일부 치과기공소의 작업장내 공기와 기공사의 혈중 니켈, 크롬 및 카드뮴함량에 대한 연구

민병국,박정덕,홍연표,장임원 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.3

To evaluate some health hazards of dental technician by metal pollution, nickel, chromium and cadmium levels in indoor air of 8 laboratories and in whole bolld of 69 male dental technicians were investigated. Six offices and 36 male office workers were studied as control group. Airborne metals were mesured at breathing zone by personal air sampling method. Collected samples were pretreated by wet digestion, and nickel, chromium and cadmium were determined by flameless method using A.A. spectrophotometer. Also, the nickel, chromium and cadmium concentrations in whole blood were determined by A.A. spectrophotometer after simple dilution with distilled water. the airborne nickel, chromium and cadmium contents were higher in dental laboratory than in office, and higher in polish section than in carving section of the dental laboratory. But all of the airborne metals were ranged within TLV(Threshold Limit Value). Blood nickel, chromium and cadmium levels in dental technician and office-worker, but was not significant difference between polish and carving section of dental technician. Blood nickel concentration of dental technician was correlated with occupational career(r=0.2439, p<0.05) and increased according to occupational duration(F=2.90, p<0.05). Blood chromium and cadmium concentations were not significant difference between dental technician and office worker. Smoking increased only bolld cadmium level in office-worker.

백서 Paraquat 두여에 의한 간과 폐 조직의 산화성 손상에서 Vitamin C와 Deferoxamine의 항산화 효과에 관한 연구

정연권,서길준,정중식,정성은,최국진,윤여규 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The toxicity of paraquat has been known to be caused by oxygen free radicals which leads to the lipid peroxidation and multiple organ failure. Although vitamin C has been known to be a potent antioxidant, recently there are numerous data which have shown that a low dose of vitamin C may act as a prooxidant due to the stimulation of the Fenton reaction with metal ions, which produces hydroxyl radicals. It has been reported that a deferoxamine in paraquat intoxication could reduce the production of the hydroxyl radicals by the inhibition of the Fenton reaction through the reduction of iron ion in tissue. The aim of this study was to evaluate the effect of the high and low dose of vitamin C and deferoxamine on lipid peroxidation and plasma TNF-α in paraquat intoxication. Methods: Female Sprague -Dawley rats were divided into seven groups: control group which was not given paraquat(20 mg/kg), P group which was given paraquat only, PVH group given paraquat and high dose of vitamin C(100 mg/kg), PVL group given paraquat and low dose of vitamin C(10 mg/kg), PVHD given paraquat, high dose of vitamine C and deferoxamine(100 mg/kg), PVLD given paraquat, low dose of vitamin C and deferoxamine, and PD given paraquat and deferoxamine. Animals were killed at 6 and 24 hours after treatment. Malondialdehyde(MDA), superoxide dismutase(SOD) and glutathione(GSH) contents, catalase activity, plasma TNF-α, and histologic changes in the lung and liver tissue were measured. Results: The lung histology in the PVH and PD or PVHD groups showed the significant decreases in the alveolar edema and interstitial thickness compared to the P group. The liver histololgy in the PVH and PVHD groups demonstrated marked differences in the central venous and sinusoidal dilatation compared to that of the P group. While the MDA levels of the lung and liver in the PVH and PD groups showed the significant reduction compared to that of the P group at 6 hours after treatment, all groups showed the significant changes compared to the P group at 24 hours. There was no significant change of the SOD levels of the lung and liver at 6 hours among all groups. At 24 hours, the SOD levels of the lung in PVH, PVL, and PVHD groups showed the significant increases compared to the P group. The increase of the SOD level in groups combined with deferoxamine, however, revealed a little reduction. The SOD level of the liver in PVH group only significantly increased compared to the P group at 24 hours. There was no significant change of the GSH level of the lung and liver among all groups at 6 hours. At 24 hours, the GSH level of the lung and liver were significantly increased in both PVH and PD group and PVH group, respectively, compared to the P group. Although the catalase activity of the lung was not significantly increased, that of liver was signiflcantly increased in both PVHD and PD groups compared to the P group at 6 hours. The catalase activities of the lung and liver were significantly increased in PVH, PD, and PVHD at 24 hours. The concentrations of the plasma TNF-α were slightly decreased at 6 hours and slightly increased at 24 hours compared to that of the P group, but they were not significant. Conclusion: This study showed that although the low dose of vitamin C had no effect, the high dose of vitamin C revealed a decrease of the MDA level and an increase of SOD, GSH, and catalase activity in the lung and liver tissues, and the effect of the high dose of vitamin C increased with time. The administration of the deferoxamine with or without high dose of vitamin C, however, significantly showed the inhibition of the lipid peroxidation and antioxidant effect and low dose vitamin C decreased the effect of deferoxamine. The effects of the vitamin C and deferoxamine on plasma TNP-α were not clearly shown.

습기제거시스템의 성능에 관한 연구

유성연,정민호,홍정표,심국진,김광영 忠南大學校 産業技術硏究所 1997 산업기술연구논문집 Vol.12 No.2

The performance of moisture removal system is investigated analytically and experimentally. The program for the moist air calculation and for the condensing tube design are developed to examine the factors which affect moisture removal rate. Experimental apparatus comprises condensing tube, cooling system, vacuum pump, measurement and control devices. Thermoelectric cooling system and vapor compression refrigeration system are used to cool the air, and the performance of two systems are compared each other. Thermoelectric cooling system is compact and free from noise and vibration, but cooling rate of it is relatively slow compared to that of vapor compression refrigeration system. Air velocity, indoor temperature and humidity, temperature of coolant, size and material of condensing tube are found to affect the performance of moisture removal.

Comparison of Quality Traits of Thigh Meat from Korean Native Chickens and Broilers

Yeon Kuk Jung,Hee Jun Jeon,Samooel Jung,Jun Ho Choe,Jun Heon Lee,Kang Nyeong Heo,Bo Seok Kang,Cheo Run Jo 한국축산식품학회 2011 한국축산식품학회지 Vol.31 No.5

The quality attributes of thigh meat from a certified meat-type commercial Korean native chicken (Woorimatdag(TM), WM) and a commercial broiler (Ross, CB) raised under the same environmental conditions, were compared. One-d-old, mixedsex WM (200), and 200 broilers (Ross, CB) each were randomly assigned to floor pens (20 chickens per pen). The production stages (I, II, and III) were selected based on similar live weight. The crude fat contents of WM thigh meat were lower than those of CB. WM thigh meat contained higher stearic and arachidonic acid contents but lower palmitoleic and oleic acid contents compared to those of CB. The thigh meat color CIE L*- and CIE b*-values of WM were lower, but inosine- 5`-monophosphate content was higher in WM than CB in whole production stages. WM thigh meat showed higher collagen content, hardness, springiness, gumminess, and chewiness than CB. In sensory evaluation, odor, taste, and overall acceptance were higher while color was lower in WM. Based on these results, it can be concluded that even if commercial broilers are raised under the same environmental conditions as WM, the unique quality attributes of WM thigh meat are distinctively unique.

Comparison of Quality Traits of Thigh Meat from Korean Native Chickens and Broilers

Jung, Yeon-Kuk,Jeon, Hee-Jun,Jung, Samooel,Choe, Jun-Ho,Lee, Jun-Heon,Heo, Kang-Nyeong,Kang, Bo-Seok,Jo, Cheo-Run Korean Society for Food Science of Animal Resource 2011 한국축산식품학회지 Vol.31 No.5

The quality attributes of thigh meat from a certified meat-type commercial Korean native chicken (WoorimatdagTM, WM) and a commercial broiler (Ross, CB) raised under the same environmental conditions, were compared. One-d-old, mixedsex WM (200), and 200 broilers (Ross, CB) each were randomly assigned to floor pens (20 chickens per pen). The production stages (I, II, and III) were selected based on similar live weight. The crude fat contents of WM thigh meat were lower than those of CB. WM thigh meat contained higher stearic and arachidonic acid contents but lower palmitoleic and oleic acid contents compared to those of CB. The thigh meat color CIE $L^*$- and CIE $b^*$-values of WM were lower, but inosine-5'-monophosphate content was higher in WM than CB in whole production stages. WM thigh meat showed higher collagen content, hardness, springiness, gumminess, and chewiness than CB. In sensory evaluation, odor, taste, and overall acceptance were higher while color was lower in WM. Based on these results, it can be concluded that even if commercial broilers are raised under the same environmental conditions as WM, the unique quality attributes of WM thigh meat are distinctively unique.

Differences in Clinical Manifestations according to the Positivity of Interferon-γ Assay in Patients with Intestinal Tuberculosis

Hye Jin Jung,Young-Ho Kim,김유선,Seong Yeon Jeong,Sung Won Park,Ji Yeon Seo,Hyemi Jung,Jong Pil Im,Ji Won Kim,Sung Noh Hong,Kuk Lae Lee 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4

Intestinal tuberculosis (ITB) remains prevalent in Asia. An interferon-γ assay (QuantiFERON-TB gold test [QFT]) is considered to be an effective supplementary tool for diagnosing ITB. We retrospectively analyzed the clinical features of ITB patients based on the initial results of QFT. A total of 109 patients with ITB were enrolled, and 82 patients (75.2%) showed positive QFT results. In the QFT-positive group, the mean age (44.1±12.0 years) was significantly higher than that in the QFT-negative group (37.0±14.8, p=0.0096). Abdominal pain (p=0.006) and diarrhea (p=0.030) were more frequent in the QFT-negative group. Further, C-reactive protein (CRP) levels were significantly higher in the QFTnegative group (6.4±9.9 mg/dL) than in the QFT-positive group (1.3±2.3, p<0.001). Multivariate analysis confirmed that younger age (p=0.016), diarrhea (p=0.042), and high levels of CRP (p=0.029) were independent predictors of QFTnegative results in patients with ITB. These results suggest that prior exposure to TB, reflected by QFT positivity, may cause mild inflammation in patients with ITB.

복부 자상의 치료 방법에의 접근

박지연 ( Ji Yeon Park ),정민 ( Min Chung ),이영돈 ( Yeong Don Lee ),이정남 ( Jung Nam Lee ),이운기 ( Woon Ki Lee ),박연호 ( Yeon Ho Park ),백정흠 ( Jung Heum Baek ),박흥규 ( Heung Gyu Park ),김건국 ( Keon Kuk Kim ),강진모 ( Jin M 대한외상학회 2010 大韓外傷學會誌 Vol.23 No.2

Purpose: A classic approach to abdominal stab wounds has been a routine laparotomy for the purpose of diagnosis or treatment. However, management protocols for abdominal stab wounds are still contentious in most trauma centers. We examined the relationship between the character of the stab wound and the injured intraabdominal organs by retrospectively analyzing the medical records of patients with abdominal stab wounds admitted to Gil hospital, and the findings for our patients are then confronted with a review of the literature. We aimed to propose proper management protocols to approach abdominal stab wounds. Methods: The medical records of all 80 patients sustaining abdominal stab wounds, admitted at the Department of Surgery, Gil Hospital, Gachon Medical School, from January 2004 to December 2008 were retrospectively reviewed. All the abdominal stab wounds were collated based on the site and the character of the injury, investigations performed on admission, results of investigations, operations performed and findings at the time of the operation. Results: The most prevalent age group was patients in their forties and the average age of the patients was 41 years for both genders. The stab wounds were most commonly located at the periumbilical area (16.9%), followed by the epigastric area (15.6%), and 18.2% of the patients had multiple wounds. The most commonly eviscerated organ was the omentum (9 out of 16 cases); 61.7% of non-eviscerated patients underwent a therapeutic laparotomy while 81.3% of eviscerated patients underwent a therapeutic laparotomy. The small bowel was the most commonly injured organ (22.7%, 17 out of 75 injuries). The review revealed a relatively common diaphragmatic injury in abdominal stab wound patients (8 cases, 10.5%). The average hospital stay was 11 days. Conclusion: This review revealed commonly eviscerated and injured intraabdominal organs in abdominal stab wound patients and their relationship with a therapeutic laparotomy. Although the management is still controversial, the authors suggest indications for an immediate laparotomy and a protocol for managing abdominal stab wounds. Hemodynamic instability and peritoneal irritation signs are definite indicators for an immediate laparotomy, but the review revealed intraabdominal organ evisceration alone not to be a statistically significant factor. In addition, the authors suggest that abnormal CT findings can be valuable for making a decision on management of hemodynamically stable stab wound patients. Further study may clarify a role for a more selective approach to operative intervention and for a more extensive use of selective observation. (J Korean Soc Traumatol 2010;23:134-141)

폴리카보네이트 용융중합 초기의 촉매기반 에스터 교환반응 동력학

정주연(Ju Yeon Jung),이지목(Ji Mok Lee),홍성권(Sung Kwon Hong),이진국(Jin Kuk Lee),정현민(Hyun Min Jung),김용석(Yong Seok Kim) 한국고분자학회 2015 폴리머 Vol.39 No.2

본 연구에서는 디올 단량체로서 바이오 유래 isosorbide 및 bisphenol A가 적용된 폴리카보네이트의 단일 및 공중합체를 얻기 위한 촉매로서 LiOH, Cu(acac)2 및 n-butyltin hydroxide oxide hydrate를 각각 적용하여 용융중합 초기 단계에서 에스터 교환반응의 동력학 분석을 실시하여 촉매활성도를 비교하였다. 단일 중합의 경우, Cu(acac)2가 가장 큰 촉매활성도를 나타내었으나, 서로 다른 두 가지 디올 단량체가 적용된 용융 공중합의 경우에는 촉매의 적용 메커니즘 및 단량체의 화학구조에 의존하여 LiOH의 촉매활성이 가장 큼을 확인하였다. 이러한 연구결과는 최근 관심이 집중된 바이오 유래 친환경 폴리카보네이트용 촉매선정에 활용 가능함을 제시한다. In this work, we evaluated catalytic activity of LiOH, Cu(acac)2 and n-butyltin hydroxide oxide hydrate in the early stage of the melt transesterification of isosorbide and bisphenol A as diol monomers and diphenylcarbonate for the melt polymerizaiton of polycarbonate. Cu(acac)2 proved to be the most active catalyst for homopolymerization process, while the catalytic activity of LiOH was higher than the others in case of melt copolymerization depending on the catalytic mechanism and chemical structure of catalyst. We suggested that evaluation of catalytic activity can be used for selection of catalyst system in bio-based copolymerization of polycarbonate.

충수돌기에 발생한 점액낭종

박승연(Seung Yeon Park),이정남(Jung Nam Lee),정민(Min Chung),이운기(Un Gi Lee),이영돈(Yeong Don Lee),오재환(Jae Hwan Oho),백정흠(Jung Hum Bak),박연호(Yeon Ho Park),김현영(Hyeon Yeong Kim),김건국(Keon Kuk Kim),최상태(Sang Tae Choi) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.2

Appendiceal mucocele is a cystic dilatation of the appendiceal lumen with mucus, which may be caused by either benign or malignant diseases. In this report, five cases of appendiceal mucocele are reported, three of which had a preoperative diagnosis of mucocele, whereas the others were found incidentally during the operation under the diagnosis of intussusception and periappendiceal abscess. All five patients underwent surgical resections, including one ileocecal resection and four right hemicolectomies. Histopathology revealed a mucinous cystadenoma in four cases, and a mucinous cystadenocarcinoma in one. There was no disease-related death during 18 months of follow-up.

Screening of Specific Genes Expressed in the Swine Tissues and Development of a Functional cDNA Chip

Chul Wook Kim,장규태,Yeon Hee Hong,Eun Jung Kwon,Won Yong Jung,Kwang Keun Cho,Ki Hwa Chung,Byeong Woo Kim,Jung Gyu Lee,Jung Sou Yeo,Yang Su Kang,Young Kuk Joo 아세아·태평양축산학회 2005 Animal Bioscience Vol.18 No.7

To develop a functional cDNA chip, specific genes expressed in the tissues of swine Kagoshima Berkshire were screened. A total of 4,434 ESTs were obtained by constructing a cDNA library from total RNA isolated from the muscle and fat tissues, affirming their functions by investigating similarity of nucleotide sequences with the database at the NCBI. Among them, 1,230 ESTs were confirmed as novel genes, which, to date, have not been identified. Attaching the genes to a cDNA microarray slide revealed expression patterns of genes in muscle and fat according to the growth stages of swine. As specific genes expressed in the muscle tissues of swine with body weight of 30 kg, 60 genes including actin, myosin, tropomysin, transfer RNA-trp synthetase, Kel-like protein 23, KIAA0182 and COI, Foocen-m, etc were obtained. In addition, 18 novel genes were obtained. As specific genes expressed in fat tissues of swine with body weight of 30 kg, 47 genes including annexin II, Collagen, Fibronectin, Pleckstrin homology domain, serine protease, etc were obtained. 21 novel genes were also obtained. The genes specifically expressed in the muscle and fat tissues of swine affect contraction and relaxation of the muscle and the fat. However, studies on the expression mechanisms of the genes are insufficient. To reveal species of structural genes in swine muscle and fat tissue, interrelation studies in expression and function of genes by using the cDNA chip should be conducted.