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대한간학회지 제6차 춘계학술대회 초록집 : 구연 ; 1990년대 간경변증의 원인, 합병증 및 사망원인 변화에 관한 고찰
한요셉 ( Han Yo Seb ),김병호 ( Kim Byeong Ho ),백일현 ( Baeg Il Hyeon ),이동근 ( Lee Dong Geun ),김경진 ( Kim Gyeong Jin ),동석호 ( Dong Seog Ho ),김효종 ( Kim Hyo Jong ),장영운 ( Jang Yeong Un ),이정일 ( Lee Jeong Il ),장린 ( Ja 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
헬리코박터 파이로리 제균 전후의 위액 내 암모니아와 표피성장인자 농도의 변화
장재영 ( Jae Young Jang ),장영운 ( Young Woon Chong ),최선영 ( Sun Young Choi ),김남훈 ( Nam Hoon Kim ),임근우 ( Keun Woo Lim ),정용희 ( Yong Hee Jung ),한요셉 ( Yo Seb Han ),동석호 ( Seok Ho Dong ),김효종 ( Hyo Jong Kim ),김병호 대한소화기학회 2004 대한소화기학회지 Vol.43 No.5
Background/Aims: Helicobacter pylori (H. pylori) infection is the cause of peptic ulcer diseases, and gastric cancer. Hydrolysis of urea generating ammonia may cause cytotoxic effects on the gastric epithelium. The ammonia may induce the synthesis of epidermal growth factor (EGF) in gastric epithelium as an adaptive cytoprotective mechanism. The first aim was to examine the concentration of ammonia and EGF in gastric juice before and after H. pylori eradication in functional dyspepsia patients. The second aim was to examine the correlation among ammonia concentration, EGF concentration, and inflammatory score of gastritis. Methods: The concentration of ammonia and EGF were measured by ELISA. The grade and severity of gastritis were measured according to the updated Sydney system. Results: The concentration of ammonia in gastric juice was much higher in the H. pylori positive subjects (10,787±6,584㎛ol/L) than in the negative subjects (2,339±1,158㎛ol/L, p<0.0001). The concentrations of EGF in gastric juice was much higher in the positive subjects (1,462±393pg/㎖) than in the negative subjects (1,088±499pg/㎖, p<0.005). The concentration of ammonia and EGF in gastric juice showed significant correlation (r=0.63, p<0.0001). The concentrations of ammonia and histologic severities showed significant correlation (r=0.41, p<0.0001). Moreover, the level of EGF in gastric juice and histologic severities showed positive correlation (r=0.20, p<0.005). Conclusions: As the concentration of ammonia in gastric juices increased, the concentration of EGF was also increased in functional dyspepsia with H. pylori infection. The concentration of EGF in gastric juice may play a role in the adaptive cytoprotection in H. pylori- induced gastritis. (Korean J Gastroenterol 2004;43:283-290)