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Photon-beam-position-monitor in PLS Diagnostic Beamline
Kim, Changbum,Yoon, Jong Chel,Kim, Seung-nam,Kim, Myong-jin,Kim, Hee Seob,Ryu, Chun Kil,Lee, Chae-soon,Seo, In Deuk,Park, Chongdo,Lee, Hae Cheol,Hong, Man-soo,Huang, Jung-Yun,Han, Yeongjin,Park, Jaehu Korean Physical Society 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.6
Development of Particle Flow-Based Inflatable Robot Body for Shape Rigidity Modulation
Hyunho Kim,Sangjoon Jonathan Kim,Junghoon Park,Handdeut Chang,Namkeun Kim,Yeongjin Kim 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.10
Disaster robots are needed to perform various tasks through narrow gaps between building debris to be used for rescue. A soft material-based disaster robot can have easy access to the rescue site through the narrow gaps. To ensure the robust control and better performance of the soft robot operation, a joint stiff ness modulation mechanism is required. In this paper, we have proposed a noble stiff ness modulation mechanism that includes shape change and self-assembly by using a particle flow-based inflatable robot body. We analyzed the particle filling completion time by injecting air and particles at a constant pressure into the soft chamber depending on several parameters (the size of the particle, the size of the reservoir, the volume ratio between the chamber volume and the total volume of the particle, and the injected air pressure). Of these, the most dominant factors influencing the completion time were particle size and pressure. It was observed that the smaller the size of the particle, the shorter time. The completion time tended to decrease as the air pressure increased.
Kim, Jeong Tae,Barua, Sonia,Kim, Hyeongmin,Hong, Seong-Chul,Yoo, Seung-Yup,Jeon, Hyojin,Cho, Yeongjin,Gil, Sangwon,Oh, Kyungsoo,Lee, Jaehwi The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.4
In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as particle composition and drug loading efficiency and amount were similarly controlled to mainly evaluate the effect of different particle sizes of the solid lipid particulate systems on drug dissolution behavior and oral bioavailability. The results showed that genistein-loaded solid lipid microparticles and nanoparticles exhibited a considerably increased drug dissolution rate compared to that of genistein bulk powder and suspension. The microparticles gradually released genistein as a function of time while the nanoparticles exhibited a biphasic drug release pattern, showing an initial burst drug release, followed by a sustained release. The oral bioavailability of genistein loaded in solid lipid microparticles and nanoparticles in rats was also significantly enhanced compared to that in bulk powders and the suspension. However, the bioavailability from the microparticles increased more than that from the nanoparticles mainly because the rapid drug dissolution rate and rapid absorption of genistein because of the large surface area of the genistein-solid lipid nanoparticles cleared the drug to a greater extent than the genistein-solid lipid microparticles did. Therefore, the findings of this study suggest that controlling the particle size of solid-lipid particulate systems at a micro-scale would be a promising strategy to increase the oral bioavailability of genistein.
Kim, Sangjoon J.,Kim, Yeongjin,Lee, Hyosang,Ghasemlou, Pouya,Kim, Jung Springer-Verlag 2018 Medical & biological engineering & computing Vol.56 No.2
<P>Following advances in robotic rehabilitation, there have been many efforts to investigate the recovery process and effectiveness of robotic rehabilitation procedures through monitoring the activation status of the brain. This work presents the development of a two degree-of-freedom (DoF) magnetic resonance (MR)-compatible hand device that can perform robotic rehabilitation procedures inside an fMRI scanner. The device is capable of providing real-time monitoring of the joint angle, angular velocity, and joint force produced by the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints of four fingers. For force measurement, a custom reflective optical force sensor was developed and characterized in terms of accuracy error, hysteresis, and repeatability in the MR environment. The proposed device consists of two non-magnetic ultrasonic motors to provide assistive and resistive forces to the MCP and PIP joints. With actuation and sensing capabilities, both non-voluntary-passive movements and active-voluntary movements can be implemented. The MR compatibility of the device was verified via the analysis of the signal-to-noise ratio (SNR) of MR images of phantoms. SNR drops of 0.25, 2.94, and 11.82% were observed when the device was present but not activated, when only the custom force sensor was activated, and when both the custom force sensor and actuators were activated, respectively.</P>
Kim, Young Ok,Yun, Misun,Jeong, Jae-Ho,Choi, Seong Min,Kim, Seul Kee,Yoon, Woong,Park, Chungoo,Hong, Yeongjin,Woo, Young Jong The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11
<P>Progressive cerebellar ataxias are rare diseases during childhood, especially under 6 years of age. In a single family, three affected siblings exhibited Friedreich's-ataxia-like phenotypes before 2 years of age. They had progressive cerebellar atrophy, intellectual disability, and scoliosis. Although their phenotypes were similar to those observed in patients with autosomal recessive cerebellar ataxias, other phenotypes (e.g., seizure, movement disorders, ophthalmologic disturbance, cardiomyopathy, and cutaneous disorders) were not noted in this family. Whole-exome sequencing of the family members revealed one potential heterozygous mutation (c.1209delG, NM_181733.2; p.Met403IlefsX3, NP_859422.2) of the gene encoding conserved oligomeric Golgi complex subunit 5 (COG5). The heterozygous deletion at the fifth base in exon 12 of <I>COG5</I> caused a frameshift and premature stop. Western blotting of COG5 proteins in the skin tissues from an affected proband showed a significantly decreased level of full length COG5 and smaller, aberrant COG5 proteins. We reported a milder form of COG5 defect showing Friedreich's-ataxia-like phenotypes without hypotonia, microcephaly, and short stature that were observed in most patients with COG5 defect.</P>
Dual-Side Optimization for Cost-Delay Tradeoff in Mobile Edge Computing
Kim, Yeongjin,Kwak, Jeongho,Chong, Song IEEE 2018 IEEE Transactions on Vehicular Technology VT Vol.67 No.2
<P>Mobile code offloading (MCO) is a technology that offloads computing tasks from mobile devices to remote servers managed by code offload service providers (CSPs). Nowadays, it is recommended that the remote servers be placed on the edge of the network to support modern applications, e.g., augmented reality, which demand stringent and ultralow latency or high bandwidth. To date, previous studies have independently addressed code offloading policy in mobile devices and pricing/server provisioning policies in the CSP; moreover, the system models for both user side and CSP side have not adequately reflected their practical aspects. This paper designs a practical model for the both sides and takes account of them in an integrated MCO framework simultaneously. By leveraging Lyapunov drift-plus-penalty technique, we propose code offloading, local CPU clock frequency, and network interface selection policies for mobile users, and propose MCO service pricing and server provisioning policies for the CSP in each of a competition scenario and a cooperation scenario. In the competition scenario, we propose a Com-UC algorithm for mobile users and a Com-PC algorithm for the CSP with the aim to minimize each cost for each queue stability constraint. In the cooperation scenario, we propose a Coo-JC algorithm with the aim to minimize their sum cost for both mobile users and CSP. Via trace-driven simulations, we demonstrate that Com-UC saves at most 71% of its cost and Com-PC attains 82% profit gain for the same delay compared to existing algorithms; moreover, the cooperation between mobile users and CSP additionally reduces costs and delays.</P>
Secure Integrated Circuit with Physical Attack Detection based on Reconfigurable Top Metal Shield
Yeongjin Mun,Hyungseup Kim,Byeoncheol Lee,Kwonsang Han,Jae-SungKim,Ji-Hoon Kim,Byong-Deok Choi,Dong Kyue Kim,Hyoungho Ko 대한전자공학회 2019 Journal of semiconductor technology and science Vol.19 No.3
Invasive physical attacks on integrated circuits (ICs), such as de-packaging, focused ion beam (FIB) chip editing, and micro-probing attempts, constitute security threats for chips with potentially valuable information, such as smart cards. Using a state-of-the-art circuit-editing technique, an attacker can remove an IC’s top metal layer, leaving its secure information exposed to micro-probing attacks. Security ICs can be seriously threatened by such attacks and thus require on-chip countermeasures. Conventional active shields, however, have difficulty coping with physical attacks based on FIB chip editing (i.e., bypassing the top metal shield). This study presents a novel countermeasure against physical attacks based on the use of a reconfigurable metal shield for both top metal removal and micro-probing attack detection. This shield consists of two circuits: an FIB chip editing detection circuit consisting of a random number generator and a micro-probing attempt detection circuit consisting of two conditionally synchronized ring oscillators. Both circuits share a randomly reconfigured top metal shield, which represents a promising solution for security against state-of-the-art invasive attacks.
Design of an MR-Compatible Biopsy Needle Manipulator using Pull-Pull Cable Transmission
Kim, Seong-Tae,Kim, Yeongjin,Kim, Jung Korean Society for Precision Engineering 2016 International Journal of Precision Engineering and Vol.17 No.9
Magnetic resonance (MR) compatible needle manipulators can assist physicians with the insertion of biopsy needles and needle-like therapeutic instruments directly into millimeter-size tumors, using MR images as feedback. However, magnetic resonance imaging (MRI) systems present a challenging operational environment with high magnetic fields and limited space, making the development of MR-compatible robots difficult. In this paper, we present design requirement analysis and a novel prototype design for an MRI-guided biopsy needle manipulator and an MR-compatible transmission that provides sufficient driving forces for needle manipulation inside an MR scanner. The actuators of the manipulator are placed outside the MR room, which are several meters away from the scanner. A combination of a pull-pull cable-sheath and a cable-pulley transmission is used to transmit the actuator force to the manipulator. This configuration can be used to achieve MR-compatibility and leads to the ability to use conventional actuators such as DC motors, which have sufficiently high power to perform needle biopsy. We also studied the feasibility of the proposed transmission and actuation with the proposed manipulator. The accuracy and precision of the needle tip are evaluated and MR-compatibility is verified.
Kim, Yeongjin,Ahn, Bummo,Na, Youngjin,Shin, Taeyoung,Rha, Koonho,Kim, Jung 한국정밀공학회 2014 International Journal of Precision Engineering and Vol.15 No.1
Computerized palpation systems have been studied for the quantitative characterization of prostate properties. The aim of this study was to evaluate the reliability of mechanical tumor localization maps by estimating correlation with pathological maps. A total of 120 indentations were performed on 10 specimens by using a sweeping palpation system in simulated environment conditions. Suspicious tumor lesions from the mechanical localization were compared to those of the pathological maps. The concordance rate between the mechanical localization maps and pathological maps was 81.7% (98/120). The positive predictive value (PPV) and the negative predictive value (NPV) of the proposed localization system were 78.6% (59/75) and 86.7% (39/45), respectively. Based on these data, the suspicious tumor lesions of mechanical localization maps were in close agreement with those from the pathological maps. The findings suggest that the high compatibility and detection rate of prostate tumor could be enhanced if computerized palpation and the conventional diagnosis are used synergistically. This study may contribute to technological progress in overcoming diagnostic limitations, which include many complications from digital rectal examination (DRE) and transrectal ultrasound (TRUS) guided needle biopsy.