 10 days fermented compost.

정규기상관측자료를 이용한 주간의 현열 플러스 추정

이종범,김용국,박철용 江原大學校 附設 環境硏究所 2001 環境硏究 Vol.18 No.-

The purpose of the present study is to develope the estimation scheme for sensible heat flux by semi-empirical approach using routine meteorological data such as solar radiation and air temperature. To compare observed sensible heat flux with estimated sensible heat flux, the sensible heat fluxes were measured by three dimensional sonic anemometer-thermometer. The field observation was performed during 1 year from December 1, 1995 to November 30, 1996 on a rice paddy field in Chunchon basin. The heat fluxes were measured at a heights of 5m and mean meteorological variables were obtained at two levels, 2.5m(or 1.5m) and 10m. Since condition of rice paddy field such as, wetness of the field, roughness length, vary widely, we devided annual data to 5 periods. Comparing with two sensible heat fluxes, the results showed that the correlation coefficients were more than 0.86. Thus, we can conclude that the estimation method of sensible heat fluxes using routine meteorological data is practical and reliable enough.

Tape casting 공정을 이용한 Glass-ceramics기판의 제조

강원호,김용철 단국대학교 1998 論文集 Vol.33 No.-

Crystallization characteristics of Li20-MgO-MgF2-Si02-B203 system glass which is Low firing Temperature substrate were investigated. Glass-ceramics was prepared by the process of nucleation and crystal growth with the glass of Li_2O-MgO-MgF_2-SiO_2 having lithium fluorhectorite crystal phase and Li_2O-MgO-MgF_2-SiO_2-B_2O_3 having lithium boron fluorphlo-gopite. The nucleation temperature of the base glass was 490℃, and crystallization temperature was 750℃. Powderization of the glass ceramics was prepared by water swelling. Binder system of slurry were Ethanol and Toluene as a solvent and Menhaden Fish Oil as a dispersion, also PVB and DBP were used as a binder and plasticizer, respectively. The appropriate ratio of solvent and powder was 1.8:1 for the tape casting. As the results, green density was 1.34(g/㎤), linear shrinkage rate was 1.2∼2.21% after drying. Optimum temperature of burn-out and Firing were 414℃ and 1.050℃, respectively. The dielectric constant and dissipation factor were 13.1 and 0.369 (at 1㎒).