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국내외 장애학생 대상 도식기반교수 및 수정된 도식기반교수 연구 분석
승예린(Yerin Seung),옥민욱(Min-Wook Ok) 한국학습장애학회 2021 학습장애연구 Vol.18 No.3
본 연구는 국내외 장애학생을 대상으로 한 도식기반교수 및 수정된 도식기반교수 연구를 분석하여 개괄적인 연구의 특징, 중재방법, 중재 및 유지효과를 살펴보았다. 문헌 선정 준거에 따라 선정된 국내외 도식기반교수 연구 14편과 수정된 도식기반교수 연구 13편을 분석하였다. 분석 결과, 도식기반교수와 수정된 도식기반교수 모두 최근 연구가 활발하게 이루어지고 있으며, 국내 연구는 국외 연구에 비해 상대적으로 적은 편이었다. 연구대상의 경우 도식기반교수 연구는 초등 학습장애 학생, 수정된 도식기반교수 연구는 중등 지적장애 학생 대상으로 가장 많이 이루어졌다. 또한 도식기반교수와 수정된 도식기반교수 연구 모두 덧셈과 뺄셈 영역에 더 중점을 두어 이루어졌으며, 대부분 연구자가 중재를 제공한 것으로 나타났다. 비중복 비율기법으로 중재 및 유지 효과를 분석한 결과, 평균적으로 도식기반교수는 중간 크기, 수정된 도식기반교수는 높은 크기의 중재 및 유지 효과를 보였다. 도출된 결과를 바탕으로 국내 장애학생을 위한 도식기반 및 수정된 도식기반교수 현장적용과 후속연구 방향에 대해 제언하였다. The purpose of this study was to investigate research on schema-based instruction(SBI) and modified schema-based instruction(MSBI) for students with disabilities. The studies were analyzed on the overall characteristics of studies, research methods and the intervention effects. Based on inclusion criteria, a systematic search identified fourteen SBI studies and thirteen MSBI studies. The results showed that both SBI and MSBI studies have been actively investigated recently, but domestic studies were relatively fewer than foreign ones. Most of the participants were elementary school sstudents with learning disabilities in SBI studies, whereas middle school students with intellectual disabilities took the largest part in MSBI studies. Research on both SBI and MSBI mainly focused on addition and subtraction, and researchers served as interventionists in the majority of them. The results on intervention and maintenance effect size revelaed that both SBI and MSBI had a positive effect on students’ word problems performance, with a moderate and a large effect respectively. Based on the findings of this study, implications for practice and future research were discussed.
( Jang Hyun Kim ),( Min Hyung Park ),( Yerin Kim ),( Dongyan Nan ),( Fernando Travieso ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.5
Owing to the unprecedented COVID-19 pandemic, the pharmaceutical industry has attracted considerable attention, spurred by the widespread expectation of vaccine development. In this study, we collect relevant topics from news articles related to COVID-19 and explore their links with two South Korean pharmaceutical indices, the Drug and Medicine index of the Korea Composite Stock Price Index (KOSPI) and the Korean Securities Dealers Automated Quotations (KOSDAQ) Pharmaceutical index. We use generalized Dirichlet-multinomial regression (g-DMR) to reveal the dynamic topic distributions over metadata of index values. The results of our analysis, obtained using g-DMR, reveal that a greater focus on specific news topics has a significant relationship with fluctuations in the indices. We also provide practical and theoretical implications based on this analysis.
Soung, Nak-Kyun,Kim, Hye-Min,Asami, Yukihiro,Kim, Dong Hyun,Cho, Yangrae,Naik, Ravi,Jang, Yerin,Jang, Kusic,Han, Ho Jin,Ganipisetti, Srinivas Rao,Cha-Molstad, Hyunjoo,Hwang, Joonsung,Lee, Kyung Ho,Ko, Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.2
<▼1><P>Hypoxia-inducible factor-1α (HIF-1α) mediates tumor cell adaptation to hypoxic conditions and is a potentially important anticancer therapeutic target. We previously developed a method for synthesizing a benzofuran-based natural product, (R)-(-)-moracin-O, and obtained a novel potent analog, MO-460 that suppresses the accumulation of HIF-1α in Hep3B cells. However, the molecular target and underlying mechanism of action of MO-460 remained unclear. In the current study, we identified heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) as a molecular target of MO-460. MO-460 inhibits the initiation of HIF-1α translation by binding to the C-terminal glycine-rich domain of hnRNPA2B1 and inhibiting its subsequent binding to the 3’-untranslated region of <I>HIF-1α</I> mRNA. Moreover, MO-460 suppresses HIF-1α protein synthesis under hypoxic conditions and induces the accumulation of stress granules. The data provided here suggest that hnRNPA2B1 serves as a crucial molecular target in hypoxia-induced tumor survival and thus offer an avenue for the development of novel anticancer therapies.</P></▼1><▼2><P><B>Cancer: How a plant metabolite analog suppresses tumor growth</B></P><P>A synthetic analog of a chemical found in fruit suppresses tumor growth by targeting an RNA-binding protein (hnRNPA2B1) and preventing the production of a pro-cancer regulatory factor. Nak-Kyun Soung from the Korea Research Institute of Bioscience and Biotechnology, Cheongju, South Korea, and coworkers built on their previous discovery that a compound derived from a medicinal plant metabolite can suppress the activity of hypoxia-inducible factor-1α (HIF-1α). This protein, which is involved in many aspects of cancer biology, is activated in the low-oxygen microenvironments found inside tumors. The researchers show that the compound binds to a protein that helps with the conversion of HIF-1α–encoding RNA transcripts into HIF-1α proteins. Liver cancer cells treated with the compound grew slowly and produced less HIF-1α under both normal and low-oxygen culture conditions, highlighting the potential of this anti-cancer strategy.</P></▼2>