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Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
Wei, Ying,Lu, Yao,Li, Chenxi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10
Purpose: To study the clinical application value of ultrasound guided thyroid fine needle aspiration biopsy and thinprep cytology testing in diagnosis of thyroid disease. Methods: A total of 78 patients with thyroid nodules were enrolled, 34 males and 44 females, aged 33-64 years old with mean age of 47.6 years. All underwent thyroid module fine needle puncture after surgery to assess cell pathology and histopathological features. Results: Sufficient specimens were obtained from all of 78 patients, the cytological results of 73 cases (93.6 %) being consistent with pathological results. While 20 cases (25.6 %) were malignant tumors, 44 (56.4 %) were benign and 9 (11.5 %) were non-tumor lesions. The sensitivity of benign and malignant thyroid nodule by thyroid fine needle puncture was 90.9 %, specificity was 98.1 % and the positive predictive value was 96.3 %. Conclusions: It is demonstrated that ultrasound-guided thyroid fine needle aspiration biopsy and thinprep cytology testing have diagnostic value in clinical application for thyroid disease,showing good diagnostic coincidence rates with histopathological examination. They can thus be regarded as safe and effective for preoperative diagnosis and providing an appropriate basis for selection of surgery.
Ying-Ying Zhang,Jungwoo Oh,In-Shik Han,Zhun Zhong,Shi-Guang Li,Soon-Yen Jung,Kee-Young Park,Hong-Sik Shin,Won-Ho Choi,Hyuk-Min Kwon,Wei-Yip Loh,Majhi, P.,Jammy, R.,Hi-Deok Lee IEEE 2009 IEEE transactions on electron devices Vol.56 No.2
<P>Highly thermally stable Ni germanide technology for high performance germanium metal-oxide-semiconductor field-effect transistors (Ge MOSFETs) is proposed, utilizing Pd incorporation into Ni germanide. The proposed Ni germanide shows not only the improvement of thermal stability but also the reduction of hole barrier height, which can improve the device on-current by reducing the Ni germanide to p+ source/drain contact resistance. The proposed Ni germanide showed a stable sheet resistance of up to 500 degrees C 30-min postgermanidation annealing due to the suppression of agglomeration and oxidation of Ni germanide and the diffusion of Ni and Ge atoms by the incorporated Pd. Therefore, the proposed Ni0.95Pd0.05, alloy could be promising for the high mobility Ge MOSFET applications.</P>
Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity
Wei Zhao,Jian Xin Pu,Xue Du,Yong Zhao,Fei He,Hai Bo Zhang,Yong Bo Xue,Wei Lie Xiao,Han Dong Sun,Ying Li Wu,Guo Qiang Chen 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.12
Three new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC50 values of 2.52, 3.06, 2.14 μM, respectively.
ECG Signal Denoising Based on Improved MP Algorithm
Wei A-ying,Guo Yin-jing,Cheng Xue-zhen 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11
The electrocardiogram (ECG) signal processing plays an important role in diagnosing cardiopathy. Sparse decomposition provides a new tool for ECG signal processing. Matching pursuit (MP) algorithm uses overcomplete dictionary to decompose the signal, so it can reflect the properties of the signal. In decomposition process, searching a best atom of the dictionary is an optimal problem; Genetic Algorithm (GA) is used to solve this problem. This paper proposed an improved MP algorithm based on GA to denoise the ECG signal, whose dictionary is composed of Gabor atoms. The experiment simulation results show that the proposed method can get a good denosing effect in a shorter time than not use GA algorithm.
Research on Early Age Deformation of High Performance Concrete by Fiber Bragg Grating Sensor
Ying-Wei Yun,장일영 대한토목학회 2008 KSCE Journal of Civil Engineering Vol.12 No.5
For high performance concrete (HPC), due to its low water cement ratio and addition of mineral admixtures, pretty high autogenous shrinkage and thermal deformation occur at early age of HPC casting (especially before hardening), which may lead to early age cracking of HPC structures, and influence the durability of HPC. This paper has monitored the early age properties of HPC successfully by embedded FBG strain sensor. The results show that the deformation increases rapidly within the first day after HPC casting. And its value is up to 57 me, which is the 35% of two-week deformation (165 me). Considering the durability and permeability of HPC, first-day deformation is pretty high and can not be neglected. Also, FBG monitoring system has been used to measure early age deformation and temperature of HPC retaining wall simultaneously. Temperature compensation for FBG strain sensor is always necessary for accurate strain monitoring. The monitoring technique used here can be extended to concrete early age behavior monitoring in mass concrete structure with any size.