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폐암 수술 후 흉벽의 종양 재발 검출에 있어 TI-201 폐 SPECT의 유용성
유영훈 ( Yu Yeong Hun ),김형중 ( Kim Hyeong Jung ),안철민 ( An Cheol Min ),김세규 ( Kim Se Gyu ),백효채 ( Baeg Hyo Chae ),이두연 ( Lee Du Yeon ),정경영 ( Jeong Gyeong Yeong ),윤미진 ( Yun Mi Jin ),박상준 ( Park Sang Jun ),문성욱 ( 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.5
송영수 ( Song Yeong Su ),최훈영 ( Choe Hun Yeong ),유태현 ( Yu Tae Hyeon ),강신욱 ( Kang Sin Ug ),이중민 ( Lee Jung Min ),정현주 ( Jeong Hyeon Ju ),이호영 ( Lee Ho Yeong ),한대석 ( Han Dae Seog ),최규헌 ( Choe Gyu Heon ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.1
배 경 : 성인 원발성 초점성 분절형 사구체 경화증은 성인 신증후군의 한 원인으로 과거에는 치료에 대한 반응이 적은 것으로 생각되었으나 최근에는 치료의 관해율과 예후가 향상되고 일부 임상 및 병리 지표들은 예후 측면에서 의미가 있다고 보고되고 있다. 그러나 현재까지 일관되게 보고된 예후 인자는 없는 실정이다. 이에 저자는 치료 반응에 대한 예측인자와 신부전의 진행에 영향을 주는 위험인자를 알아보고자 하였다. 방 법 : 1991년부터 2002년까지 연세의료원에서 일차성 초점성 분절형 사구체 경화증으로 진단받은 성인 환자 40명을 대상으로 진단시 임상 및 병리조직학적 지표를 후향적으로 분석하였다. 결 과 : 신생검시 환자 26명 (65%)에서 신증후역의 단백뇨가 있었으며, 14명 (35%)에서 비신증후역의 단백뇨가 있었다. 신증후역의 단백뇨 환자군이 비신증후역의 단백뇨 환자군보다 혈청 크레아티닌치가 높았으며 (p<0.05), 혈청 알부민과 총 콜레스테롤치를 제외하고 두 군간에 기타 임상 및 병리조직학적 지표의 차이는 없었다. 27명에게 면역억제 치료를 하였으며 15명 (55.6%)에서 반응이 있었고, 치료 반응군과 무반응군 간에 임상 및 병리조직학적 지표의 차이는 없었다. 추적관찰 기간동안 정상 신기능을 유지한 군과 만성 신부전으로 진행한 군을 비교하였을 때 진단시 혈청 크레아티닌치의 증가와 치료에 대한 반응 유무가 의미있는 예후인자로 분석되었다 (p<0.05). 신 생존분석시 치료군이 치료하지 않은 군보다 생존율이 높은 경향을 보였으나 통계학적인 차이는 없었고 (p>0.05), 치료 반응군은 무반응군보다 의미있게 높은 생존율을 보였다 (P<0.05). 결 론 : 진단시 혈청 크레아티닌치의 증가 소견이 있거나 치료에 반응이 없는 환자들은 불량한 예후를 보일 수 있으므로 보다 집중적인 치료와 주기적인 신기능의 관찰이 필요할 것으로 보인다. Background : Primary focal segmental glomerulosclerosis (FSGS) is a cause of nephrotic syndrome in adult. Although primary FSGS has been known to be refractory to treatment, recent studies reveal higher remission rate and better prognosis. And it has been reported that some clinical and histopathologic paramenters are significant to prognosis. But, confirmative prognostic indices remain to be defined. In order to further clarify the prognostic factors for therapeutic response and risk factors for progression to chronic renal failure (CRF), we reviewed the medical records of primary adult FSGS patients. Methods : Forty-adult patients diagnosed as primary FSGS between 1991 to 2002 were enrolled. We retrospectively analyzed the clinical and histopathological parameters of all patinents at the time of renal biopsy. In addition, the therapeutic responses to immunosuppressants and the renal survival were analyzed. Results : At the time of renal biopsy, 26 patients (65%) had proteinuria of the nephrotic range and 14 patients (35%) had proteinuria of the non-nephrotic range. The serum creatinine level was higher in nephrotic-ranged patients than that in non nephroticranged patients (p<0.05). The other parameters were not significantly different between two groups. Twenty-seven patients were treated with immunosuppressants and 15 patients (55.6%) responded to the treatment. There was no significant difference in clinical or histopathological variables between the responders and the non-responders. High serum creatinine level at diagnosis and responsiveness to treatment appeared to be significant as risk factors for progression to CRF (p<0.05). The paticnts treated with immunosuppressants had longer survival period, compared with those without treatment. And the responders had significantly longer survival period compared with the non-responders (p<0.05). Conclusion : The patients with initial impairment of renal function or poor response to therapy may have worse prognosis, and the intense treatment with regular follow-up of renal function should be recommended for these patients. (Korean J Nephrol 2004;23(1)36-45)
폐 결절에서 FDG-PET의 유용성과 표준섭취계수와 혈당농도의 상관관계
김규식 ( Kim Gyu Sig ),임성철 ( Im Seong Cheol ),고영춘 ( Go Yeong Chun ),박경화 ( Park Gyeong Hwa ),주진영 ( Ju Jin Yeong ),조계중 ( Jo Gye Jung ),김수옥 ( Kim Su Og ),오인재 ( O In Jae ),김유일 ( Kim Yu Il ),김영철 ( Kim Yeong C 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.6
폐 상피세포에서 NF-κB/IκB 경로에 의한 염증매개 사이토카인의 발현
박계영 ( Park Gye Yeong ),이승희 ( Lee Seung Hui ),황보빈 ( Hwangbo Bin ),임재준 ( Im Jae Jun ),이춘택 ( Lee Chun Taeg ),김영환 ( Kim Yeong Hwan ),한성구 ( Han Seong Gu ),심영수 ( Sim Yeong Su ),유철규 ( Yu Cheol Gyu ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.3
급성 위식도정맥류 출혈에 내시경 N-butyl-2-cyanoacryl주입요법의 효과 TIPS의 치료 효과와의 비교 검토
노두영 ( No Du Yeong ),박선영 ( Park Seon Yeong ),주소영 ( Ju So Yeong ),박창환 ( Park Chang Hwan ),이완식 ( Lee Wan Sig ),주영은 ( Ju Yeong Eun ),김현수 ( Kim Hyeon Su ),최성규 ( Choe Seong Gyu ),유종선 ( Yu Jong Seon ),김세종 ( 대한소화기학회 2004 대한소화기학회지 Vol.43 No.3
Background/Aims: Though endoscopic therapies such as variceal ligation and sclerotherapy has been performed, bleeding from the large esophageal and gastric varices still poses significant risk of death. Decrease of portal pressure by TIPS (transjugular intrahepatic portosystemic shunt) or surgical shunt was indicated as cause of failure of endoscopic therapies. Treatment of N-butyl-2-cyanoacrylate has been especially effective for gastric variceal bleeding, but comparison with other treatments had not been reported yet. In this study, the effect of cyanoacrylate injection therapy was cross-examined with the result of TIPS in acute esophagogastric variceal bleedings. Methods: From April 1995 to June 2002, endoscopic cyanoacrylate injection therapy (43 cases) and TIPS (63 cases) were performed in our hospital. Each group was analysed regarding their clinical results including initial hemostasis rate, rebleeding rate, survival duration, mortality and morbidity. Results: Initial hemostasis rate was 95.3% in cyanoacrylate group and 92.1% in TIPS group. Cumulative probability of rebleeding was not different between two groups. Overall complication rates associated with the procedure were 50.8% in TIPS group and 9.3% in cyanoacrylate group. There was no significant difference between two groups in their survival rates. Conclusions: Cyanoacrylate injection therapy was relatively safe, and has comparable results with TIPS for uncontrollable and severe esophagogastric variceal bleedings. (Korean J Gastroenterol 2004;43:186-195)
폐렴을 의심하여 Levofloxacin과 Amikacin을 사용 후 일시적 호전을 보여 진단이 늦어진 폐결핵
이희석 ( Lee Hui Seog ),강영애 ( Kang Yeong Ae ),오진영 ( O Jin Yeong ),이재호 ( Lee Jae Ho ),유철규 ( Yu Cheol Gyu ),이춘택 ( Lee Chun Taeg ),김영환 ( Kim Yeong Hwan ),한성구 ( Han Seong Gu ),심영수 ( Sim Yeong Su ),임재준 ( Im J 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.4